Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences

Infection and Immunity

Volumn 67, Issue 9, 1999, Pages 4780-4786

  Li, Zhongming ^a   Howard, Angela ^a   Kelley, Cynthia ^a   Delogu, Giovanni ^a   Collins, Frank ^a   Morris, Sheldon ^a,b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; DNA VACCINE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; HYBRID PROTEIN; KATG PROTEIN; PROTEIN HBHA; PROTEIN MPT64; SIGNAL PEPTIDE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BCG VACCINATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG EFFICACY; FEMALE; HUMORAL IMMUNITY; IMMUNOGENICITY; INFECTION RESISTANCE; INTRAMUSCULAR DRUG ADMINISTRATION; LUNG; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; TISSUE SPECIFICITY; TUBERCULOSIS; TUBERCULOSIS CONTROL; VACCINE PRODUCTION;

EID: 0032786615     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.9.4780-4786.1999     Document Type: Article

References (45)

1. Baldwin, S. L., C. D'Souza, A. D. Roberts, B. P. Kelley, A. A. Frank, M. A. Lui, J. B. Ulmer, K. Huygen, D. M. McMurray, and I. M. Orme. 1998. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect. Immun. 66:2951-2959.
2. Brandt, L., T. Oettinger, A. Holm, A. B. Andersen, and P. Andersen. 1996. Key epitopes on Esat-6 recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J. Immunol. 157:3527-3533.
3. Chattergoon, M., J. Bare, and D. B. Weiner. 1997. Genetic immunization: a new era in vaccines and immunotherapy. FASEB J. 11:753-763.
4. Clernik, F., J. A. Berzosky, and D. P. Carbone. 1996. Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J. Immunol. 156:2369-2375.
5. Colditz, G. A., T. F. Brewer, C. S. Berkey, M. E. Wilson, E. Bordich, H. V. Fineberg, and F. Mosteller. 1994. Efficacy of BCG vaccine in the prevention of tuberculosis: meta analysis of the published literature. JAMA 271:698-702.
6. Collins, F. M. 1985. Protection afforded by BCG vaccines against an aerogenic challenge by three mycobacteria of decreasing virulence. Tubercle 66:267-276.
7. Cooper, A. M., J. E. Callahan, M. Keen, J. T. Belisle, and I. M. Orme. 1997. Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis. Tuber. Lung Dis. 78:67-73.
8. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon-γ gene disrupted mice. J. Exp. Med. 178:2243-2247.
9. Dolin, P. J., M. C. Ravigliane, and A. Kochi. 1994. Global tuberculosis epidemic and mortality during 1990-2000. Bull. W. H. O. 72:213-220.
10. Donnelly, J. J., J. B. Ulmer, J. W. Shiver, and M. A. Lui. 1997. DNA vaccines. Ann. Rev. Immunol. 15:617-648.
11. Dooley, S. W., W. R. Jarvis, W. J. Martone, and D. E. Snider. 1992. Multidrug resistant tuberculosis. Ann. Intern. Med. 117:257-259.
12. Flynn, J. A., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon-γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2251.
13. Flynn, J. L., M. M. Goldstein, J. Chan, K. J. Triebold, K. Pfeffer, C. J. Lowenstein, R. Schreiber, T. W. Mar, and B. R. Bloom. 1995. Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561-572.
14. Haddad, D., S. Lildequist, S. Stahl, I. Andersson, P. Perlman, K. Berzins, and N. Ahlborg. 1997. Comparative study of DNA-based immunization vectors: effect of secretion signals on the antibody responses in mice. FEMS Immunol. Med. Microbiol. 18:193-202.
15. Hamajima, K., S. Sosaki, J. Pukushima, T. Kaneko, K. Xin, I. Kudoh, and K. Okuda. 1998. Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune responses. Clin. Immunol. Immunopathol. 88:205-210.
16. Hariharan, M. J., D. A. Driver, K. Townsend, D. Brimm, J. M. Polo, B. A. Belli, D. J. Catton, D. Hsu, D. Mittelstaedt, J. E. McCormick, L. Karavodin, T. W. Dubensky, S. M. W. Chang, and T. A. Banks. 1998. DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector. J. Virol. 72:950-958.
17. Hosken, N. A., K. Shibuya, A. W. Heath, K. M. Murphy, and A. O'Garra. 1995. The effect of antigen dose on CD4+ helper cell phenotype development in a T cell receptor-αβ transgenic model. J. Exp. Med. 82:1579-1584.
18. Huygen, K. 1998. DNA vaccines: application to tuberculosis. Int. J. Tuberc. Lung Dis. 2:971-978.
19. Huygen, K., J. Content, O. Denis, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. Dewitt, I. A. Drene, S. Baldwin, C. D'Souza, A. Drowart, E. Lozes, P. Vandenbussche, J. P. van Vooren, M. A. Liu, and J. B. Ulmer. 1996. Immunogenic and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2:893-898.
20. Jacobs, G. G., J. L. Johnson, W. H. Boom, R. S. Wallis, C. C. Whalen, and A. M. Ginsberg. 1997. Tuberculosis vaccines: how close to human testing? Tuber. Lung Dis. 78:159-169.
21. Kaji, D., B. Lederman, K. Burke, H. Hengartner, and R. M. Zinkernagel. 1994. CD8+ T-cell mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24:3068-3072.
22. Kamath, A. T., C. G. Feng, M. Macdonald, H. Briscoe, and W. J. Britton. 1999. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect. Immun. 67:1702-1707.
