Antitumor 8-chlorobenzocycloheptapyridines: A new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 1, 1997, Pages 93-99

  Mallams, A K ^a   Njoroge, F G ^a   Doll, R J ^a   Snow, M E ^a   Kaminski, J J ^a   Rossman, R R ^a   Vibulbhan, B ^a   Bishop, W R ^a   Kirschmeier, P ^a   Liu, M ^a   Bryant, M S ^a   Alvarez, C ^a   Carr, D ^a   James, L ^a   King, I ^a   Li, Z ^a   Lin, C C ^a   Nardo, C ^a   Petrin, J ^a   Remiszewski, S W ^a   Taveras, A G ^a   Wang, S ^a   Wong, J ^a   Catino, J ^a   Girijavallabhan, V ^a   Ganguly, A K ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (8 CHLORO 5,6 DIHYDRO 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE) 1 (4 PYRIDYLACETYL)PIPERIDINE; PROTEIN FARNESYLTRANSFERASE; PYRIDINE DERIVATIVE; RAS PROTEIN; SCH 55495; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL STRAIN COS1; COMPUTER SIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; REACTION ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAZEPINES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; PIPERIDINES; PYRIDINES; TUMOR CELLS, CULTURED;

EID: 0031030828     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00205-2     Document Type: Conference Paper

References (18)

1. 1. Barbacid, M. Annu. Rev. Biochem. 1987, 56, 779.
2. 2. Hall, A. Science 1994, 264, 1413.
3. 3. Rodenhuis, S. Semin. Cancer Biol. 1992, 3, 241.
4. 4. Casey, P. J.; Solski, P. A.; Der, C. J.; Buss, J. E. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 8323.
5. 5. Zhang, F. L.; Casey, P. J. Annu. Rev. Biochem. 1996, 65, 241.
6. 6. Graham, S. L. Exp. Opin. Ther. Patents 1995, 5, 1269.
7. 7. Sepp-Lorenzino, L.; Ma, Z.; Rands, E.; Kohl, N. E.; Gibbs, J. B.; Oliff, A.; Rosen, N. Cancer Res. 1995, 55, 5302.
8. 8. Nagasu, T.; Yoshimatsu, K.; Rowell, C.; Lewis, M. D.; Garcia A, M. Cancer Res. 1995, 55, 5310.
9. 9. Bishop, W. R.; Bond, R.; Petrin, J.; Wang, L.; Patton, R.; Doll, R.; Njoroge, G.; Catino, J.; Schwartz, J.; Windsor, W.; Syto, R.; Schwartz, J.; Carr, D.; James, L.; Kirschmeier, P. J. Biol. Chem. 1995, 270, 30611.
10. 10. Yokoyama, K.; Gelb, M. H. J. Biol. Chem. 1993, 268, 4055.
11. 11. Seabra, M. C.; Goldstein, J. L.; Sudhof, T. C.; Brown, M. S. J. Biol. Chem. 1992, 267, 14497.
12. 12. Catalyst v2.1 Molecular Simulations, Inc., Burlington, MA.
13. 13. Stradley, S. J.; Rizo, J.; Gierasch, L. Biochemistry 1993, 32, 12586.
14. 14. Koblan, K. S.; Culberson, J. C.; Desolms, S. J.; Giuliani, E. A.; Mosser, S. D.; Omer, C. A.; Pitzenberger, S. M.; Bogusky, M. J. Protein Sci. 1995, 4, 681.
15. 15. Piwinski, J. J.; Ganguly, A. K.; Green, M. J.; Villani, F. J.; Wong, J. U.S. Patent: 5,089,496, 18 February, 1992.
16. 16. Piwinski, J. J.; Green, M. J.; Wong, J. U.S. Patent: 5,422,351, 6 June, 1995.
17. 17. Piwinski, J. J.; Ganguly, A. K.; Green, M. J.; Villani, F. J.; Wong, J. U.S. Patent: 4,826,853, 2 May, 1989.
18. 18. Wong, J.; McPhail, A. T. Unpublished data.