-
1
-
-
0033585485
-
A Bcr/Abl kinase antagonist for chronic myelogenous leukemia: A promising path for progress emerges
-
Sausville, E. A. (1999) A Bcr/Abl kinase antagonist for chronic myelogenous leukemia: A promising path for progress emerges [editorial; comment]. J. Natl. Cancer Inst. 91, 102-103.
-
(1999)
J. Natl. Cancer Inst
, vol.91
, pp. 102-103
-
-
Sausville, E.A.1
-
2
-
-
0033614446
-
Chronic myeloid leukemia
-
Sawyers, C. L. (1999) Chronic myeloid leukemia. N. Engl. J. Med. 340, 1330-1340.
-
(1999)
N. Engl. J. Med
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
3
-
-
0028980342
-
Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis
-
Cortez, D., Kadlec, L., and Pendergast, A. M. (1995) Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. Mol. Cell. Biol. 15, 5531-5541.
-
(1995)
Mol. Cell. Biol
, vol.15
, pp. 5531-5541
-
-
Cortez, D.1
Kadlec, L.2
Pendergast, A.M.3
-
4
-
-
0029087475
-
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene
-
Goga, A., McLaughlin, J., Afar, D. E., Saffran, D. C., and Witte, O. N. (1995) Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell 82, 981-988.
-
(1995)
Cell
, vol.82
, pp. 981-988
-
-
Goga, A.1
McLaughlin, J.2
Afar, D.E.3
Saffran, D.C.4
Witte, O.N.5
-
5
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker, B. J., Tamura, S., Buchdunger, E., et al. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2, 561-566.
-
(1996)
Nat. Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
6
-
-
0031409736
-
Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
-
Gambacorti-Passerini, C., le Coutre, P., Mologni, L., et al. (1997) Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis. Blood Cells Mol. Dis. 23, 380-394.
-
(1997)
Blood Cells Mol. Dis
, vol.23
, pp. 380-394
-
-
Gambacorti-Passerini, C.1
Le Coutre, P.2
Mologni, L.3
-
7
-
-
0030853063
-
The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
-
Deininger, M. W., Goldman, J. M., Lydon, N., and Melo, J. V. (1997) The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 90, 3691-3698.
-
(1997)
Blood
, vol.90
, pp. 3691-3698
-
-
Deininger, M.W.1
Goldman, J.M.2
Lydon, N.3
Melo, J.V.4
-
8
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
le Coutre, P., Mologni, L., Cleris, L., et al. (1999) In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J. Natl. Cancer Inst. 91, 163-168.
-
(1999)
J. Natl. Cancer Inst
, vol.91
, pp. 163-168
-
-
Le Coutre, P.1
Mologni, L.2
Cleris, L.3
-
9
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker, B. J., Sawyers, C. L., Kantarjian, H., et al. (2001) Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344, 1038-1042.
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
10
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker, B. J., Talpaz, M., Resta, D. J., et al. (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031-1037.
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
11
-
-
0011391934
-
Glivec (imatinib mesylate) induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Result of a phase II study
-
Talpaz, M., Silver, R. T., Druker, B., et al. (2001) Glivec (imatinib mesylate) induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Result of a phase II study. Blood, in press.
-
(2001)
Blood
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.3
-
12
-
-
0034161460
-
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
-
le Coutre, P., Tassi, E., Varella-Garcia, M., et al. (2000) Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 95, 1758-1766.
-
(2000)
Blood
, vol.95
, pp. 1758-1766
-
-
Le Coutre, P.1
Tassi, E.2
Varella-Garcia, M.3
-
13
-
-
0034210577
-
Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
-
Weisberg, E., and Griffin, J. D. (2000) Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood 95, 3498-3505.
-
(2000)
Blood
, vol.95
, pp. 3498-3505
-
-
Weisberg, E.1
Griffin, J.D.2
-
14
-
-
0034254368
-
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
-
Mahon, F. X., Deininger, M. W., Schultheis, B., et al. (2000) Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance. Blood 96, 1070-1079.
-
(2000)
Blood
, vol.96
, pp. 1070-1079
-
-
Mahon, F.X.1
Deininger, M.W.2
Schultheis, B.3
-
15
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre, M. E., Mohammed, M., Ellwood, K., et al. (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
16
-
-
0034684075
-
Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571
-
Gambacorti-Passerini, C., Barni, R., le Coutre, P., et al. (2000) Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571. J. Natl. Cancer Inst. 92, 1641-1650.
-
(2000)
J. Natl. Cancer Inst
, vol.92
, pp. 1641-1650
-
-
Gambacorti-Passerini, C.1
Barni, R.2
Le Coutre, P.3
-
17
-
-
0035496899
-
Chronic myeloid leukemia: Current treatment options
-
Goldman, J. M., and Druker, B. J. (2001) Chronic myeloid leukemia: Current treatment options. Blood 98, 2039-2042.