23. Klinman, D. M. 1994. ELISPOT assay to detect cytokine secreting murine and human cells, p. 6.19.1-6.19.8. In J. E. Coligan, A. M. Kruisbeek, D. H. Marguiles, E. M. Shevach, and W. Struber (ed.), Current protocols in immunology. Wiley Interscience, New York, N.Y.
24. Li, Z., C. Kelley, F. Collins, D. Rouse, and S. L. Morris. 1998. Expression of KatG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs. J. Infect. Dis. 177:1030-1035.
25. Lowrie, D. B., C. L. Silva, M. J. Colston, S. Ragno, and R. E. Tascon. 1997. Protection against tuberculosis by a plasmid DNA vaccine. Vaccine 15:834-838.
26. Menozzi, F. D., R. Bischoff, E. Fort, M. J. Brennan, and C. Locht 1998. Molecular characterization of the mycobacterial heparin binding hemagglutinin, a mycobacterial adhesin. Proc. Natl. Acad. Sci. USA 95:12625-12630.
27. Montgomery, D. L., K. Huygen, A. M. Yawman, R. R. Deck, C. M. Dewitt, J. Content, M. A. Liu, and J. B. Ulmer. 1997. Induction of humoral and cellular immune responses by vaccination with Mycobacterium tuberculosis 85A DNA. Cell. Mol. Biol. 43:285-292.
28. Mor, G., G. Vamshchikov, M. Sedegah, M. Takeno, R. Wang, R. A. Houghten, S. Hoffman, and D. Klinman. 1996. Induction of neonatal tolerance by plasmid DNA vaccination of mice. J. Clin. Investig. 98:2700-2705.
29. Nass, P. H., K. L. Elkins, and J. P. Weir. 1998. Antibody response and protective capacity of plasmid vaccines expressing three different Herpes simplex virus glycoproteins. J. Infect. Dis. 178:611-617.
30. Newport, M. J., C. M. Huxley, S. Hunter, C. M. Haurylowicz, B. A. Oostra, R. Williamson, and M. Levin. 1996. A mutation in an tnterferon-γ receptor gene and susceptibility to mycobacterial infection. N. Engl. J. Med. 335: 1941-1949.
31. Orme, I., and F. M. Collins. 1994. Mouse model of tuberculosis, p. 113-134. In B. R. Bloom (ed.), Tuberculosis: pathogenesis, protection, and control. ASM Press, Washington, D.C.
32. Pablos-Mendez, A., M. C. Raviglione, A. Laozlo, N. Binkin, H. L. Rieder, F. Bustreo, D. L. Cohn, C. S. Lambregts-van Weezenbeek, S. J. Kim, P. Chaulet, and P. Nunn. 1998. Global surveillance for antituberculosis drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease working group on anti-tuberculosis drug resistance surveillance. N. Engl. J. Med. 23:1641-1649.
33. Rodriquez, F., J. Zhang, and J. L. Whitton. 1997. DNA immunization: ubiquination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J. Virol. 71:8497-8503.
34. Stenger, S., D. A. Hanson, R. Teitelbaum, P. Dewan, K. R. Niazi, C. J. Froelich, T. Ganz, S. Thoma-Vszynski, A. Melitan, C. Bogdan, S. A. Porcelli, B. R. Bloom, A. M. Krensky, and R. L. Modlin. 1998. An antimicrobial activity of cytotoxic T cells mediated by granulysin. Science 282:121-125.
35. Stevens, T. L., A. Bossic, V. M. Sanders, R. Fennaly-Botran, R. Coffman, T. R. Moseman, and E. Vitetta. 1988. Regulation of antibody isotypic secretion by subsets of antigen-specific helper T cells. Nature 334:255-258.
36. Suto, R., and P. K. Srivastara. 1995. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269:1585-1588.
37. Tascon, R. E., M. J. Colston, S. Ragno, E. Stavropoulos, D. Gregory, and D. B. Lowrie. 1996. Vaccination against tuberculosis by DNA injection. Nat. Med. 2:888-892.
38. Wheeler, C. J., P. L. Feigner, Y. J. Tsai, J. Marshall, L. Sukhu, S. G. Doh, J. Hartikka, J. Nietupski, M. Manthorpe, M. Nichols, M. Plewe, X. Liang, J. Norman, A. Smith, and S. H. Cheng. 1996. A novel cation lipid greatly enhances plasmid DNA delivery and expression in the mouse lung. Proc. Natl. Acad. Sci. USA 93:11454-11459.
39. Wilcke, J. T. R., B. N. Jensen, P. Ravn, A. B. Andersen, and K. Haslov. 1996. Clinical evaluation of MPT-64 and MPT-59, two proteins secreted from Mycobacterium tuberculosis, for skin test reagents. Tuber. Lung Dis. 77:250-256.
40. World Health Organization. 1996. Groups at risk-WHO report on the tuberculosis epidemic. WHO global tuberculosis programme, Geneva, Switzerland.
41. World Health Organization. 1997. Anti-tuberculosis drug resistance in the world. The WHO/IUATLD global project on anti-tuberculosis drug resistance surveillance. WHO global tuberculosis programme, Geneva, Switzerland.
42. Wu, Y., and T. J. Kipps. 1997. Deoxyribonucleic acid vaccines encoding antigens with rapid proteosome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes. J. Immunol. 159:6037-6043.
43. Yasutomi, Y., H. L. Robison, S. Lu, F. Mustafa, C. Lekutis, J. Arthos, J. I. Mullins, G. Voss, K. Manson, M. Wyand, and N. L. Letvin. 1996. Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys. J. Virol. 70:678-681.
44. Zhang, M., Y. Lin, D. V. Iyer, J. Gong, J. S. Abrams, and P. F. Barnes. 1995. T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect. Immun. 63:3231-3234.
45. Zhu, X., W. Venkataprasad, H. S. Thangaraj, M. Hill, M. Singh, J. Ivanyi, and H. M. Vordermeier. 1997. Functions and specificities of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J. Immunol. 158:5921-5926.