Comparison of different delivery systems of vaccination for the induction of protection against tuberculosis in mice

Vaccine

Volumn 19, Issue 25-26, 2001, Pages 3518-3525

  Lima, Karla M ^a   Bonato, Vania L D ^a   Faccioli, Lúcia H ^a   Brandão, Izaíra T ^a   Dos Santos, Sandra A ^a   Coelho Castelo, Arlete A M ^a   Leão, Sylvia C ^b   Silva, Celio L ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

BCG; Cytokines; DNA vaccination; Liposomes; Transfected macrophages; Tuberculosis

Indexed keywords

BCG VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; FREUND ADJUVANT; GAMMA INTERFERON; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 65; HERMES ANTIGEN; LIPOSOME; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS; VACCINATION;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, CD44; BACTERIAL PROTEINS; BCG VACCINE; CD8-POSITIVE T-LYMPHOCYTES; CHAPERONINS; CYTOKINES; FREUND'S ADJUVANT; LIPOSOMES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; SPLEEN; T-LYMPHOCYTES; VACCINES, DNA;

EID: 0035858130     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00042-1     Document Type: Article

References (32)

1. Tuberculosis in developing countries: Burden, intervention and cost
2. Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I
3. A single mycobacterial protein (hsp65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis
4. Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65
5. Towards a DNA vaccine against tuberculosis
6. Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65
7. An ubiquitous mammalian expression vector, pHMG, based on a housekeeping gene promoter
8. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice
9. Generation of polarized antigen-specific CD8 effector populations: Reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
10. Biochemical anatomy of antigen processing
11. Interferon-gamma inductive effect of liposomes as an immunoadjuvant
12. Modulation of murine macrophage nitric oxide synthesis by liposomal phospholipids: Correlation with liposome immune adjuvant activity
13. Immune activation by bacterial DNA: A new genetic code
14. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
15. Macrophages ingest and are activated by bacterial DNA
16. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha
17. Liposomes and ISCOMS as vaccine formulations
18. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle
19. Vaccination against tuberculosis by DNA injection
20. Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors
21. The regulation of the development of CD8 effector T cells
22. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells, which do not cross-react in the cytotoxic assay
23. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
24. Mycobacterial heat-shock proteins as carrier molecules
25. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
26. Th1 and Th2 subsets: Paradigms lost?
27. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th 1 or Th2 cytokines
28. Murine Th 1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations
29. Acquisition of lymphokine-producing phenotype by CD4+ T cells
30. Correlation between the kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis
31. Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guérin
32. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens