Binding of cyclic and linear MSH core peptides to the melanocortin receptor subtypes

European Journal of Pharmacology

Volumn 319, Issue 2-3, 1997, Pages 369-373

  Schiöth, Helgi B ^a   Muceniece, Ruta ^b   Larsson, Monika ^a   Mutulis, Felikss ^a   Szardenings, Michael ^a   Prusis, Peteris ^a   Lindeberg, Gunnar ^c   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Ligand binding; Melanocortin receptor subtype; MSH (melanocyte stimulating hormone)

Indexed keywords

CYCLOPEPTIDE; HORMONE RECEPTOR; INTERMEDIN DERIVATIVE; RECEPTOR SUBTYPE;

ARTICLE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL;

ADRENOCORTICOTROPIC HORMONE; BINDING, COMPETITIVE; CELL LINE; CLONING, MOLECULAR; EUKARYOTIC CELLS; HUMANS; LIGANDS; MELANOCYTE-STIMULATING HORMONES; PEPTIDES; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; TRANSFECTION;

EID: 0342618501     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00959-4     Document Type: Article

References (21)

1. Adan, R.A.H., R.D. Cone, J.P.H. Burbach and W.H. Gispen, 1994a, Differential effects of melanocortin peptides on neural melanocortin receptors, Mol. Pharmacol. 46, 1182.
2. 5 receptors, Eur. J. Pharmacol. 269, 331.
3. Chhajlani, V. and J.E.S. Wikberg, 1992, Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA, FEBS Lett. 309, 417.
4. Chhajlani, V., R. Muceniece and J.E.S. Wikberg, 1993, Molecular cloning of a novel human melanocortin receptor, Biochem. Biophys. Res. Commun. 195, 866.
5. Eberle, A.N., 1988, The Melanotropins; Chemistry, Physiology and Mechanisms of Action (Karger, Basel) p. 333.
6. Gantz, I., Y. Konda, T. Tashiro, Y. Shimoto, H. Miwa, G. Munzert, S.J. Watson, J. DelValle and T. Yamada, 1993a, Molecular cloning of a novel melanocortin receptor, J. Biol. Chem. 268, 8246.
7. Gantz, I., H. Miwa, Y. Konda, Y. Shimoto, T. Tashiro, S.J. Watson, J. DelValle and T. Yamada, 1993b, Molecular cloning, expression, and gene localization of a fourth melanocortin receptor, J. Biol. Chem. 268, 15174.
8. 2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors, J. Med. Chem. 38, 3454.
9. Low, M.J., R.B. Simerly and R.D. Cone, 1994, Receptors for the melanocortin peptides in the central nervous system, Curr. Opin. Endocr. Diab. 79.
10. Miwa, H., I. Gantz, Y. Konda, Y. Shimoto and T. Yamada, 1995, Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors, J. Pharmacol. Exp. Ther. 273, 376.
11. Mountjoy, K.G., L.S. Robbins, M.T. Mortrud and R.D. Cone, 1992, The cloning of a family of genes that encode the melanocortin receptors, Science 257, 1248.
12. Prusis, P., P.A. Frändberg, R. Muceniece, I. Kalvinsh and J.E.S. Wikberg, 1995, A three dimentional model for the interaction of MSH with the melanocortin 1 receptor, Biochem. Biophys. Res. Commun. 210, 205.
13. 3) receptor from rat hypothalamus: photoaffinity labelling and binding of alanine-substituted α-MSH analogues, FEBS Lett. 350, 29.
14. Sahm, U.G., G.W.J. Oliver, S.K. Branch, S.H. Moss, C.W. Pouton, 1994b, Synthesis and biological evaluation of α-MSH analogues substituted with alanine, Peptides 15, 1297.
15. 7]α-melanocyte stimulating hormone; a highly potent α-melanotropin with ultralong biological activity, Proc. Natl. Acad. Sci. USA 77, 5754.
16. Sawyer, T.K., V.J. Hruby, P.S. Darman and M.E. Hadley, 1982, [4-half-cystine, 10-half-cystine]-α-Melanocyte stimulating hormone; a cyclic α-melanotropin exibiting superagonist biological activity, Proc. Natl. Acad. Sci. USA 79, 1751.
17. Schiöth, H.B., R. Muceniece, J.E.S. Wikberg and V. Chhajlani, 1995, Characterisation of melanocortin receptor subtypes by radioligand binding analysis, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 288, 311.
18. Schiöth, H.B., A. Kuusinen, R. Muceniece, M. Szardenings, K. Keinänen and J.E.S. Wikberg, 1996a, Expression of functional melanocortin 1 receptors in insect cells, Biochem. Biophys. Res. Commun. 221, 807.
19. Schiöth, H.B., R. Muceniece and J.E.S. Wikberg, 1996b, Characterisation of melanocortin 4 receptor by radioligand binding analysis, Pharmacol. Toxicol. 79, 161.
20. Schiöth, H.B., V. Chhajlani, R. Muceniece, V. Klusa and J.E.S. Wikberg, 1996c, Major pharmacological distinction of the ACTH receptor from the other melanocortic receptors, Life Sci. 59, 797.
21. Siegrist W. and A.N. Eberle, 1995, Melanocortins and their implications in melanoma, Trends Endocrinol. Metab. 6, 115.