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Volumn 34, Issue 8, 2003, Pages 969-986

Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency

Author keywords

Apoptosis; Free radicals; Metastasis; Nitric oxide; Nitric oxide synthase II; Therapy

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

EID: 0037446221     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01364-3     Document Type: Review
Times cited : (114)

References (215)
  • 1
    • 0025083071 scopus 로고
    • Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes Memorial Award Lecture
    • Fidler I.J. Critical factors in the biology of human cancer metastasis twenty-eighth G.H.A. Clowes Memorial Award Lecture . Cancer Res. 50:1990;6130-6138.
    • (1990) Cancer Res. , vol.50 , pp. 6130-6138
    • Fidler, I.J.1
  • 3
    • 0018369716 scopus 로고
    • Cancer metastasis: A product of tumor-host interactions
    • Sugarbaker E.V. Cancer metastasis a product of tumor-host interactions . Curr. Probl. Cancer. 3:1979;1-59.
    • (1979) Curr. Probl. Cancer , vol.3 , pp. 1-59
    • Sugarbaker, E.V.1
  • 5
    • 0023301838 scopus 로고
    • The biology of cancer metastasis and implications for therapy
    • Fidler I.J., Balch C.M. The biology of cancer metastasis and implications for therapy. Curr. Probl. Surg. 24:1987;137-209.
    • (1987) Curr. Probl. Surg. , vol.24 , pp. 137-209
    • Fidler, I.J.1    Balch, C.M.2
  • 6
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain R.K. Barriers to drug delivery in solid tumors. Sci. Am. 271:1994;58-65.
    • (1994) Sci. Am. , vol.271 , pp. 58-65
    • Jain, R.K.1
  • 7
    • 0023061971 scopus 로고
    • Biologic heterogeneity of cancer metastases
    • Fidler I.J. Biologic heterogeneity of cancer metastases. Breast Cancer Res. Treat. 9:1987;17-26.
    • (1987) Breast Cancer Res. Treat. , vol.9 , pp. 17-26
    • Fidler, I.J.1
  • 8
    • 0029411141 scopus 로고
    • Modulation of the organ microenvironment for the treatment of cancer metastasis
    • (Editorial)
    • Fidler I.J. Modulation of the organ microenvironment for the treatment of cancer metastasis. (Editorial) J. Natl. Cancer Inst. 84:1995;1588-1592.
    • (1995) J. Natl. Cancer Inst. , vol.84 , pp. 1588-1592
    • Fidler, I.J.1
  • 9
    • 0022480660 scopus 로고
    • Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements
    • Price J.E., Aukerman S.L., Fidler I.J. Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements. Cancer Res. 46:1986;5172-5178.
    • (1986) Cancer Res. , vol.46 , pp. 5172-5178
    • Price, J.E.1    Aukerman, S.L.2    Fidler, I.J.3
  • 10
    • 0022529711 scopus 로고
    • Different deficiencies in the prevention of tumorigenic-low metastatic murine K-1735 melanoma cells from producing metastases
    • Aukerman S.L., Price J.E., Fidler I.J. Different deficiencies in the prevention of tumorigenic-low metastatic murine K-1735 melanoma cells from producing metastases. J. Natl. Cancer Inst. 77:1986;915-924.
    • (1986) J. Natl. Cancer Inst. , vol.77 , pp. 915-924
    • Aukerman, S.L.1    Price, J.E.2    Fidler, I.J.3
  • 11
    • 0027333411 scopus 로고
    • Tumor cell interactions with the extracellular matrix during invasion and metastasis
    • Stetler-Stevenson W.G., Aznavoorian S., Liotta L.A. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu. Rev. Cell Biol. 9:1993;541-573.
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 541-573
    • Stetler-Stevenson, W.G.1    Aznavoorian, S.2    Liotta, L.A.3
  • 12
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors a review . Cancer Rev. 49:1989;6449-6465.
    • (1989) Cancer Rev. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 13
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy
    • Boucher Y., Baxter L.T., Jain R.K. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors implications for therapy . Cancer Res. 50:1990;4478-4484.
    • (1990) Cancer Res. , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 14
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • Liotta L.A., Kleinerman J., Saidel G.M. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res. 34:1974;997-1004.
    • (1974) Cancer Res. , vol.34 , pp. 997-1004
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 15
    • 0026425631 scopus 로고
    • Tumor invasion and metastasis: An imbalance of positive and negative regulation
    • Liotta L.A., Stetler-Stevenson W.G. Tumor invasion and metastasis an imbalance of positive and negative regulation . Cancer Res. 51:1991;5054s-5059s.
    • (1991) Cancer Res. , vol.51
    • Liotta, L.A.1    Stetler-Stevenson, W.G.2
  • 16
    • 0034243929 scopus 로고    scopus 로고
    • Experimental animal models for pancreatic cancer
    • Shi Q., Xie K. Experimental animal models for pancreatic cancer. Int. J. Oncol. 17:2000;217-225.
    • (2000) Int. J. Oncol. , vol.17 , pp. 217-225
    • Shi, Q.1    Xie, K.2
  • 18
    • 0026438280 scopus 로고
    • Biomechanical interactions of cancer cells with the microvasculature during hematogenous metastasis
    • Weiss L. Biomechanical interactions of cancer cells with the microvasculature during hematogenous metastasis. Cancer Metastasis Rev. 11:1992;227-235.
    • (1992) Cancer Metastasis Rev. , vol.11 , pp. 227-235
    • Weiss, L.1
  • 19
    • 0014865396 scopus 로고
    • 125I-5-iodo-2′-deoxyuridine
    • 125I-5-iodo-2′-deoxyuridine . J. Natl. Cancer Inst. 45:1970;773-782.
    • (1970) J. Natl. Cancer Inst. , vol.45 , pp. 773-782
    • Fidler, I.J.1
  • 20
    • 0022547699 scopus 로고
    • Intravascular death of disseminated cancer cells mediated by superoxide anion
    • Glaves D. Intravascular death of disseminated cancer cells mediated by superoxide anion. Invasion Metastasis. 6:1986;101-111.
    • (1986) Invasion Metastasis , vol.6 , pp. 101-111
    • Glaves, D.1
  • 22
    • 0031005838 scopus 로고    scopus 로고
    • Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression
    • Chishima T., Miyagi Y., Wang X., Yamaoka H., Shimada H., Moossa A.R., Hoffman R.M. Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res. 57:1997;2042-2047.
    • (1997) Cancer Res. , vol.57 , pp. 2042-2047
    • Chishima, T.1    Miyagi, Y.2    Wang, X.3    Yamaoka, H.4    Shimada, H.5    Moossa, A.R.6    Hoffman, R.M.7
  • 23
    • 0032799478 scopus 로고    scopus 로고
    • Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis
    • Naumov G.N., Wilson S.M., MacDonald I.C., Schmidt E.E., Morris V.L., Groom A.C., Hoffman R.M., Chambers A.F. Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis. J. Cell Sci. 112:1999;1835-1842.
    • (1999) J. Cell Sci. , vol.112 , pp. 1835-1842
    • Naumov, G.N.1    Wilson, S.M.2    MacDonald, I.C.3    Schmidt, E.E.4    Morris, V.L.5    Groom, A.C.6    Hoffman, R.M.7    Chambers, A.F.8
  • 24
    • 0034443811 scopus 로고    scopus 로고
    • Metastasis of cancer: A conceptual history from antiquity to the 1990s
    • Weiss L. Metastasis of cancer a conceptual history from antiquity to the 1990s . Cancer Metastasis Rev. 19:2000;I-XI. 193-383.
    • (2000) Cancer Metastasis Rev. , vol.19
    • Weiss, L.1
  • 25
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler I.J., Kripke M.L. Metastasis results from preexisting variant cells within a malignant tumor. Science. 197:1977;893-895.
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 26
    • 0025301851 scopus 로고
    • The cellular basis of site-specific tumor metastasis
    • Zetter B.R. The cellular basis of site-specific tumor metastasis. N. Engl. J. Med. 322:1990;605-612.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 605-612
    • Zetter, B.R.1
  • 27
    • 0019939323 scopus 로고
    • Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors
    • Talmadge J.E., Fidler I.J. Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors. J. Natl. Cancer Inst. 69:1982;975-980.
    • (1982) J. Natl. Cancer Inst. , vol.69 , pp. 975-980
    • Talmadge, J.E.1    Fidler, I.J.2
  • 28
    • 0017234894 scopus 로고
    • The significance of hematogenous tumor cell clumps in the metastatic process
    • Liotta L.A., Kleinerman J., Saidel G.M. The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res. 36:1976;889-894.
    • (1976) Cancer Res. , vol.36 , pp. 889-894
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 29
    • 0027496195 scopus 로고
    • Paracrine growth regulation of human colon carcinoma organ-specific metastasis
    • Radinsky R. Paracrine growth regulation of human colon carcinoma organ-specific metastasis. Cancer Metastasis Rev. 12:1993;345-361.
    • (1993) Cancer Metastasis Rev. , vol.12 , pp. 345-361
    • Radinsky, R.1
  • 30
    • 0000895228 scopus 로고
    • Deformability and viability of tumor cells by transcapillary passage with reference to organ affinity in metastasis in cancer
    • L. Weiss. Amsterdam: North-Holland
    • Sato H., Suzuki M. Deformability and viability of tumor cells by transcapillary passage with reference to organ affinity in metastasis in cancer. Weiss L. Fundamental aspects of metastasis. 1976;311-317 North-Holland, Amsterdam.
    • (1976) Fundamental Aspects of Metastasis , pp. 311-317
    • Sato, H.1    Suzuki, M.2
  • 31
    • 0015603212 scopus 로고
    • The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis
    • Fidler I.J. The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis. Eur. J. Cancer. 9:1973;223-227.
    • (1973) Eur. J. Cancer , vol.9 , pp. 223-227
    • Fidler, I.J.1
  • 32
    • 0026002788 scopus 로고
    • CD44 splice variants confer metastatic behavior in rats: Homologous sequences are expressed in human tumor cell lines
    • Hofmann M., Rudy W., Zoller M., Tolg C., Ponta H., Jerrlich P., Gunthert U. CD44 splice variants confer metastatic behavior in rats homologous sequences are expressed in human tumor cell lines . Cancer Res. 51:1991;5292-5297.
    • (1991) Cancer Res. , vol.51 , pp. 5292-5297
    • Hofmann, M.1    Rudy, W.2    Zoller, M.3    Tolg, C.4    Ponta, H.5    Jerrlich, P.6    Gunthert, U.7
  • 34
    • 0019820999 scopus 로고
    • Role of platelets in tumor cell metastasis
    • Karpatkin S., Pearlstein E. Role of platelets in tumor cell metastasis. Ann. Intern. Med. 95:1981;636-674.
    • (1981) Ann. Intern. Med. , vol.95 , pp. 636-674
    • Karpatkin, S.1    Pearlstein, E.2
  • 35
    • 0021118858 scopus 로고
    • Role of plasma, platelets and endothelial cells in tumor metastasis
    • Gasic G.J. Role of plasma, platelets and endothelial cells in tumor metastasis. Cancer Metastasis Rev. 3:1984;99-105.
    • (1984) Cancer Metastasis Rev. , vol.3 , pp. 99-105
    • Gasic, G.J.1
  • 36
    • 0017665469 scopus 로고
    • Mechanism of tumor cell resistance to lysis by syngeneic lymphocytes
    • Fidler I.J., Bucana C. Mechanism of tumor cell resistance to lysis by syngeneic lymphocytes. Cancer Res. 37:1977;3945-3956.
    • (1977) Cancer Res. , vol.37 , pp. 3945-3956
    • Fidler, I.J.1    Bucana, C.2
  • 37
    • 0018630986 scopus 로고
    • Immune-mediated arrest and reversal of established visceral metastasis in athymic mice
    • Wiltrout R.H., Frost P., Morrison M.K., Kerbel R.S. Immune-mediated arrest and reversal of established visceral metastasis in athymic mice. Cancer Res. 39:1979;4034-4039.
    • (1979) Cancer Res. , vol.39 , pp. 4034-4039
    • Wiltrout, R.H.1    Frost, P.2    Morrison, M.K.3    Kerbel, R.S.4
  • 38
    • 0018869534 scopus 로고
    • The role of natural killer cells in the destruction of circulating tumor emboli
    • Hanna N., Fidler I.J. The role of natural killer cells in the destruction of circulating tumor emboli. J. Natl. Cancer Inst. 65:1980;801-809.
    • (1980) J. Natl. Cancer Inst. , vol.65 , pp. 801-809
    • Hanna, N.1    Fidler, I.J.2
  • 40
    • 0025860655 scopus 로고
    • Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells
    • Li L., Kilbourn R.G., Adams J., Fidler I.J. Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res. 51:1991;2531-2535.
    • (1991) Cancer Res. , vol.51 , pp. 2531-2535
    • Li, L.1    Kilbourn, R.G.2    Adams, J.3    Fidler, I.J.4
  • 41
    • 0026069593 scopus 로고
    • Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells
    • Li L., Nicolson G.L., Fidler I.J. Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells. Cancer Res. 51:1991;245-254.
    • (1991) Cancer Res. , vol.51 , pp. 245-254
    • Li, L.1    Nicolson, G.L.2    Fidler, I.J.3
  • 42
    • 0022357902 scopus 로고
    • Macrophages and metastasis - A biological approach to cancer therapy: Presidential address
    • Fidler I.J. Macrophages and metastasis - a biological approach to cancer therapy presidential address . Cancer Res. 45:1985;4714-4721.
    • (1985) Cancer Res. , vol.45 , pp. 4714-4721
    • Fidler, I.J.1
  • 43
    • 0027537341 scopus 로고
    • Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity
    • Dong Z., O'Brian C.A., Fidler I.J. Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity. J. Leukoc. Biol. 53:1993;53-60.
    • (1993) J. Leukoc. Biol. , vol.53 , pp. 53-60
    • Dong, Z.1    O'Brian, C.A.2    Fidler, I.J.3
  • 44
    • 0026654619 scopus 로고
    • Early steps in hematogenous metastasis of B16F1 melanoma cells in chick embryos studied by high-resolution intravital videomicroscopy
    • Chambers A.F., Schmidt E.E., MacDonald I.C., Morris V.L., Groom A.C. Early steps in hematogenous metastasis of B16F1 melanoma cells in chick embryos studied by high-resolution intravital videomicroscopy. J. Natl. Cancer Inst. 84:1992;797-803.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 797-803
    • Chambers, A.F.1    Schmidt, E.E.2    MacDonald, I.C.3    Morris, V.L.4    Groom, A.C.5
  • 45
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi K.J., MacDonald I.C., Schmidt E.E., Kerkvliet N., Morris V.L., Chambers A.F., Groom A.C. Multistep nature of metastatic inefficiency dormancy of solitary cells after successful extravasation and limited survival of early micrometastases . Am. J. Pathol. 153:1998;865-873.
    • (1998) Am. J. Pathol. , vol.153 , pp. 865-873
    • Luzzi, K.J.1    MacDonald, I.C.2    Schmidt, E.E.3    Kerkvliet, N.4    Morris, V.L.5    Chambers, A.F.6    Groom, A.C.7
  • 46
    • 0031046848 scopus 로고    scopus 로고
    • Apoptosis and disease: Regulation and clinical relevance of programmed cell death
    • Rudin C.M., Thompson C.B. Apoptosis and disease regulation and clinical relevance of programmed cell death . Annu. Rev. Med. 48:1997;267-281.
    • (1997) Annu. Rev. Med. , vol.48 , pp. 267-281
    • Rudin, C.M.1    Thompson, C.B.2
  • 47
    • 0027172322 scopus 로고
    • Molecular regulation of apoptosis: Genetic controls on cell death
    • Williams G.T., Smith C.A. Molecular regulation of apoptosis genetic controls on cell death . Cell. 74:1993;777-779.
    • (1993) Cell , vol.74 , pp. 777-779
    • Williams, G.T.1    Smith, C.A.2
  • 48
    • 0032436412 scopus 로고    scopus 로고
    • The CD95(APO-1/Fas)/CD95L system
    • Krammer P.H. The CD95(APO-1/Fas)/CD95L system. Toxicol. Lett. 102-103:1998;131-137.
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 131-137
    • Krammer, P.H.1
  • 49
    • 0032877668 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in cancer
    • Reed J.C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 17:1999;2941-2953.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2941-2953
    • Reed, J.C.1
  • 51
    • 0027231742 scopus 로고
    • Nitric oxide-mediated apoptosis in murine peritoneal macrophages
    • Albina J.E., Cui S., Mateo R.B., Reichner J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol. 150:1993;5080-5085.
    • (1993) J. Immunol. , vol.150 , pp. 5080-5085
    • Albina, J.E.1    Cui, S.2    Mateo, R.B.3    Reichner, J.S.4
  • 53
    • 0001826912 scopus 로고
    • TNF-mediated cytotoxicity in sensitive and resistant L929 fibroblasts correlates with nitric oxide-independent and -dependent mechanisms, respectively
    • Xie K., Fidler I.J. TNF-mediated cytotoxicity in sensitive and resistant L929 fibroblasts correlates with nitric oxide-independent and -dependent mechanisms, respectively. J. Leukoc. Biol. 3:(Suppl.):1992;45.
    • (1992) J. Leukoc. Biol. , vol.3 , Issue.SUPPL. , pp. 45
    • Xie, K.1    Fidler, I.J.2
  • 54
    • 0027376463 scopus 로고
    • Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric oxide
    • Xie K., Huang S., Dong Z., Fidler I.J. Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric oxide. Int. J. Oncol. 3:1993;1043-1047.
    • (1993) Int. J. Oncol. , vol.3 , pp. 1043-1047
    • Xie, K.1    Huang, S.2    Dong, Z.3    Fidler, I.J.4
  • 57
    • 0028302827 scopus 로고
    • Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms
    • Cui S., Reichner J.S., Mateo R.B., Albina J.E. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res. 54:1994;2462-2467.
    • (1994) Cancer Res. , vol.54 , pp. 2462-2467
    • Cui, S.1    Reichner, J.S.2    Mateo, R.B.3    Albina, J.E.4
  • 58
    • 0028179849 scopus 로고
    • Interleukin-1 β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells
    • Ankarcrona M., Dypbukt J.M., Brune B., Nicotera P. Interleukin-1 β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp. Cell Res. 213:1994;172-177.
    • (1994) Exp. Cell Res. , vol.213 , pp. 172-177
    • Ankarcrona, M.1    Dypbukt, J.M.2    Brune, B.3    Nicotera, P.4
  • 59
    • 0028982354 scopus 로고
    • Interleukin-1β suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production
    • 3120-2127
    • Chun S.Y., Eisenhauer K.M., Kubo M., Hsueh A.J. Interleukin-1β suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production. Endocrinology. 136:1995;. 3120-2127.
