CCR3: A key to mast cell phenotypic and functional diversity?

American Journal of Respiratory Cell and Molecular Biology

Volumn 28, Issue 4, 2003, Pages 405-409

  Forsythe, Paul ^a   Befus, A Dean ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR4; CHYMASE; EOTAXIN; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; OVALBUMIN; RANTES; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRYPTASE; TUMOR NECROSIS FACTOR;

AIRWAY; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL TYPE; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL; HUMAN; INFLAMMATION; MAST CELL; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW;

ASTHMA; BRONCHI; BRONCHIAL HYPERREACTIVITY; CHEMOKINES; HUMANS; MAST CELLS; MUSCLE, SMOOTH; PHENOTYPE; RECEPTORS, CHEMOKINE; VARIATION (GENETICS);

BRONCHUS;

EID: 0037385484     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.F265     Document Type: Review

References (56)

1. Price, K. S., D. S. Friend, E. A. Mellor, N. De Jesus, G. F. M. Watts, and J. A. Boyce. 2003. CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates Immunoglobulin E-dependent generation of interleukin 13. Am. J. Respir. Cell Mol. Biol. 28:420-427.
2. Cosmi, L., F. Annunziato, E. Maggi, S. Romagnani, and R. Manetti. 2001. Chemoattractant receptors expressed on type 2 T cells and their role in disease. Int. Arch. Allergy Immunol. 125:273-279.
3. Nagase, H., M. Miyamasu, M. Yamaguchi, T. Fujisawa, H. Kawasaki, K. Ohta, K. Yamamoto, Y. Morita, and K. Hirai. 2001. Regulation of chemokine receptor expression in eosinophils. Int. Arch. Allergy Immunol. 125:29-32.
4. Kimata, H., A. Yoshida, C. Ishioka, M. Fujimoto, I. Lindley, and K Furusho. 1996. RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells. J. Exp. Med. 183:2397-2402.
5. Kannan, S. 2001. Neutrophil degranulation: coactivation of chemokine receptor(s) is required for extracellular nucleotide-induced neutrophil degranulation. 57:306-309.
6. Leung, B. P., S. Culshaw, J. A. Gracie, D. Hunter, C. A. Canetti, C. Campbell, F. Cunha, F. Y. Liew, and I. B. McInnes. 2001. A role for IL-18 in neutrophil activation. J. Immunol. 167:2879-2886.
7. Wong, M. M., and E. N. Fish. 2002. Chemokines: attractive mediators of the immune response. Semin. Immunol. 15:5-14.
8. Romagnani, S. 2002. Cytokines and chemoattractants in allergic inflammation. Mol. Immunol. 38:881-885.
9. Murdoch, C., and A. Finn. 2000. Chemokine receptors and their role in inflammation and infectious diseases. Blood 95:3032-3043.
10. Kitaura, M., T. Nakajima, T. Imai, S. Harada, C. Combadiere, H. L. Tiffany, P. M. Murphy, and O. Yoshie. 1996. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 271:7725-7730.
11. de Paulis, A., F. Annunziato, L. Di Gioia, S. Romagnani, M. Carfora, C. Beltrame, G. Marone, and P. Romagnani. 2001. Expression of the chemokine receptor CCR3 on human mast cells. Int. Arch. Allergy Immunol. 124:146-150.
12. Menzies-Gow, A., S. Ying, I. Sabroe, V. L. Stubbs, D. Soler, T. J. Williams, and A. B. Kay. 2002. Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers. J. Immunol. 169:2712-2718.
13. Ying, S., Q. Meng, K. Zeibecoglou, D. S. Robinson, A. Macfarlane, M. Humbert, and A. B. Kay. 1999. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. J. Immunol. 163:6321-6329.
14. Ying, S., D. S. Robinson, Q. Meng, J. Rottman, R. Kennedy, D. J. Ringler, C. R. Mackay, B. L. Daugherty, M. S. Springer, S. R. Durham, T. J. Williams, and A. B. Kay. 1997. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma: association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur. J. Immunol. 27:3507-3516.
15. Sabroe, I., M. J. Peck, B. J. Van Keulen, A. Jorritsma, G. Simmons, P. R. Clapham, T. J. Williams, and J. E. Pease. 2000. A small molecule antagonist of chemokine receptors CCR1 and CCR3: potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J. Biol. Chem. 275:25985-25992.
