Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4+ T cells

Infection and Immunity

Volumn 68, Issue 6, 2000, Pages 3090-3096

  Martin, Ela ^a   Kamath, Arun T ^a   Triccas, James A ^a   Britton, Warwick J ^a  

^a CENTENARY INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DNA VACCINE; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HELPER CELL; LYMPHOCYTE PROLIFERATION; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, CD44; ANTIGENS, CD45; BACTERIAL PROTEINS; BCG VACCINE; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MYCOBACTERIUM AVIUM; SPLEEN; T-LYMPHOCYTES, HELPER-INDUCER; TUBERCULOSIS; VACCINATION; VACCINES, DNA;

EID: 0034039112     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.6.3090-3096.2000     Document Type: Article

References (39)

1. Appelberg, R. 1994. Protective rule of interferon gamma, tumour necrosis factor alpha and interleukin-6 in Mycobacterium tuberculosis infection. J. Immunobiol. 191:520-526.
2. Appelberg, R., and J. Pedrosa. 1992. Induction and expression of protective T cells during Mycobacterium avium infections in mice. Clin. Exp. Immunol. 87:379-385.
3. Benson, C. A. 1994. Treatment of disseminated disease due to the Mycobacterium avium complex in patients with AIDS. Clin. Infect. Dis. 18:S273-S242.
4. Coligan, J. E., A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober. 1995. Current protocols in immunology. Coordinating ed., R. Coico. Wiley, London, England.
5. Collins, F. M. 1989. Mycobacterial disease, immunosuppression, and acquired immunodeficiency syndrome. Clin. Microbiol. Rev. 2:360-367.
6. Cooper, A. M., R. Appelberg, and I. M. Orme. 1998. Immunopathogenesis of Mycobacterium avium infection. Front. Biosci. 3:141-148.
7. Demangel, C., A. G. D. Bean, E. Martin, C. G. Feng, A. T. Kamath, and W. J. Britton. 1999. Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells. Eur. J. Immunol. 29:1972-1979.
8. +, T cells in lungs following aerosol infection with Mycobacterium tuberculosis. Infect. Immun. 67:3242-3247.
9. Fine, P. E. M., and L. C. Rodrigues. 1991. Modern vaccines: mycobacterial diseases. Lancet 335:1016-1020.
10. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
11. Gelber, R. H., P. J. Brennan, S. W. Hunter, M. W. Munn, J. M. Monson, L. P. Murray, P. Siu, M. Tsang, E. G. Engleman, and N. Mohagheghpour. 1990. Effective vaccination of mice against leprosy bacilli subunit of Mycobacterium leprae. Infect. Immun. 58:711-718.
12. Horsburgh, C. R. J., J. A. Havlik, D. A. Ellis, E. Kennedy, S. A. Fann, R. E. DuBois, and S. E. Thompson. 1991. Survival of patients with acquired immune deficiency syndrome and disseminated Mycobacterium avium complex infection with and without antimycobacterial chemotherapy. Am. Rev. Respir. Dis. 144:557-559.
13. Hubbard, R. D., C. M. Flory, and F. M. Collins. 1992. T-cell immune responses in Mycobacteriuin avium-infected mice. Infect. Immun. 60:150-153.
14. Hunter, S. W., B. Rivoire, V. Mehra, B. R. Bloom, and P. J. Brennan. 1990. The major native proteins of the leprosy bacillus. J. Biol. Chem. 265:14065-14068.
15. Huygen, K., J. Content, D. Olivier, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. De Witt, I. M. Orme, S. Baldwin, C. D'Souza, A. Drowart, E. Lozes, P. Vandenbussche, J. P. Van Vooren, M. A. Liu, and J. B. Ulmer. 1996. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2:893-898.
16. Ivanyi, J., J. A. Morris, and M. Keen. 1985. Studies with monoclonal antibodies to mycobacteria, p. 51. In J. L. Macario and E. C. de Macario (ed.), Monoclonal antibodies to bacteria. Academic Press, London, England.
17. Ivanyi, J., S. Sinha, R. Aston, D. Cussel, M. Kenn, and U. Sengupta. 1983. Definition of species-specific and cross-reactive antigenic determinants of Mycobacterium leprae using monoclonal antibodies. Clin. Exp. Immunol. 52:528-536.
18. Kamath, A. T., C. G. Feng, M. MacDonald, H. Briscoe, and W. J. Britton. 1999. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect. Immun. 67:1702-1707.
19. Lai, W. C., M. Bennet, S. A. Johnston, M. A. Barry, and S. P. Pakes. 1995. Protection against Mycoplasma pulmonis infection by genetic vaccination. Cell Biol. 14:643-648.
20. Li, Z., A. Howard, C. Kelley, G. Delogu, F. Collins, and S. Morris. 1999. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences. Infect. Immun. 67:4780-4786.
21. Lowrie, D. B., R. E. Tascon, V. L. D. Bonato, V. M. F. Lima, L. H. Facciolo, E. Stavropoulos, M. J. Colston, R. G. Hewinson, K. Moelling, and C. L. Silva. 1999. Therapy of tuberculosis in mice by DNA vaccination. Nature 400:269-271.
22. Mohagheghpour, N., M. W. Munn, R. H. Gelber, and E. G. Engleman. 1990. Identification of an immunostimulating protein from Mycobacterium leprae. Infect. Immun. 58:703-710.
23. Morris, S. L., L. Bermudez, and S. D. Chaparas. 1991. Mycobacterium avium complex disease in patients with AIDS: seroreactivity to native and recombinant mycobacterial antigens. J. Clin. Microbiol. 29:2715-2719.
24. Orme, I. M., P. Andersen, and W. H. Boom. 1993. T cell response to Mycobacterium tuberculosis. J. Infect. Dis. 167:1481-1497.
25. Orme, I. M., and F. M. Collins. 1985. Prophylactic effect in mice of BCG vaccination against non-tuberculosis mycobacterial infections in mice. Tubercle 6:117-120.
26. Prince, D. S., D. D. Peterson, R. M. Steiner, J. E. Gottlieb, R. Scott, H. L. Israel, W. G. Figeroa, and J. E. Fish. 1989. Infection with Mycobacterium avium complex in patients without predisposing conditions. N. Engl. J. Med. 321:863-868.
27. Romanus, V. 1983. Childhood tuberculosis in Sweden. Tubercle 64:101-110.
28. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
29. Silva, C. L., R. L. R. Pietro, A. Januario, V. L. D. Bonato, V. M. F. Lima, M. F. Silva, and D. B. Lowrie. 1995. Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65. Immunology 86:519-524.
30. Sinha, S., U. Sengupta, G. Ramu, and J. Ivanyi. 1985. Serological survey of leprosy and control subjects by a monoclonal antibody-based immunoassay. Int. J. Lepr. 53:33-38.
31. Tanghe, A., P. Lefevre, O. Denis, S. D'Souza, M. Braibant, E. Lozes, M. Singh, D. Montgomery, J. Content, and K. Huygen. 1999. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J. Immunol. 162:1113-1119.
32. Tascon, R. E., M. J. Colston, S. Ragno, E. Stavropoulos, D. Gregory, and D. B. Lowrie. 1996. Vaccination against tuberculosis by DNA injection. Nat. Med. 2:888-892.
33. Tighe, H., M. Corr, M. Roman, and E. Raz. 1998. Gene vaccination: plasmid DNA is more than just a blueprint. Immunol. Today 19:89-96.
34. Triccas, J. A., P. W. Roche, N. Winter, C. G. Feng, C. R. Butlin, and W. J. Britton. 1996. A 35-kDa protein is a major target of the human immune response to Mycobacterium leprae. Infect. Immun. 64:5171-5177.
35. Triccas, J. A., N. Winter, P. W. Roche, A. Gilpin, K. E. Kendrick, and W. J. Britton. 1998. Molecular and immunological analysis of the Mycobacterium avium homologue of the immunodominant Mycobacterium leprae 35-kDa protein. Infect. Immun. 66:2684-2690.
36. Ulmer, J. B., M. A. Liu, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. DeWitt, J. Content, and K. Huygen. 1997. Expression and immunogenicity of Mycobacterium tuberculosis antigen 85 by DNA vaccination. Vaccine 15:792-794.
37. Velaz-Faircloth, M., A. J. Cobb, A. L. Horstman, S. C. Henry, and R. Frothingham. 1999. Protection against Mycobacterium avium by DNA vaccines expressing mycobacterial antigens as fusion proteins with green fluorescent protein. Infect. Immun. 67:4243-4250.
38. Winter, N., J. A. Triccas, B. Rivoire, M. C. Pessolani, K. Eiglmeier, E. M. Lim, S. W. Hunter, P. J. Brennan, and W. J. Britton. 1995. Characterisation of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae. Mol. Microbiol. 16:865-876.
39. Zhu, X., N. Venkataprasad, H. S. Thangaraj, M. Hill, M. Singh, J. Ivanyi, and H. M. Vordermeier. 1997. Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J. Immunol. 158:5921-5926.