Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator

Neurobiology of Disease

Volumn 5, Issue 3, 1998, Pages 177-187

  Bhagavan, Seetha ^a   Ibarreta, Dolores ^a   Ma, Dawei ^b   Kozikowski, Alan P ^a   Etcheberrigaray, René ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Alzheimer's disease; Calcium; Fibroblast; Protein kinase C; TEA

Indexed keywords

CALCIUM; ISOENZYME; LACTAM; POTASSIUM; POTASSIUM CHANNEL; PROTEIN KINASE C ACTIVATOR;

ALZHEIMER DISEASE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PATCH CLAMP; PRIORITY JOURNAL;

EID: 0031797871     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1998.0195     Document Type: Article

References (48)

1. + channels by cytoplasmic and membrane-associated C-kinase. J. Neurochem. 51, 903-917.
2. Baker, A. C., Ko, L.-W., & Blass, J. P. (1988) Systemic manifestations of Alzheimer's disease. Age 11, 60-65.
3. Bergamaschi, S., Binetti, G., Govoni, S., Wetsel, W. C., Battaini, F., Trabucchi, M., Bianchetti, A., & Racchi, M. (1995) Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci. Lett. 201, 1-4.
4. + channels in Alzheimer's disease. J. Psychiat. Res. 30, 217-227.
5. Buxbaum, J. D., Gandy, S. E., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Untrebeck, A. J., & Greengard, P. (1990) Processing of Alzheimer β/A4 amyloid precursor protein: Modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. USA 87, 6003-6006.
6. Cristofalo, V. J., & Carpentier, R. (1988) A standard procedure for cultivating human diploid fibroblastlike cells to study cellular aging. J. Tissue Cult. Methods 6, 171-211.
7. Cole, G., Dobkins, K. R., Hansen, L. A., Terry, R. D., & Saitoh, T. (1988) Decreased levels of protein kinase C in Alzheimer brain. Brain Res. 452, 165-174.
8. Covarrubias, M., Wei, A., Salkoff, L., & Vyas, T. B. (1994) Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. Neuron 13, 1403-1412.
9. Desdouits, F., Buxbaum, J. D., Desdouits-Magnen, J., Nairn, A. C., & Greengard, P. (1996) Amyloid β peptide formation in cell free preparations: Regulation by protein kinase C, calmodulin, and calcineurin. J. Biol. Chem. 271, 24670-24674.
10. Dunbar, B. S. (1994) Protein Blotting - A Practical Approach. Oxford Univ. Press, New York.
11. Efhimiopoulos, S., Punj, S., Manopoulos, V., Pangalos, M., Wang, G. P., Refolo, L. M., & Robakis, N. K. (1996) Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein. J. Neurochem. 67, 872-875.
12. Etcheberrigaray, R., Ito, E., Oka, K., Tofel-Grehl, B., Gibson, G. E., & Alkon, D. L. (1993) Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer's disease. Proc. Natl. Acad. Sci. USA 90, 8209-8213.
13. + channels. Science 264, 276-279.
14. Etcheberrigaray, R., & Alkon, D. L. (1997) Potassium channels and calcium release. In: Molecular Mechanisms of Dementia (W. Wasco & R. R. Tanzi, Eds.), pp. 239-252. Humana Press, Totowa, NJ.
15. Favit, A., Grimaldi, M., Nelson, T. J., & Alkon, D. L. (1997) PKC isoenzymes are differentially affected by low concentrations of soluble β-amyloid protein in Alzheimer's disease. Soc. Neurosci. Abstr. 23, 293a.
16. Fraser, S. P., Suh, Y.-H., & Djamgoz, M. B. A. (1997) Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments. Trends Neurosci. 20, 67-72.
17. Gandy, S., & Greengard, P. (1994) Processing of Alzheimer Aβ-amyloid precursor protein: Cell biology, regulation, and role in Alzheimer disease. Int. Rev. Neurobiol. 36, 29-50.
18. Gasparini, L., Racchi, M., Binetti, G., Trabucchi, M., Solerte, B., Alkon, D. L., Etcheberrigaray, R., Gibson, G., Blass, J., Paoletti, R., & Govoni, S. (1998) Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease. FASEB J. 12, 17-34.
19. Gillespie, S. L., Golde, T. E., & Younkin, S. G. (1992) Secretory processing of the Alzheimer β/A4 amyloid precursor is increased by protein phosphorylation. Biochem. Biophys. Res. Commun. 187, 1285-1290.
20. + current in rat hippocampal neurons. Biophys. J. 70, 296-304.
21. Govoni, S., Bergamaschi, S., Racchi, M., Battaini, F., Binetti, G., Bianchetti, A., & Trabucchi, M. (1993) Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients. Neurology 43, 2581-2586.
22. Govoni, S., Racchi, M., Bergamaschi, S., Trabucchi, M., Battaini, F., Bianchetti, A., & Binetti, G. (1996) Defective protein kinase C α leads to impaired secretion of soluble β-amyloid precursor protein from Alzheimer's disease fibroblasts. Ann. N. Y. Acad. Sci. 777, 332-337.
