Reporter gene assays for algal-derived toxins

Natural Toxins

Volumn 7, Issue 6, 1999, Pages 415-421

  Fairey, Elizabeth R ^a   Ramsdell, John S ^a  

^a CENTER FOR COASTAL ENVIRONMENTAL HEALTH AND BIOMOLECULAR RESEARCH   (United States)

Author keywords

Brevetoxin; Ciguatoxin; Maitotoxin; Pfiesteria piscicida; Saxitoxin

Indexed keywords

BREVETOXIN; BREVETOXIN 1; CALCIUM; CALCIUM CHANNEL; CIGUATOXIN; CIGUATOXIN 1; LUCIFERASE; MAITOTOXIN; MARINE TOXIN; PROTEIN C FOS; SAXITOXIN; SODIUM; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ALGA; ANIMAL CELL; ARTICLE; ASSAY; CELL MEMBRANE POTENTIAL; CONCENTRATION RESPONSE; CONTAMINATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; FRACTIONATION; GENETIC TRANSFECTION; GENOTOXICITY; HUMAN; HYPOPHYSIS CELL; MOLECULAR STABILITY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; ONCOGENE C FOS; PFIESTERIA; PROTEIN EXPRESSION; RAT; REPORTER GENE; SCREENING TEST; SEA FOOD; SODIUM CURRENT; TOXICITY TESTING; TOXIN ANALYSIS; TRANSCRIPTION REGULATION;

ANIMALS; BIOLOGICAL ASSAY; CIGUATOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, FOS; GENES, REPORTER; LUCIFERASES; MARINE TOXINS; MICE; NEUROBLASTOMA; NEUROTOXINS; OXOCINS; PFIESTERIA PISCICIDA; PITUITARY GLAND; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RNA, MESSENGER; SAXITOXIN; TRANSFECTION; TUMOR CELLS, CULTURED;

ALGAE; ANIMALIA; PFIESTERIA; PFIESTERIA PISCICIDA;

EID: 0033286412     PISSN: 10569014     EISSN: None     Source Type: Journal    
DOI: 10.1002/1522-7189(199911/12)7:6<415::AID-NT81>3.0.CO;2-E     Document Type: Article

References (26)

1. The voltage sensitive sodium channel: A receptor for multiple neurotoxins
2. Toxin T46 from Ptychodiscus brevis enhances activation of voltage-sensitive channels by veratridine
3. Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels
4. Development of a rapid and sensitive high throughput reporter gene assay for estrogenic contaminants
5. A cell based assay for brevetoxins, saxitoxins and ciguatoxins using a stably expressed c-fos-luciferase reporter gene
6. Reporter gene assay for fish-killing activity produced by Pfiesteria piscicida
7. In vitro models for toxicological research and testing
8. The saxitoxins: Sources, chemistry and pharmacology
9. A companion to methods in neurosciences
10. Analytical methods for marine toxins
11. Paralytic shellfish poison (saxitoxin family) bioassays: Automated endpoint determination and standardization of the in vitro tissue culture bioassay, and comparison with the standard mouse bioassay
12. A tissue culture assay for tetrodotoxin, saxitoxin and related toxins
13. Tetrazolium-based cell bioassay for neurotoxins active on voltage-sensitive sodium channels: Semiautomated assay for saxitoxins, brevetoxins, and ciguatoxins
14. In vitro analysis of ciguatoxins, brevetoxins, and saxitoxins
15. Brain Fos is a sensitive biomarker for the lowest observed neuroexcitatory effects of domoic acid
16. Neuroexcitatory and neurotoxic actions of the amnesic shellfish poison, domoic acid
17. Neuroexcitatory actions of ciguatoxin on brain regions associated with thermoregulation
18. Glutamate receptor agonists increase the expression of Fos, FRA, and AP-1 DNA binding activity in the mammalian brain
19. Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity
20. Maitotoxin, a Ca2+ channel activator candidate
21. 1 cells
22. 1 pituitary cells via activation of type L-voltage-dependent calcium channels
23. 1 pituitary cells
24. In vitro bioassays for assessing estrogenic substances