Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model

Cancer Immunology Immunotherapy

Volumn 49, Issue 2, 2000, Pages 71-77

  Kimura, Keiko ^a   Nishimura, Hitoshi ^a   Matsuzaki, Takeshi ^b   Yokokura, Teruo ^b   Nimura, Yuji ^a   Yoshikai, Yasunobu ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

IL 12; IL 15; Malignant pleurisy; MethA

Indexed keywords

RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 15;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; DRUG POTENTIATION; FIBROSARCOMA; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLEURISY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; DRUG SYNERGISM; FIBROSARCOMA; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-15; KILLER CELLS, NATURAL; MALE; METHYLCHOLANTHRENE; MICE; MICE, INBRED BALB C; PLEURISY; RATS; RECOMBINANT PROTEINS;

EID: 0033944615     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050604     Document Type: Article

References (34)

1. 1. Alleva DG, Kaser SB, Monroy MA, Fenton MJ, Beller DI (1997) IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition. J Immunol 159: 2941
2. 2. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH (1995) IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154: 483
3. 3. Bamford RN, Grant AJ, Burton JD, Peters C, Kurys CG, Goldman CK, Brennan J, Roessler E, Waldmann TA (1994) The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91: 4940
4. 4. Boem U, Klamp T, Groot M, Howard JC (1997) Cellular responses to interferon-γ. Anuu Rev Immunol 15: 749
5. 5. Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, Wolf SF, Gately MK (1993) Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 178: 1223
6. 6. Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein K, Caligiuri MA (1995) Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest 96: 2578
7. 7. Carson WE, Fehniger TA, Haldar S, Eckhert K, Lindemann MJ, Lai CF, Croce CM, Baumann H, Caligiuri MA (1997) A potential role for interleukin-15 in the regulation of human natural killer cell survival. J Clin Invest 99: 937
8. 8. Coughlin CM, Wysocka M, Kurzawa HL, Lee WM, Trinchieri G, Eck SL (1995) B7-1 and interleukin 12 synergistically induce effective antitumor immunity. Cancer Res 55: 4980
9. 9. Coughlin CM, Wysocka M, Trinchieri G, Lee WM (1997) The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12. Cancer Res 57: 2460
10. 10. Evans R, Fuller JA, Christianson G, Krupke DM, Troutt AB (1997) IL-15 mediates anti-tumor effects after cyclophosphamide injection of tumor-bearing mice and enhances adoptive immunotherapy: the potential role of NK cell subpopulations. Cell Immunol 179: 66
11. 11. Gamero AM, Ussery D, Reintgen DS, Puleo C, Djeu JY (1995) Interleukin 15 induction of lymphokine-activated killer cell function against autologous tumor cells in melanoma patient lymphocytes by a CD18-dependent, perforin-related mechanism. Cancer Res 55: 4988
12. 12. Gately MK, Warrier RR, Honasoge S, Carvajal DM, Faherty DA, Connaughton SE, Anderson TD, Sarmiento U, Hubbard BR, Murphy M (1994) Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int Immunol 6: 157
13. 13. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Anderson MR, Watoson JD, Anderson DM, Giri JG (1994) Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264: 965
14. 14. Inagaki-Ohara K, Nishimura H, Mitani A, Yoshikai Y (1997) Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice. Eur J Immunol 27: 2885
15. 15. Kimura K, Nishimura H, Hirose K, Matsuguchi T, Nimura Y, Yoshikai Y (1999) Immunogene therapy fibrosarcoma using the IL-15 gene with high translation efficiency. Eur J Immunol 29: 1532
16. 16. Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma A (1998) IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9: 669
17. 17. Matsuzaki T, Hashimoto S, Yokokura T (1996) Effects on antitumor activity and cytokine production in the thoracic cavity by intrapleural administration of Lactobacillus casei in tumor-bearing mice. Med Microbiol Immunol (Berl) 185: 157
18. 18. Matsuzaki T, Yokokura T, Mutai M (1988) Antitumor effect of intrapleural administration of Lactobacillus casei in mice. Cancer Immunol Immunother 26: 209
19. 19. Matsuzaki T, Yokokura T, Mutai M (1988) The role of lymph node cells in the inhibition of metastasis by subcutaneous injection of Lactobacillus casei in mice. Med Microbiol Immunol (Berl) 177: 245
20. 20. McInnes IB, Mughales J, Field M, Leung BP, Huang F, Dixon R, Sturrock RD, Wilkinson PC, Liew FY (1996) The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 2: 175
21. 21. Munger W, Quinn S Sr, Jeyaseelan DR, Torley LW, Garbstein KH, Eisenmann J, Paxton R, Cox T, Wick MM, Kerwar SS (1995) Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor:comparison with interleukin-2. Cell Immunol 165: 289
22. 22. Nastala CL, Edington HD, McKinney TG, Tahara H, Nalesnik MA, Brunda MJ, Gately MK, Wolf SF, Schreiber RD, Storkus WJ 1 (1994) Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol 153: 1697
23. 23. Nieto A, Sanchez-Madris F (1996) Interleukin-15 induces adhesion receptor redistribution in T lymphocytes. Eur J Immunol 26: 1302
24. 24. Ogawa M, Tsutsui T, Zou JP, Mu J, Wijesuriya R, Yu WG, Herrmann S, Kubo T, Fujiwara H, Hamaoka T (1997) Enhanced induction of very late antigen 4-lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12. Cancer Res 57: 2216
25. 25. Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA (1996) IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4: 329
26. 26. Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y (1996) IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. J Immunol 156: 663
27. 27. Nishimura H, Washizu J, Nakamura N, Enomoto A, Yoshikai Y (1998) Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J Immunol 160: 936
28. 28. Tagaya Y, Burton JD, Miyamoto Y, Waldmann TA (1996) Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J 15: 4928
29. 29. Takeuchi E, Yanagawa H, Yano S, Haku T, Sone S (1996) Induction by interleukin-15 of human killer cell activity against lung cancer cell lines and its regulatory mechanisms. Jpn J Cancer Res 87: 1251
30. 30. Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13: 251
31. 31. Washizu J, Nishimura H, Nakamura N, Nimura Y, Yoshikai Y (1998) NF-κB binding site is essential for transcriptional activation of IL-15. Immunogenetics 48: 1
32. 32. Wu C, Warrier RR, Wang X, Presky DH, Gately MK (1997) Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells. Eur J Immunol 27: 147
33. 33. Zeh HJD, Hurd S, Storkus WJ, Lotze MT (1993) Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer. J Immunother 14: 155
34. + T cells in vivo by IL-15. Immunity 8: 591