Killing cancer cells by poly-drug elevation of ceramide levels: A hypothesis whose time has come?

European Journal of Biochemistry

Volumn 268, Issue 2, 2001, Pages 193-204

  Radin, Norman S ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Apt S5 ^*  (United States)

Author keywords

Apoptosis; Cancer chemotherapy; Ceramide concentration; Ceramide metabolism; Glucosylceramide synthesis inhibition; Hormone effects on ceramide; Multi drug resistance; Sphingomyelin ceramide pathway

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; ANTIINFECTIVE AGENT; BUTHIONINE SULFOXIMINE; CERAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; DRONABINOL; ENZYME INHIBITOR; ETHANOLAMINE; GLUCOSYLCERAMIDE; LACTOSYLCERAMIDE; MIFEPRISTONE; MIGLUSTAT; N BUTYLDEOXYGALACTONOJIRIMYCIN; N OLEOYLETHANOLAMINE; N,N DIMETHYLSPHINGOSINE; NOJIRIMYCIN; PHENYLACETIC ACID; PHORBOL ESTER; SAFINGOL; SITOSTEROL; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; STAUROSPORINE; TAMOXIFEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSPODAR; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CANCER GROWTH; CELL VIABILITY; CHEMICAL STRUCTURE; DRUG EFFECT; ENZYME ACTIVITY; GLYCOSYLATION; HOMEOSTASIS; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOGENESIS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME;

EID: 0034829843     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2001.01845.x     Document Type: Review

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