Modulation of carcinoembryonic antigen release by glucosylceramide implications for HT29 cell differentiation

European Journal of Biochemistry

Volumn 258, Issue 1, 1998, Pages 233-242

  Babia, Teresa ^a   Veldman, Robert Jan ^a   Hoekstra, Dick ^a   Kok, Jan Willem ^a,b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Dept of Physiological Chemistry ^*  (Netherlands)

Author keywords

Carcinoembryonic antigen; Cell differentiation; Ceramide; Glucosylceramide; PDMP

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; CARCINOEMBRYONIC ANTIGEN; GLUCOSYLCERAMIDE; GLYCOLIPID; VILLIN;

APICAL MEMBRANE; ARTICLE; BRUSH BORDER; CELL DIFFERENTIATION; CELL STRAIN HT29; COLON TUMOR; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; MICROVILLUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CARCINOEMBRYONIC ANTIGEN; CELL DIFFERENTIATION; GLUCOSYLCERAMIDES; HT29 CELLS; HUMANS;

EID: 0032533734     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2580233.x     Document Type: Article

References (55)

1. Babia, T., Kok, J. W., Hulstaert, C., De Weerd, H. & Hoekstra, D. (1993) Differential metabolism and trafficking of sphingolipids in differentiated versus undifferentiated HT29 cells, Int. J. Cancer 54, 839-845.
2. Mehlhorn, I. E., Florio, E., Barber, K. R., Lordo, C. & Grant, C. W. (1988) Evidence that transbilayer interdigitation of glycosphingolipid long chain fatty acids may be a general phenomenon, Biochim. Biophys. Acta 939, 151-159.
3. Pascher, I. (1976) Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability, Biochim. Biophys. Acta 455, 433-451.
4. Thompson, T. E. & Tillack, T. W. (1985) Organization of glycosphingolipids in bilayers and plasma membranes of mammalian cells, Annu. Rev. Biophys. Chem. 14, 361-386.
5. Merrill, A. H. Jr, Schmelz, E. M., Dillehay, D. L., Spiegel, S., Shayman, J. A., Schroeder. J. J., Riley, R. T., Voss, K. A. & Wang, E. (1997) Sphingolipids - The enigmatic lipid class: biochemistry, physiology, and pathophysiology, Toxicol. Appl. Pharmacol. 142, 208-225.
6. Ghosh, S., Strum, J. C. & Bell, R. M. (1997) Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling, FASEB J. 11, 45-50.
7. Hannun, Y. A. (1994) The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269, 3125-3128.
8. Hannun, Y. A. (1996) Functions of ceramide in coordinating cellular responses to stress, Science 274, 1855-1859.
9. Igarashi, Y. (1997) Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways, J. Biochem. 122, 1080-1087.
10. Hakomori, S. & Igarashi, Y. (1995) Functional role of glycosphingolipids in cell recognition and signaling, J. Biochem. 118, 1091-1103.
11. Hoekstra, D. & Kok, J. W. (1992) Trafficking of glycosphingolipids in eukaryotic cells; sorting and recycling of lipids, Biochim. Biophys. Acta 1113, 277-294.
12. Kok, J. W., Babia, T. & Hoekstra, D. (1991) Sorting of sphingolipids in the endocytic pathway of HT29 cells, J. Cell Biol. 114, 231-239.
13. Sando, G. N., Howard, E. J. & Madison, K. C. (1996) Induction of ceramide glucosyltransferase activity in cultured human keratinocytes. Correlation with culture differentiation, J. Biol. Chem. 271, 22044-22051.
14. Hoffman, L. M., Brooks, S. E., Stein, M. R. & Schneck, L. (1994) Cyclic AMP causes differentiation and decreases the expression of neutral glycosphingolipids in cell cultures derived froma malignant glioma, Biochim. Biophys. Acta 1222, 37-44.
15. Holleran, W. M., Takagi, Y., Imokawa, G., Jackson, S., Lee, J. M. & Elias, P. M. (1992) β-glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation, J. Lipid. Res. 33, 1201-1209.
