DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis

Infection and Immunity

Volumn 70, Issue 1, 2002, Pages 292-302

  Delogu, G ^a   Li, A ^a   Repique, C ^a   Collins, F ^a   Morris, S L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; DNA VACCINE; HYBRID PROTEIN; TISSUE PLASMINOGEN ACTIVATOR; UBIQUITIN CONJUGATED ANTIGEN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MIXTURE; DRUG TARGETING; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; LUNG TUBERCULOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TREATMENT OUTCOME; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BCG VACCINE; DISEASE MODELS, ANIMAL; FEMALE; INTERFERON TYPE II; LUNG; MICE; MICE, INBRED C57BL; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN SORTING SIGNALS; RECOMBINANT FUSION PROTEINS; SPLEEN; TISSUE PLASMINOGEN ACTIVATOR; TUBERCULOSIS, PULMONARY; UBIQUITIN; VACCINES, COMBINED; VACCINES, DNA;

EID: 0036137144     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.1.292-302.2002     Document Type: Article

References (40)

1. Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine
2. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis
3. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis
4. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
5. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature
6. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
7. Molecular cloning and immunologic reactivity, of a novel low molecular mass antigen of Mycobacterium tuberculosis
8. Protection to mice afforded by BCG vaccines against an aerogenic challenge by three mycobacteria of decreasing virulence
9. The relationship of delayed hypersensitivity to acquired antituberculous immunity. I. Tuberculin sensitivity and resistance to reinfection in BCG-vaccinated mice
10. In vivo priming by DNA injection occurs predominantly by antigen transfer
11. Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis
12. DNA vaccination against tuberculosis: Expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity
13. Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family
14. CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A
15. Immunology of tuberculosis
16. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes
17. Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid
18. DNA vaccines: Immunology, application, and optimization
19. Nucleic acid vaccination with HIV regulatory genes: A combination of HIV-1 genes in separate plasmids induces strong immune responses
20. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
21. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis
22. Immunity to mycobacteria with emphasis on tuberculosis: Implications for rational design of an effective tuberculosis vaccine
23. Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage colony-stimulating factor gene
24. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences
25. Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs
26. Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis
27. + T-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis
28. The immunogenicity of single and combination DNA vaccines against tuberculosis
29. - T cells in vivo
30. New vaccines against tuberculosis. The status of current research
31. Granuloma-specific expression of mycobacterium virulence proteins from the glycinerich PE-PGRS family
32. Progression of chronic pulmonary, tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis
33. DNA immunization: Ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction
34. Vaccination against tuberculosis by DNA injection
35. Expression and immunogenicity of Mycobacterium tuberculosis antigen 85 by DNA vaccination
36. Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test
37. Capture and processing of exogenous antigens for presentation on MHC molecules
38. Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis
39. Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes