Structure-based design of potent inhibitors of scytalone dehydratase: Displacement of a water molecule from the active site

Biochemistry

Volumn 37, Issue 51, 1998, Pages 17735-17744

  Chen, James M ^a,b   Xu, Simon L ^a   Wawrzak, Zdzislaw ^a   Basarab, Gregory S ^a   Jordan, Douglas B ^a  

^a DUPONT COMPANY   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLYASE; SCYTALONE DEHYDRATASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; FUNGUS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RICE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

AMINOQUINOLINES; ASPARAGINE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; MACROMOLECULAR SUBSTANCES; MAGNAPORTHE; MODELS, MOLECULAR; PYRIDAZINES; QUINAZOLINES; SALICYLAMIDES; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0032558981     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981848r     Document Type: Article

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