16. Kan, C. & Kolesnick, R. N. (1992) A synthetic ceramide analog, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, selectively inhibits adherence during macrophage differentiation of human leukemia cells, J. Biol. Chem. 267, 9963-9967.
17. Shi, Z. R., Tsao, D. & Kim, Y. S. (1983) Subcellular distribution, synthesis, and release of carcinoembryonic antigen in cultured human colon adenocarcinoma cell lines, Cancer Res. 43, 4045-4049.
18. Fantini, J., Rognoni, J. B., Culouscou, J. M., Pommier, G., Marvaldi, J. & Tirard, A. (1989) Induction of polarized apical expression and vectorial release of carcinoembryonic antigen (CEA) during the process of differentiation of HT29-D4 cells, J. Cell. Physiol. 147, 126-134.
19. Simons, K. & Ikonen, E. (1997) Functional rafts in cell membranes, Nature 387, 569-572.
20. Brown, D. A. (1992) Interactions between glycosyl-PtdIns-anchored proteins and membrane lipids, Trends Cell Biol. 2, 338-343.
21. Inokuchi, J. & Radin, N. S. (1987) Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, an inhibitor of murine glucocerebroside synthetase, J. Lipid Res. 28, 565-571.
22. Kyogashima, M., Inoue, M., Seto, A. & Inokuchi, J. (1996) Glucosylceramide synthase inhibitor, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol exhibits a novel decarcino-genic activity against Shope carcinoma cells, Cancer Lett. 101, 25-30.
23. Barbour, S., Edidin, M., Felding-Habermann, B., Taylor-Norton, J., Radin, N. S. & Fenderson, B. A. (1992) Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion and membrane lipid organization in human A431 cells, J. Cell. Physiol. 150, 610-619.
24. Shayman, J. A., Deshmukh, G. D., Mahdiyoun, S., Thomas, T. P., Wu, D., Barcelon, F. S. & Radin, N. S. (1991) Modulation of renal epithelial cell growth by glucosylceramide, J. Biol. Chem. 266, 22968- 22974.
25. Inokuchi, J., Jimbo, M., Momosaki, K., Shimeno, H., Nagamatsu, A. & Radin, N. S. (1990) Inhibition of experimental metastasis of murine lewis long carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action, Cancer Res. 50, 6731-6737.
26. Inokuchi, J., Usuki, S. & Jimbo, M. (1995) Stimulation of glycosphingolipid biosynthesis by L-threo-1-phenyl-2-decanoylamino-1-propanol and its homologs in B16 melanoma cells, J. Biochem. 117, 766-773.
27. Chatterjee, S., Cleveland, T., Shi, W., Inokuchi, J. & Radin, N. S. (1996) Studies of the action of ceramide-like substances (D and L-PDMP) on sphingolipid glycosyltransferases and purified lactosylceramide synthase, Glycoconjugate J. 13, 481-486.
28. Kishimoto, Y. (1975) A facile synthesis of ceramides, Chem. Phys. Lip. 15, 33-36.
29. Zweibaum, A., Pinto, M., Chevalier, G., Dussaulx, N. T., Lacroix, B., Haffen, K., Bru, J.-L. & Rousset, M. (1985) Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose, J. Cell Physiol. 122, 21-29.
30. Garnet, L., Cazenave, Y., Trocheris, V., Denis-Pouxviel, C. & Murat, J.-C. (1991) Involvement of ornithine decarboxylase in the control of proliferation of the HT29 human colon cancer cell line. Effect of vasoactive intestinal peptide on enzyme activity, Int. J. Cancer 47, 633-638.
31. Van Echten, G. & Sandhoff, K. (1989) Modulation of ganglioside biosynthesis in primary cultured neurons, J. Neurochem. 52, 207-214.
32. Nichols, G. E., Shiraishi, T. & Toung, W. W. Jr (1988) Polarity of neutral glycolipids, gangliosides and sulfated lipids in MDCK epithelial cells, J. Lipid Res. 29, 1205-1213.
33. Bligh, E. J. & Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
34. Van Meer, G., Stelzer, E. H., Wijnaendts-van Resandt, R. W. & Simons, K. (1987) Sorting of sphingolipids in epithelial (Madin-Darby-canine kidney) cells, J. Cell Biol. 105, 1623-1635.
