Pulmonary necrosis resulting from DNA vaccination against tuberculosis

Infection and Immunity

Volumn 71, Issue 4, 2003, Pages 2192-2198

  Taylor, Jennifer L ^a   Turner, Oliver C ^a   Basaraba, Randall J ^a   Belisle, John T ^a   Huygen, Kris ^b   Ormel, Ian M ^a  

^a Immunology and Pathology   (United States)

^b PASTEUR INSTITUTE OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; DEXAMETHASONE; DNA VACCINE; HEAT SHOCK PROTEIN 60; IMMUNOSUPPRESSIVE AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BCG VACCINATION; CELL DEATH; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; GENETIC CODE; IMMUNOTHERAPY; LUNG GRANULOMA; MOUSE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

ANIMALS; ANTIGENS, BACTERIAL; CHAPERONIN 60; FEMALE; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NECROSIS; SPECIFIC PATHOGEN-FREE ORGANISMS; TUBERCULOSIS VACCINES; TUBERCULOSIS, PULMONARY; VACCINATION; VACCINES, DNA;

EID: 0037378872     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.4.2192-2198.2003     Document Type: Article

References (28)

1. BaIdwin, S. L., C. D'Souza, A. D. Roberts, B. P. Kelly, A. A. Frank, M. A. Lui, J. B. Ulmer, K. Huygen, D. M. McMurray, and I. M. Orme. 1998. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect. Immun. 66:2951-2959.
2. Brooks, J. V., S. K. Furney, and I. M. Orme. 1999. Metronidazole therapy in mice infected with tuberculosis. Antimicrob. Agents Chemother. 43:1285-1288.
3. Colditz, G. A., T. F. Brewer, C. S. Berkey, M. E. Wilson, E. Burdick, H. V. Fineberg, and F. Mosteller. 1994. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA 271:698-702.
4. phox-/- mice. Infect. Immun. 68:1231-1234.
5. Dye, C., S. Scheele, P. Dolin, V. Pathania, M. C. Raviglione, et al. 1999. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. JAMA 282:677-686.
6. Flynn, J. L., and J. Chan. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19:93-129.
7. Flynn, J. L., C. A. Scanga, K. E. Tanaka, and J. Chan. 1998. Effects of aminoguanidine on latent murine tuberculosis. J. Immunol. 160:1796-1803.
8. Huygen, K., J. Content, O. Denis, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. DeWitt, I. M. Orme, S. Baldwin, C. DeSouza, A. Drowart, E. Lozes, P. Vandenbussche, J. P. Van Vooren, M. A. Liu, and J. P. Ulmer. 1996. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2:893-898.
9. Huygen, K., D. Abramowicz, P. Vandenbussche, F. Jacobs, J. De Bruyn, A. Kentos, A. Drowart, J. P. Van Vooren, and M. Goldman. 1992. Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice. Infect. Immun. 60:2880-2886.
10. Kaufmann, S. H., U. Vath, J. E. Thole, J. D. Van Embden, and F. Emmrich. 1987. Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur. J. Immunol. 17:351-357.
11. Koch, R. 1891. Fortsetzung der Mitteilungen über ein Heilmittel gegen Tuberkulose. Dtsch. Med. Wochenschr. 17:101-102.
12. Lowrie, D. B., R. E. Tascon, V. L. Bonato, V. M. Lima, L. H. Faccioli, E. Stavropoulos, M. J. Colston, R. G. Hewinson, K. Moelling, and C. L. Silva. 1999. Therapy of tuberculosis in mice by DNA vaccination. Nature 400:269-271.
13. Moreira, A. L., L. Tsenova, M. H. Aman, L. G. Bekker, S. Freeman, B. Mangaliso, U. Schroder, J. Jagirdar, W. N. Rom, M. G. Tovey, V. H. Freedman, and G. Kaplan. 2002. Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect. Immun. 70:2100-2107.
14. Orme, I. M. 1999. Beyond BCG: the potential for a more effective TB vaccine. Mol. Med Today 5:487-492.
15. Orme, I. M., P. Andersen, and W. H. Boom. 1993. T cell response to Mycobacterium tuberculosis. J. Infect. Dis. 167:1481-1497.
16. Orme, I. M., D. N. McMurray, and J. T. Belisle. 2001. Tuberculosis vaccine development: recent progress. Trends Microbiol. 9:115-118.
17. Repique, C. J., A. Li, F. M. Collins, and S. L. Morris. 2002. DNA immunization in a mouse model of latent tuberculosis: effect of DNA vaccination on reactivation of disease and on reinfection with a secondary challenge. Infect. Immun. 70:3318-3323.
18. Rhoades, E. R., A. A. Frank, and I. M. Orme. 1997. Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis. Tuber. Lung Dis. 78:57-66.
19. Scanga, C. A., V. P. Mohan, H. Joseph, K. Yu, J. Chan, and J. L. Flynn. 1999. Reactivation of latent tuberculosis: variations on the Cornell murine model. Infect. Immun. 67:4531-4538.
20. Silva, C. L., M. F. Silva, R. C. Pietro, and D. B. Lowrie. 1996. Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect. Immun. 64:2400-2407.
21. Sterne, J. A., L. C. Rodrigues, and I. N. Guedes. 1998. Does the efficacy of BCG decline with time since vaccination? Int. J. Tuberc. Lung Dis. 2:200-207.
22. Tripathy, S. P. 1987. Fifteen year follow-up of the Indian BCG Prevention trial. Bull. Int. Union Tubercle Lung Dis. 62:69-72.
23. Turner, J., E. R. Rhoades, M. Keen, J. T. Belisle, A. A. Frank, and I. M. Orme. 2000. Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode. Infect. Immun. 68:1706-1709.
24. Turner, O. C., A. D. Roberts, A. A. Frank, S. W. Phalen, D. M. McMurray, J. Content, O. Denis, S. D'Souza, A. Tanghe, K. Huygen, and I. M. Orme. 2000. Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis. Infect. Immun. 68:3674-3679.
25. Ulmer, J. B., R. R. Deck, C. M. DeWitt, J. J. Donnelly, A. Friedman, D. L. Montgomery, A. M. Yawman, I. M. Orme, O. Denis, J. Content, K. Huygen, and M. A. Liu. 1997. Induction of immunity by DNA vaccination: application to influenza and tuberculosis. Behring Inst. Mitt. 98:79-86.
26. van Eden, W., E. J. Hogervorst, R. van der Zee, J. D. van Embden, E. J. Hensen, and I. R. Cohen. 1989. The mycobacterial 65 kD heat-shock protein and autoimmune arthritis. Rheumatol. Int. 9:187-191.
27. Wiegeshaus, E. H., and D. W. Smith. 1989. Evaluation of the protective potency of new tuberculosis vaccines. Rev. Infect. Dis. 11(Suppl. 2):S484-S490.
28. Zugel, U., and S. H. Kaufmann. 1997. Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice. Infect. Immun. 65:3947-3950.