Cytochrome P4501a induction potencies of polycyclic aromatic hydrocarbons in a fish hepatoma cell line: Demonstration of additive interactions

Environmental Toxicology and Chemistry

Volumn 19, Issue 8, 2000, Pages 2047-2058

  Fent, Karl ^a   Bätscher, Roger ^a  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

Cytochrome P4501A induction; Fish cell line; Induction equivalency concept; Mixtures; Polycyclic aromatic hydrocarbons

Indexed keywords

CYTOCHROME P450; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONCENTRATION RESPONSE; CYTOTOXICITY; ECOTOXICOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATOMA CELL; LANDFILL; LEACHING; NONHUMAN; PRIORITY JOURNAL; WATER POLLUTION;

ANIMALIA;

EID: 0040949911     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1002/etc.5620190813     Document Type: Article

References (52)

1. Balch GC, Metcalfe CD, Huestis SY. 1995. Identification of potential fish carcinogens in sediment from Hamilton Harbour, Ontario, Canada. Environ Toxicol Chem 14:79-91.
2. Piskorska-Pliszczynska J, Keys B, Safe S, Newman MS. 1986. The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons. Toxicol Lett 34:67-74.
3. Brunström B, Broman D, Näf C. 1991. Toxicity and EROD-inducing potency of 24 polycyclic aromatic hydrocarbons (PAHs) in chick embryos. Arch Toxicol 65:485-489.
4. Varanasi U. 1989. Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment. CRC, Boca Raton, FL, USA.
5. Schultz ME, Kaplan LAE, Schultz RJ. 1989. Initiation of cell proliferation in livers of viviparous fish Poeciliopsis lucida with 7.12-dimethylbenz(a)thracene. Environ Res 48:248-254.
6. Vogelbein WK, Fournie JW, Veld PAV, Huggett RJ. 1990. Hepatic neoplasms in the mummichog Fundulus heteroclitus from a creosote-contaminated site. Cancer Res 50:5978-5986.
7. Stegeman JJ, Hahn ME. 1994. Biochemistry and molecular biology of monooxygenases: Current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species. In Ostrander GK, Malins D, eds, Biochemistry and Molecular Biological Perspectives in Aquatic Toxicology. Lewis, Boca Raton, FL, USA, pp 87-206.
8. Bucheli TD, Fent K. 1995. Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems. Crit Rev Environ Sci Technol 25:201-268.
9. Stegeman JJ, Lech JJ. 1991. Cytochrome P450 systems in aquatic species: Carcinogen metabolism and biomarkers for carcinogen and pollutant exposure. Environ Health Perspect 90:101-109.
10. Woodin BR, Smolowitz RM. Stegeman JJ. 1997. Induction of cytochrome P4501A in the intertidal fish Anoplarchus purpurescens by Prudhoe Bay crude oil and environmental induction in fish from Prince William Sound. Environ Sci Technol 31:1198-1205.
11. Safe S. 1994. Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24:87-149.
12. Walker MK, Peterson RE. 1991. Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 21:219-238.
13. Hightower LE, Renfro JL. 1988. Recent applications of fish cell culture to biomedical research. J Exn Zool 248:290-302.
14. Hahn ME, Lamb TM, Schultz ME, Smolowitz RM, Stegeman JJ. 1993. Cytochrome P4501A induction and inhibition by 3,3′,4,4′-tetrachlorobiphenyl in an Ah receptor-containing fish hepatoma cell line (PLHC-1). Aquat Toxicol 26:185-208.
15. Hahn ME, Woodward BL, Stegeman JJ, Kennedy SW. 1996. Rapid assessment of induced cytochrome P4501A protein and catalytic activity in fish hepatoma cells grown in multiwell plates: Response to TCDD, TCDF and two planar PCBs. Environ Toxicol Chem 15:582-591.