    • (1995) Endocrinology , vol.136
    • Chun, S.Y.1    Eisenhauer, K.M.2    Kubo, M.3    Hsueh, A.J.4
  • 60
    • 0030000690 scopus 로고    scopus 로고
    • DNA strand breakage, activation of poly (ADP-ribose)synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
    • Szabo C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage, activation of poly (ADP-ribose)synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA. 93:1996;1753-1758.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1753-1758
    • Szabo, C.1    Zingarelli, B.2    O'Connor, M.3    Salzman, A.L.4
  • 62
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures . Proc. Natl. Acad. Sci. USA. 92:1995;7162-7166.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Krainc, D.2    Ankarcrona, M.3    Nicotera, P.4    Lipton, S.A.5
  • 63
    • 0026629902 scopus 로고
    • Nitric oxide as a secretory product of mammalian cells
    • Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
    • (1992) FASEB J. , vol.6 , pp. 3051-3064
    • Nathan, C.1
  • 64
    • 0027325255 scopus 로고
    • Nitric oxide synthase structure and mechanism
    • Marletta M.A. Nitric oxide synthase structure and mechanism. J. Biol. Chem. 268:1993;12231-12234.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12231-12234
    • Marletta, M.A.1
  • 66
    • 0032957595 scopus 로고    scopus 로고
    • Nitric oxide: Discovery and impact on clinical medicine
    • Moncada S. Nitric oxide discovery and impact on clinical medicine . J. R. Soc. Med. 92:1999;164-169.
    • (1999) J. R. Soc. Med. , vol.92 , pp. 164-169
    • Moncada, S.1
  • 67
    • 0023505509 scopus 로고
    • Endothelial-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro L.J., Buga G.M., Wood K.S., Byrns R.E., Chaudhuri G. Endothelial-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA. 84:1987;9265-9269.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 68
    • 0023092102 scopus 로고
    • Macrophage cytotoxicity: Role for L-arginine deiminase activity and amino nitrogen to nitrate
    • Hibbs J.B. Jr, Taintor R.R., Vavrin Z. Macrophage cytotoxicity role for L-arginine deiminase activity and amino nitrogen to nitrate . Science. 235:1987;473-476.
    • (1987) Science , vol.235 , pp. 473-476
    • Hibbs J.B., Jr.1    Taintor, R.R.2    Vavrin, Z.3
  • 69
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases structure, function and inhibition . Biochem. J. 357:2001;593-615.
    • (2001) Biochem. J. , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 71
    • 0028106830 scopus 로고
    • Role of interferon regulatory factor 1 in induction of nitric oxide synthase
    • Martin E., Nathan C., Xie Q.W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:1994;977-984.
    • (1994) J. Exp. Med. , vol.180 , pp. 977-984
    • Martin, E.1    Nathan, C.2    Xie, Q.W.3
  • 72
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie Q.W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:1994;4705-4708.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4705-4708
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 73
    • 0028238576 scopus 로고
    • Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells
    • Adcock I.M., Brown C.R., Kwon O., Barnes P.J. Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells. Biochem. Biophys. Res. Commun. 199:1994;1518-1524.
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , pp. 1518-1524
    • Adcock, I.M.1    Brown, C.R.2    Kwon, O.3    Barnes, P.J.4
  • 74
    • 0027203305 scopus 로고
    • Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta
    • Vodovotz Y., Bogdan C., Paik J., Xie Q.W., Nathan C. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J. Exp. Med. 178:1993;605-613.
    • (1993) J. Exp. Med. , vol.178 , pp. 605-613
    • Vodovotz, Y.1    Bogdan, C.2    Paik, J.3    Xie, Q.W.4    Nathan, C.5
  • 75
    • 0029941097 scopus 로고    scopus 로고
    • Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: Evidence for tissue specificity
    • Kolyada A.Y., Savikovsky N., Madias N.E. Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages evidence for tissue specificity . Biochem. Biophys. Res. Commun. 220:1996;600-605.
    • (1996) Biochem. Biophys. Res. Commun. , vol.220 , pp. 600-605
    • Kolyada, A.Y.1    Savikovsky, N.2    Madias, N.E.3
  • 76
    • 0029938522 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase gene for inhibition of cancer metastasis
    • Xie K., Dong Z., Fidler I.J. Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J. Leukoc. Biol. 59:1996;797-803.
    • (1996) J. Leukoc. Biol. , vol.59 , pp. 797-803
    • Xie, K.1    Dong, Z.2    Fidler, I.J.3
  • 77
    • 0031949941 scopus 로고    scopus 로고
    • Gene therapy with the inducible nitric oxide synthase for induction of apoptosis to control tumor growth and metastasis
    • Xie K., Fidler I.J. Gene therapy with the inducible nitric oxide synthase for induction of apoptosis to control tumor growth and metastasis. Cancer Metastasis Rev. 17:1998;55-75.
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 55-75
    • Xie, K.1    Fidler, I.J.2
  • 78
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G., Musso T., Sica A., Taylor L.S., Cox G.W., Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182:1995;1683-1693.
    • (1995) J. Exp. Med. , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 79
    • 0032570596 scopus 로고    scopus 로고
    • Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation
    • Bellocq A., Suberville S., Philippe C., Bertrand F., Perez J., Fouqueray B., Cherqui G., Baud L. Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation. J. Biol. Chem. 273:1998;5086-5092.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5086-5092
    • Bellocq, A.1    Suberville, S.2    Philippe, C.3    Bertrand, F.4    Perez, J.5    Fouqueray, B.6    Cherqui, G.7    Baud, L.8
  • 80
    • 0035893981 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia
    • Lacza Z., Puskar M., Figueroa J.P., Zhang J., Rajapakse N., Busija D.W. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia. Free Radic. Biol. Med. 31:2001;1609-1615.
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 1609-1615
    • Lacza, Z.1    Puskar, M.2    Figueroa, J.P.3    Zhang, J.4    Rajapakse, N.5    Busija, D.W.6
  • 81
    • 0027958098 scopus 로고
    • Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells
    • Dong Z., Staroselsky A.H., Qi X., Xie K., Fidler I.J. Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res. 54:1994;789-793.
    • (1994) Cancer Res. , vol.54 , pp. 789-793
    • Dong, Z.1    Staroselsky, A.H.2    Qi, X.3    Xie, K.4    Fidler, I.J.5
  • 82
    • 0030864875 scopus 로고    scopus 로고
    • Nitric oxide-mediated apoptosis of K-1735 murine melanma cells is associated with down-regulation of Bcl-2
    • Xie K., Wang Y., Huang S., Xu L., Bielenberg D., Salas T., McConkey D.J., Jiang W., Fidler I.J. Nitric oxide-mediated apoptosis of K-1735 murine melanma cells is associated with down-regulation of Bcl-2. Oncogene. 15:1997;771-779.
    • (1997) Oncogene , vol.15 , pp. 771-779
    • Xie, K.1    Wang, Y.2    Huang, S.3    Xu, L.4    Bielenberg, D.5    Salas, T.6    McConkey, D.J.7    Jiang, W.8    Fidler, I.J.9
  • 83
    • 0033135593 scopus 로고    scopus 로고
    • Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53
    • Shi Q., Huang S., Jiang W., Kutach L.S., Ananthaswamy H.N., Xie K. Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53. Cancer Res. 59:1999;2072-2075.
    • (1999) Cancer Res. , vol.59 , pp. 2072-2075
    • Shi, Q.1    Huang, S.2    Jiang, W.3    Kutach, L.S.4    Ananthaswamy, H.N.5    Xie, K.6
  • 85
    • 0034657272 scopus 로고    scopus 로고
    • Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis
    • Shi Q., Xiong Q., Wang B., Le X., Khan N.A., Xie K. Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. Cancer Res. 60:2000;2579-2583.
    • (2000) Cancer Res. , vol.60 , pp. 2579-2583
    • Shi, Q.1    Xiong, Q.2    Wang, B.3    Le, X.4    Khan, N.A.5    Xie, K.6
  • 86
    • 0035132925 scopus 로고    scopus 로고
    • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma
    • Wang B., Xiong Q., Shi Q., Le X., Abbruzzese J.L., Xie K. Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. Cancer Res. 61:2001;71-75.
    • (2001) Cancer Res. , vol.61 , pp. 71-75
    • Wang, B.1    Xiong, Q.2    Shi, Q.3    Le, X.4    Abbruzzese, J.L.5    Xie, K.6
  • 87
    • 0035909513 scopus 로고    scopus 로고
    • Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase
    • Wang B., Xiong Q., Shi Q., Le X., Xie K. Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase. Oncogene. 20:2001;6930-6937.
    • (2001) Oncogene , vol.20 , pp. 6930-6937
    • Wang, B.1    Xiong, Q.2    Shi, Q.3    Le, X.4    Xie, K.5
  • 88
    • 0035284055 scopus 로고    scopus 로고
    • Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion
    • Wang B., Xiong Q., Shi Q., Tan D., Le X., Xie K. Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion. Int. J. Cancer. 91:2001;607-611.
    • (2001) Int. J. Cancer , vol.91 , pp. 607-611
    • Wang, B.1    Xiong, Q.2    Shi, Q.3    Tan, D.4    Le, X.5    Xie, K.6
  • 89
    • 0028035106 scopus 로고
    • The high-output nitric oxide pathway: Role and regulation
    • Xie Q., Nathan C. The high-output nitric oxide pathway role and regulation . J. Leukoc. Biol. 56:1994;576-582.
    • (1994) J. Leukoc. Biol. , vol.56 , pp. 576-582
    • Xie, Q.1    Nathan, C.2
  • 92
    • 0032484562 scopus 로고    scopus 로고
    • Increase in experimental pulmonary metastasis in mice by L-arginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester
    • Yamamoto T., Terada N., Seiyama A., Nishizawa Y., Akedo H., Kosaka H. Increase in experimental pulmonary metastasis in mice by L-arginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester. Int. J. Cancer. 75:1998;140-144.
