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Some of these compounds showed weak antitumor activity against several tumor cell lines but no activity in an in-vitro anti-HIV assay. Thanks are due to the NIH for providing in vitro testing results by the NIH National Cancer Institute Developmental Therapeutics Program.
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In addition, derivatization of (±)-22 using (1 R)-menthyl chloroformate, (1 R)-menthyloxy acetyl chloride, (1 S) camphanic acid chloride or (+)-di-O-acetyl- L-tartaric anhydride to afford diastereomers differing sufficiently in their properties to allow a separation failed. The corresponding mixtures of diastereomers were obtained in fair to excellent yields but they could not be separated by chromatography, nor by distillation nor by fractional crystallization.
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