Synthesis of 5,6-Dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1- piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 601-605

  Cooper, Alan B ^a   Strickland, Corey L ^a   Wang, James ^a   Desai, Jagdish ^a   Kirschmeier, Paul ^a   Patton, Robert ^a   Bishop, W Robert ^a   Weber, Patricia C ^a   Girijavallabhan, V ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINE DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; DICYANDIAMIDO; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; P21(RAS) FARNESYL PROTEIN TRANSFERASE; P21(RAS) FARNESYL-PROTEIN TRANSFERASE; TRANSFERASE;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GUANIDINES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037169995     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00826-5     Document Type: Article

References (36)