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Volumn 15, Issue 11, 2001, Pages 1025-1033
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Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin
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Author keywords
5 HT4R receptor; Antagonist binding; Drug design; G protein coupled receptors; Molecular modeling; Serotonin; Transmembrane helices
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Indexed keywords
ACTIVATION ANALYSIS;
BINDING ENERGY;
CHEMICAL ACTIVATION;
COMPUTATIONAL METHODS;
CRYSTAL STRUCTURE;
ETHERS;
FREE ENERGY;
HYDROGEN BONDS;
OXYGEN;
POLYCYCLIC AROMATIC HYDROCARBONS;
PROTEINS;
5-HT4R RECEPTOR;
ANTAGONIST BINDING;
BINDING AFFINITIES;
COMPUTATIONAL MODELLING;
CRYSTALS STRUCTURES;
DRUG DESIGN;
G PROTEIN COUPLED RECEPTORS;
SEROTONIN;
SITE DIRECTED MUTAGENESIS;
TRANSMEMBRANE HELIX;
LIGANDS;
1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER;
AMINE;
ASPARAGINE;
ASPARTIC ACID;
CYSTEINE;
ETHER;
G PROTEIN COUPLED RECEPTOR;
HYDROGEN;
HYDROGEN SULFIDE;
INDOLE DERIVATIVE;
LEUCINE;
NEUROTRANSMITTER;
NITROGEN;
OXYGEN;
PHENYLALANINE;
PIPERIDINE;
RHODOPSIN;
SERINE;
SEROTONIN 4 ANTAGONIST;
SEROTONIN 4 RECEPTOR;
TYROSINE;
ANIMAL CELL;
ARTICLE;
BINDING AFFINITY;
BINDING SITE;
CATTLE;
CHEMICAL INTERACTION;
CRYSTAL STRUCTURE;
DRUG STRUCTURE;
GENE MUTATION;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
LIGAND BINDING;
MOLECULAR MODEL;
MOLECULAR RECOGNITION;
NONHUMAN;
NUCLEOTIDE SEQUENCE;
PRIORITY JOURNAL;
PROTEIN DOMAIN;
PROTEIN FAMILY;
PROTEIN STRUCTURE;
PROTON TRANSPORT;
SITE DIRECTED MUTAGENESIS;
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EID: 0035731824
PISSN: 0920654X
EISSN: None
Source Type: Journal
DOI: 10.1023/A:1014895611874 Document Type: Article |
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Times cited : (16)
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References (42)
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