Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2, and bax protein levels

Molecular Carcinogenesis

Volumn 19, Issue 2, 1997, Pages 101-113

  Ho, Yuan Soon ^a   Lee, Horng Mo ^a   Mou, Tung Chang ^a   Wang, Ying Jan ^b   Lin, Jen Kun ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Antioxidant; Apoptosis; Bax; Bcl 2; Nitric oxide

Indexed keywords

2,2,6,6 TETRAMETHYL 1 PIPERIDINYLOXY; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; CURCUMIN; GLUTATHIONE; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; COLON CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL LINE;

ACETYLCYSTEINE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; COLONIC NEOPLASMS; DNA FRAGMENTATION; GENES, BCL-2; GLUTATHIONE; HT29 CELLS; HUMANS; NITRIC OXIDE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0030748314     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199707)19:2<101::AID-MC5>3.0.CO;2-I     Document Type: Article

References (57)

1. Andrew FG, Slater C, Stefan I, et al. The role of intracellular oxidants in apoptosis. Biochem Biophys Acta 1271:59-62, 1995.
2. Mebmer UK, Ankarcrona M, Nicotera P, et al. p53 expression in nitric oxide-induced apoptosis. FEBS Lett 355:23-26, 1994.
3. Bredt DS, Snyder SH. Nitric oxide: A physiologic messenger molecule. Annu Rev Biochem 63:175-195, 1994.
4. Arroyo PL, Hatch-Pigott V, Mower HF, et al. Mutagenicity of nitric oxide and its inhibition by antioxidants. Mutat Res 281:193-202, 1992.
5. Nguyen TD, Brunson CL, Crespi BW, et al. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci USA 89:3030-3034, 1992.
6. Isomura KM, Chikahira KT, Hamada K. Induction of mutations and chromosome aberrations in lung cells following in vivo exposure of rats to nitrogen oxides. Mutat Res 136:119-125, 1984.
7. Sarih M, Souvannavong V, Adam A. Nitric oxide synthase induces macrophage death by apoptosis. Biochem Biophys Res Commun 191:503-508, 1993.
8. Albina JE, Cui S, Mateo RB, et al. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol 11:5080-5085, 1993.
9. Cui S, Reichner JS, Mateo RB, et al. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or independent mechanisms. Cancer Res 54:2462-2467, 1994.
10. Ankarcrona M, Dypbukt JM, Brne B, et al. interleukine-1-β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp Cell Res 213:172-177, 1994.
11. Ho YS, Wang YJ, Lin JK. Induction of p53 and p21/WAF1/CIPl expression by nitric oxide and their association with apoptosis in human cancer cells. Mol Carcinog 16:20-31, 1996.
12. Hogman G. Prevention of cancer: Vegetables and plants. Comp Biochem Physiol 936:201-212, 1989.
13. Wattenberg LW. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 52:2085s-2091s, 1992.
14. Chang DJ, Ringold GM, Heller RA. Cell killing and induction of manganous super oxide dismutase by tumor necrosis factor-α is mediated by lipoxygenase metabolites of arachidonic acid. Biochem Biophys Res Commun 188:538-546, 1992.
15. Mayer M, Noble M. N-acetyl-cysteine is a pluripotent protector against cell death and enhancer of tropic factor-mediated cell survival in vitro. Proc Natl Acad Sci USA 91:7496-7500, 1994.
16. Malorni W, Rivabene R, Santini MT, et al. N-acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells. FEBS Lett 327:75-78, 1993.
17. Matsuda M, Masutani H, Nakamura H. Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells. J Immunol 147:3837-3841, 1991.
18. Andrew FG, Slate C, Stefan I, et al. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. J Biochem 306:771-778, 1995.
19. Tsujimoto Y, Gorham J, Cossman J, et al. The t(14:18) chromosome translocation involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229:1390-1393, 1985.
20. Chen-Levy Z, Nourse J, Cleary ML. The bcl-2 candidate protooncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14:18) translocation. Mol Cell Biol 9:701-710, 1989.
21. Hockenbery DM, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondria membrane protein that blocks programmed cell death. Nature 348:334-336, 1990.
22. YinX-M,OltvaiZN, KorsmeyerSJ. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature 369:321-323, 1994.
23. Sentman CL, Shutter JR, Hockenbery DM, et al. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879-888, 1991.
24. Miyashita T, Reed JC. Bcl-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 52:5407-5411, 1992.
