Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide

International Journal of Cancer

Volumn 76, Issue 5, 1998, Pages 713-719

  Kundu, Namita ^a,b   Dorsey, Russell ^b   Jackson, Marian J ^b   Gutierrez, Peter ^a   Wilson, Keith ^b,c   Fu, Sedong ^c   Ramanujam, Kalathur ^c   Thomas, Emily ^b   Fulton, Amy M ^a,b  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; CULTURE MEDIUM; DNA TRANSFECTION; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; GENE TRANSFER; HUMAN; IMMUNOHISTOCHEMISTRY; MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031780623     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980529)76:5<713::AID-IJC17>3.0.CO;2-4     Document Type: Article

References (31)

1. APPELBERG, R., Opposing effects of interleukin-10 on mouse macrophage functions. Scand. J. Immunol., 41, 539-544 (1995).
2. BASTIEN, N.R., YIM, C.-Y., HIBBS, H.B. and SAMLOWSKI, W.E., Induction of iron-derived EPR signals in murine cancers by nitric oxide. J. biol. Chem. 269, 5127-5131 (1994).
3. BERMAN, R.M., SUZUKI, T., TAHARA, H., ROBBINS, P.D., NARULA, S.K. and LOTZF., M.T., Systemic administration of cellular IL-10 induces an effective, specific and long-lived immune response against established tumors in mice. J. Immunol. 157, 231-238 (1996).
4. BOGDAN, C., VODOVOTZ, Y. and NATHAN, C., Macrophage deactivation by interleukin 10. J. exp. Med. 174, 1549-1555 (1991).
5. CALDERON, C., HUANG, Z.-H., GAGE, D.A., SOTOMAYOR, E.M. and LOPEZ, D.M., Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine. J. exp. Med., 180, 945-958 (1994).
6. CHHATWAU, V.J.S., MOOCHHALA, S.M., CHAN, S.T.F. and NGOI, S.S., Nitric oxide and cancer. Med. Hypotheses, 46, 21-24 (1996).
7. CORRADIN, S.B., FASEL, N., BUCHMULLER-ROUILLER, Y., RANSIJN, A., SMITH, J. and MAUEL, J., Induction of macrophage nitric oxide production by imerferon-γ and tumor necrosis factor-α is enhanced by interleukin-10. Europ. J. Immunol., 23, 2045-2048 (1993).
8. CUNHA, F.Q., MONCADA, S. and LIEW, F.Y., Interleukin 10 inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem. biophys. Res. Comm. 182, 1155-1159 (1992).
9. DONG, S., STAROSELSKY, A.H., QI, X., XIE, K. and FIDLER, I.J., Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res., 54, 789-793 (1994).
10. FARIAS-EISNER, R. CHAUDHURI, G., AEBERHARD, E. and FUKUTO, J., The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistance/susceptibility. J. biol. Chem. 271, 6144-6151 (1996).
11. GIOVARELLI, M., MUSIANI, P., MODESTI, A., DELLABONA, P., CASORATI, G., ALLIONE, A., CONSALVO, M., CAVALLO, F., DE PIERRO, F., DE GIOVANNI, C., MUSSO, T. and FORNI, G., Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J. Immunol., 155, 3112-3123 (1995).
12. GUTIERREZ, P.L., SWARTZ, H.M. and WILKINSON, E.J., Paramagnetic changes in cancer: DMBA-induced tumours studied in non-lyophilized and lyophilized tissues. Brit. J. Cancer, 39, 330-336 (1979).
13. HIBBS, J.B., VAVRIN, Z. and TAINTOR, R.R., L-arginine is required for the expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol., 138, 550-565 (1987).
14. HUANG, S., ZIE, K., BUCANA, C.D., ULLRICH, S.E. and BAR-ELI, M., Interleukin-10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin. Cancer Res., 2, 1969-1979 (1996).