-
(2001)
Blood
, vol.98
, pp. 2039-2042
-
-
Goldman, J.M.1
Druker, B.J.2
-
18
-
-
0035929652
-
Roots of clinical resistance to STI-571 cancer therapy
-
Gambacorti-Passerini, C., Corneo, G., and D'Incalci, M. (2001) Roots of clinical resistance to STI-571 cancer therapy. Science 293, 2163.
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Gambacorti-Passerini, C.1
Corneo, G.2
D'Incalci, M.3
-
19
-
-
79960970642
-
Elevated levels of the plasma protein alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis mediate pharmacological resistance to Gleevec (STI571, imatinib) in vitro and are associated with primary resistance in vivo
-
American Society of Hematology, 43th Annual Meeting, Orlando, Florida
-
Larghero, J., Mahon, F., Madalaine-Chambrin, I., et al. (2001) Elevated levels of the plasma protein alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis mediate pharmacological resistance to Gleevec (STI571, imatinib) in vitro and are associated with primary resistance in vivo. American Society of Hematology, 43th Annual Meeting, Orlando, Florida. Blood 98, 616a n, 2582.
-
(2001)
Blood
, vol.98
, pp. 616an
-
-
Larghero, J.1
Mahon, F.2
Madalaine-Chambrin, I.3
-
20
-
-
18344396578
-
Determination of α1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571
-
le Coutre, P., Kreuzer, K., Na, I., et al. (2002) Determination of α1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571. Blood Cells Mol. Dis. 28, 75-85.
-
(2002)
Blood Cells Mol. Dis
, vol.28
, pp. 75-85
-
-
Le Coutre, P.1
Kreuzer, K.2
Na, I.3
-
21
-
-
0035929652
-
Roots of clinical resistance to STI-571 cancer therapy
-
Hochhaus, A., Kreil, S., Corbin, A., et al. (2001) Roots of clinical resistance to STI-571 cancer therapy. Science 293, 2163.
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.3
-
22
-
-
0035929652
-
Roots of clinical resistance to STI-571 cancer therapy
-
Barthe, C., Cony-Makhoul, P., Melo, J. V., and Mahon, J. R. (2001) Roots of clinical resistance to STI-571 cancer therapy. Science 293, 2163.
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Barthe, C.1
Cony-Makhoul, P.2
Melo, J.V.3
Mahon, J.R.4
-
23
-
-
0034095603
-
The pyrido[2, 3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells
-
Dorsey, J. F., Jove, R., Kraker, A. J., and Wu, J. (2000) The pyrido[2, 3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells. Cancer Res. 60, 3127-3131.
-
(2000)
Cancer Res
, vol.60
, pp. 3127-3131
-
-
Dorsey, J.F.1
Jove, R.2
Kraker, A.J.3
Wu, J.4
-
24
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
-
von Bubnoff, N., Schneller, F., Peschel, C., and Duyster, J. (2002) BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study. Lancet 359(9305), 487-491.
-
(2002)
Lancet
, vol.359
, Issue.9305
, pp. 487-491
-
-
Von Bubnoff, N.1
Schneller, F.2
Peschel, C.3
Duyster, J.4
-
25
-
-
0036566540
-
High frequency of point mutation clustered within the ATP binding region of BCR/ABL in CML and Ph-positive ALL patients who develop Imatinib (STI57) resistance
-
Branford, S., Rudzki, Z., Walsh, S., et al. (2002) High frequency of point mutation clustered within the ATP binding region of BCR/ABL in CML and Ph-positive ALL patients who develop Imatinib (STI57) resistance. Blood 99(9), 3472-3475.
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
26
-
-
0345405480
-
Alpha(1)-Acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571
-
Jorgensen, H. G., Elliott, M. A., Allan, E. K., Carr, C. E., Holyoake, T. L., and Smith, K. D. (2002) alpha(1)-Acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571. Blood 99, 713-715.
-
(2002)
Blood
, vol.99
, pp. 713-715
-
-
Jorgensen, H.G.1
Elliott, M.A.2
Allan, E.K.3
Carr, C.E.4
Holyoake, T.L.5
Smith, K.D.6
-
27
-
-
85072814005
-
Binding of imatinib by alpha 1 acid glycoprotein
-
Gambacorti-Passerini, C., le Coutre, P., Zucchetti, M., and D'Incalci, M. (2002) Binding of imatinib by alpha 1 acid glycoprotein. Blood 100, in press.
-
(2002)
Blood
, vol.100
-
-
Gambacorti-Passerini, C.1
Le Coutre, P.2
Zucchetti, M.3
D'Incalci, M.4
|