    • (1998) Int. J. Cancer , vol.75 , pp. 140-144
    • Yamamoto, T.1    Terada, N.2    Seiyama, A.3    Nishizawa, Y.4    Akedo, H.5    Kosaka, H.6
  • 94
    • 0035917613 scopus 로고    scopus 로고
    • Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
    • Berge D.L., Ridder M.D., Verovski V.N., Janssens M.Y., Monsaert C., Storme G.A. Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase. Br. J. Cancer. 84:2001;1122-1125.
    • (2001) Br. J. Cancer , vol.84 , pp. 1122-1125
    • Berge, D.L.1    Ridder, M.D.2    Verovski, V.N.3    Janssens, M.Y.4    Monsaert, C.5    Storme, G.A.6
  • 95
    • 0035328635 scopus 로고    scopus 로고
    • Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis
    • Tendler D.S., Bao C., Wang T., Huang E.L., Ratovitski E.A., Pardoll D.A., Lowenstein C.J. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 61:2001;3682-3688.
    • (2001) Cancer Res. , vol.61 , pp. 3682-3688
    • Tendler, D.S.1    Bao, C.2    Wang, T.3    Huang, E.L.4    Ratovitski, E.A.5    Pardoll, D.A.6    Lowenstein, C.J.7
  • 96
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1989;1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 97
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger D.R., Galli S.J., Dvorak A.M., Perruzzi C.A., Harvey V.S., Dvorak H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 219:1983;983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 98
    • 0035872399 scopus 로고    scopus 로고
    • Constitutive sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma
    • Shi Q., Le X., Peng Z., Tang H., Xiong Q., Wang B., Li X.-C., Abbruzzese J.L., Xie K. Constitutive sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res. 61:2001;4143-4154.
    • (2001) Cancer Res. , vol.61 , pp. 4143-4154
    • Shi, Q.1    Le, X.2    Peng, Z.3    Tang, H.4    Xiong, Q.5    Wang, B.6    Li, X.-C.7    Abbruzzese, J.L.8    Xie, K.9
  • 99
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • Shi Q., Le X., Wang B., Abbruzzese J.L., Xiong Q., He Y., Xie K. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene. 20:2001;3751-3756.
    • (2001) Oncogene , vol.20 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 100
    • 0030889934 scopus 로고    scopus 로고
    • Metabolic and clonogenic consequences of ischaemia reperfusion insult in solid tumours
    • Parkins C.S., Hill S.A., Stratford M.R., Dennis M.F., Chaplin D.J. Metabolic and clonogenic consequences of ischaemia reperfusion insult in solid tumours. Exp. Physiol. 82:1997;361-368.
    • (1997) Exp. Physiol. , vol.82 , pp. 361-368
    • Parkins, C.S.1    Hill, S.A.2    Stratford, M.R.3    Dennis, M.F.4    Chaplin, D.J.5
  • 101
    • 0024950154 scopus 로고
    • Free-radical pathology and medicine. A review
    • Dormandy T.L. Free-radical pathology and medicine. A review. J. R. Coll. Physicians Lond. 23:1989;221-227.
    • (1989) J. R. Coll. Physicians Lond. , vol.23 , pp. 221-227
    • Dormandy, T.L.1
  • 102
    • 0027408080 scopus 로고
    • Free radicals as mediators of tissue injury and disease
    • Kehrer J.P. Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol. 23:1993;21-48.
    • (1993) Crit. Rev. Toxicol. , vol.23 , pp. 21-48
    • Kehrer, J.P.1
  • 103
    • 0029900905 scopus 로고    scopus 로고
    • Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
    • 6770-6704
    • Xia Y., Dawson V.L., Dawson T.M., Snyder S.H., Zweier J.L. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc. Natl. Acad. Sci. USA. 93:1996;. 6770-6704.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93
    • Xia, Y.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4    Zweier, J.L.5
  • 104
    • 0028856579 scopus 로고
    • Liver endothelial cells participate in T-cell-dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo
    • Rocha M., Kruger A., Van Rooijen N., Schirrmacher V., Umansky V. Liver endothelial cells participate in T-cell-dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo. Int. J. Cancer. 63:1995;405-411.
    • (1995) Int. J. Cancer , vol.63 , pp. 405-411
    • Rocha, M.1    Kruger, A.2    Van Rooijen, N.3    Schirrmacher, V.4    Umansky, V.5
  • 105
    • 0032054970 scopus 로고    scopus 로고
    • Role of nitric oxide and superoxide anion in elimination of low metastatic human colorectal carcinomas by unstimulated hepatic sinusoidal endothelial cells
    • Edmiston K.H., Shoji Y., Mizoi T., Ford R., Nachman A., Jessup J.M. Role of nitric oxide and superoxide anion in elimination of low metastatic human colorectal carcinomas by unstimulated hepatic sinusoidal endothelial cells. Cancer Res. 58:1998;1524-1531.
    • (1998) Cancer Res. , vol.58 , pp. 1524-1531
    • Edmiston, K.H.1    Shoji, Y.2    Mizoi, T.3    Ford, R.4    Nachman, A.5    Jessup, J.M.6
  • 106
    • 0034667417 scopus 로고    scopus 로고
    • B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal cytotoxicity: A natural hepatic defense against metastasis
    • Wang H.H., McIntosh A.R., Hasinoff B.B., Rector E.S., Ahmed N., Nance D.M., Orr F.W. B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal cytotoxicity a natural hepatic defense against metastasis . Cancer Res. 60:2000;5862-5869.
    • (2000) Cancer Res. , vol.60 , pp. 5862-5869
    • Wang, H.H.1    McIntosh, A.R.2    Hasinoff, B.B.3    Rector, E.S.4    Ahmed, N.5    Nance, D.M.6    Orr, F.W.7
  • 107
    • 0027325770 scopus 로고
    • Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccride-responsive and lipopolysaccride-nonresponsive murine macrophages
    • Dong Z., Qi X., Xie K., Fidler I.J. Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccride-responsive and lipopolysaccride-nonresponsive murine macrophages. J. Immunol. 151:1993;2717-2724.
    • (1993) J. Immunol. , vol.151 , pp. 2717-2724
    • Dong, Z.1    Qi, X.2    Xie, K.3    Fidler, I.J.4
  • 108
    • 0029594582 scopus 로고
    • Activation of inducible nitric oxide synthase in the murine macrophages by interferon-gamma and lipopolysacchride required protein phosphatase I and protein phosphatase 2A activities
    • Dong Z., Yang X., Xie K., Juang S.-H., Llansa N., Fidler I.J. Activation of inducible nitric oxide synthase in the murine macrophages by interferon-gamma and lipopolysacchride required protein phosphatase I and protein phosphatase 2A activities. J. Leukoc. Biol. 58:1995;725-732.
    • (1995) J. Leukoc. Biol. , vol.58 , pp. 725-732
    • Dong, Z.1    Yang, X.2    Xie, K.3    Juang, S.-H.4    Llansa, N.5    Fidler, I.J.6
  • 109
    • 0034959722 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in tumor cells
    • Umansky V., Schirrmacher V. Nitric oxide-induced apoptosis in tumor cells. Adv. Cancer Res. 82:2001;107-131.
    • (2001) Adv. Cancer Res. , vol.82 , pp. 107-131
    • Umansky, V.1    Schirrmacher, V.2
  • 111
    • 0029016170 scopus 로고
    • Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362
    • Xie K., Huang S., Dong Z., Gutman M., Fidler I.J. Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362. Cancer Res. 55:1995;3123-3131.
    • (1995) Cancer Res. , vol.55 , pp. 3123-3131
    • Xie, K.1    Huang, S.2    Dong, Z.3    Gutman, M.4    Fidler, I.J.5
  • 112
    • 0026336186 scopus 로고
    • Human colorectal adenocarcinoma cells: Differential nitric oxide synthesis determines their ability to aggregate platelets
    • Radomski M.K., Jenkins D.C., Holmes L., Moncada S. Human colorectal adenocarcinoma cells differential nitric oxide synthesis determines their ability to aggregate platelets . Cancer Res. 51:1991;6073-6077.
    • (1991) Cancer Res. , vol.51 , pp. 6073-6077
    • Radomski, M.K.1    Jenkins, D.C.2    Holmes, L.3    Moncada, S.4
  • 113
    • 0018702002 scopus 로고
    • Speculations on the role of ultraviolet radiation in the development of malignant melanoma
    • Kripke M.L. Speculations on the role of ultraviolet radiation in the development of malignant melanoma. J. Natl. Cancer Inst. 63:1979;541-545.
    • (1979) J. Natl. Cancer Inst. , vol.63 , pp. 541-545
    • Kripke, M.L.1
  • 114
    • 0019787737 scopus 로고
    • Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin
    • Fidler I.J., Gruys E., Cifone M.A., Barnes Z., Bucana C.D. Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin. J. Natl. Cancer Inst. 67:1981;947-956.
    • (1981) J. Natl. Cancer Inst. , vol.67 , pp. 947-956
    • Fidler, I.J.1    Gruys, E.2    Cifone, M.A.3    Barnes, Z.4    Bucana, C.D.5
  • 115
    • 0026317633 scopus 로고
    • Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma
    • Staroselsky A.H., Pathak S., Chernajovsky Y., Tucker S.I., Fidler I.J. Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma. Cancer Res. 51:1991;6292-6297.