15. JAFPREY, S.R. and SNYDER, S.H., PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science, 274, 774-777 (1996).
16. JENKINS, D.C., CHARLES, I.G., THOMSEN, L.L., MOSS, D.W., HOLMES, L.S., BAYLIS, S.A., RHODES, P., WESTMORE, K., EMSON, P.C. and MONCADA, S., Roles of nitric oxide in tumor growth. Proc. nat. Acad. Sci. (Wash.), 92, 4392-4396 (1995).
17. KUNDU, N., BEATY, T.L., JACKSON, M.J. and FULTON, A.M., Amimetastatic and antitumor activities of interleukin-10 in a murine model of breast cancer. J. nat. Cancer Inst., 88, 536-541 (1996).
18. KUNDU, N. and FULTON, A.M., Interleukin 10 inhibits tumor metastasis, downregulates MHC class I and enhances NK lysis. Cell. Immunol. 180, 55-61 (1997).
19. LI, L., KILBOURN, R.G., ADAMS, J. and FIDLER, I.J., Role of nitric oxide in lysis of tumor cells by cytokine-activated murine vascular endothelial cells. Cancer Res., 51, 245-254 (1991).
20. LOFTIS, L.L., MEALS, E.A. and ENGLISH, B.K., Differential effects of pentoxifylline and interleukin-10 on production of tumor necrosis factor and inducible nitric oxide synthase by murine macrophages. J. infections Dis., 175, 1008-1011 (1997).
21. MOOCHHALA, S., CHHATWAL, V.J.S., CHAN, S.T.T., NGOI, S.S., CHIA, Y.W. and RAUFF, A., Nitric oxide synthase activity and expression in human colorectal cancer. Carcinogenesis, 17, 1171-1174 (1996).
22. NATHAN, C., Nitric oxide as a secretory product of mammalian cells. FASEB J., 6, 3051-3064 (1992).
23. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis, on imerleukin-2-induced capillary leakage and antitumor responses in healthy and tumor-bearing mice. Cancer Immunol. Immunother, 42, 38-46 (1996).
24. RADOMSKI, M.W., JENKINS, D.C., HOLMES, L.S. and MONCADA, S., Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets. Cancer Res., 51, 6073-6078 (1991).
25. SUNYER, T., ROTHE, L., JIANG, X., OSDOBY, P. and COLLIN-OSDOBY, P., Proinflammatory agents, IL-8 and IL-10, upregulate inducible nitric oxide synthase expression and nitric oxide production in avian osteoclast-like cells. J. cell. Biochem., 60, 469-483 (1996).
26. TAMIR, S., DEROJAS-WALKER, T., WISHNOK, J.S. and TANNEBAUM, S.R., DNA damage and genotoxicity by nitric oxide. Methods Enzymol., 269, 230-243 (1996).
27. THOMSEN, L.L., MILES, D.W., HAPPERFIELD, L., BORROW, L.G., KNOWLES, R.G. and MONCADA, S., Nitric oxide synthase activity in human breast cancer. Brit. J. Cancer. 72, 41-44 (1995).
28. WINK, D.A., KASPRZAK, K.S., MARAOOS, C.M., ELESPRU, R.K., MISRA, M., DUNAMS, T.M., CEBULA, T.A., KOCH, W.H., ANDREWS, A.W., ALEEN, J.S. and KEEPER, L.K., DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science, 254, 1001-1003 (1991).
29. XIE, B.K., HUANG, S., DONG, Z., JUANG, S.-H., GUTMAN, M., XIE, Q.-W., NATHAN, C. and FIDLER, I.J., Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J. exp. Med. 181, 1333-1343 (1995).
30. XIE, Q.-W., CHO, H.J., CALAYCAY, J., MUMFORD, R.A., SWIDEREK, K.M., LEE, T.D., DING, A., TROSO, T. and NATHAN, C., Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science, 256, 225-228 (1992).
31. ZHANG, L.M., OJCIUS, D.M., GARAUD, F., ROTH, C., MAXWELL, E., LI, A., RONG, H., CHEN, J., WANG, X.Y., CATINO, J.J. and KING, I., Interleukin 10 inhibits tumor metastasis through an NK cell dependent mechanism. J. exp. Med., 184, 579-584 (1996).