16. Brüschweiler BJ, Würgler F, Fent K. 1996. An ELISA for the determination of cytochrome P4501A in fish cell cultures. Environ Toxicol Chem 15:592-596.
17. Zabel EW, Pollenz R, Peterson RE. 1996. Relative potencies of individual polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners and congener mixtures based on induction of cytochrome P4501A mRNA in a rainbow trout gonadal cell line (RTG-2). Environ Toxicol Chem 15:2310-2318.
18. Clemons JH, van den Heuvel MR, Stegeman JJ, Dixon DG, Bols NC. 1994. Comparison of toxic equivalent factors for selected dioxin and furan congeners derived using fish and mammalian liver cell lines. Can J Fish Aquat Sci 51:1577-1584.
19. Brüschweiler BJ, Würgler FE, Fent K. 1995. Cytotoxicity in vitro of organotin compounds to fish hepatoma cells PLHC-1 (Poeciliopsis lucida). Aquat Toxicol 32:143-160.
20. Brüschweiler BJ, Würgler FE, Fent K. 1996. Inhibition of cytochrome P4501A by organotins in fish hepatoma cells PLHC-1. Environ Toxicol Chem 15:728-735.
21. U.S. Environmental Protection Agency. 1992. Test methods for organic chemical analysis of municipal and industrial wastewater. EPA-610. Washington, DC.
22. U.S. Environmental Protection Agency. 1986. Test methods for evaluating solid waste. SW-846-8270. Washington, DC.
23. Stegeman JJ, Hahn ME, Weisbrod R, Woodin BR, Joy JS, Najibi S, Cohen RA. 1995. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol Pharmacol 47:296-306.
24. Kennedy SW, Lorenzen A, Norstrom RJ. 1996. Chicken embryo hepatocyte bioassay for measuring cytochrome P4501A based 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentrations in environmental samples. Environ Sci Technol 30:706-715.
25. Hahn ME, Chandran K. 1996. Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls. Arch Biochem Biophys 329:163-174.
26. Tillitt DE, Giesy JP, Ankley GT. 1991. Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples. Environ Sci Technol 25:87-92.
27. Huuskonen SE, Hahn ME, Lindström-Seppä P. 1998. A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts. Chemosphere 36:2921-2932.
28. Tillitt DE, Ankley GT, Verbrugge DA, Giesy JP, Ludwig JP, Kubiak TJ. 1991. H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes. Arch Environ Contain Toxicol 21:91-101.
29. Zacharewski T, Safe L, Safe S, Chittim B, DeVault D, Wiberg K, Bergqvist P-A, Rappe C. 1989. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in vitro enzyme induction activities. Environ Sci Technol 23:730-735.
30. Brunström B, Engwall M, Hjelm K, Lindqvist L, Zebühr Y. 1995. EROD induction in cultured chick embryo liver: A sensitive bioassay for dioxin-like environmental pollutants. Environ Toxicol Chem 14:837-842.
31. Behrens A, Schirmer K, Bols NC, Segner H. 1998. Microassey for rapid measurement of 7-ethoxyresorufin-O-deethylase activity in intact fish hepatocyles. Mar Environ Res 46:369-373.
32. Villeneuve DL, Crunkilton RL, DeVita WM. 1997. Aryl hydrocarbon receptor-mediated toxic potency of dissolved lipophilic organic contaminants collected from Lincoln Creek, Milwaukee, Wisconsin, USA, to PLHC-1 (Poeciliopsix licida) fish hepatoma cells. Environ Toxicol Chem 16:977-984.
33. 10 air particulatc material using in vitro gene expression assays. Environ Sci Technol 32:1853-1860.
34. Schirmer K, Chan AGJ, Joyce EM, Greenberg BM, Dixon DG, Bols NC. 1997. Toxic potencies of PAHs to fish cells: A perspective on phototoxicity and cytochrome P4501A1 induction. Abstracts, 18th Annual Meeting, Society of Environmental Toxicology and Chemistry. San Francisco, CA, USA, November 16-20, p 179.
