Novel tricyclic aminoacetyl and sulfonamide inhibitors of ras farnesyl protein transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 24, 1996, Pages 2977-2982

  Njoroge, F George ^a   Vibulbhan, Bancha ^a   Alvarez, Carmen S ^a   Bishop, W Robert ^a   Petrin, Joanne ^a   Doll, Ronald J ^a   Girijavallabhan, V ^a   Ganguly, Ashit K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21; RAS PROTEIN; TRANSFERASE;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0030591869     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00558-6     Document Type: Article

References (30)

1. 1. (a) Barbacid, M. Annu. Rev. Biochem. 1987, 56, 779.
2. (b). Bourne, H. R.; Saunders, D. A.; McCormick, F. Nature (London) 1990, 348, 125.
3. (c) Hall, A. Science 1990, 249, 635.
4. 2. (a) McCormick, F. Cell 1989, 56, 5.
5. (b) Gutierrez, L.; Magee, A. I.; Marshall, C. J.; Hancock, J. F. Embo J. 1989, 8, 1093.
6. (c) Gibbs, J.; Sigal, I.; Poe, M.; Scolnick, E. Proc. Natl. Acad. Sci U.S.A .1984, 81, 5704.
7. (d) Barbacid, M. European J. Clin. Invest. 1990, 20, 225.
8. 3. (a) Rodenhuis, S. Semin. Cancer Biol 1992, 3, 241.
9. (b) Bos, J. L. Cancer Res. 1989, 49, 4682.
10. 4. (a) Schafer, W. R.; Kim, R.; Sterne, R.; Thorner, J.; Kim, S -H.; Rine, J. Science 1989, 245, 379.
11. (b) Casey, P. J.; Solski, P. A.; Der, C. I.; Buss, J. E. Proc. Natl. Acad. Sci U.S.A. 1989, 86, 8223.
12. (c) Clarke, S.; Vogel, J. P.; Deschenes, R. J.; Stock, J. Proc. Natl. Acad. Sci U.S.A. 1988, 85, 4643.
13. (d) Deschenes, R. J.; Stimmel, J. B.; Clarke, S.; Stock, J.; Broach, J. R. J. Biol. Chem. 1989, 204, 11865.
14. (e) Fujima, A.; Tamanoi, F. J. Biol. Chem. 1990, 265, 3362.
15. 5. For reviews see: Gibbs, J. B. Cell 1990, 65, 1; and Graham, S. L. Exp. Opin. Ther. Patents 1995, 5, 1269.
16. 5. For reviews see: Gibbs, J. B. Cell 1990, 65, 1; and Graham, S. L. Exp. Opin. Ther. Patents 1995, 5, 1269.
17. 6. Goldstein, J. L.; Brown, M. S.; Stradley, S. J.; Reiss, Y.; Gierasch, L. M. J. Biol. Chem. 1991, 266, 15575.
18. 7. (a) James, G. L; Goldstein, J. L.; Brown, M. S; Somers, T. C; McDowell, R. S.; Crowley, C.; Lucas, B.; Levinson, A.; Marsters, J. C. Science 1993, 260, 1937.
19. (b) Kohl, N. E.; Mosser, S. D.; De Solms, J.; Giuliani, E. A.; Pompliano, D. L.; Graham, S. L.; Smith, R. L.; Scolnick, E. M.; Oliff, A.; Gibbs, J. B. Science 1993, 260, 1934.
20. (c) Garcia, A. M.; Rowell, C.; Ackermann, K.; Kowalczyk, J. J.; Lewis, M. D. J. Biol. Chem. 1993, 268, 18415.
21. (e) Vogt, A.; Qian Y.; Blaskovich, M. A.; Possum, R. D.; Hamilton, A. D.; Sebti, S. M. J. Biol. Chem. 1995, 270, 660.
22. (f) Wai J. S.; Bamberger, D. L.; Fisher, T. E; Graham, S. L.; Smith, R. L.; Kohl, N. E.; Mosser, S. D.; Oliff, A. I.; Pompliano, D. L.; Rand, E.; Gibbs, J. B. Bioorg. Med. Chem. Lett. 1994, 4, 2777.
23. 8. (a) Pompliano, D. L.; Rand, E.; Schaber, M. D.; Mosser, S. D.; Anthony, N. J.; Gibbs, J. B. Biochemistry 1992, 31, 3800.
24. (b) Cohen, L. H.; Valentijn A. R. P. M.; Roodenburg, L.; Vanleeuwen R. E. W.; Huisman, R. H.; Lutz, R. J.; Vandermarel G. A.; Vanbooms, J. H. Biochem. Pharmacol. 1995, 49, 839.
25. (c) Manne, V.; Ricca, C. S.; Brown, J. G.; Tuomari, A. V.; Yan, N.; Patel, D.; Schimidt, R.; Lynch, M. J.; Closek, C. P. Jr.; Carboni, J. M.; Robinson, S.; Gordon, E. M.; Barbacid, M.; Seizinger B. R.; Biller, S. A. Drug Dev. Res. 1995, 34, 121.
26. 9. Qian, Y.; Vogt, A.; Sebti, S. M.; Hamilton, A. D. J. Med. Chem. 1996, 39, 217.
27. 10. Bishop, W. R.; Bond, R.; Petrin, J.; Wang, L.; Patton, R.; Doll, R.; Njoroge, G.; Catino, J.; Shwartz, J.; Carr, D.; James, L.; Kirschmeier, P. J. Biol. Chem. 1995, 270, 30611.
28. 11. Villani, F. J.; Magatti, C. V.; Vashi, D. B., Wong, J., Popper, T. L. Arzneim-Forsch. Drug Res. 1986, 36, 1311.
29. 12. Edwards, M. L.; Stemerick, D. M.; McCarthy, J. R. Tetrahedron Lett. 1990, 31, 3417.
30. 13. Reiss Y.; Goldstein, J. L.; Seabra, M. C.; Casey, P. J.; Brown, M. S. Cell 1990, 62, 81.