메뉴 건너뛰기




Volumn 63, Issue 2, 2003, Pages 476-483

Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN P16; PROTEIN P53; RAS PROTEIN; TELOMERASE; VIRUS PROTEIN;

EID: 0037439799     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (99)

References (56)
  • 4
    • 0035129549 scopus 로고    scopus 로고
    • Genetic mechanisms in squamous cell carcinoma of the head and neck
    • Jefferies, S., and Foulkes, W. D. Genetic mechanisms in squamous cell carcinoma of the head and neck. Oral Oncol., 37: 115-126, 2001.
    • (2001) Oral Oncol. , vol.37 , pp. 115-126
    • Jefferies, S.1    Foulkes, W.D.2
  • 5
    • 0030829892 scopus 로고    scopus 로고
    • Telomerase in human development and cancer
    • Shay, J. W. Telomerase in human development and cancer. J. Cell. Physiol., 173: 266-270, 1997.
    • (1997) J. Cell. Physiol. , vol.173 , pp. 266-270
    • Shay, J.W.1
  • 6
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
    • Wright, W. E., Pereira-Smith, O. M., and Shay, J. W. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol. Cell. Biol., 9: 3088-3092, 1989.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3088-3092
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.W.3
  • 7
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay, J. W., Pereira-Smith, O. M., and Wright, W. E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res., 196: 33-39, 1991.
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 8
    • 0029894237 scopus 로고    scopus 로고
    • Telomere length regulation
    • Greider, C. W. Telomere length regulation. Annu. Rev. Biochem., 65: 337-365, 1996.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 337-365
    • Greider, C.W.1
  • 9
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., Smogorzewska, A., and de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell, 92: 401-413, 1998.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 10
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., and de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (Wash. DC), 283: 1321-1325, 1999.
    • (1999) Science (Wash. DC) , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 11
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi, S. E., Chang, S., Lee, S. L., Alson, S., Gottlieb, G. J., Chin, L., and DePinho, R. A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (Lond.), 406: 641-645, 2000.
    • (2000) Nature (Lond.) , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 12
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G. B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell, 59: 521-529, 1989.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 13
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu, G. L., Bradley, J. D., Attardi, L. D., and Blackburn, E. H. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (Lond.), 344: 126-132, 1990.
    • (1990) Nature (Lond.) , vol.344 , pp. 126-132
    • Yu, G.L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 16
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W., and Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer, 33: 787-791, 1997.
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 21
    • 0034730196 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle
    • Duensing, S., Lee, L. Y., Duensing, A., Basile, J., Piboonniyom, S., Gonzalez, S., Crum, C. P., and Munger, K. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc. Natl. Acad. Sci. USA, 97: 10002-10007, 2000.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10002-10007
    • Duensing, S.1    Lee, L.Y.2    Duensing, A.3    Basile, J.4    Piboonniyom, S.5    Gonzalez, S.6    Crum, C.P.7    Munger, K.8
  • 22
    • 0035866774 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype
    • Duensing, S., Duensing, A., Crum, C. P., and Munger, K. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res., 61: 2356-2360, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 2356-2360
    • Duensing, S.1    Duensing, A.2    Crum, C.P.3    Munger, K.4
  • 23
    • 0035956258 scopus 로고    scopus 로고
    • Biological activities and molecular targets of the human papillomavirus E7 oncoprotein
    • Munger, K., Basile, J. R., Duensing, S., Eichten, A., Gonzalez, S. L., Grace, M., and Zacny, V. L. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene, 20: 7888-7898, 2001.
    • (2001) Oncogene , vol.20 , pp. 7888-7898
    • Munger, K.1    Basile, J.R.2    Duensing, S.3    Eichten, A.4    Gonzalez, S.L.5    Grace, M.6    Zacny, V.L.7
  • 24
    • 0031662487 scopus 로고    scopus 로고
    • Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue
    • Krisanaprakornkit, S., Weinberg, A., Perez, C. N., and Dale, B. A. Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect. Immun., 66: 4222-4228, 1998.
    • (1998) Infect. Immun. , vol.66 , pp. 4222-4228
    • Krisanaprakornkit, S.1    Weinberg, A.2    Perez, C.N.3    Dale, B.A.4
  • 25
    • 0036178622 scopus 로고    scopus 로고
    • Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity
    • Piboonniyom, S., Timmermann, S., Hinds, P., and Munger, K. Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity. Oral Oncol., 38: 179-186, 2002.
    • (2002) Oral Oncol. , vol.38 , pp. 179-186
    • Piboonniyom, S.1    Timmermann, S.2    Hinds, P.3    Munger, K.4
  • 27
    • 0032512668 scopus 로고    scopus 로고
    • Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins
    • Yang, Z., Delgado, R., Xu, L., Todd, R. F., Nabel, E. G., Sanchez, A., and Nabel, G. J. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science (Wash. DC), 279: 1034-1037, 1998.
    • (1998) Science (Wash. DC) , vol.279 , pp. 1034-1037
    • Yang, Z.1    Delgado, R.2    Xu, L.3    Todd, R.F.4    Nabel, E.G.5    Sanchez, A.6    Nabel, G.J.7
  • 28
    • 0026024632 scopus 로고
    • The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
    • Halbert, C. L., Demers, W., and Galloway, D. A. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J. Virol., 65: 473-478, 1991.
    • (1991) J. Virol. , vol.65 , pp. 473-478
    • Halbert, C.L.1    Demers, W.2    Galloway, D.A.3
  • 29
    • 0024460181 scopus 로고
    • Improved retroviral vectors for gene transfer and expression
    • Miller, A. D., and Rosman, G. J. Improved retroviral vectors for gene transfer and expression. Biotechniques, 7: 980-982, 984-986, 989-990, 1989.
    • (1989) Biotechniques , vol.7 , pp. 980-982
    • Miller, A.D.1    Rosman, G.J.2
  • 30
    • 0032585651 scopus 로고    scopus 로고
    • ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
    • ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state. Oncogene, 17: 3445-3453, 1998.
    • (1998) Oncogene , vol.17 , pp. 3445-3453
    • Timmermann, S.1    Hinds, P.W.2    Munger, K.3
  • 33
  • 36
    • 0029834371 scopus 로고    scopus 로고
    • E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
    • Boyer, S. N., Wazer, D. E., and Band, V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res., 56: 4620-4624, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4620-4624
    • Boyer, S.N.1    Wazer, D.E.2    Band, V.3
  • 37
    • 1842293961 scopus 로고    scopus 로고
    • 1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein
    • 1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. J. Virol., 71: 2905-2912, 1997.
    • (1997) J. Virol. , vol.71 , pp. 2905-2912
    • Jones, D.L.1    Münger, K.2
  • 38
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., and Klingelhutz, A. J. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature (Lond.), 396: 84-88, 1998.
    • (1998) Nature (Lond.) , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 39
    • 0031899814 scopus 로고    scopus 로고
    • Inactivation of p16 in human mammary epithelial cells by CpG island methylation
    • Foster, S. A., Wong, D. J., Barrett, M. T., and Galloway, D. A. Inactivation of p16 in human mammary epithelial cells by CpG island methylation. Mol. Cell. Biol., 18: 1793-1801, 1998.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1793-1801
    • Foster, S.A.1    Wong, D.J.2    Barrett, M.T.3    Galloway, D.A.4
  • 40
    • 0028983491 scopus 로고
    • Growth suppression by p16ink4 requires functional retinoblastoma protein
    • Medema, R. H., Herrera, R. E., Lam, F., and Weinberg, R. A. Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA, 92: 6289-6293, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6289-6293
    • Medema, R.H.1    Herrera, R.E.2    Lam, F.3    Weinberg, R.A.4
  • 41
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn, W. C., and Weinberg, R. A. Modelling the molecular circuitry of cancer. Nat. Rev. Cancer, 2: 331-341, 2002.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 42
    • 0026724882 scopus 로고
    • Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity
    • Sedman, S. A., Hubbert, N. L., Vass, W. C., Lowy, D. R., and Schiller, J. T. Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity. J. Virol., 66: 4201-4208, 1992.
    • (1992) J. Virol. , vol.66 , pp. 4201-4208
    • Sedman, S.A.1    Hubbert, N.L.2    Vass, W.C.3    Lowy, D.R.4    Schiller, J.T.5
  • 44
    • 0036288508 scopus 로고    scopus 로고
    • A two-stage, p16INK4A- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
    • Rheinwald, J. G., Hahn, W. C., Ramsey, M. R., Wu, J. Y., Guo, Z., Tsao, H., De Luca, M., Catricala, C., and O'Toole, K. M. A two-stage, p16INK4A- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell. Biol., 22: 5157-5172, 2002.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5157-5172
    • Rheinwald, J.G.1    Hahn, W.C.2    Ramsey, M.R.3    Wu, J.Y.4    Guo, Z.5    Tsao, H.6    De Luca, M.7    Catricala, C.8    O'Toole, K.M.9
  • 45
    • 0037048297 scopus 로고    scopus 로고
    • Human papillomaviruses and centrosome duplication errors: Modeling the origins of genomic instability
    • Duensing, S., and Munger, K. Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability. Oncogene, 21: 6241-6248, 2002.
    • (2002) Oncogene , vol.21 , pp. 6241-6248
    • Duensing, S.1    Munger, K.2
  • 46
    • 0014265469 scopus 로고
    • Human cells and aging
    • Hayflick, L. Human cells and aging. Sci. Am., 218, 32-37, 1968.
    • (1968) Sci. Am. , vol.218 , pp. 32-37
    • Hayflick, L.1
  • 49
    • 0037142606 scopus 로고    scopus 로고
    • Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function
    • Morris, M., Hepburn, P., and Wynford-Thomas, D. Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function. Oncogene, 21: 4277-4288, 2002.
    • (2002) Oncogene , vol.21 , pp. 4277-4288
    • Morris, M.1    Hepburn, P.2    Wynford-Thomas, D.3
  • 50
    • 0034933793 scopus 로고    scopus 로고
    • Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
    • Alani, R. M., Young, A. Z., and Shifflett, C. B. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a. Proc. Natl. Acad. Sci. USA, 98: 7812-7816, 2001.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7812-7816
    • Alani, R.M.1    Young, A.Z.2    Shifflett, C.B.3
  • 51
    • 0030916439 scopus 로고    scopus 로고
    • Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines
    • Timmermann, S., Hinds, P., and Münger, K. Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines. Cell Growth Differ., 8: 361-370, 1997.
    • (1997) Cell Growth Differ. , vol.8 , pp. 361-370
    • Timmermann, S.1    Hinds, P.2    Münger, K.3
  • 52
    • 0028869884 scopus 로고
    • Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16(INK4/MTS1) tumour suppressor gene product
    • Parry, D., Bates, S., Mann, D. J., and Peters, G. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16(INK4/MTS1) tumour suppressor gene product. EMBO J., 14: 503-511, 1995.
    • (1995) EMBO J. , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4
  • 53
    • 0029890863 scopus 로고    scopus 로고
    • Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells
    • Reznikoff, C. A., Yeager, T. R., Belair, C. D., Savelieva, E., Puthenveettil, J. A., and Stadler, W. M. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Res., 56: 2886-2890, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 2886-2890
    • Reznikoff, C.A.1    Yeager, T.R.2    Belair, C.D.3    Savelieva, E.4    Puthenveettil, J.A.5    Stadler, W.M.6
  • 55
    • 0024809865 scopus 로고
    • Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
    • Münger, K. Werness, B. A., Dyson, N., Phelps, W. C., Harlow, E., and Howley, P. M. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J., 8: 4099-4105, 1989.
    • (1989) EMBO J. , vol.8 , pp. 4099-4105
    • Münger, K.1    Werness, B.A.2    Dyson, N.3    Phelps, W.C.4    Harlow, E.5    Howley, P.M.6
  • 56
    • 0034899522 scopus 로고    scopus 로고
    • Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7
    • Gonzalez, S. L., Stremlau, M., He, X., Basile, J. R., and Münger, K. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J. Virol., 75: 7583-7591, 2001.
    • (2001) J. Virol. , vol.75 , pp. 7583-7591
    • Gonzalez, S.L.1    Stremlau, M.2    He, X.3    Basile, J.R.4    Münger, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.