Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 49631-49637

  Chen, Xu ^a,b   Resh, Marilyn D ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHOLESTEROL; ENZYMES;

EPIDERMAL GROWTH FACTOR;

BIOLOGICAL MEMBRANES;

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CELL PROTEIN; CHOLESTEROL; EPIDERMAL GROWTH FACTOR RECEPTOR; FILIPIN; LIGAND; MEMBRANE LIPID; METHYL BETA CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN COS1; CROSS LINKING; DIMERIZATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BETA-CYCLODEXTRINS; BLOTTING, WESTERN; CELL MEMBRANE; CHOLESTEROL; COS CELLS; CROSS-LINKING REAGENTS; CULTURE MEDIA, SERUM-FREE; CYCLODEXTRINS; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; ENZYME INHIBITORS; IMMUNOBLOTTING; ISOENZYMES; LIGANDS; MASS SPECTROMETRY; MEMBRANE MICRODOMAINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TYROSINE; TYRPHOSTINS;

ANIMALIA;

EID: 0037147320     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208327200     Document Type: Article

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