23. Hardy, J. (1997) Amyloid, the presinilins and Alzheimer's disease. Trends Neurosci. 20, 154-159.
24. Hirashima, N., Etcheberrigaray, R., Bergamaschi, S., Racchi, M., Battaini, F., Binetti, G., Govoni, S., & Alkon, D. L. (1996) Calcium responses in human fibroblasts: A diagnostic molecular profile for Alzheimer's disease. Neurobiol. Aging 17, 549-555.
25. Hofmann, J. (1997) The potential for isozyme selective modulation of protein kinase C. FASEB J. 11, 649-669.
26. + current in human rabbit ventricular myocytes. Circ. Res. 78, 492-498.
27. Huang, H.-M., Martins, R., Gandy, S., Etcheberrigaray, R., Ito, E., Alkon, D. L., Blass, J., & Gibson, G. (1994) Use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease. Ann. N. Y. Acad. Sci. 747, 225-243.
28. 125I]apamin binding sites in Alzheimer hippocampus: A quantitative autoradiographic study. Brain Res. 567, 51-56.
29. Kozikowski, A. P., Wang, S., Ma, D., Yao, J., Ahmad, S., Glazer, R. I., Bogi, K., Acs, P., Modarres, S., Lewin, N. E., & Blumberg, P. M. (1997) Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCδ and discovery of an ILV analogue of improved isozyme selectivity. J. Med. Chem. 40, 1316-1326.
30. Masliah, E., Cole, G., Shimohada, S., Hansen, L., DeTeresa, R., Terry, R. D., & Saitoh, T. (1990) Differential involvement of protein kinase C isozymes in Alzheimer's disease. J. Neurosci. 10, 2113-2124.
31. Masliah, E., Cole, G. M., Hansen, L. A., Mallory, M., Albright, Terry, R. D., & Saitoh, T. (1991) Protein kinase C is an early biochemical marker in Alzheimer's disease. J. Neurosci. 11, 2759-2767.
32. Motulksy, H. (1995) Intuitive Biostatistics. Oxford Univ. Press, New York.
33. National Institute of Aging. (1994) Catalog of Cell Lines.
34. Nee, L. E., Polinsky, R. J., Eldridge, R., Weingartner, H., Smallberg, S., & Ebert, M. (1983) A family with histologically confirmed Alzheimer's disease. Arch. Neurol. 40, 203-208.
35. Racchi, M., Bergamaschi, S., Govoni, S., Wetsel, W. C., Bianchetti, A., Binetti, G., Battaini, F., & Trabucchi, M. (1994) Characterization and distribution of protein kinase C isoforms in human skin fibroblasts. Arch. Biochem. Biophys. 314, 107-111.
36. Remington, R. D., & Schork, M. A. (1985) Statistics with Applications to the Biological and Health Sciences, 2nd ed. Prentice Hall Int., Englewood Cliffs, NJ.
37. Sakmann, B., & Neher, E. (1995) Single-Channel Recording, 2nd ed. Plenum, New York.
38. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D., & Younkin, S. (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
39. Scott, R. B. (1993) Extra neuronal manifestations of Alzheimer's disease. J. Am. Geriatr. Soc. 41, 268-276.
40. Selkoe, D. J. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
41. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.-F., Bruni, A. C., Montesi, M. P., Sorbi, S., Rainiero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R. J., Wasco, W., Da Silva, H. A. R., Haines, J. L., Pericak-Vance, M. A., Tanzi, R. E., Roses, A. D., Fraser, P. E., Rommens, J. M., & St. George-Hyslop, P. H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
42. Shimohama, S., Narita, M. A., Matsushima, H., Kimura, J., Kamejama, M., Hagiwara, M., Hidaka, H., & Taniguchi, T. (1993) Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology 43, 1407-1413.
43. St. George-Hyslop, P., Haines, J. L., Rogaev, E., Montilla, M., Vaula, G., Pericak-Vance, M., Foncin, J.-F., Montesi, M., Bruni, A., Sorbi, S., Rainiero, I., Pinessi, L., Pollen, D., Polinsky, R., Nee, L., Kennedy, J., Macciardi, F., Rogaeva, E., Liang, Y., Alexandrova, N., Lukiw, W., Schlumpf, K., Tanzi, R., Tsuda, T., Farrer, L., Cantu, J.-M., Duara, R., Amaducci, L., Bergamini, L., Gusella, J., Roses, A., & McLachlan, D. (1992) Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat. Genet. 2, 330-334.
44. Tanzi, R. E., Kovacs, D. M., Kim, T.-W., Moir, R. D., Guenette, S. Y., & Wasco, W. (1996) The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis. 3, 159-168.
45. Thomas, A. P., & Delaville, F. (1991) In: Cellular Calcium (J. G. McCormack & P. H. Cobbold, Eds.), pp. 1-54. IRL Press, Oxford.
46. Van Huynh, T., Cole, G., Katzman, R., Huang, K. P., & Saitoh, T. (1989) Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. Arch. Neurol. 46, 1195-1199.
47. Wang, H.-Y., Pisano, M. R., & Friedman, E. (1994) Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol. Aging 15, 293-298.
48. Yankner, B. (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932.