Interleukin-2 receptor signaling mechanisms

Advances in Immunology

Volumn 61, Issue , 1996, Pages 147-199

  Karnitz, Larry M ^a   Abraham, Robert T ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; RAPAMYCIN; RAS PROTEIN; TACROLIMUS; TRANSCRIPTION FACTOR;

CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; GENE ACTIVATION; HUMAN; LYMPHOCYTE PROLIFERATION; MITOGENESIS; NONHUMAN; ONCOGENE C MYC; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0030049012     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (255)

1. Ajchenbaum F, Ando K, DeCaprio JA, and Griffin JD: J. Biol. Chem. 268:4113-4119.
2. Akira S, Nishio Y, Inoue M, Wang X-J, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, and Kishimoto T: Cell 77: 63-71, 1994.
3. Albers MW, Brown EJ, Tanaka A, Williams RT, Hall FL, and Schreiber SL: Ann. N.Y. Acad. Sci. 696:54-62, 1993.
4. Alland L, Peseckis SM, Atherton RE, Berthiaume L, and Resh MD: J. Biol. Chem. 269:16701-16705, 1994.
5. Asao H, Takeshita T, Ishii N, Kumake S, Nakamura M, and Sugamura K: Proc. Natl. Acad. Sci. USA 90:4127-4131, 1993.
6. Asao H, Tanaka N, Ishii N, Higuchi M, Takeshita T, Nakamura M, Shirasawa T, and Sugamura K: FEBS Lett. 351:201-206, 1994.
7. Auger KR, Serunian LA, Soltoff SP, Libby P, and Cantley LC: Cell 57:167-175, 1989.
8. Augustine JA, Schlager JW, and Abraham RT: Biochim. Biophys. Acta 1052:313-322,1990.
9. Augustine JA, Sutor SL, and Abraham RT: Mol. Cell. Biol. 11:4431-4440, 1991.
10. Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun X-J, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, and White MF: EMBO J. 11:3469-3479, 1992.
11. Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, and Rudd CE: Proc. Natl. Acad. Sci. USA 86:3277-3281, 1989.
12. Baumann H, Ziegler SF, Mosley B, Morella KK, Pajovic S, and Gearing DP: J. Biol. Chem. 268:2414-2417, 1993.
13. Bich-Thuy LT, Dukovich M, Peffer NJ, Fauci AS, Kehrl JH, and Greene WC: J. Immunol. 139:1550-1556, 1987.
14. Bierer BE, Martila PS, Standaert RF, Herzenberg LA, Burakoff SJ, Crabtree G, and Schreiber SL: Proc. Natl. Acad. Sci. USA 87:9231-9235, 1990.
15. Blaikie P, Immanuel D, Wu J, Li N, Yajnik V, and Margolis B: J. Biol. Chem. 269:32031-32034, 1994.
16. Bolen JB, Thompson PA, Eiseman E, and Horak ID: Adv. Cancer Res. 57:103-149, 1991.
17. Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, and Schreiber SL: Nature 369:756-758, 1994.
18. Brunn GJ, Falls EL, Nilson AE, and Abraham RT: J. Biol. Chem. 270:11628-11635, 1995.
19. Burns LA, Kamitz LM, Sutor SL, and Abraham RT: J. Biol. Chem. 268:17659-17661,1993.
20. Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng W-K, Johnson RK, and Livi GP: Mol. Cell. Biol. 13:6012-6023, 1993.
21. Calvo V, Crews CM, Vik TA, and Bierer BE: Proc. Natl. Acad. Sci. USA 89:7571-7575, 1992.
22. Cantrell DA, and Smith KA: Science 224:1312-1316, 1984.
23. Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russell SM, Drago J., Noguchi M, Grinberg A, Bloom ET, Paul WE, Katz SI, Love PE, and Leonard WJ: Immunity 2:223-238, 1995.
24. Carrera AC, Paradis H, Borlado LR, Roberts TM, and Martinez A-C: J. Biol. Chem. 270: 3385-3391, 1995.
25. Chan AC, Desai DM, and Weiss A: Annu. Rev. Immunol. 12:555-592, 1994.
26. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, and Kahn CR: Mol. Cell. Biol. 14:4902-4911, 1994.
27. Chin MI, Katz H, and Berlin V: Proc. Natl. Acad. Sci. USA 91:12574-12578, 1994.
28. Chuang L-M, Myers MG Jr, Backer JM, Shoelson SE, White MF, Birnbaum MJ, and Kahn CR: Mol. Cell. Biol. 13:6653-6660, 1993.
29. Chung J, Kuo CJ, Crabtree GR, and Blenis J: Cell 69:1227-1236, 1992.
30. Clevenger CV, Russell DH, Appasamy PM, and Prystowsky MB: Proc. Natl. Acad. Sci. USA 87:6460-6464, 1990.
31. Cohen B, Liu Y, Druker B, Roberts RM, and Schaffhausen BS: Mol. Cell. Biol. 10:2909-2915, 1990.
32. Cohen GB, Ren R, and Baltimore D: Cell 80:237-248, 1995.
33. Cooper JA, and Howell B: Cell 73:1051-1054, 1993.
34. Cosman D: Cytokine 5:95-106, 1993.
35. Cosman D, Cerretti DP, Larsen A, Park L, March C, Dower S, Gillis S, and Urdal D: Nature 312:768-771, 1984.
36. Crabtree GR, and Clipstone NA: Annu. Rev. Biochem. 63:1045-1083, 1994.
37. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, and Wells JA: Science 254:821-825, 1991.
38. Cutler RL, Liu L, Damen JE, and Krystal G: J. Biol. Chem. 288:21463-21465, 1993.
39. Darnell JE Jr, Kerr IM, and Stark GR: Science 264:1415-1421, 1994.
40. Daum G, Eisenmann-Tappe I, Fries H-W, Troppmair J, and Rapp UR: Trends Biochem. Sci. 19:474-480, 1994.
41. Davis S, Aldrich TH, Stahl N, Pan L, Taga T, Kishimoto T, Ip NY, and Yancopoulos GD: Science 260:1805-1808, 1993.
42. Decker SJ: J. Biol. Chem. 268:9176-9179, 1993.
43. de Groot RP, Ballou LM, and Sassone-Corsi P: Cell 79:81-91, 1994.
44. Desdouets C, Matesic G, Molina CA, Foulkes NS, Sassone-Corsi P, Brehot C, and Sobczak-Thepot J: Mol. Cell. Biol. 15:3301-3309, 1995.
45. Dhand R, Hara K, Hiles I, Bax B, Gout I, Panayotou G, Fry MJ, Yonezawa K, Kasuga M, and Waterfield MD: EMBOJ. 13:511-521, 1994a.
46. Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ, Gout I, Totty NF, Truong O, Vicendo P, Yonezawa K, Kasuga M, Courtneidge SA, and Waterfield MD: EMBO J. 13:522-533, 1994b.
47. DiSanto JP, Muller W, Guy-Grand D, Fischer A, and Rajewsky K: Proc. Natl. Acad. Sci. USA 92:377-381, 1995.
48. Downes CP, and Carter AN: Cell. Signal. 3:501-513, 1991.
49. Downward J: FEBS Lett. 338:113-117, 1994.
50. Dumont FJ, Altmeyer A, Kastner C, Fischer PA, Lemon KP, Chung J, Blenis J, and Staruch MJ: J. Immunol. 152:992-1003, 1994.
51. Dumont FJ, Melino MR, Staruch MJ, Koprak SL, Fischer PA, and Sigal NH: J. Immunol. 144:1418-1424, 1990.
52. Duronio V, Welham MJ, Abraham S, Dryden P, and Schrader JW: Proc. Natl. Acad. Sci. USA 89:1587-1591, 1992.
53. Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, and Williams LT: Cell 69:413-423, 1992.
54. Farrar WL, and Ferris DK: J. Biol. Chem. 264:12562-12567, 1989.
55. Ferrari S, Pearson, RB, Siegmann M, Kozma SC, and Thomas G.J. Biol. Chem. 268:16091-16094, 1993.
56. Ferrari S, and Thomas G: Crit. Rev. Biochem. Mol. Biol. 29:385-413, 1994.
57. Feuerstein N, Huang D, and Prystowsky MB: J. Biol. Chem. 270:9454-9458, 1995.
58. Firpo EJ, Koff A, Solomon MJ, and Roberts JM: Mol. Cell. Biol. 14:4889-4901, 1994.
59. Fu X-Y: Cell 70:323-335, 1992.
60. Fukunaga R, Ishizaka-Ikeda E, Pan C-X, Seto Y, and Nagata S: EMBO J. 10:2855-2865, 1991.
61. Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, Ziegler SF, and Cosman D: Science 255:1434-1437, 1992.
62. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, and Anderson D: EMBOJ. 13:2822-2820, 1994.
63. Goldsmith MA, Xu W, Amaral MC, Kuczek ES, and Greene W.C: J. Biol. Chem. 269:14698-14704, 1994.
64. Gordon J, and MacLean LD: Nature 208:795-796, 1965.
65. Gouilleux F, Pallard C, Dusanter-Fourt I, Wakao H, Haldosen L-A, Norstedt G, Levy D, and Groner B: EMBOJ. 14:2005-2013, 1995.
66. Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, and Leonard WJ: J. Exp. Med. 162:363-368, 1985.
67. Guadagno TM, Ohtsubo M, Roberts JM, and Assoian RK: Science 262:1572-1575, 1993.
68. Guan K-L: Cell. Signal. 6:581-589, 1994.
69. Gustafson TA, He W, Craparo A, Schaub CD, and O'Neill TJ: Mol. Cell. Biol. 15:2500-2508, 1995.
70. Hartwell LH, and Kastan MB: Science 266:1821-1828, 1994.
71. Hatakeyama M, Kawahara A, Mori H, Shibuya H, and Taniguchi T: Proc. Natl. Acad. Sci. USA 89:2022-2026, 1992.
72. Hatakeyama M, Kono T, Kobayashi N, Kawahara A, Levin SD, Perlmutter RM, and Taniguchi T: Science 252:1523-1528, 1991.
73. Hatakeyama M, Mori H, Doi T, and Taniguchi T: Cell 59:837-845, 1989a.
74. Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyaska M, and Taniguchi T: Science 244:551-556, 1989b.
75. Hawkins PT, Jackson TR, and Stephens LR: Nature 358:157-159, 1992.
76. Hayashi H, Kamohara S, Nishioka Y, Kanai F, Miyake N, Fukiu Y, Shibasaki F, Takenawa T, and Ebina Y: J. Biol. Chem. 267:22575-22580, 1992.
77. Hayashi H, Nishioka Y, Kamohara S, Kanai F, Ishii K, Fukiu Y, Shibasaki F, Takenawa T, Kido H, Katsunuma N, and Ebina Y: J. Biol. Chem. 268:7107-7117, 1993.
78. He T-C, Jiang N, Zhuang H, and Wojchowski DM: J. Biol. Chem. 270:11055-11061, 1995.
79. Heim MH, Kerr IM, Stark GR, and Darnell JE Jr: Science 267:1347-1349, 1995.
80. Helliwell SB, Wagner P, Kunz J, Deuter-Reinhard M, Henriquez R, and Hall MN: Mol. Biol. Cell 5:105-118, 1994.
81. Hibi M, Murakami M, Saito M, Hirano T, Taga T, and Kishimoto T: Cell 63:1149-1157,1990.
82. Horak ID, Gress RE, Lucas PJ, Horak EM, Waldmann TA, and Bolen JB: Proc. Natl. Acad. Sci. USA 88:1996-2000, 1991.
83. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, and McKnight SL: Science 265:1701-1706, 1994.
84. Hou J, Schindler U, Henzel WJ, Wong SC, and McKnight SL: Immunity 2:321-329, 1995.
85. Hu Q, Klippel A, Muslin AJ, Fantl WJ, and Williams LT: Science 268:100-102, 1995.
86. Hunter T, and Pines J: Cell 79:573-582, 1994.
87. Ihle JN, and Kerr IM: Trends Genet. 11:69-74, 1995.
88. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, and Silvennoinen O: TIBS 19:222-227, 1994.
89. Israel A, Kimura A, Foumier A, Fellous M, and Kourilski P: Nature 322:743-746, 1986.
90. Jayaraman T, and Marks AR: J. Biol. Chem. 268:25385-25388, 1993.
91. Jefferies HBJ, Reinard C, Kozma SC, and Thomas G: Proc. Natl. Acad. Sci. USA 91:4441-4445, 1994.
92. Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, and Olefsky JM: Mol. Cell. Biol. 14:7466-7475, 1994.
93. Johnston JA, Kawamura M, Kirken RA, Chen Y-Q, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, and O'Shea JJ: Nature 370:151-153, 1994.
