Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain

Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2003, Pages 237-243

  Zhuang, Zhi Ping ^a   Kung, Mei Ping ^a   Wilson, Alan ^b   Lee, Chi Wan ^a   Plössl, Karl ^a   Hou, Catherine ^a   Holtzman, David M ^c   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4' DIMETHYLAMINOPHENYL) 6 IODOBENZOTHIAZOLE; 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE; AMYLOID BETA PROTEIN; BENZOTHIAZOLE DERIVATIVE; DIRECT YELLOW 7; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; IODINE 123; IODINE 125; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; DIAGNOSTIC VALUE; DRUG BINDING; DRUG DISTRIBUTION; DRUG SELECTIVITY; DRUG UPTAKE; FLUORESCENCE; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; IMIDAZOLES; IODINE RADIOISOTOPES; LIGANDS; MALE; MICE; MICE, INBRED ICR; PYRIDINES; RADIOPHARMACEUTICALS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037448350     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020351j     Document Type: Article

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