On the use of DNA vaccines for the prophylaxis of mycobacterial diseases

Infection and Immunity

Volumn 71, Issue 4, 2003, Pages 1613-1621

  Huygen, Kris ^a  

^a PASTEUR INSTITUTE OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BCG VACCINE; DNA VACCINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; PLASMID VECTOR; PROTEIN MPB83; UNCLASSIFIED DRUG;

ANIMAL DISEASE; BACTERIAL VIRULENCE; CELLULAR IMMUNITY; CPG ISLAND; DISEASE MODEL; DNA TRANSFECTION; DRUG MECHANISM; GENE GUN; HUMAN; IMMUNOTHERAPY; INFECTION PREVENTION; MYCOBACTERIOSIS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM ULCERANS; NONHUMAN; PARATUBERCULOSIS; PRIORITY JOURNAL; SHORT SURVEY; TUBERCULIN TEST; VACCINATION;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; CATTLE; GUINEA PIGS; HUMANS; MICE; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; VACCINES, DNA;

EID: 0037378046     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.4.1613-1621.2003     Document Type: Short Survey

References (79)

1. Baldwin, S. L., C. D'Souza, A. D. Roberts, B. P. Kelly, A. A. Frank, M. A. Liu, J. B. Ulmer, K. Huygen, D. M. Mc Murray, and I. M. Orme. 1998. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect. Immun. 66:2951-2959.
2. Baldwin, S. L., C. D. D'Souza, I. M. Orme, M. A. Liu, K. Huygen, O. Denis, A. Tang, L. Zhu, D. Montgomery, and J. B. Ulmer. 1999. Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A. Tuber. Lung Dis. 79:251-259.
3. Banu, S., N. Honoré, B. Saint-Joanis, D. Philpott, M.-C. Prévost, and S. T. Cole. 2002. Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens? Mol. Microbiol. 44:9-19.
4. Bonato, V. L. D., V. M. F. Lima, R. E. Tascon, D. B. Lowrie, and C. L. Silva. 1998. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect. Immun. 66:169-175.
5. Calarota, S., G. Bratt, S. Nordlund, J. Hinkula, A.-C. Leandersson, E. Sandström, and B. Wahren. 1998. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet 351:1320-1325.
6. Chambers, M. A., H.-M. Vordermeier, A. Whelan, N. Commander, R. Tascon, D. Lowrie, and R. G. Hewinson. 2000. Vaccination of mice and cattle with plasmid DNA encoding the Mycobacterium bovis antigen MPB83. Clin. Infect. Dis. 30(Suppl. 3):S283-S287.
7. Chambers, M. A., A. Williams, G. Hatch, D. Gavier-Widén, G. Hall, K. Huygen, D. Lowrie, P. D. Marsh, and R. G. Hewinson. 2002. Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis. Infect. Immun. 70:2159-2165.
8. Coler, R. N., Y. A. Skeiky, T. Vedvick, T. Bement, P. Ovendale, A. Campos-Neto, M. Alderson, and S. G. Reed. 1998. Molecular cloning and immunological reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis. J. Immunol. 161:2356-2364.
9. Delogu, G., and M. J. Brennan. 2001. Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis. Infect. Immun. 69:5606-5611.
10. Delogu, G., A. Howard, F. M. Collins, and S. L. Morris, 2000. DNA vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity. Infect. Immun. 68:3097-3102.
11. Delogu, G., A. Li, C. Repique, F. Collins, and S. L. Morris. 2002. DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect. Immun. 70:292-302.
12. Denis, O., A. Tanghe, K. Palfliet, F. Jurion, T. P. van den Berg, A. Vanonckelen, J. Ooms, E. Saman, J. B. Ulmer, J. Content, and K. Huygen. 1998. Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4- and CD8- T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection. Infect. Immun. 66:1527-1533.
13. Dillon, D. C., M. R. Alderson, C. H. Day, D. M. Lewinsohn, R. Coler, T. Bement, A. Campos-Neto, Y. A. W. Skeiky, I. M. Orme, A. Roberts, S. Steen, W. Dalemans, R. Badaro, and S. G. Reed. 1999. Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family. Infect. Immun. 67:2941-2950.
14. Donnelly, J. J., J. B. Ulmer, J. W. Shiver, and M. A. Liu. 1997. DNA vaccines. Annu. Rev. Immunol. 15:617-648.
15. + T cells, in mice vaccinated with DNA encoding Ag85A. Eur. J. Immunol. 30:2455-2459.
16. D'Souza, S., V. Rosseels, O. Denis, A. Tanghe, N. De Smet, F. Jurion, K. Palfliet, N. Castiglioni, A. Vanonckelen, C. Wheeler, and K. Huygen. 2002. Improved tuberculosis DNA vaccines by formulation in cationic lipids. Infect. Immun. 70:3681-3688.