94. Joly M, Kazlauskas A, Fay FS, and Corvera S: Science 263:684-687, 1994.
95. Kapeller R, Prasad KVS, Janssen O, Hou W, Schaffhausen BS, Rudd CE, and Cantley LC: J. Biol. Chem. 269:1927-1933, 1994.
96. Karnitz LM, and Abraham RT: Curr. Op. Immunol. 7:320-326, 1995.
97. Karnitz LM, Burns LA, Sutor SL, Blenis J, and Abraham RT: Mol. Cell. Biol. 15:3049-3057, 1995.
98. Karnitz LM, Sutor SL, and Abraham RT: J. Exp. Med. 179:1799-1808, 1994.
99. Karnitz LM, Sutor SL, Torigoe T, Reed JC, Bell MP, McKean DJ, Leibson PJ, and Abraham RT: Mol. Cell. Biol. 12:4521-4530, 1992.
100. Kasakura S, and Lowenstein L: Nature 208:794-795, 1965.
101. Kato J-Y, Matsuchime H, Hiebert SW, Ewen ME, and Sherr CJ: Genes Devel. 7:331-342, 1993.
102. Kavanaugh WM, Klippel A, Escobedo JA, and Williams LT: Mol. Cell. Biol. 12:3415-3424, 1992.
103. Kavanaugh WM, Turck CW, and Williams LT: Science 368:1177-1179, 1995.
104. Kavanaugh WM, and Williams LT: Science 266:1862-1864, 1994.
105. Kinoshita T, Yokota T, Arai K-I, and Miyajima A: EMBO J. 14:266-275, 1995.
106. Kirschner MW: In DeVita VT Jr, Hellman S, and Rosenberg SA, Eds., Important Advances in Oncology: The Biochemical Nature of the Cell Cycle. J. B. Lippincott, Philadelphia, PA, pp. 3-16, 1992.
107. Klippel A, Escobedo JA, Hu Q, and Williams LT: Mol. Cell. Biol. 13:5560-5566, 1993.
108. Kobayashi N, Kono T, Hatakeyama M, Minami Y, Miyazaki T, Perlmutter RM, and Taniguchi T: Proc. Natl. Acad. Sci USA 90:4201-4205, 1993.
109. Kodalti T, Woscholski R, Hallberg B, Rodriguez-Viciana P, Downward J, and Parker PJ: Curr. Biol. 4:798-806, 1994.
110. Kondo M, Takeshita T, Higuchi M, Nakamura M, Sudo T, Nishikawa S-I, and Sugamura K: Science 263:1453-1454, 1994.
111. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K-I, and Sugamura K: Science 262:1874-1877, 1993.
112. Kotanides H, and Reich NC: Science 262:1265-1267, 1993.
113. Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Mowa NR, and Hall MN: Cell 73:585-596, 1993.
114. Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, and Crabtree GR: Nature 358:70-73, 1992.
115. Lam K, Carpenter CL, Ruderman NB, Friel JC, and Kelly KL: J. Biol. Chem. 269:20648-20652, 1994.
116. Lane HA, Fernandez A, Lamb NJC, and Thomas G: Nature 363:170-172, 1993.
117. Larner AC, David M, Feldman GM, Igarashi K-I, Hackett RH, Webb DSA, Sweitzer SM, Petricoin EF III, and Finbloom DS: Science 261:1730-1733, 1993.
118. Leevers SJ, Paterson HF, and Marshall CJ: Nature 369:411-414, 1994.
119. Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik PB, Peffer NJ, Waldmann TA, and Greene WC: Nature 311:626-631, 1984.
120. Lew D, Decker T, Strehlow I, and Darnell JE: Mol. Cell. Biol. 182:182-191, 1991.
121. Lin J-X, Migone T-S, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, and Leonard WJ: Immunity 2:331-339, 1995.
122. Dps DL, and Majerus PW: J. Biol. Chem. 264:8759-8763, 1989.
123. Uu L, Damen JE, Cutler RL, and Krystal G: Mol. Cell. Biol. 14:6926-6935, 1994.
124. Lopez AF, Elliott MJ, Woodcock J, and Vadas MA: Immunol. Today 13:495-500, 1992.
125. Lukas J, Bartkova J, Rohde M, Strauss M, and Bartek J: Mol. Cell. Biol. 15:2600-2611,1995.
126. Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yashikawa K, Taga T, Kishimoto T, Barbieri G, Pellegrini S, Sendrner M, Heinrich PC, and Horn F: Science 263:89-91, 1994.