35. Raha A, Joyce T, Gusky S, Bresnick E. 1995. Glycine N-methyltransferase is a mediator of cytochrompe P4501A1 gene expression. Arch Biochem Biophys 322:395-404.
36. Raha A, Reddy V, Houser WH, Bresnick E. 1990. Binding characteristics of 4S PAH-binding and Ah receptor from rats and mice. J Toxicol Environ Health 29:339-355.
37. Willet KL, Gardinali PR, Sericano JL, Wade TL, Safe SH. 1997. Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs). Arch Environ Contam Toxicol 32:442-448.
38. Leece B, Denomme MA, Towner R, Li SMA, Safe S. 1985. Polychlorinated biphenyls: Correlation between in vivo and in vitro quantitative structure-activity relationships. J Toxicol Environ Health 16:379-388.
39. Bradlaw JA, Garthoff LH, Hurley NE, Firestone D. 1980. Comparative induction of aryl hydrocarbon hydroxylase activity in vitro by analogues of dibenzo-p-dioxin. Food Cosmet Toxicol 18: 627-635.
40. Celander M, Bremer J, Hahn ME, Stegeman JJ. 1997. Glucocorticoid-xenobiotic interactions: Dexamethasone-mediated potentiation of cytochrome P4501A induction by β-naphthoflavone in a fish hepatoma cell line (PLHC-1). Environ Toxicol Chem 16:900-907.
41. Haasch ML, Quardokus EM, Sutherland LA, Goodrich MS, Lech JJ. 1993. Hepatic CYP1A1 induction in rainbow trout by continuous flowthrough exposure to β-naphthoflavone. Fundam Appl Toxicol 20:72-82.
42. Gooch JW, Elskus AA, Kloepper-Sams PJ, Hahn ME, Stegeman JJ. 1989. Effects of ortho and non-ortho substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops). Toxicol Appl Pharmacol 98:422-433.
43. Willett KL, Randerath K, Zhou GD, Safe SH. 1998. Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Biochem Pharmacol 55:831-839.
44. Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD. Koeman JH, Brouwer A. 1998. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43:161-171.
45. Ahlborg UG, et al. 1994. Toxic equivalency factors for dioxinlike PCBs. Chemosphere 28:1049-1067.
46. Van den Berg M, Birnbaum L, Bosveld ATC. Brunström B, Cook P, Feeley M, Giesy JP. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perpect 106:775-790.
47. Nisbet ICT, LaGoy PK. 1992. Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Reg Toxicol Pharmacol 16:290-300.
48. Petry T, Schmid P, Schlatter C. 1996. The use of toxic equivalency factors in assessing occupational and environmental health risk associated with exposure to airborne mixtures of polycyclic aromatic hydrocarbons (PAHs). Chemosphere 32:639-648.
49. Thorslund T, Farrer D. 1991. Development of relative potency estimates for PAHs and hydrocarbon combustion product fractions compared to benzo(a)pyrene and their use in carcinogenic risk assessments. EPA600/R/92/134. Technical Report. U.S. Environmental Protection Agency, Washington, DC.
50. Van der Weiden MEJ, Hanegraaf FHM, Eggens ML, Celander M, Seinen W, Van den Berg M. 1994. Temporal induction of cytochrome P450 1A in the mirror carp (Cyprinus) after administration of several polycyclic aromatic hydrocarbons. Environ Toxicol Chem 13:797-802.
51. Jung DKJ, Klaus T, Fent K. 2000. Cytochrome P450 induction by nitrated polycyclic aromatic hydrocarbons, azaarenes, and binary mixtures in the fish hepatoma cell line PLHC-1. Environ Toxicol Chem (in press).
52. Chaloupka K, Harper N, Krishnan V, Santostefano M, Rodriguez LV, Safe S. 1993. Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists. Chem Biol Interactions 89:141-158.