17. D'Souza, S., V. Rosseels, M. Romano, A. Tanghe, O. Denis, F. Jurion, N. Castiglione, A. Vanonckelen, K. Palfliet, and K. Huygen. 2003. Mapping of murine Th1 helper T-cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis. Infect. Immun. 71:483-493.
18. D'Souza, S., A. Tanghe, O. Denis, V. Rosseels, and K. Huygen. 2001. DNA vaccines for tuberculosis, p. 65-74. In H. Goossens, W. Peetermans, and M. Struelens (ed.), Emerging bacterial pathogens. Proceedings of 2nd Elzenveld Workshop on Infectious Diseases. Bristol-Myers Squibb Belgium, Waterloo, Belgium.
19. + T cell priming against the identified peptides after DNA vaccination of mice. Vaccine 16:692-697.
20. Feng, C. G., U. Palendira, C. Demangel, J. M. Spratt, A. S. Malin, and W. J. Britton. 2001. Priming by DNA immunization augments protective efficacy of Mycobacterium bovis BCG against tuberculosis. Infect. Immun. 69:4174-4176.
21. Fonseca, D. P. A. J., B. Benaissa-Trouw, M. Van Engelen, C. A. Kraaijeveld, H. Snippe, and A. F. M. Verheul. 2001. Induction of cell-mediated immunity against Mycobacterium tuberculosis using DNA vaccines encoding cytotoxic and helper T-cell epitopes of the 38-kilodalton protein. Infect. Immun. 69:4839-4845.
22. Freidag, B. L., G. B. Melton, F. Collins, D. M. Klinman, A. Cheever, L. Stobie, W. Suen, and R. A. Seder. 2000. CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect. Immun. 68:2948-2953.
23. Garapin, A., L. Ma, P. Pescher, M. Lagranderie, and G. Marchal. 2001. Mixed immune responses induced in rodents by two naked DNA genes coding for mycobacterial glycosylated proteins. Vaccine 19:2830-2841.
24. - T cells in HLA-transgenic mice and humans. J. Immunol. 165:6463-6471.
25. Gurunathan, S., D. M. Klinman, and R. A. Seder. 2000. DNA vaccines: immunology, application and optimization. Annu. Rev. Immunol. 18:927-974.
26. Hariharan, M. J., D. A. Driver, K. Townsend, D. Brumm, J. M. Polo, B. A. Belli, D. J. Catton, D. Hsu, D. Mittelstaedt, J. E. McCormack, L. Karavodin, T. W. Dubensky, S. M. W. Chang, and T. A. Banks. 1998. DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector. J. Virol. 72:950-958.
27. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
28. Huygen, K., J. Content, O. Denis, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. DeWitt, I. M. Orme, S. Baldwin, C. D'Souza, A. Drowart, E. Lozes, P. Vandenbussche, J.-P. Van Vooren, M. A. Liu, and J. B. Ulmer. 1996. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2:893-898.
29. Kamath, A. T., C. G. Feng, M. MacDonald, H. Briscoe, and W. J. Britton. 1999. Differential protective efficacy of DNA vaccines expressing secreted proteins of M. tuberculosis. Infect. Immun. 67:1702-1707.
30. Kamath, A. T., T. Hanke, H. Briscoe, and W. J. Britton. 1999. Co-immunization with DNA vaccines expressing granulocyte-macrophage colony-stimulating factor and mycobacterial proteins enhances T-cell immunity, but not protective efficacy against M. tuberculosis. Immunology 96:511-516.
31. Klinman, D. M., A.-K. Yi, S. L. Beaucage, J. Konover, and A. M. Krieg. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ. Proc. Natl. Acad. Sci. USA 93:2879-2883.
32. Krieg, A. M., T. Wu, R. Weeratna, S. M. Efler, L. Love-Homan, L. Yang, A. K. Yi, D. Short, and H. L. Davis. 1998. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95:12631-12636.
33. Launois, P., R. DeLeys, M. N'Diaye Niang, A. Drowart, M. Andrien, P. Dierckx, J.-L. Cartel, J.-L. Sarthou, J.-P. Van Vooren, and K. Huygen. 1994. T-cell epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy. Infect. Immun. 62:3679-3687.
34. Lefevre, P., O. Denis, L. De Wit, A. Tanghe, P. Vandenbussche, J. Content, and K. Huygen. 2000. Cloning of the gene encoding a 22-kDa cell surface antigen of Mycobacterium bovis BCG and analysis of its potential for DNA vaccination against tuberculosis. Infect. Immun. 68:1040-1047.
35. Li, Z., A. Howard, C. Kelley, G. Delogu, F. Collins, and S. Morris. 1999. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences. Infect. Immun. 67:4780-4786.