    • (1991) Cancer Res. , vol.51 , pp. 6292-6297
    • Staroselsky, A.H.1    Pathak, S.2    Chernajovsky, Y.3    Tucker, S.I.4    Fidler, I.J.5
  • 116
    • 0031950475 scopus 로고    scopus 로고
    • Nonactivated macrophage-induced nitric oxide production by tumor cells differing in tumorigenic and spontaneous metastatic activities
    • Burdelya L.G., Grosheva I.A., Dyakova N.A., Deichman G.I. Nonactivated macrophage-induced nitric oxide production by tumor cells differing in tumorigenic and spontaneous metastatic activities. Tumour Biol. 19:1998;346-355.
    • (1998) Tumour Biol. , vol.19 , pp. 346-355
    • Burdelya, L.G.1    Grosheva, I.A.2    Dyakova, N.A.3    Deichman, G.I.4
  • 117
    • 0028929559 scopus 로고
    • Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis in K-1735 murine melanoma cells
    • Xie K., Huang S., Dong Z., Juang S.-H., Gutman M., Xie Q.-W., Nathan C., Fidler I.J. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis in K-1735 murine melanoma cells. J. Exp. Med. 181:1995;1333-1343.
    • (1995) J. Exp. Med. , vol.181 , pp. 1333-1343
    • Xie, K.1    Huang, S.2    Dong, Z.3    Juang, S.-H.4    Gutman, M.5    Xie, Q.-W.6    Nathan, C.7    Fidler, I.J.8
  • 118
    • 0035207172 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptors: Apeutic target in solid tumors
    • George D. Platelet-derived growth factor receptors apeutic target in solid tumors . Semin. Oncol. 28:2001;27-33.
    • (2001) Semin. Oncol. , vol.28 , pp. 27-33
    • George, D.1
  • 119
    • 0025366847 scopus 로고
    • An L-arginine/nitric oxide pathway present in human platelets regulates aggregation
    • Radomski M.W., Palmer R.M.J., Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. USA. 87:1990;5193-5197.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5193-5197
    • Radomski, M.W.1    Palmer, R.M.J.2    Moncada, S.3
  • 120
    • 0022628504 scopus 로고
    • Tumor-induced platelet aggregation and growth promoting factors as determinants for successful tumor metastasis
    • Tsuruo T., Kawabata H., Iida H., Yomori T. Tumor-induced platelet aggregation and growth promoting factors as determinants for successful tumor metastasis. Clin. Exp. Metastasis. 7:1986;25-29.
    • (1986) Clin. Exp. Metastasis , vol.7 , pp. 25-29
    • Tsuruo, T.1    Kawabata, H.2    Iida, H.3    Yomori, T.4
  • 121
    • 0026336186 scopus 로고
    • Human colorectal adenocarcinoma cells: Differential nitric oxide synthesis determines their ability to aggregate platelets
    • Radomski M.W., Jenkins D.C., Holmes L., Moncada S. Human colorectal adenocarcinoma cells differential nitric oxide synthesis determines their ability to aggregate platelets . Cancer Res. 51:1991;6073-6078.
    • (1991) Cancer Res. , vol.51 , pp. 6073-6078
    • Radomski, M.W.1    Jenkins, D.C.2    Holmes, L.3    Moncada, S.4
  • 122
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelial-derived relaxing factor
    • Palmer R.M.J., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelial-derived relaxing factor. Nature. 327:1987;524-526.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.J.1    Ferrige, A.G.2    Moncada, S.3
  • 123
    • 0001510164 scopus 로고
    • Biology of tumor metastases
    • Hart I.R., Saini A. Biology of tumor metastases. Lancet. 339:1992;1437-1453.
    • (1992) Lancet , vol.339 , pp. 1437-1453
    • Hart, I.R.1    Saini, A.2
  • 124
    • 0029903717 scopus 로고    scopus 로고
    • Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules
    • Kong L., Dunn G.D., Keefer L.K., Korthuis R.J. Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules. Clin. Exp. Metastasis. 14:1996;335-343.
    • (1996) Clin. Exp. Metastasis , vol.14 , pp. 335-343
    • Kong, L.1    Dunn, G.D.2    Keefer, L.K.3    Korthuis, R.J.4
  • 125
    • 0029159779 scopus 로고
    • Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
    • De Caterina R., Libby P., Peng H.B., Thannickal V.J., Rajavashisth T.B., Gimbrone M.A. Jr, Shin W.S., Liao J.K. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96:1995;60-68.
    • (1995) J. Clin. Invest. , vol.96 , pp. 60-68
    • De Caterina, R.1    Libby, P.2    Peng, H.B.3    Thannickal, V.J.4    Rajavashisth, T.B.5    Gimbrone M.A., Jr.6    Shin, W.S.7    Liao, J.K.8
  • 126
    • 0029997906 scopus 로고    scopus 로고
    • Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. The role of constitutive NF-kappa B activity
    • Shin W.S., Hong Y.H., Peng H.B., De Caterina R., Libby P., Liao J.K. Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. The role of constitutive NF-kappa B activity. J. Biol. Chem. 271:1996;11317-11324.
    • (1996) J. Biol. Chem. , vol.271 , pp. 11317-11324
    • Shin, W.S.1    Hong, Y.H.2    Peng, H.B.3    De Caterina, R.4    Libby, P.5    Liao, J.K.6
  • 127
    • 0027458804 scopus 로고
    • Nitric oxide from polymorphonuclear leukocytes modulates red blood cell deformability in vitro
    • Korbut R., Gryglewski R.J. Nitric oxide from polymorphonuclear leukocytes modulates red blood cell deformability in vitro. Eur. J. Pharmacol. 234:1993;17-22.
    • (1993) Eur. J. Pharmacol. , vol.234 , pp. 17-22
    • Korbut, R.1    Gryglewski, R.J.2
  • 129
    • 0028820014 scopus 로고
    • Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouse
    • Perretti M., Szabo C., Thiemermann C. Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouse. Br. J. Pharmacol. 116:1995;2251-2257.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2251-2257
    • Perretti, M.1    Szabo, C.2    Thiemermann, C.3
  • 131
    • 0000270743 scopus 로고    scopus 로고
    • Decreased matrix metalloproteinase-2 (MMP-2) expression correlates with suppressin of tumorigenicity and metastasis of K-1735 murine melanoma cells transfected with the inducible nitric oxide synthase (iNOS) gene
    • Xie K., Fidler I.J. Decreased matrix metalloproteinase-2 (MMP-2) expression correlates with suppressin of tumorigenicity and metastasis of K-1735 murine melanoma cells transfected with the inducible nitric oxide synthase (iNOS) gene. Proc. Am. Assoc. Cancer Res. 38:1999;1113.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 1113
    • Xie, K.1    Fidler, I.J.2
  • 132
    • 0026441233 scopus 로고
    • Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation
    • Nunokawa Y., Tanaka S. Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation. Biochem. Biophys. Res. Commun. 188:1992;409-415.
    • (1992) Biochem. Biophys. Res. Commun , vol.188 , pp. 409-415
    • Nunokawa, Y.1    Tanaka, S.2
  • 133
    • 0030033842 scopus 로고    scopus 로고
    • Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells
    • Sarkar R., Meinberg E.G., Stanley J.C., Gordon D., Webb R.C. Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ. Res. 78:1996;225-230.
    • (1996) Circ. Res. , vol.78 , pp. 225-230
    • Sarkar, R.1    Meinberg, E.G.2    Stanley, J.C.3    Gordon, D.4    Webb, R.C.5
  • 134
    • 0027260899 scopus 로고
    • Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia
    • Kourembanas S., McQuillan L.P., Leung G.K., Faller D.V. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest. 92:1993;99-104.
    • (1993) J. Clin. Invest. , vol.92 , pp. 99-104
    • Kourembanas, S.1    McQuillan, L.P.2    Leung, G.K.3    Faller, D.V.4
  • 135
    • 0028940664 scopus 로고
    • Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide
    • Tuder R.M., Flook B.E., Voelkel N.F. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95:1995;1798-1807.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1798-1807
    • Tuder, R.M.1    Flook, B.E.2    Voelkel, N.F.3
  • 136
    • 0029998870 scopus 로고    scopus 로고
    • Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth
    • Doi K., Akaike T., Horie H., Noguchi Y., Fujii S., Beppu T., Ogawa M., Maeda H. Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth. Cancer. 77:1996;1598-1604.
    • (1996) Cancer , vol.77 , pp. 1598-1604
    • Doi, K.1    Akaike, T.2    Horie, H.3    Noguchi, Y.4    Fujii, S.5    Beppu, T.6    Ogawa, M.7    Maeda, H.8
  • 137
    • 0028143547 scopus 로고
    • Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P
    • Ziche M., Morbidelli L., Masini E., Amerini S., Granger H.J., Maggi C.A., Geppetti P., Ledda F. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94:1994;2036-2044.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2036-2044
    • Ziche, M.1    Morbidelli, L.2    Masini, E.3    Amerini, S.4    Granger, H.J.5    Maggi, C.A.6    Geppetti, P.7    Ledda, F.8
  • 138
    • 0028265599 scopus 로고
    • Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism
    • Leibovich S.J., Polverini P.J., Fong T.W., Harlow L.A., Koch C.J. Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism. Proc. Natl. Acad. Sci. USA. 91:1994;4190-4194.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4190-4194
    • Leibovich, S.J.1    Polverini, P.J.2    Fong, T.W.3    Harlow, L.A.4    Koch, C.J.5
  • 139
    • 0028842112 scopus 로고
    • Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques
    • Fukuo K., Inoue T., Morimoto S., Nakahashi T., Yasuda O., Kitano S., Sasada R., Ogihara T. Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques. J. Clin. Invest. 95:1995;669-676.
    • (1995) J. Clin. Invest , vol.95 , pp. 669-676
    • Fukuo, K.1    Inoue, T.2    Morimoto, S.3    Nakahashi, T.4    Yasuda, O.5    Kitano, S.6    Sasada, R.7    Ogihara, T.8
  • 140
    • 0028881129 scopus 로고
    • Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level
    • Andrew P.J., Harant H., Lindley I.J. Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level. Biochem. Biophys. Res. Commun. 214:1995;949-956.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 949-956
    • Andrew, P.J.1    Harant, H.2    Lindley, I.J.3
  • 141
    • 0034828008 scopus 로고    scopus 로고
    • Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma
    • Xiong Q., Shi Q., Le X., Wang B., Abbruzzeze J.L., Xie K. Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma. J. Interferon Cytokine Res. 21:2001;529-537.
    • (2001) J. Interferon Cytokine Res. , vol.21 , pp. 529-537
    • Xiong, Q.1    Shi, Q.2    Le, X.3    Wang, B.4    Abbruzzeze, J.L.5    Xie, K.6
  • 142
    • 0034849755 scopus 로고    scopus 로고
    • Interleukin-8 and human cancer biology
    • Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev. 12:2001;375-391.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 375-391
    • Xie, K.1
  • 144
    • 0031306928 scopus 로고    scopus 로고
    • Role of nitric oxide in growth of solid tumours: A balancing act
    • Chinje E.C., Stratford I.J. Role of nitric oxide in growth of solid tumours a balancing act . Essays Biochem. 32:1997;61-72.
    • (1997) Essays Biochem. , vol.32 , pp. 61-72
    • Chinje, E.C.1    Stratford, I.J.2
  • 145
    • 0028071229 scopus 로고
    • Overcoming obstacles to metastasis - Defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells
    • Denhardt D.T., Chambers A.F. Overcoming obstacles to metastasis - defenses against host defenses osteopontin (OPN) as a shield against attack by cytotoxic host cells . J. Cell. Biochem. 56:1994;48-51.
    • (1994) J. Cell. Biochem. , vol.56 , pp. 48-51
    • Denhardt, D.T.1    Chambers, A.F.2
  • 146
    • 0028853856 scopus 로고
    • Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: Evidence from cell lines down-regulated for OPN expression by a targeted ribozyme
    • Feng B., Rollo E.E., Denhardt D.T. Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity evidence from cell lines down-regulated for OPN expression by a targeted ribozyme . Clin. Exp. Metastasis. 13:1995;453-462.
    • (1995) Clin. Exp. Metastasis , vol.13 , pp. 453-462
    • Feng, B.1    Rollo, E.E.2    Denhardt, D.T.3
  • 147
    • 0034855758 scopus 로고    scopus 로고
    • Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: Implication of galectin-3 function during metastasis
    • Moon B.K., Lee Y.J., Battle P., Jessup J.M., Raz A., Kim H.R. Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis implication of galectin-3 function during metastasis . Am. J. Pathol. 159:2001;1055-1060.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1055-1060
    • Moon, B.K.1    Lee, Y.J.2    Battle, P.3    Jessup, J.M.4    Raz, A.5    Kim, H.R.6
  • 148
    • 0031031148 scopus 로고    scopus 로고
    • Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression
    • Kim Y.M., de Vera M.E., Watkins S.C., Billiar T.R. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272:1997;1402-1411.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1402-1411
    • Kim, Y.M.1    De Vera, M.E.2    Watkins, S.C.3    Billiar, T.R.4
  • 149
    • 0024584020 scopus 로고
    • Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
    • Stuehr D.J., Nathan C.F. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169:1989;1543-1555.
    • (1989) J. Exp. Med. , vol.169 , pp. 1543-1555
    • Stuehr, D.J.1    Nathan, C.F.2
  • 150
    • 0026751947 scopus 로고
    • The 1991 Ulf von Euler Lecture. The L-arginine: Nitric oxide pathway
    • Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine nitric oxide pathway . Acta Physiol. Scand. 145:1992;201-227.
    • (1992) Acta Physiol. Scand. , vol.145 , pp. 201-227
    • Moncada, S.1
  • 151
    • 0025938548 scopus 로고
    • Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
    • Kwon N.S., Stuehr D.J., Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med. 174:1991;761-767.
    • (1991) J. Exp. Med. , vol.174 , pp. 761-767
    • Kwon, N.S.1    Stuehr, D.J.2    Nathan, C.F.3
  • 152
    • 0027231210 scopus 로고
    • Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: A comparison with oxidative burst
    • Kurose I., Miura S., Fukumura D., Yonei Y., Saito H., Tada S., Suematsu M., Tsuchiya M. Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells a comparison with oxidative burst . Cancer Res. 53:1993;2676-2682.
    • (1993) Cancer Res. , vol.53 , pp. 2676-2682
    • Kurose, I.1    Miura, S.2    Fukumura, D.3    Yonei, Y.4    Saito, H.5    Tada, S.6    Suematsu, M.7    Tsuchiya, M.8
  • 155
    • 0030175704 scopus 로고    scopus 로고
    • Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA
    • Dunger A., Augstein P., Schmidt S., Fischer U. Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA. J. Autoimmun. 9:1996;309-313.
    • (1996) J. Autoimmun. , vol.9 , pp. 309-313
    • Dunger, A.1    Augstein, P.2    Schmidt, S.3    Fischer, U.4
  • 156
    • 0031868114 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAF1/CIP1
    • Gansauge S., Nussler A.K., Beger H.G., Gansauge F. Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAF1/CIP1. Cell Growth Differ. 9:1998;611-617.
    • (1998) Cell Growth Differ. , vol.9 , pp. 611-617
    • Gansauge, S.1    Nussler, A.K.2    Beger, H.G.3    Gansauge, F.4
  • 157
    • 0033621365 scopus 로고    scopus 로고
    • Endogenous endothelial cell nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally regulated by p53
    • Mortensen K., Skouv J., Hougaard D.M., Larsson L.I. Endogenous endothelial cell nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally regulated by p53. J. Biol. Chem. 274:1999;37679-37684.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37679-37684
    • Mortensen, K.1    Skouv, J.2    Hougaard, D.M.3    Larsson, L.I.4
  • 158
    • 0033389017 scopus 로고    scopus 로고
    • Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells
    • Binder C., Schulz M., Hiddemann W., Oellerich M. Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells. Lab. Invest. 79:1999;1703-1712.
    • (1999) Lab. Invest. , vol.79 , pp. 1703-1712
    • Binder, C.1    Schulz, M.2    Hiddemann, W.3    Oellerich, M.4
  • 159
    • 0030748314 scopus 로고    scopus 로고
    • Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels
    • Ho Y.S., Lee H.M., Mou T.C., Wang Y.J., Lin J.K. Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels. Mol. Carcinog. 19:1997;101-113.
    • (1997) Mol. Carcinog. , vol.19 , pp. 101-113
    • Ho, Y.S.1    Lee, H.M.2    Mou, T.C.3    Wang, Y.J.4    Lin, J.K.5
  • 161
    • 0030601118 scopus 로고    scopus 로고
    • Macrophage cytotoxicity against murine meth A sarcoma involves nitric oxide-mediated apoptosis
    • Sveinbjornsson B., Olsen R., Seterne O.M., Seljelid R. Macrophage cytotoxicity against murine meth A sarcoma involves nitric oxide-mediated apoptosis. Biochem. Biophys. Res. Commun. 223:1996;643-649.
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 643-649
    • Sveinbjornsson, B.1    Olsen, R.2    Seterne, O.M.3    Seljelid, R.4
  • 162
    • 0030039911 scopus 로고    scopus 로고
    • Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to IFN-γ and TNF-α
    • Geng Y.J., Hellstrand K., Wennmalm A., Hansson G.K. Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to IFN-γ and TNF-α Cancer Res. 56:1996;866-874.
    • (1996) Cancer Res. , vol.56 , pp. 866-874
    • Geng, Y.J.1    Hellstrand, K.2    Wennmalm, A.3    Hansson, G.K.4
  • 163
    • 0029950767 scopus 로고    scopus 로고
    • Involvement of nitric oxide in target-cell lysis and DNA fragmentation induced by murine natural killer cells
    • Filep J.G., Baron C., Lachance S., Perreault C., Chan J.S. Involvement of nitric oxide in target-cell lysis and DNA fragmentation induced by murine natural killer cells. Blood. 87:1996;5136-5143.
    • (1996) Blood , vol.87 , pp. 5136-5143
    • Filep, J.G.1    Baron, C.2    Lachance, S.3    Perreault, C.4    Chan, J.S.5
  • 164
    • 0028818420 scopus 로고
    • Nitric oxide synthase pathway may mediate human natural killer cell cytotoxicity
    • Xiao L., Eneroth P.H., Qureshi G.A. Nitric oxide synthase pathway may mediate human natural killer cell cytotoxicity. Scand. J. Immunol. 42:1995;505-511.
    • (1995) Scand. J. Immunol. , vol.42 , pp. 505-511
    • Xiao, L.1    Eneroth, P.H.2    Qureshi, G.A.3
  • 167
    • 0029942690 scopus 로고    scopus 로고
    • Nitric oxide induces cultured cortical neuron apoptosis
    • Palluy O., Rigaud M. Nitric oxide induces cultured cortical neuron apoptosis. Neurosci. Lett. 208:1996;1-4.
    • (1996) Neurosci. Lett. , vol.208 , pp. 1-4
    • Palluy, O.1    Rigaud, M.2
  • 168
    • 0029871698 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide antagonizes transforming growth factor beta 1-induced apoptosis in primary cultures of hepatocytes
    • Martin-Sanz P., Diaz-Guerra M.J., Casado M., Bosca L. Bacterial lipopolysaccharide antagonizes transforming growth factor beta 1-induced apoptosis in primary cultures of hepatocytes. Hepatology. 23:1996;1200-1207.
    • (1996) Hepatology , vol.23 , pp. 1200-1207
    • Martin-Sanz, P.1    Diaz-Guerra, M.J.2    Casado, M.3    Bosca, L.4
  • 172
    • 0028944339 scopus 로고
    • Nitric oxide-induced apoptosis in RAW264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds
    • Messmer U.K., Lapetina E.G., Brune B. Nitric oxide-induced apoptosis in RAW264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds. Mol. Pharmacol. 47:1995;757-765.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 757-765
    • Messmer, U.K.1    Lapetina, E.G.2    Brune, B.3
  • 173
    • 0030058801 scopus 로고    scopus 로고
    • High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme
    • Laubach V.E., Garvey E.P., Sherman P.A. High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme. Biochem. Biophys. Res. Commun. 218:1996;802-807.
    • (1996) Biochem. Biophys. Res. Commun. , vol.218 , pp. 802-807
    • Laubach, V.E.1    Garvey, E.P.2    Sherman, P.A.3
  • 175
    • 0028794890 scopus 로고    scopus 로고
    • Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways
    • Brune B., Mohr S., Messmer U.K. Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways. Rev. Physiol. Biochem. Pharmacol. 127:1996;1-30.
    • (1996) Rev. Physiol. Biochem. Pharmacol. , vol.127 , pp. 1-30
    • Brune, B.1    Mohr, S.2    Messmer, U.K.3
  • 176
    • 0029942290 scopus 로고    scopus 로고
    • Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells
    • Ho Y.S., Wang Y.J., Lin J.K. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells. Mol. Carcinog. 16:1996;20-31.
    • (1996) Mol. Carcinog. , vol.16 , pp. 20-31
    • Ho, Y.S.1    Wang, Y.J.2    Lin, J.K.3
  • 177
    • 0033302523 scopus 로고    scopus 로고
    • Programmed cell death and the regulation of homeostasis
    • Korsmeyer, S. J. Programmed cell death and the regulation of homeostasis. Harvey Lect. 95:21-41; 1999-2000.
    • Harvey Lect. , vol.95 , Issue.21-41 , pp. 1999-2000
    • Korsmeyer, S.J.1
  • 178
    • 0034320568 scopus 로고    scopus 로고
    • Mechanisms of apoptosis
    • Reed J.C. Mechanisms of apoptosis. Am. J. Pathol. 157:2000;1415-1430.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1415-1430
    • Reed, J.C.1
  • 179
    • 0029328602 scopus 로고
    • Bcl-2, a novel regulator of cell death
    • Hockenbery D.M. Bcl-2, a novel regulator of cell death. Bioessays. 17:1995;631-638.
    • (1995) Bioessays , vol.17 , pp. 631-638
    • Hockenbery, D.M.1
  • 181
    • 0029982517 scopus 로고    scopus 로고
    • B cell lymphoma-2 transfected P815 cells resist reactive nitrogen intermediate-mediated macrophage-dependent cytotoxicity
    • Albina J.E., Martin B.A., Henry W.L. Jr, Louis C.A., Reichner J.S. B cell lymphoma-2 transfected P815 cells resist reactive nitrogen intermediate-mediated macrophage-dependent cytotoxicity. J. Immunol. 157:1996;279-283.
    • (1996) J. Immunol. , vol.157 , pp. 279-283
    • Albina, J.E.1    Martin, B.A.2    Henry W.L., Jr.3    Louis, C.A.4    Reichner, J.S.5
  • 182
    • 0000591744 scopus 로고    scopus 로고
    • Bcl-2 protects macrophages from nitric oxide-induced apoptosis
    • Messmer U.K., Reed U.K., Brune B. Bcl-2 protects macrophages from nitric oxide-induced apoptosis. J. Biol. Chem. 271:1996;20192-20197.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20192-20197
    • Messmer, U.K.1    Reed, U.K.2    Brune, B.3
  • 183
    • 0035113742 scopus 로고    scopus 로고
    • Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity
    • Chang C.I., Liao J.C., Kuo L. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. Cancer Res. 61:2001;1100-1106.
    • (2001) Cancer Res. , vol.61 , pp. 1100-1106
    • Chang, C.I.1    Liao, J.C.2    Kuo, L.3
  • 184
    • 0028558753 scopus 로고
    • Differential sensitivity to nitric oxide in immortalized, cloned murine oligodendrocyte cell lines
    • Mackenzie-Graham A.J., Mitrovic B., Smoll A., Merrill J.E. Differential sensitivity to nitric oxide in immortalized, cloned murine oligodendrocyte cell lines. Dev. Neurosci. 16:1994;162-171.
    • (1994) Dev. Neurosci. , vol.16 , pp. 162-171
    • Mackenzie-Graham, A.J.1    Mitrovic, B.2    Smoll, A.3    Merrill, J.E.4
  • 185
    • 0034646663 scopus 로고    scopus 로고
    • Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals
    • Espey M.G., Miranda K.M., Pluta R.M., Wink D.A. Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals. J. Biol. Chem. 275:2000;11341-11347.
    • (2000) J. Biol. Chem. , vol.275 , pp. 11341-11347
    • Espey, M.G.1    Miranda, K.M.2    Pluta, R.M.3    Wink, D.A.4
  • 186
    • 0034937590 scopus 로고    scopus 로고
    • Cytotoxicity related to oxidative and nitrosative stress by nitric oxide
    • Wink D.A., Miranda K.M., Espey M.G. Cytotoxicity related to oxidative and nitrosative stress by nitric oxide. Exp. Biol. Med. (Maywood). 226:2001;621-623.
    • (2001) Exp. Biol. Med. (Maywood) , vol.226 , pp. 621-623
    • Wink, D.A.1    Miranda, K.M.2    Espey, M.G.3
  • 187
    • 0029682870 scopus 로고    scopus 로고
    • Oxidative damage and tyrosine nitration from peroxynitrite
    • Beckman J.S. Oxidative damage and tyrosine nitration from peroxynitrite. Chem. Res. Toxicol. 9:1996;836-844.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 836-844
    • Beckman, J.S.1
  • 188
    • 0030602876 scopus 로고    scopus 로고
    • Protection by glutathione against the antiproliferative effects of nitric oxide. Dependence on kinetics of no release
    • Petit J.F., Nicaise M., Lepoivre M., Guissani A., Lemaire G. Protection by glutathione against the antiproliferative effects of nitric oxide. Dependence on kinetics of no release. Biochem. Pharmacol. 52:1996;205-212.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 205-212
    • Petit, J.F.1    Nicaise, M.2    Lepoivre, M.3    Guissani, A.4    Lemaire, G.5
  • 190
    • 0029918676 scopus 로고    scopus 로고
    • The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistence/susceptibility
    • Farias-Eisner R., Chaudhuri G., Aeberhard E., Fukuto J.M. The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistence/susceptibility. J. Biol. Chem. 271:1996;6144-6151.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6144-6151
    • Farias-Eisner, R.1    Chaudhuri, G.2    Aeberhard, E.3    Fukuto, J.M.4
  • 191
    • 0030986262 scopus 로고    scopus 로고
    • Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression
    • Ambs S., Hussain S.P., Harris C.C. Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. 11:1997;443-448.
    • (1997) FASEB J. , vol.11 , pp. 443-448
    • Ambs, S.1    Hussain, S.P.2    Harris, C.C.3
  • 192
    • 0033135593 scopus 로고    scopus 로고
    • Direct correlation between nitric oxide synthase II inducibility an d metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53
    • Shi Q., Huang S., Jiang W., Kutach L.S., Ananthaswamy H.N., Xie K. Direct correlation between nitric oxide synthase II inducibility an d metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53. Cancer Res. 59:1999;2072-2075.
    • (1999) Cancer Res. , vol.59 , pp. 2072-2075
    • Shi, Q.1    Huang, S.2    Jiang, W.3    Kutach, L.S.4    Ananthaswamy, H.N.5    Xie, K.6
  • 194
    • 0344431242 scopus 로고    scopus 로고
    • U937 apoptotic cell death by nitric oxide: Bcl-2 downregulation and caspase activation
    • Brockhaus F., Brune B. U937 apoptotic cell death by nitric oxide Bcl-2 downregulation and caspase activation . Exp. Cell Res. 238:1998;33-41.
    • (1998) Exp. Cell Res. , vol.238 , pp. 33-41
    • Brockhaus, F.1    Brune, B.2
  • 195
    • 0030789576 scopus 로고    scopus 로고
    • Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis
    • Sandau K., Pfeilschifter J., Brune B. Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis. Kidney Int. 52:1997;378-386.
    • (1997) Kidney Int. , vol.52 , pp. 378-386
    • Sandau, K.1    Pfeilschifter, J.2    Brune, B.3
  • 196
    • 0032705798 scopus 로고    scopus 로고
    • Induction of apoptosis by S-nitrosoglutathione and Cu2+ or Ni2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells
    • Ho Y.S., Liu H.L., Duh J.S., Chen R.J., Ho W.L., Jeng J.H., Wang Y.J., Lin J.K. Induction of apoptosis by S-nitrosoglutathione and Cu2+ or Ni2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells. Mol. Carcinog. 26:1999;201-211.
