Metabolic and clonogenic consequences of ischaemia-reperfusion insult in solid tumours

Experimental Physiology

Volumn 82, Issue 2, 1997, Pages 361-368

  Parkins, Charles S ^a   Hill, Sally A ^a   Stratford, Michael R L ^a   Dennis, Madeleine F ^a   Chaplin, Dai J ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; OXYGEN RADICAL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL OCCLUSION; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; METABOLISM; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; REPERFUSION INJURY; RESPIRATORY BURST; SOLID TUMOR; TUMOR BLOOD FLOW; TUMOR VASCULARIZATION;

EID: 0030889934     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.1997.sp004031     Document Type: Article

References (22)

1. CHAPLIN, D. J. & HILL, S. A. (1995). Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. British Journal of Cancer 71, 1210-1213.
2. CHAPLIN, D. J., OLIVE, P. L. & DURAND, R. E. (1987). Intermittent blood flow in a murine tumour: radiobiological effects. Cancer Research 47, 597-601.
3. DENEKAMP, J. (1990). Vascular attack as a therapeutic strategy for cancer. Cancer and Metastasis Reviews 9, 267-282.
4. DENEKAMP, J. & HARRIS, S. R. (1975). Test of two electron-affinic radiosensitizers in vivo using regrowth of an experimental tumour. Radiation Research 61, 191-203.
5. DENEKAMP, J., HILL, S. A. & HOBSON, B. (1983). Vascular occlusion and tumour cell death. European Journal of Cancer Clinical Oncology 19, 271-275.
6. JAIN, R. K. (1994). Barriers to drug delivery in solid tumours. Scientific American 271, 42-49.
7. KUBES, P., SUZUKI, M. & GRANGER, D. N. (1991). Nitric oxide: an endogenous modulator of leukocyte adhesion. Proceedings of the National Academy of Sciences of the USA 88, 4651-4655.
8. KUKREJA, R. C. & HESS, M. L. (1993). Oxygen radicals, neutrophil-derived oxidants, and myocardial reperfusion injury. In Pathophysiology of Reperfusion Injury, ed. DAS, D., pp. 221-241. CRC Press, Boca Raton, FL, USA.
9. OKAMOTO K., TOYOKUNI, S., UCHIDA, K., OGAWA, O., TAKENEWA, J., KAKEHI, Y., KINOSHITA, H., HATTORI-NAKAKUKI, Y., HIAI, H. & YOSHIDA, O. (1994). Formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. International Journal of Cancer 58, 825-829.
10. 31P-NMR for non-invasive evaluation of tumour metabolic status. International Journal of Radiation, Oncology, Biology and Physics 12, 793-799.
11. PARKINS, C. S., CHADWICK, J. A. & CHAPLIN, D. J. (1994a). Enhancement of chlorambucil cytotoxicity by combination with flavone acetic acid in a murine tumour. Anticancer Research 14, 1603-1608.
12. PARKINS, C. S., DENNIS, M. F., STRATFORD, M. R. L., HILL, S. A. & CHAPLIN, D. J. (1995). Ischaemia reperfusion injury in tumours: the role of oxygen radicals and nitric oxide. Cancer Research 55, 6026-6029.
13. PARKINS, C. S., HILL, S. A., LONERGAN, S. J., HORSMAN, M. R., CHADWICK, J. A. & CHAPLIN, D. J. (1994b). Ischaemia induced cell death in tumours: Importance of temperature and pH. International Journal of Radiation Oncology, Biology and Physics 29, 499-503.
14. PARKINS, C. S., HILL, S. A., STRATFORD, M. R. L., DENNIS, M. F. & CHAPLIN, D. J. (1996). Oxidative stress and vascular function within solid tumours: role of nitric oxide and oxygen radicals. Journal of Physiology 491.P, 10P.
15. PARKS, D. A. & GRANGER, D. N. (1983). Ischaemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals. American Journal of Physiology 245, G285-289.
16. SAPERSTEIN, L. A. (1958). Regional blood flow by fractional distribution of indicators. American Journal of Physiology 193, 161-168.
17. SHOJI, Y., UEDONON, Y., ISHIKURA, H., TAKEYAMA, N. & TANAKA, T. (1995). DNA damage induced by tumour necrosis factor in L929 cells is mediated by mitochondrial oxygen radical formation. Immunology 84, 543-548.
18. STRATFORD, M. R. L. & DENNIS, M. F. (1994). Determination of adenine nucleotides by fluorescence detection using high-performance liquid chromatography and post-column derivatisation with chloroacetaldehyde. Journal of Chromatography B 662, 15-20.
19. TOYOKUNI, S., OKAMOTO, K., YODOI, J. & HIAI, H. (1995). Persistent oxidative stress in cancer. FEBS Letters 358, 1-3.
20. WEISHAUPT, K. R., GOMER, C. J. & DOUGHERTY, T. J. (1976). Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumour. Cancer Research 36, 2326-2329.
21. YOSHIKAWA, T., KOKURA, S., OYAMADA, H., IINUMA, S., NISHIMURA, S., KANEKO, T., NAITO, Y. & KONDO, M. (1994). Antitumour effect of ischaemia reperfusion injury induced by transient embolisation. Cancer Research 54, 5033-5035.
22. YOSHIKAWA, T., KOKURA, S., TAINAKA, K., NAITO, Y. & KONDO, M. (1995). A novel cancer therapy based on oxygen radicals. Cancer Research 55, 1617-1620.