The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle

Journal of Virology

Volumn 74, Issue 14, 2000, Pages 6622-6631

  Flores, Elsa R ^a   Allen Hoffmann, B Lynn ^b   Lee, Denis ^a   Lambert, Paul F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN;

ARTICLE; DNA REPLICATION; DNA SYNTHESIS; GENE AMPLIFICATION; KERATINOCYTE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VIRION; WART VIRUS;

APOPTOSIS; BLOTTING, SOUTHERN; CAPSID; CAPSID PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA, VIRAL; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KERATINOCYTES; NUCLEAR PROTEINS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RAS PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; VIRUS REPLICATION;

EID: 0033947269     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.14.6622-6631.2000     Document Type: Article

References (33)

1. Allen-Hoffmann, B. L., S. J. Schlosser, C. A. Ivarie, C. A. Sattler, L. F. Meissner, and S. L. O'Connor. 2000. Normal growth and differentiation in a spontaneously immortalized near-diploid keratinocyte cell line, NIKS. J. Investig. Dermatol. 114:444-455.
2. Auborn, K. J., R. D. Little, T. H. Platt, M. A. Vaccariello, and C. L. Schildkraut. 1994. Replicative intermediates of human papillomavirus type 11 in laryngeal papillomas: site of replication initiation and direction of replication. Proc. Natl. Acad. Sci. USA 91:7340-7344.
3. Cheng, S., D.-C. Schmidt-Grimminger, T. Murant, T. R. Broker, and L. T. Chow. 1995. Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev. 9:2335-2349.
4. Chengiss, M. L., and E. R. Unger. 1993. Application of a manual capillary action workstation to colorimetric in situ hybridization. J. Histotechnol. 16:33-38.
5. Chow, L. T., and T. R. Broker. 1994. Papillomavirus DNA replication. Intervirology 37:150-158.
6. Dazard, J.-E., D. Augias, H. Neel, V. Mils, V. Marechal, N. Basset-Séquin, and J. Piette. 1997. MDM-2 protein is expressed in different layers of normal human skin. Oncogene 14:1123-1128.
7. Demeter, L. M., M. H. Stoler, T. R. Broker, and L. T. Chow. 1994. Induction of proliferating cell nuclear antigen in differentiated keratinocytes of human papillomavirus-infected lesions. Hum. Pathol. 25:343-348.
8. Flores, E. R., B. L. Allen-Hoffmann, D. Lee, C. A. Sattler, and P. F. Lambert. 1999. Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line. Virology 262:344-354.
9. Flores, E. R., and P. F. Lambert. 1997. Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle. J. Virol. 71:7167-7179.
10. Fuchs, E. 1993. Epidermal differentiation and keratin gene expression. J. Cell Sci. 17:197-208.
11. Fuchs, E. 1990. Epidermal differentiation: the bare essentials. J. Cell Biol. 111:2807-2814.
12. Funk, J. O., S. Waga, J. B. Harry, E. Espling, B. Stillman, and D. A. Galloway. 1997. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:2090-2100.
13. Gilbert, D. M., and S. N. Cohen. 1987. Bovine papillomavirus plasmids replicate randomly in mouse fibroblasts throughout S phase of the cell cycle. Cell 50:59-68.
14. Green, H. 1977. Terminal differentiation of cultured human epidermal cells. Cell 11:405-416.
15. Hirt, B. 1967. Selective extraction of polyoma DNA from infected cell cultures. J. Mol. Biol. 36:365-369.
16. Howley, P. M. 1996. Papillomavirinae: the viruses and their replication, p. 2045-2076. In B. N. Fields and D. M. Knipe (ed.), Fields virology, 3rd ed. Raven Press, New York, N.Y.
17. Jeon, S., B. L. Allen-Hoffmann, and P. F. Lambert. 1995. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J. Virol. 69:2989-2997.
18. Jones, D. L., R. M. Alani, and K. Munger. 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11:2101-2111.
19. Lundgren, K., R. Montes de Oca Luna, Y. B. McNeill, E. P. Emerick, B. Spencer, C. R. Barfield, G. Lorano, M. P. Rosnberg, and C. A. Finlay. 1997 Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 11:714-725.
20. Martin, K., D. Trouche, C. Hagemeier, T. S. Sorensen, N. B. La Thangue, and T. Kouzarides. 1995. Stimulation of E2F/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375:691-694.
21. McCance, D. J., K. R, E. Fuchs, and L. A. Laimins. 1988. Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc. Natl. Acad. Sci. USA 85:7169-7173.
22. Ruesch, M. N., F. Stubenrauch, and L. A. Laimins. 1998. Activation of papillomavirus late gene expression and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10. J. Virol. 72:5016-5024.
23. Sachsenmeier, K. F., N. Sheibani, S. J. Schlosser, and B. L. Allen-Hoffmann. 1996. Transforming growth factor-B1 inhibits nucleosomal fragmentation in human keratinocytes following loss of adhesion. J. Biol. Chem. 271:5-8.
24. ARF. J. Virol. 73:7590-7598.
25. Song, S., H. C. Pitot, and P. F. Lambert. 1999. The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals. J. Virol. 73:5887-5893.
26. Stanley, M. A., H. M. Browne, M. Appleby, and A. C. Minson. 1989. Properties of a non-tumorgenic human cervical keratinocyte cell line. Int. J Cancer 43:672-676.
27. Sterling, J., M. Stanley, G. Gatward, and T. Minson. 1990. Production of human papillomavirus type 16 virions in a keratinocyte cell line. J. Virol. 64:6305-6307.
28. Teoh, G., M. Urashima, A. Ogata, D. Chauhan, J. A. DeCaprio, S. P. Treon, R. L. Schlossman, and K. C. Anderson. 1997. MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells. Blood 90: 1982-1992.
29. Thomas, J. T., W. G. Hubert, M. N. Ruesch, and L. A. Laimins. 1999. Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes. Proc. Natl. Acad. Sci. USA 96:8449-8454.
30. Thomas, J. T., and L. A. Laimins. 1998. Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint. J. Virol. 72:1131-1137.
31. Woodworth, C. D., S. Cheng, S. Simpson, L. Harnacher, L. T. Chow, T. R. Broker, and J. A. DiPaolo. 1992. Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection. Oncogene 7:619-626.
32. Yang, L., and M. Botchan. 1990. Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element. J. Virol. 64: 5903-5911.
33. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.