127. Marengere LEM, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stem MJ, Cantley LC, and Pawson T: Nature 369:502-505, 1994.
128. Marshall CJ: Curr. Biol. 4:82-89, 1994.
129. Matsushima H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, and Kato J-Y: Mol. Cell. Biol. 14:2066-2076, 1994.
130. McGlade J, Cheng A, Pelicci G, Pelicci PG, and Pawson T: Proc. Natl. Acad. Sci. USA 89:8869-8873, 1992.
131. Merida I, Diez E, and Gaulton GN: J. Immunol. 147:2202-2207, 1991.
132. Merida I, and Gaulton GN: J. Biol. Chem. 265:5690-5694, 1990
133. Merida I, Williamson P, Kuziel WA, Greene WC, and Gaulton GN: J. Biol. Chem. 268:6765-6770, 1993.
134. Migone T-S, Lin J-X, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, and Leonard WJ: Science 269:79-81, 1995.
135. Minami Y, Kono T, Yamada K, Kobayashi N, Kawahara A, Perlmutter RM, and Taniguchi T: EMBO J. 12:759-768, 1993.
136. Minami Y, Kono T, Yamada K, and Taniguchi T: Biochim. Biophys. Acta 1114:163-177, 1992.
137. Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H, and Taniguchi T: Immunity 2:89-100, 1995.
138. Minamoto S, Mori H, Hatakeyama M, Kono T, Doi T, Ide T, Uede T, and Taniguchi T: J. Immunol. 145:2177-2182, 1990.
139. Ming X-F, Burgering BMT, Wennstrom S, Claesson-Welsh L, Heldin C-H, Bos JL, Kozma SC, and Thomas G: Nature 371:426-429, 1994.
140. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Z-J, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, and Taniguchi T: Science 266:1045-1047, 1994.
141. Miyazaki T, Maruyama M, Yamada G, Hatakeyama M, and Taniguchi T: EMBO J. 10:3191-3197, 1991.
142. Monfar M, Lemon KP, Grammer TC, Cheatham L, Chung J, Vlahos CJ, and Blenis J: Mol. Cell. Biol. 15:326-337, 1995.
143. Morice WG, Brunn GJ, Wiederrecht G, Siekierka JJ, and Abraham RT: J. Biol. Chem. 268:3734-3738, 1993a.
144. Morice WG, Wiederrecht G, Brunn GJ, Siekierka JJ, and Abraham RT: J. Biol. Chem. 268:22737-22745, 1993b.
145. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, Pellegrini S, Wilks AF, Ihle JN, Stark GR, and Kerr IM: Nature 366:129-135, 1993.
146. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T, and Kishimoto T: Proc. Natl. Acad. Sci. USA 88:11349-11353, 1991.
147. Muslin AJ, Klippel A, and Williams LT: Mol. Cell. Biol. 13:6661-6666, 1993.
148. Myers MG Jr, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, and White MF: Proc. Natl. Acad. Sci. USA 89:10350-10354, 1992.
149. Nakamura Y, Russell SM, Mess SA, Friedman M, Erdos M, Francois C, Jacques Y, Adelstein S, and Leonard WJ: Nature 369:330-333, 1994.
150. Nelson BH, Lord JD, and Greenberg PD: Nature 369:333-336, 1994.
151. Nielsen M, Svejgaard A, Skov S, and Odum N: Eur. J. Immunol. 24:3082-3086, 1994.
152. Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, and Honjo T: Nature 311:631-635, 1984.
153. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, and Leonard WJ: Science 262:1877-1880, 1993a.
154. Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, and Leonard WJ: Cell 73:147-157, 1993b.
155. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee M-H, Massague J, Crabtree GR, and Roberts JM: Nature 372:570-573, 1994.
156. Okada T, Sakuma L, Fukui Y, Hazeki O, and Ui M: J. Biol. Chem. 269:3563-3567, 1994.
157. Otani H, Siegel JP, Erdos M, Gnarra JR, Toledano MB, Sharon M, Mostowski H, Feinberg MB, Pierce JH, and Leonard WJ: Proc. Natl. Acad. Sci. USA 89:2789-2793, 1992.