    • (1999) Mol. Carcinog. , vol.26 , pp. 201-211
    • Ho, Y.S.1    Liu, H.L.2    Duh, J.S.3    Chen, R.J.4    Ho, W.L.5    Jeng, J.H.6    Wang, Y.J.7    Lin, J.K.8
  • 197
    • 0033593596 scopus 로고    scopus 로고
    • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x
    • Ing D.J., Zang J., Dzau V.J., Webster K.A., Bishopric N.H. Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. Circ. Res. 84:1999;21-33.
    • (1999) Circ. Res. , vol.84 , pp. 21-33
    • Ing, D.J.1    Zang, J.2    Dzau, V.J.3    Webster, K.A.4    Bishopric, N.H.5
  • 198
    • 0033276681 scopus 로고    scopus 로고
    • NO-Evoked macrophage apoptosis is attenuated by cAMP-induced gene expression
    • von Knethen A., Brockhaus F., Kleiter I., Brune B. NO-Evoked macrophage apoptosis is attenuated by cAMP-induced gene expression. Mol. Med. 5:1999;672-684.
    • (1999) Mol. Med. , vol.5 , pp. 672-684
    • Von Knethen, A.1    Brockhaus, F.2    Kleiter, I.3    Brune, B.4
  • 199
    • 0033627736 scopus 로고    scopus 로고
    • Nitric oxide-mediated apoptosis in human breast cancer cells requires changes in mitochondrial functions and is independent of CD95 (APO-1/Fas)
    • Umansky V., Ushmorov A., Ratter F., Chlichlia K., Bucur M., Lichtenauer A., Rocha M. Nitric oxide-mediated apoptosis in human breast cancer cells requires changes in mitochondrial functions and is independent of CD95 (APO-1/Fas). Int. J. Oncol. 16:2000;109-117.
    • (2000) Int. J. Oncol. , vol.16 , pp. 109-117
    • Umansky, V.1    Ushmorov, A.2    Ratter, F.3    Chlichlia, K.4    Bucur, M.5    Lichtenauer, A.6    Rocha, M.7
  • 200
    • 0032100446 scopus 로고    scopus 로고
    • Caspase activation is required for nitric oxide-mediated, CD95(APO-1/Fas)-dependent and independent apoptosis in human neoplastic lymphoid cells
    • Chlichlia K., Peter M.E., Rocha M., Scaffidi C., Bucur M., Krammer P.H., Schirmacher V., Umansky V. Caspase activation is required for nitric oxide-mediated, CD95(APO-1/Fas)-dependent and independent apoptosis in human neoplastic lymphoid cells. Blood. 91:1998;4311-4320.
    • (1998) Blood , vol.91 , pp. 4311-4320
    • Chlichlia, K.1    Peter, M.E.2    Rocha, M.3    Scaffidi, C.4    Bucur, M.5    Krammer, P.H.6    Schirmacher, V.7    Umansky, V.8
  • 201
    • 0031031148 scopus 로고    scopus 로고
    • Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression
    • Kim Y.M., de Vera M.E., Watkins S.C., Billiar T.R. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272:1997;1402-1411.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1402-1411
    • Kim, Y.M.1    De Vera, M.E.2    Watkins, S.C.3    Billiar, T.R.4
  • 202
    • 0034769244 scopus 로고    scopus 로고
    • Protective effects of noradrenaline against tumor necrosis factor-alpha-induced apoptosis in cultured rat brown adipocytes: Role of nitric oxide-induced heat shock protein 70 expression
    • Nisoli E., Regianini L., Bulbarelli A., Briscini L., Breacale R., Carruba M.O. Protective effects of noradrenaline against tumor necrosis factor-alpha-induced apoptosis in cultured rat brown adipocytes role of nitric oxide-induced heat shock protein 70 expression . Int. J. Obes. Relat. Metab. Disord. 25:2001;1421-1430.
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , pp. 1421-1430
    • Nisoli, E.1    Regianini, L.2    Bulbarelli, A.3    Briscini, L.4    Breacale, R.5    Carruba, M.O.6
  • 203
    • 0028658374 scopus 로고
    • Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
    • Mannick J.B., Asano K., Izumi K., Kieff E., Stamler J.S. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell. 79:1994;1137-1146.
    • (1994) Cell , vol.79 , pp. 1137-1146
    • Mannick, J.B.1    Asano, K.2    Izumi, K.3    Kieff, E.4    Stamler, J.S.5
  • 204
    • 0028917191 scopus 로고
    • Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels
    • Genaro A.M., Hortelano S., Alvarez A., Martinez C., Bosca L. Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels. J. Clin. Invest. 95:1995;1884-1890.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1884-1890
    • Genaro, A.M.1    Hortelano, S.2    Alvarez, A.3    Martinez, C.4    Bosca, L.5
  • 205
    • 0030918451 scopus 로고    scopus 로고
    • Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver
    • Saavedra J.E., Billiar T.R., Williams D.L., Kim Y.M., Watkins S.C., Keefer L.K. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J. Med. Chem. 40:1997;1947-1954.
    • (1997) J. Med. Chem. , vol.40 , pp. 1947-1954
    • Saavedra, J.E.1    Billiar, T.R.2    Williams, D.L.3    Kim, Y.M.4    Watkins, S.C.5    Keefer, L.K.6
  • 206
    • 0031855881 scopus 로고    scopus 로고
    • Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis
    • Tzeng E., Billiar T.R., Williams D.L., Li J., Lizonova A., Kovesdi L., Kim Y.M. Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis. Surgery. 124:1998;278-283.
    • (1998) Surgery , vol.124 , pp. 278-283
    • Tzeng, E.1    Billiar, T.R.2    Williams, D.L.3    Li, J.4    Lizonova, A.5    Kovesdi, L.6    Kim, Y.M.7
  • 207
    • 0031923844 scopus 로고    scopus 로고
    • Role of nitric oxide in IL-2 therapy-induced capillary leak syndrome
    • Orucevic A., Lala P.K. Role of nitric oxide in IL-2 therapy-induced capillary leak syndrome. Cancer Metastasis Rev. 17:1998;127-142.
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 127-142
    • Orucevic, A.1    Lala, P.K.2
  • 208
    • 0035296203 scopus 로고    scopus 로고
    • Role of nitric oxide in carcinogenesis and tumor progression
    • Lala P.K., Chakraborty C. Role of nitric oxide in carcinogenesis and tumor progression. Lancet Oncol. 2:2001;149-156.
    • (2001) Lancet Oncol. , vol.2 , pp. 149-156
    • Lala, P.K.1    Chakraborty, C.2
  • 209
    • 0031003224 scopus 로고    scopus 로고
    • Destruction of bystander cells by tumor cells transfected with the inducible nitric oxide synthase gene
    • Xie K., Huang S., Dong Z., Juang S.-H., Wang Y., Fidler I.J. Destruction of bystander cells by tumor cells transfected with the inducible nitric oxide synthase gene. J. Natl. Cancer Inst. 89:1997;421-427.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 421-427
    • Xie, K.1    Huang, S.2    Dong, Z.3    Juang, S.-H.4    Wang, Y.5    Fidler, I.J.6
  • 210
    • 0001517847 scopus 로고    scopus 로고
    • Transfection of interleukin-10 suppresses tumorigenicity and metastasis of human melanoma by inhibiting angiogenesis
    • Huang S., Xie K., Ullrich S.E., Bar-Eli M. Transfection of interleukin-10 suppresses tumorigenicity and metastasis of human melanoma by inhibiting angiogenesis. Clin. Cancer Res. 2:1996;1961-1979.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1961-1979
    • Huang, S.1    Xie, K.2    Ullrich, S.E.3    Bar-Eli, M.4
  • 212
    • 0033972177 scopus 로고    scopus 로고
    • Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages
    • Bruns C.J., Shinohara H., Harbison M.T., Davis D.W., Nelkin G., Killion J.J., McConkey D.J., Dong Z., Fidler I.J. Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages. Cancer Res. 60:2000;2-7.
    • (2000) Cancer Res. , vol.60 , pp. 2-7
    • Bruns, C.J.1    Shinohara, H.2    Harbison, M.T.3    Davis, D.W.4    Nelkin, G.5    Killion, J.J.6    McConkey, D.J.7    Dong, Z.8    Fidler, I.J.9
  • 213
    • 0028059949 scopus 로고
    • Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidylserine
    • Calderon C., Huang Z.H., Gage D.A., Sotomayor E.M., Lopez D.M. Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidylserine. J. Exp. Med. 180:1995;945-958.
    • (1995) J. Exp. Med. , vol.180 , pp. 945-958
    • Calderon, C.1    Huang, Z.H.2    Gage, D.A.3    Sotomayor, E.M.4    Lopez, D.M.5
  • 214
    • 0032503018 scopus 로고    scopus 로고
    • Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene
    • Juang S.-H., Xie K., Xu L., Shi Q., Wang Y., Yoneda J., Fidler I.J. Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene. Hum. Gene Ther. 9:1998;845-854.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 845-854
    • Juang, S.-H.1    Xie, K.2    Xu, L.3    Shi, Q.4    Wang, Y.5    Yoneda, J.6    Fidler, I.J.7
  • 215
    • 0012766111 scopus 로고    scopus 로고
    • Suppression of tumor growth and metastasis of human pancreatic adenocarcinoma by p202 gene transfer
    • Yong W., Yan D., Wang B., Spohn B., Ding D., Shao R., Zou Y., Xie K., Hung M.-C. Suppression of tumor growth and metastasis of human pancreatic adenocarcinoma by p202 gene transfer. Cancer Res. 61:2001;7142-7147.
    • (2001) Cancer Res. , vol.61 , pp. 7142-7147
    • Yong, W.1    Yan, D.2    Wang, B.3    Spohn, B.4    Ding, D.5    Shao, R.6    Zou, Y.7    Xie, K.8    Hung, M.-C.9


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