New insights into the relationship between airway inflammation and asthma

Clinical Science

Volumn 103, Issue 2, 2002, Pages 201-211

  Wardlaw, A J ^a   Brightling, C E ^a   Green, R ^a   Woltmann, G ^a   Bradding, P ^a   Pavord, I D ^a  

^a GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

Airway hyper responsiveness; Airway smooth muscle; Asthma; Eosinophils; Inflammation

Indexed keywords

AIRWAY OBSTRUCTION; ALLERGIC RHINITIS; ASTHMA; BRONCHITIS; BRONCHUS HYPERREACTIVITY; COUGHING; DANDER; DERMATOPHAGOIDES PTERONYSSINUS; DISEASE ASSOCIATION; DISEASE SEVERITY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MAST CELL; PRIORITY JOURNAL; REVIEW; TH2 CELL;

EID: 0036346110     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs1030201     Document Type: Review

References (69)

1. Pathology of mild, severe, and fatal asthma
2. Airway smooth muscle in health and disease; methods of measurement and relation to function
3. The structure of large and small airways in nonfatal and fatal asthma
4. The use of induced sputum to investigate airway inflammation
5. Consequences of long-term inflammation. Airway remodeling
6. Differences and similarities between chronic obstructive pulmonary disease and asthma
7. The epidemiology of childhood asthma
8. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity
9. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
10. T cells as orchestrators of the asthmatic response
11. The British guidelines on asthma management
12. Novel therapy for asthma
13. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
14. The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy
15. Eosinophils in asthma and other allergic diseases
16. Eosinophilic bronchitis is an important cause of chronic cough
17. National and international guidelines for the diagnosis and treatment of asthma
18. Clinicians should be proactive in testing for asthma
19. Responses to isoproterenol in a general population sample
20. Do asthmatic patients correctly record home spirometry measurements?
21. Evaluation of peak expiratory flow variability in an adolescent population sample. The Odense Schoolchild Study
22. How often is the diagnosis bronchial asthma correct?
23. Objective measures and the diagnosis of asthma. We need a simple diagnostic test - But don't yet have one
24. A comparison of the validity of different diagnostic tests in adults with asthma
25. Comparison of bronchial reactivity and peak expiratory flow variability measurements for epidemiologic studies
26. Atopy, immunological changes, and respiratory function in bronchiectasis
27. Asthma and wheezing in young children
28. The relationship between inflammation and hyperreactivity of the airways in asthma
29. Analysis of sputum in adults with asthma: Identification of a sub-group with neutrophilic, inhaled corticosteroid resistant disease
30. Changes in the cellular profile of induced sputum after allergen-induced asthmatic responses
31. Non-eosinophilic corticosteroid unresponsive asthma
32. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
33. Does anti-IL-5 deplete bronchial mucosal eosinophils in mild atopic asthma?
34. Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
35. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
36. Heterogeneity of airway inflammation in persistent asthma: Evidence of neutrophilic inflammation and increased sputum interleukin-8
37. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: A randomised controlled trial
38. Reduced asthma exacerbations with a management strategy directed at normalising the sputum eosinophil count. A randomised comparison with traditional management
39. Chronic cough: Eosinophilic bronchitis without asthma
40. Mast-cell infiltration of airway smooth muscle in asthma
41. Cytokine expression in bronchoalveolar lavage T-lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
42. Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma
43. The role of mast cells and basophils in inflammation
44. Regulation of the inflammatory response in asthma by mast cell products
45. Mast cell numbers are increased in the smooth muscle of human sensitized isolated bronchi
46. Tryptase-induced mitogenesis in airway smooth muscle cells. Potency, mechanisms, and interactions with other mast cell mediators
47. Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth-muscle cells: Importance of proteolytic events, time course, and role in mediating mitogenesis
48. Roles of mast cell tryptase and chymase in airway function
49. Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine
50. Effects of nedocromil sodium (Tilade) on the activation of human eosinophils and neutrophils and the release of histamine from mast cells
51. Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol
52. Bronchial mucosal manifestations of atopy: A comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls
53. Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: Regulation by T helper 2 cytokines and corticosteroids
54. Airway smooth muscle as a target in asthma
55. Human bronchial smooth muscle cells in culture produce stem cell factor
56. Airway hyperresponsiveness to acetylcholine: Segregation analysis and evidence for linkage to murine chromosome 6
57. Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: Collaborative study on the genetics of asthma
58. Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients
59. Dosage and time effects of inhaled budesonide on bronchial hyperreactivity
60. Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs
61. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
62. Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle
63. Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function
64. Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness
65. Mechanism of cooperative effects of rhinovirus and atopic sensitization on airway responsiveness
66. The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness
67. Potent bronchoprotective effect of deep inspiration and its absence in asthma
68. Strain increases airway smooth muscle cell proliferation
69. Allergy and asthma in elite summer sport athletes