158. Paige LA, Nadler MJS, Harrison ML, Cassady JM, and Geahlen RL: J. Biol. Chem. 268:8669-8674, 1993.
159. Panchamoorthy G, Fukazawa T, Stolz L, Payne G, Reedquist K, Shoelson S, Songyang Z, Cantley L, Walsh C, and Band H: Mol. Cell. Biol. 14:6372-6385, 1994.
160. Pardee AB: Science 246:603-608, 1989.
161. Pawson T: Nature 373:573-580, 1995.
162. Perkins GR, Marvel J, and Collins MKL: J. Exp. Med. 178:1429-1434, 1993.
163. Pleiman CM, Clark MR, Gauen LKT, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, and Cambier JC: Mol. Cell. Biol. 13:5877-5887, 1993.
164. Pleiman CM, Hertz WM, and Cambier JC: Science 263:1609-1612, 1994.
165. Polyak K, Lee M-H, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, and Massague J: Cell 78:59-66, 1994.
166. Powis G, Bonjouklian R, Berggren MM, Gallegos A, Abraham R, Ashendel C, Zalkow L, Matter WF, Dodge J, Grindey G, and Vlahos CJ: Cancer Res. 54:2419-2423, 1994.
167. Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, and Rudd CE: Proc. Natl. Acad. Sci. USA 90:7366-7370, 1993.
168. Price DJ, Grove JR, Calvo V, Avruch J, and Bierer BE: Science 257:973-977, 1992.
169. Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, and Ihle JN: Mol. Cell. Biol. 14:4335-4341, 1994.
170. Ravichandran KS, and Burakoff SJ: J. Biol. Chem. 269:1599-1602, 1994.
171. Ravichandran KS, Lorenz U, Shoelson SE, and Burakoff SJ: Mol. Cell. Biol. 15:593-600, 1995.
172. Reid LE, Brasnett AH, Gilbert CS, Porter ACG, Gewert DR, Stark GR, and Kerr IM: Proc. Natl. Acad. Sci. USA 86:840-844, 1989.
173. Remillard B, Petrillo R, Maslinski W, Tsudo M, Strom TB, Cantley L, and Varticovski L: J. Biol. Chem. 266:14167-14170, 1991.
174. Resh MD: Cell 76:411-413, 1994.
175. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, and Downward J: Nature 370:527-532, 1994.
176. Rothman P, Kreider B, Azam M, Levy D, Wegenka U, Eilers A, Decker T, Horn F, Kashleva H, Ihle J, and Schindler C: Immunity 1:457-468, 1994.
177. Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, and Schlossman SF: Proc. Natl. Acad. Sci. USA 85:5190-5194, 1988.
178. Ruiz-Larrea F, Vicendo P, Yaish P, End P, Panayotou G, Fry MJ, Morgan SJ, Thompson A, Parker PJ, and Waterfield MD: Biochem. J. 290:609-616, 1993.
179. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, Goldman AS, Schmalstieg FC, Ihle JN, O'Shea JJ, and Leonard WJ: Science 266:1042-1045, 1994.
180. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Pun RK, Paul WE, and Leonard WJ: Science 262:1880-1883, 1993.
181. Sabatini DM, Erdjument-Bromage H, Liu M, Tempst P, and Synder SH: Cell 78:35-43, 1994.
182. Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, and Abraham, RT: J. Biol. Chem. 270:815-822, 1995.
183. Sadowski HB, Shuai K, Darnell JE Jr, and Gilman MZ: Science 261:1739-1744, 1993.
184. Saito Y, Tada H, Sabe H, and Honjo T: J. Biol. Chem. 266:22186-22191, 1991.
185. Saltzman EM, Thorn RR, and Casnellie JE: J. Biol. Chem. 263:6956-6959, 1988.
186. Sato N, Sakamaki K, Terada N, Arai K-I, and Miyajima A: EMBOJ. 12:4181-4189, 1993.
187. Satoh T, Nakafuku M, Miyajima A, and Kaziro Y: Proc. Natl. Acad. Sci. USA 88:3314-3318, 1991.
188. Satoh T, Minami Y, Kono T, Yamada K, Kawahara A, Taniguchi T, and Kaziro Y: J. Biol. Chem. 267:25423-25427, 1992.
189. Savitski K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik, R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NGJ, Taylor MR, Arlett CF, Mild T, Weissman SM, Lovett MF, Collins FS, and Shiloh Y: Science 268:1749-1753, 1995.