36. Lima, K. M., V. L. D. Bonato, L. H. Faccioli, I. T. Brandao, S. A. dos Santos, A. A. M. Coelho-Castelo, S. C. Leao, and C. L. Silva. 2001. Comparison of different delivery systems of vaccination for the induction of protection against tuberculosis in mice. Vaccine 19:3518-3525.
37. Lowrie, D. B., C. L. Silva, M. J. Colston, S. Ragno, and R. E. Tascon. 1997. Protection against tuberculosis by a plasmid DNA vaccine. Vaccine 15:834-838.
38. Lowrie, D. B., R. E. Tascon, V. L. D. Bonato, V. M. F. Lima, L. H. Faccioli, E. Stavropoulos, M. J. Colston, R. G. Hewinson, K. Moelling, and C. L. Silva. 1999. Therapy of tuberculosis in mice by DNA vaccination. Nature 400:269-271.
39. Manca, C., K. Lyashchenko, H. G. Wiker, D. Usai, R. Colangeli, and M. L. Gennaro. 1997. Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis. Infect. Immun. 65:16-23.
40. + T cells. Infect. Immun. 68:3090-3096.
41. Martin, E., P. W. Roche, J. A. Triccas, and W. J. Britton. 2001. DNA encoding a single mycobacterial antigen protects against leprosy infection. Vaccine 19:1391-1396.
42. McShane, H. 2002. Prime-boost immunization strategies for infectious diseases. Curr. Opin. Mol. Ther. 4:23-27.
43. +-T-cell epitopes from antigen 85A. Infect. Immun. 70:1623-1626.
44. + T-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis. Infect. Immun. 69:681-686.
45. Mollenkopf, H. J., D. Groine-Triebkorn, P. Andersen, J. Hess, and S. H. Kaufmann. 2001. Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier and expressed by naked DNA. Vaccine 19:4028-4035.
46. Montgomery, D. L., K. Huygen, A. M. Yawman, R. R. Deck, C. M. Dewitt, J. Content, M. A. Liu, and J. B. Ulmer. 1997. Induction of humoral and cellular immune responses by vaccination with M-tuberculosis antigen 85 DNA. Cell. Mol. Biol. 43:285-292.
47. Moreira, A. L., L. Tsenova, M. H. Aman, L.-G. Bekker, S. Freeman, B. Mangaliso, U. Schröder, J. Jagirdar, W. N. Rom, M. G. Tovey, V. H. Freedman, and G. Kaplan. 2002. Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect. Immun. 70:2100-2107.
48. Nichols, W. W., B. J. Lewith, S. V. Manam, and P. J. Troilo. 1995. Potential DNA vaccine integration into host cell genome. Proc. Natl. Acad. Sci. USA 772:30-39.
49. Ohara, N., N. Ohara-Wada, H. Kitaura, T. Nishiyama, S. Matsumoto, and T. Yamada. 1997. Analysis of the genes encoding the antigen 85 complex and MPT51 from Mycobacterium avium. Infect. Immun. 65:3680-3685.
50. Orme, I. M. 1988. Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection. J. Immunol. 140:3589-3593.
51. Palendira, U., A. T. Kamath, C. G. Feng, E. Martin, P. J. Chaplin, J. A. Triccas, and W. J. Britton. 2002. Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis. Infect. Immun. 70:1949-1956.
52. Portaels, F., J. Aguiar, M. Debacker, C. Steunou, C. Zinsou, A. Guedenon, and W. M. Meyers. 2002. Prophylactic effect of Mycobacterium bovis BCG vaccination against osteomyelitis in children with Mycobacterium ulcerans disease (Buruli ulcer). Clin. Diagn. Lab. Immunol. 9:1389-1391.
53. Repique, C. J., A. Li, F. M. Collins, and S. L. Morris. 2002. DNA immunization in a mouse model of latent tuberculosis: effect of DNA vaccination on reactivation of disease and on reinfection with a secondary challenge. Infect. Immun. 70:3318-3323.
54. Roche, P. W., K. D. Neupane, S. S. Failbus, A. Kamath, and W. J. Britton. 2001. Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae. Int. J. Lepr. Other Mycobact. Dis. 69:93-98.
55. Sasaki, S., R. R. Amara, A. E. Oran, J. M. Smith, and H. L. Robinson. 2001. Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases. Nat. Biotechnol. 19:543-547.
56. Sato, Y., M. Roman, J. Tighe, D. Lee, M. Corr, M. D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352-354.
57. Singh, M., M. Briones, G. Ott, and D. O'Hagan. 2000. Cationic microparticles: a potent delivery system for DNA vaccines. Proc. Natl. Acad. Sci. USA 97:811-816.
58. + CTL specific for the mycobacterial major secreted antigen 85A. J. Immunol. 165:7088-7095.
59. Snewin, V. A., M.-P. Gares, P. O. Gaora, Z. Hasan, I. Brown, and D. B. Young. 1999. Assessment of immunity to mycobacterial infection with luciferase reporter constructs. Infect. Immun. 67:4586-4593.
60. Tang, D., M. Devit, and S. A. Johnston. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356:152-154.
61. Tanghe, A., J. Content, J.-P. Van Vooren, F. Portaels, and K. Huygen. 2001. Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer. Infect. Immun. 69:5403-5411.
62. Tanghe, A., S. D'Souza, V. Rosseels, O. Denis, T. H. M. Ottenhoff, W. Dalemans, C. Wheeler, and K. Huygen. 2001. Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting. Infect. Immun. 69:3041-3047.
63. Tanghe, A., O. Denis, B. Lambrecht, V. Motte, T. van den Berg, and K. Huygen. 2000. Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection, but not by epidermal gene gun bombardment. Infect. Immun. 68:3854-3860.
64. Tanghe, A., P. Lefèvre, O. Denis, S. D'Souza, M. Braibant, E. Lozes, M. Singh, D. Montgomery, J. Content, and K. Huygen, 1999. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J. Immunol. 162:1113-1119.
65. Tascon, R. E., M. J. Colston, S. Ragno, E. Stavropoulos, D. Gregory, and D. B. Lowrie. 1996. Vaccination against tuberculosis by DNA injection. Nat. Med. 2:888-892.
66. Taylor, J. L., O. C. Turner, R. J. Basaraba, J. T. Belisle, K. Huygen, and I. M. Orme. 2003. Pulmonary necrosis resulting from DNA vaccination against tuberculosis. Infect. Immun. 71:1465-02.
67. Tollefsen, S., T. E. Tjelle, J. Schneider, M. Harboe, H. G. Wiker, G. Hewinson, K. Huygen, and I. Mathiesen. 2002. Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunization combined with muscle electroporation. Vaccine 20:3370-3378.
68. Tonkinson, J. L., and C. A. Stein. 1994. Patterns of intracellular compartmentalization, trafficking and acidification of 5′-fluorescein labeled phosphodiester and phosphorothioate oligodeoxynucleotides in HL60 cells. Nucleic Acids Res. 22:4268.
69. Turner, J., E. R. Rhoades, M. Keen, J. T. Belisle, A. A. Frank, and I. M. Orme. 2000. Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode. Infect. Immun. 68:1706-1709.
70. Ulmer, J. B. 2001. Tuberculosis DNA vaccines. Scand. J. Infect. Dis. 33:246-248.
71. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Feigner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M. DeWitt, A. Friedman, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
72. Velaz-Faircloth, M., A. J. Cobb, A. L. Horstman, S. C. Henry, and R. Frothingham. 1999. Protection against Mycobacterium avium by DNA vaccines expressing mycobacterial antigens as fusion proteins with green fluorescent protein. Infect. Immun. 67:4243-4250.
73. Vordermeier, H. M., P. J. Cockle, A. O. Whelan, S. Rhodes, M. A. Chambers, D. Clifford, K. Huygen, R. Tascon, D. Lowrie, M. J. Colston, and R. G. Hewinson. 2001. Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test. Vaccine 19:1246-1255.
74. Wang, R., D. L. Doolan, T. P. Le, R. C. Hedstrom, K. M. Coonan, Y. Charoenvit, T. R. Jones, P. Hobart, M. Margalith, J. Ng, W. R. Weiss, M. Sedegah, C. de Taisne, J. A. Norman, and S. L. Hoffman. 1998. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282:476-480.
75. + type 1 responses in humans by a malaria DNA vaccine. Proc. Natl. Acad. Sci. USA 98:10817-10822.
76. Wolff, J. A., J. J. Lutdke, G. Ascadi, P. Williams, and A. Jani. 1992. Long-term persistence of plasmid DNA and foreign gene expression in muscle cells. Hum. Mol. Genet. 1:363-369.
77. Wolff, J. A., R. W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P. L. Feigner. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
78. Yeremeev, V. V., I. V. Lyadova, B. V. Nikonenko, A. S. Apt, C. Abou-Zeid, J. Inwald, and D. B. Young. 2000. The 19-kD antigen and protective immunity in a murine model of tuberculosis. Clin. Exp. Immunol. 120:274-279.
79. Zhu, X. J., N. Venkataprasad, H. S. Thangaraj, M. Hill, M. Singh, J. Ivanyi, and H. M. Vordermeier. 1997. Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J. Immunol. 158:5921-5926.