35. Böttcher, C. J. F., Van Gent, C. M. & Pries, C. (1961) A rapid and sensitive submicro phosphorus determination, Anal. Chim. Acta 24, 203-204.
36. Preiss, J. E., Loomis, C. R., Bell, R. M. & Niedel, J. E. (1987) Quantitative measurement of sn-1,2-diacylglycerols, Methods Enzymol. 141, 294-300.
37. Merrill, A. H. Jr, Wang, E., Mullins, R. E., Jamison, W. C., Nimkar, S. & Liotta, D. C. (1988) Quantitation of free sphingosine in liver by high-performance liquid chromatography, Anal. Biochem. 171, 373-381.
38. Touchstone, J. C., Levin, S. S., Dobbins, M. F., Matthews, L., Beers, P. C. & Gabbe, S. G. (1983) (3-sn-Phosphatidyl)cholines (lecithins) in amniotic fluid, Clin. Chim. 29, 1951-1954.
39. rev cells, Biochem. J. 331, 563-569.
40. Senn, H. J., Orth, M., Fitzke, E., Wieland, H. & Gerok, W. (1989) Gangliosides in normal human serum. Concentration, pattern and transport by lipoproteins, Eur. J. Biochem. 181, 657-662.
41. Peterson, G. L. (1979) A simplification of the protein assay method by Lowry et al. which is more generally applicable, Anal. Biochem. 83, 346-356.
42. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
43. Towbin, H., Staehelin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some implications, Proc. Natl Acad. Sci. USA 76, 4350-4354.
44. Shayman, J. A., Mahdiyoun, S., Deshmukh, G. D., Barcelon, F. S., Inokuchi, J. & Radin, N. S. (1990) Glycosphingolipid dependence of hormone-stimulated inositol triphosphate formation, J. Biol. Chem. 265, 12135-12138.
45. Felding-Habermann, B., Igarashi, Y., Fenderson, B. A., Park, L. S., Radin, N. S., Inokuchi, J., Strassmann, G., Handa, K. & Hakomori, S. (1990) A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N, N-dimethylsphingosine synthesis. Biochemistry 29, 6314-6322.
46. Dressier, K. A. & Kolesnick, R. N. (1990) Ceramide 1-phosphate. a novel phospholipid in human leukemia (HI-60) cells, J. Biol. Chem. 265, 14917-14921.
47. Mano, N., Oda, Y., Yamada, K., Asakawa, N. & Katayama, K. (1997) Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ ionspray ionization tandem mass spectrometry, Anal. Biochem. 244, 291-300.
48. Rosenwald, A. G. & Pagano, R. E. (1994) Effects of the glycosphingolipid synthase inhibitor, PDMP, on lysosomes in cultured cells, J. Lipid Res. 35, 1232-1240.
49. Usuki, S., Hamanoue, M., Kohsaka, S. & Inokuchi, J. (1996) Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoyl-3-morpholino-1-propanol, J. Neurochem. 67, 1821-1830.
50. Inokuchi, J., Mizutani, A., Jimbo, M., Usuki, S., Yamagishi, K., Mochizuki, H., Muramoto, M., Kobayashi, K., Kuroda, Y., Iwasaki, K., Ohgami, Y. & Fujiwara, M. (1997) Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP), Biochem. Biophys. Res. Commun. 237, 595-600.
51. Schwarzmann, G. & Sandhoff, K. (1990) Metabolism and intracellular transport of glycosphingolipids, Biochemistry 29, 10865-10871.
52. Gomez-Muñoz, A., Frago, L. M., Alvarez, L. & Varela-Nieto, I. (1997) Stimulation of DNA synthesis by natural ceramide 1-phosphate, Biochem. J. 325, 435-44.
53. Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brooker, G. & Spiegel, S. (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation, J. Cell Biol. 114, 155-167.
54. Rosenwald, A. G., Machamer, C. E. & Pagano, R. E. (1992) Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway, Biochemistry 31, 3581-3590.
55. Fantini, J., Rognoni, J. B., Roccabianca, M., Pommier, G. & Marvaldi, J. (1989) Suramin inhibits cell growth and glycolytic activity and triggers differentiation of the human colonic adenocarcinoma cell clone HT29-D4, J. Biol Chem. 264, 10282-10286.