25. Hennet T, Bertoni G, Richter C, et al. Expression of bcl-2 protein enhances the survival of mouse fibrosacroid cells in tumor necrosis factor-mediated cytotoxicity. Cancer Res 53:1456-1460, 1993.
26. Zhong L-T, Sarafin T, Kane DJ, et al. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 90:4533-4537, 1993.
27. Kane DJ, Sarafin TA, Anton R, et al. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262:1247-1277, 1993.
28. Hockenbery DM, Oltvai ZN, Yin X-M, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251, 1993.
29. Semple TU, Quinn LA, Woods LK, et al. Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxic model. Cancer Res 38:1345-1355, 1978.
30. Aden DP, Fogel A, Plotkin S, et al. Controlled synthesis of HBs Ag in a differentiated human liver carcinoma-derived cell line. Nature 282:615-616, 1979.
31. Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209:497-499, 1980.
32. Darlington GJ, Kelly JH, Buffone GJ. Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell Dev Biol 23:349-354, 1987.
33. Bressac B, Galvin KM, Liang TJ, et al. Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci USA 87:1973-1977, 1990.
34. Niewolik D, Vojtesek B, Kovarik J. p53 derived from human tumor cell lines and containing distinct point mutations can be activated to bind its consensus target sequence. Oncogene 10:881-890, 1995.
35. Tsuda H, Kushi A, Yoshida D, et al. Chromosomal aberrations and sister chromatid exchanges induced by gaseous nitrogen oxide in cultured Chinese hamster cells. Mutat Res 89:303-309, 1981.
36. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mammalian blood and other tissue. Anal Biochem 27:502-522, 1969.
37. Ferrai G, Yan CYI, Greene LA. N-acetylcysteme (D and L-steroisomers) prevents apoptotic death of neural cells. J Neurosci 15(4):2857-2866, 1995.
38. Ratan RR, Murphy TH, Baraban JM. Molecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J Neurosci 14(7):4385-4392, 1994.
39. Cossarizza A, Franceschi C, Monti D, et al. Protection effect of N-acetylcysteine in tumor necrosis factor-α-induced apoptosis in U937 cells: The role of mitochondria. Exp Cell Res 220:232-240, 1995.
40. Steinman HM. Thebcl-2 oncoprotein functions as a pro-oxidant. J Biol Chem 270:3487-3490, 1995.
41. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide ranking implication in tissue kinetics. Br J Cancer 26:238-257, 1972.
42. Sato T, Hanada M, Bodrug S, et al. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA 91:9238-9242, 1994.
43. Oltvai Z, Milliman C, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerate programmed cell death. Cell 74:609-619, 1993.
44. Sedlak TW, Oltvai ZN, Yang L, et al. Multiple bcl-2 family members demonstrate selective dimerizations with bax. Proc Natl Acad Sci USA 92:7834-7838, 1995.
45. Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805, 1994.
46. Zhan Q, Fan S, Bae I, et al. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9:3743-3751, 1994.
47. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299, 1995.
48. Knudson CM, Tung KSK, Tourtellotte WG, et al. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99, 1995.
49. Miyashita T, Harigai M, Hanada M, et al. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54:3131-3135, 1994.
50. Miyashita T, Kitada S, Krajewski S, et al. Over expression of the bcl-2 protein increase the half-life of p21bax. J Biol Chem 270:26049-26052, 1995.
51. Wosikowski K, Regis JT, Robey RW, et al. Normal p53 status and function despite the development of drug resistance in human breast cancer cells. Cell Growth Differ 6:1395-1403, 1995.
52. Aruoma Ol, Halliwell, Hoey BM, et al. The antioxidant action of N-acetylcysteine, its reaction with hydrogen peroxide, hydroxyl radical, Superoxide and hypochlorous acid. Free Radic Biol Med 6:593-597, 1989.
53. Meister A. Glutathione metabolism and its selective modification. J Biol Chem 263:17205-17208, 1988.
54. Asoh K, Watanabe Y, Mizoguchi H, et al. Induction of manga- nese Superoxide dismutase by tumor necrosis factor in human breast cancer MCF-7 cell line and its TNF-resistant variant. Biochem Biophys Res Commun 162:794-801, 1989.
55. Miyashita T, Reed JC. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81:1 151-157, 1993.
56. Oka A, Belliveou MJ, Rosenberg PA, et al. Vulnerability of oligodendroglia to glutamate. J Neurosci 13:1441-1453, 1993.
57. Meister A, Anderson ME. Glutathione (review). Annu Rev Biochem 52:711-760, 1983.