Tricyclic antidepressant-induced lipidosis in human peripheral monocytes in vitro, as well as in a monocyte-derived cell line, as monitored by spectrofluorimetry and flow cytometry after staining with Nile red

Biochemical Pharmacology

Volumn 53, Issue 10, 1997, Pages 1521-1532

  Xia, Zhenlei ^b   Appelkvist, Eewa Liisa ^b   DePierre, Joseph W ^b   Nässberger, Lennart ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b NONE

Author keywords

Flow cytometry; Fluorescent probe; Lipidosis; Monocytes; Spectrofiuorimetry; Tricyclic antidepressants

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; IMIPRAMINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG INDUCED DISEASE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LIPIDOSIS; MENTAL DISEASE; MONOCYTE; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; SPECTROFLUOROMETRY;

EID: 0030787568     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)82443-4     Document Type: Article

References (27)

1. Lüllmann-Rauch R and Scheid D, Intraalveolar foam cell associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. Virchows Arch B Cell Path 19: 255-268, 1975
2. Lüllmann-Rauch R and Nässberger L, Citalopram-induced generalized lipidosis in rats. Acta Pharmacol Toxicol 52: 161-167, 1983.
3. Lüllmann-Rauch R, Lipidosis-like ultrastructural alterations in rat lymph nodes after treatment with tricyclic antidepressants or neuroleptics. Naunyn-Schmiedeberg's Arch Pharmacol 286: 165-179, 1974.
4. Frisch W and Lüllmann-Rauch R, Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus. Acta Neuropathol 46: 203-208, 1979.
5. Lüllmann-Rauch R, Lipidosis-like alterations in dorsal root ganglion cells of rats treated with tricyclic antidepressants. Naunyn-Schmiedeberg's Arch Pharmacol 283: 219-222, 1974.
6. Lüllmann-Rauch R, Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants. Acta Neuropathol 35: 55-67, 1976.
7. Geist SH and Lüllmann-Rauch R, Experimentally induced lipidosis in uterine and vaginal epithelium of rats. Ann Anat 176: 3-9, 1994.
8. Palmeri S, Mangano L, Battisti C, Malandrini A and Federico A, Imipramine induced lipidosis and dexamethasone effect: morphological and biochemical study in normal and chronic GM2 gangliosidosisfibroblasts. J Neurol Sci 110: 215-221, 1992.
9. Greenspan P and Fowler SD, Spectrofluorometric studies of the lipid probe, nile red. J Lipid Res 26: 781-789, 1985.
10. Greenspan P, Mayer EP and Fowler SD, Nile red: A selective fluorescent stain for intracellular lipid droplets. J Cell Biol 100: 965-973, 1985.
11. Brown WJ, Warfel J and Greenspan P, Use of nile red stain in the detection of cholesteryl ester accumulation in acid lipase-deficient fibroblasts. Arch Pathol Lab Med 112: 295-297, 1988.
12. Nässberger L, Bergstrand A and DePierre JW, An electron and fluorescence microscopic study of LLC-PK1 cells, a kidney epithelial cell line: Normal morphology and cyclosporin A- and cremophor-induced alterations. Int J Exp Path 72: 365-378, 1991.
13. Curtis SK, Cowden RR and Benner DB, Reactions of seven basic fluorochromes with unfixed cells obtained from the salivary glands of the dipteran fly Megaselia scalaris Loew (Phoridae). Histochemistry 85: 475-481, 1986.
14. Cooksey KE, Guckert JB, Williams SA and Callis PR, Fluorometric determination of the neutral lipid content of microalgal cells using nile red. J Microbiol Methods 6: 333-345, 1987.
15. Cole TA, Use of nile red as a rapid measure of lipid content in ciliates. Europ J Protistol 25: 361-368, 1990.
16. Carman KR, Thistle D, Ertman SC and Foy M, Nile red as a probe for lipid-storage products in benthic copepods. Mar Ecol Prog Ser 74: 307-311, 1991.
17. Ducibella T and Batten BE, Lipid distributions in mouse eggs and preimplantation embryos as revealed by the vital fluorescent dye nile red. Anat Record 218: A36-37, 1987.
18. Brown WJ, Sullivan TR and Greenspan P, Nile red staining of lysosomal phospholipid inclusions. Histochemistry 97: 349-354, 1992.
19. Bøyum A, Separation of leucocytes from blood and bone marrow. Scand J Clin Lab Invest 97:(suppl. 21) 9-108, 1968.
20. Morgan A and Burke LM, Comparison of mitogen responses of lymphocyte subpopulations separated using coated metal beads and by traditional methods. J Immunol Methods 126: 1-6, 1990.
21. +B lymphocytes positively selected from buffy coats by immunomagnetic separation. Europ J Immunol 20: 201-206, 1990.
22. Sundstrom C and Nilsson K, Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17: 565-577, 1976.
23. Lüllmann H, Lüllmann-Rauch R and Reil GH, A comparative ultrastructural study of the effects of chlorphentermine and triparanol in rat lung and adrenal gland. Virchows Arch Abt B Zellpath 12: 91-103, 1973.
24. Lüllmann-Rauch R, Reil GH, Rossen E and Seiler KU, The ultrastructure of rat lung changes induced by an anorectic drug (chlorphentermine). Virchows Arch B Zellpath 11: 167-181, 1972.
25. Sackett DL and Wolff J, Nile red as a polarity-sensitive fluorescence probe of Hydrophobic protein surfaces. Anal Biochem 167: 228-234, 1987.
26. Reasor MJ, Drug-induced lipidosis and the alveolar macrophage Toxicology 20: 1-33, 1981.
27. Appelkvist E-L, Söderström M, Nässberger L, Damberg C, Dallner G and DePierre JW, Characterization of the lipid and protein contents of myelin bodies isolated from the renal cortex of gentamicin-treated rats. Biochem Biophys Res Commun 181: 894-901, 1991.