190. Schindler C, Fu X-Y, Improta T, Aebersold R, and Darnell JE Jr: Proc. Natl. Acad. Sci. USA 89:7836-7839, 1992.
191. Schorle H, Holtschke T, Hunig T, Schimpl A, and Horak I: Nature 352:621-624, 1991.
192. Schreiber SL: Science 251:283-287, 1991.
193. Schreiber SL: Cell 70:365-368, 1992.
194. Schreiber SL, and Crabtree GR: Immunol. Today 13:136-142, 1992.
195. Serunian LA, Haber MT, Fukui T, Kim JW, Rhee SG, Lowenstein JM, and Cantley LC: J. Biol. Chem. 264:17809-17815, 1989.
196. Sharon M, Gnarra JR, and Leonard WJ: J. Immunol. 143:2530-2533, 1989.
197. Sharon M, Klausner RD, Cullen BR, Chizzonite R, and Leonard WJ: Science 234:859-863, 1986.
198. Shenoy-Scaria AM, Gauen LKT, Kwong J, Shaw AS, and Lublin DM: Mol. Cell. Biol. 13:6385-6392, 1993.
199. Sherr CJ: Cell 73:1059-1065, 1993.
200. Sherr CJ: Cell 79:551-555, 1994.
201. Sherr CJ, and Roberts JM: Genes Devel. 9:1149-1163, 1995.
202. Shoelson SE, Sivaraja M, Williams KP, Hu P, Schlessinger J, and Weiss MA: EMBO J. 12:795-802, 1993.
203. Shuai K: Curr. Op. Cell Biol. 6:253-259, 1994.
204. Shuai K, Horvath CM, Huang LHT, Qureshi SA, Cowburn D, and Darnell JE Jr: Cell 76:821-828, 1994.
205. Shuai K, Schindler C, Prezioso VR, and Darnell JE Jr: Science 259:1808-1812, 1992.
206. Shuai K, Stark GR, Kerr IM, and Darnell JE Jr: Science 261:1744-1746, 1993.
207. Shurtleff SA, Downing JR, Rock CO, Hawkins SA, Roussel MF, and Sherr CJ: EMBO J. 9:2415-2421, 1990.
208. Sigal CT, Zhou W, Buser CA, McLaughlin S, and Resh MD: Proc. Natl. Acad. Sci. USA 91:12253-12257, 1994.
209. Sigal NH, and Dumont FJ: Annu. Rev. Immunol. 10:519-560, 1992.
210. Silvennoinen O, Schindler C, Schlessinger J, and Levy DE: Science 261:1736-1739, 1993.
211. Silverman L, and Resh MD: J. Cell. Biol. 119:415-425, 1992.
212. Slingerland JM, Hengst L, Pan C-H, Alexander D, Stampfer MR, and Reed SI: Mol. Cell. Biol. 14:3683-3694, 1994.
213. Smith KA: Science 240:1169-1178, 1988.
214. Soler C, Alvarez CV, Beguinot L, and Carpenter G: Oncogene 9:2207-2215, 1994.
215. Soltoff SP, Rabin SL, Cantley LC, and Kaplan DR: J. Biol. Chem. 267:17472-17477, 1992.
216. Stahl N, Boulton TG, Farruggella T, Ip NY, Davis S, Witthuhn BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S, Ihle JN, and Yancopoulos GD: Science 263:92-95, 1994.
217. Stahl N, Farruggella TJ, Boulton TF, Zhong Z, Darnell JE Jr, and Yancopoulos GD: Science 267:1349-1353, 1995.
218. Stahl N, and Yancopoulos GD: Cell 74:587-590, 1993.
219. Stokoe D, Macdonald SG, Cadwallader K, Symons M, and Hancock JF: Science 264:1463-1467, 1994.
220. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, and Kishimoto T: Cell 58:573-581, 1989.
221. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, and Sugamura K: Science 257:379-382, 1992.
222. Taniguchi T: Science 268:251-255, 1995.
223. Terada N, Lucas JJ, Szepesi A, Franklin RA, Domenico J, and Gelfand EW: J. Cell. Phys. 154:7-15, 1993.
224. Terada N, Patel HR, Takase K, Kohno K, Nairn AC, and Gelfand EW: Proc. Natl. Acad. Sci. USA 91:11477-11481, 1994.
225. Teshigawara K, Wang H-M, Kato K, and Smith KA: J. Exp. Med. 165:223-238, 1987.
226. Toker A, Meyer M, Reddy KK, Falck JR, Aneja R, Aneja A, Parra A, Burns DJ, Ballas LM, and Cantley LC: J. Biol. Chem. 269:32358-32367, 1994.
