Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: Evidence for contingent unequal binding sites

Pharmaceutical Research

Volumn 20, Issue 4, 2003, Pages 537-544

  Wang, Er Jia ^a   Casciano, Christopher N ^a   Clement, Robert P ^a   Johnson, William W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ABC B11; BSEP; Cholestasis; Drug interaction; Inhibition; Sister P glycoprotein

Indexed keywords

CHLORPROMAZINE; CIMETIDINE; CLOFAZIMINE; CYCLOSPORIN A; DIHYDROFLUORESCEIN; EPIGALLOCATECHIN GALLATE; FLUORESCENT DYE; GLIBENCLAMIDE; GLYCOPROTEIN P; KETOCONAZOLE; PACLITAXEL; PROGESTERONE; RESERPINE; RIFAMYCIN; SISTER P GLYCOPROTEIN; TAMOXIFEN; TAUROLITHOCHOLIC ACID; TROGLITAZONE; UNCLASSIFIED DRUG; VALINOMYCIN; VERAPAMIL; VINBLASTINE;

ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TRANSPORT KINETICS;

ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; DRUG INTERACTIONS; FLUORESCENT DYES; HUMANS;

EID: 0037391057     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023278211849     Document Type: Article

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