16. White, J. R., J. M. Lee, K. Dede, C. S. Imburgia, A. J. Jurewicz, G. Chan, J. A. Fornwald, D. Dhanak, L. T. Christmann, M. G. Darcy, K. L. Widdowson, J. J. Foley, D. B. Schmidt, and H. M. Sarau. 2000. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J. Biol. Chem. 275:36626-36631.
17. Gurish, M. F., and K. F. Austen. 2001. The diverse roles of mast cells. J. Exp. Med. 194:F1-F5.
18. Forsythe, P., and M. Ennis. 2000. Clinical consequences of mast cell heterogeneity. Inflamm. Res. 49:147-154.
19. Wardlaw, A. J., C. E. Brightling, R. Green, G. Woltmann, P. Bradding, and I. D. Pavord. 2002. New insights into the relationship between airway inflammation and asthma. Clin. Sci. (Lond.) 103:201-211.
20. Sommerhoff, C. P. 2001. Mast cell tryptases and airway remodeling. Am. J. Respir. Crit. Care Med. 164(Suppl.):S52-S58.
21. Rodewald, H. R., M. Dessing, A. M. Dvorak, and S. J. Galli. 1996. Identification of a committed precursor for the mast cell lineage. Science 271:818-822.
22. Romagnani, P., A. de Paulis, C. Beltrame, F. Annunziato, V. Dente, E. Maggi, S. Romagnani, and G. Marone. 1999. Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Am. J. Pathol. 155:1195-1204.
23. Okuda, M. 1999. Functional heterogeneity of airway mast cells. Allergy 54 (Suppl. 57):50-62.
24. Welle, M. 1997. Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J. Leukoc. Biol. 61:233-245.
25. Enerback, L. 1966. Mast cells in rat gastrointestinal mucosa. 2. Dye-binding and metachromatic properties. Acta Pathol. Microbiol. Scand. 66:303-312.
26. Bradding, P., Y. Okayama, P. H. Howarth, M. K. Church, and S. T. Holgate. 1995. Heterogeneity of human mast cells based on cytokine content. J. Immunol. 155:297-307.
27. Furitsu, T., H. Saito, A. M. Dvorak, L. B. Schwartz, A. M. Irani, J. F. Burdick, K. Ishizaka, and T. Ishizaka. 1989. Development of human mast cells in vitro. Proc. Natl. Acad. Sci. USA 86:10039-10043.
28. Sato, E., M. Haniuda, H. Numanami, T. Ushiyama, A. Tsukadaira, S. Takashi, Y. Okubo, and S. Koyama. 2002. Histamine and serotonin stimulate eotaxin production by a human lung fibroblast cell line. Int. Arch. Allergy Immunol. 128(Suppl. 1):12-17.
29. Mochizuki, M., J. Schroder, E. Christophers, and S. Yamamoto. 1999. IL-4 induces eotaxin in human dermal fibroblasts. Int. Arch. Allergy Immunol. 120(Suppl. 1):19-23.
30. Jippo, T., K. Tsujino, H. M. Kim, D. K. Kim, Y. M. Lee, Y. Nawa, and Y. Kitamura. 1997. Expression of mast-cell-specific proteases in tissues of mice studied by in situ hybridization. Am. J. Pathol. 150:1373-1382.
31. Weidner, N., and K. F. Austen. 1993. Heterogeneity of mast cells at multiple body sites. Fluorescent determination of avidin binding and immunofluorescent determination of chymase, tryptase, and carboxypeptidase content. Pathol. Res. Pract. 189:156-162.
32. Shim, J. J., K. Dabbagh, I. F. Ueki, T. Dao-Pick, P. R. Burgel, K. Takeyama, D. C. Tam, and J. A. Nadel. 2001. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L134-L140.
33. Hart, P. H. 2001. Regulation of the inflammatory response in asthma by mast cell products. Immunol. Cell Biol. 79:149-153.
34. Richter, A., S. M. Puddicombe, J. L. Lordan, F. Bucchieri, S. J. Wilson, R. Djukanovic, G. Dent, S. T. Holgate, and D. E. Davies. 2001. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am. J. Respir. Cell Mol. Biol. 25:385-391.
35. Moore, P. E., T. L. Church, D. D. Chism, R. A. Panettieri, Jr., and S. A. Shore. 2002. IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L847-L853.