227. Torigoe T, Saragovi HU, and Reed JC: Proc. Natl. Acad. Sci. USA 89:2674-2678, 1992.
228. Treisman R: Curr. Op. Genet Dev. 4:96-101, 1994.
229. Trouche D, Robin P, Robillard O, Sassone-Corsi P, and Harel-Bellan A: J. Immunol. 147:2398-2403, 1991.
230. Truitt KE, Mills GB, Turck CW, and Imboden JB: J. Biol. Chem. 269:5937-5943, 1994.
231. Tsudo M, Karasuyama H, Kitamura F, Tanaka T, Kubo S, Yamamura Y, Tamatani T, Hatakeyama M, Taniguchi T, and Miyasaka M: J. Immunol. 145:599-606, 1990.
232. Tsudo M, Kozak RW, Goldman CK, and Waldmann TA: Proc. Natl. Acad. Sci. USA 83:9694-9698, 1986.
233. Turner B, Rapp U, App H, Greene H, Dobashi K, and Reed J: Proc. Natl. Acad. Sci. USA 88:1227-1231, 1991.
234. Ullman KS, Northrop JP, Verweij CL, and Crabtree GR: Annu. Rev. Immunol. 8:421-452, 1990.
235. Ullrich A, and Schlessinger J: Cell 61:203-212, 1990.
236. Valius M, and Kazlauskas A: Cell 73:321-334, 1993.
237. Veillette A, Bookman MA, Horak EM, and Bolen JB: Cell 55:301-308, 1988.
238. Velazquez L, Fellous M, Stark GR, and Pellegrini S: Cell 70:313-322, 1992.
239. Vlahos CJ, Matter WF, Hui KY, and Brown RF: J. Biol. Chem. 269:5241-5248, 1994.
240. Vogel J, Kres M, Khoury G, and Jay G: Mol. Cell. Biol. 6:3550-3554, 1986.
241. Wang L-M, Keegan AD, Paul WE, Heidaran MA, Gutkind JS, and Pierce JH: EMBO J. 11:4899-4908, 1992.
242. Watling D, Guschin D, Muller M, Silvennoinen O, Witthuhn BA, Quelle FW, Rogers NC, Schindler C, Stark GR, Ihle JN, and Kerr IM: Nature 366:166-170, 1993.
243. Wegenka UM, Lutticken C, Buschmann J, Yuan J, Lottspeich F, Muller-Esterl W, Schindler C, Roeb E, Heinrich PC, and Horn F: Mol. Cell. Biol. 14:3186-3196, 1994.
244. Weinberg RA: Cell 81:323-330, 1995.
245. Welham MJ, Duronio V, Leslie KB, Bowtell D, and Schrader JW: J. Biol. Chem. 269:21165-21176, 1994a.
246. Welham MJ, Duronio V, and Schrader JW: J. Biol. Chem. 269:5865-5873, 1994b.
247. Weng Q-P, Andrabi K, Kozlowski MT, Grove JR, and Avruch J: Mol. Cell. Biol. 15:2333-2340, 1995.
248. Williamson P, Merida I, Greene WC, and Gaulton G: Leukemia 8:5186-5189, 1994.
249. Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, and Ihle JN: Nature 370:153-157, 1994.
250. Xu H, and Littman DR: Cell 74:633-643, 1993.
251. Yamauchi K, Holt K, and Pessin JE: J. Biol. Chem. 268:14597-14600, 1993.
252. Yoshimura A, Zimmers T, Neurmann D, Longmore G, Yoshimura Y, and Lodish HF: J. Biol. Chem. 267:11619-11625, 1992.
253. Zhang X, Blenis J, Li H-C, Schindler C, and Chen-Kiang S: Science 267:1990-1994, 1995.
254. Zhong Z, Wen Z, and Darnell JE Jr: Science 264:95-98, 1994.
255. Zhu X, Suen K-L, Barbacid M, Bolen JB, and Fargnoli J: J. Biol. Chem. 269:5518-5522,1994.