Mutagenesis of the GABAA receptor α1 subunit reveals a domain that affects sensitivity to GABA and benzodiazepine-site ligands

Journal of Neurochemistry

Volumn 79, Issue 1, 2001, Pages 55-62

  Davies, Martin ^a   Newell, J Glen ^a   Dunn, Susan M J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Benzodiazepines; GABA; GABAA receptor; Mutagenesis

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; FLUMAZENIL; FLUNITRAZEPAM; RECEPTOR SUBUNIT;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DRUG EFFICACY; ELECTROPHYSIOLOGY; LIGAND BINDING; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR SENSITIVITY;

ALLOSTERIC REGULATION; BENZODIAZEPINES; BINDING SITES; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; FLUNITRAZEPAM; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; ION CHANNEL GATING; MUTAGENESIS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034785541     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00527.x     Document Type: Article

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