36. Conti, P., M. Reale, R. C. Barbacane, M. Felaco, A. Grilli, and T. C. Theoharides. 1998. Mast cell recruitment after subcutaneous injection of RANTES in the sole of the rat paw. Br. J. Haematol. 103:798-803.
37. Humbles, A. A., B. Lu, D. S. Friend, S. Okinaga, J. Lora, A. Al-Garawi, T. R. Martin, N. P. Gerard, and C. Gerard. 2002. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc. Natl. Acad. Sci. USA 99:1479-1484.
38. Gurish, M. F., A. Humbles, H. Tao, S. Finkelstein, J. A. Boyce, C. Gerard, D. S. Friend, and K. F. Austen. 2002. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J. Immunol. 168:5730-5736.
39. Brightling, C. E., P. Bradding, F. A. Symon, S. T. Holgate, A. J. Wardlaw, and I. D. Pavord. 2002. Mast-cell infiltration of airway smooth muscle in asthma. N. Engl. J. Med. 346:1699-1705.
40. Page, S., A. J. Ammit, J. L. Black, and C. L. Armour. 2001. Human mast cell and airway smooth muscle cell interactions: implications for asthma. Am. J. Physiol. Lung Cell. Mol. Physiol. 281:L1313-L1323.
41. Williams, C. M. and S. J. Galli. 2000. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J. Exp. Med. 192:455-462.
42. Takeda, K., E. Hamelmann, A. Joetham, L. D. Shultz, G. L. Larsen, C. G. Irvin, and E. W. Gelfand. 1997. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J. Exp. Med. 186:449-454.
43. Ma, W., P. J. Bryce, A. A. Humbles, D. Laouini, A. Yalcindag, H. Alenius, D. S. Friend, H. C. Oettgen, C. Gerard, and R. S. Geha. 2002. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J. Clin. Invest. 109:621-628.
44. Devouassoux, G., D. D. Metcalfe, and C. Prussin. 1999. Eotaxin potentiates antigen-dependent basophil IL-4 production. J. Immunol. 163:2877-2882.
45. Vollrath, I. B., B. F. Gibbs, H. H. Wolff, and U. E. Amon. 1997. Relationship between basophil chemotaxis and histamine releasability to immunological stimulation. Inflamm. Res. 46(Suppl. 1):S11-S12.
46. Ochi, H., W. M. Hirani, Q. Yuan, D. S. Friend, K. F. Austen, and J. A. Boyce. 1999. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J. Exp. Med. 190:267-280.
47. Supajatura, V., H. Ushio, A. Nakao, S. Akira, K. Okumura, C. Ra, and H. Ogawa. 2002. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J. Clin. Invest. 109:1351-1359.
48. McCurdy, J. D., T. J. Lin, and J. S. Marshall. 2001. Toll-like receptor 4-mediated activation of murine mast cells. J. Leukoc. Biol. 70:977-984.
49. Manes, S., R. A. Lacalle, C. Gomez-Mouton, G. del Real, E. Mira, and C. Martinez-A. 2001. Membrane raft microdomains in chemokine receptor function. Semin. Immunol. 13:147-157.
50. Vereb, G., J. Matko, G. Vamosi, S. M. Ibrahim, E. Magyar, S. Varga, J. Szollosi, A. Jenei, R. Gaspar, Jr., T. A. Waldmann, and S. Damjanovich. 2000. Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. Proc. Natl. Acad. Sci. USA 97:6013-6018.
51. Pralle, A.. P. Keller, E. L. Florin, K. Simons, and J. K. Horber. 2000. Sphingo-lipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J. Cell Biol. 148:997-1008.
52. Triantafilou, M., K. Miyake, D. T. Golenbock, and K. Triantafilou. 2002. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J. Cell Sci. 115:2603-2611.
53. Rodriguez-Frade, J. M., M. Mellado, and C. Martinez-A. 2001. Chemokine receptor dimerization: two are better than one. Trends. Immunol. 22:612-617.
54. Mellado, M., J. M. Rodriguez-Frade, S. Manes, and C. Martinez-A. 2001. Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. Annu. Rev. Immunol. 19:397-421.
55. Mellado, M., J. M. Rodriguez-Frade, A. J. Vila-Coro, S. Fernandez, A. Martin de Ana, D. R. Jones, J. L. Toran, and C. Martinez-A. 2001. Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J. 20:2497-2507.
56. El-Shazly, A., and T. Ishikawa. 1999. Novel co-operation between eotaxin and substance-P in inducing eosinophil-derived neurotoxin release. Mediators Inflamm. 8:177-179.