-
1
-
-
0024535442
-
Evidence that the antimalarial activity of artemisinin is not mediated via intercalation with nucleotides
-
Aboul-Enein H. Y. (1989) Evidence that the antimalarial activity of artemisinin is not mediated via intercalation with nucleotides. Drug. Des. Deliv. 4, 129-133.
-
(1989)
Drug. Des. Deliv.
, vol.4
, pp. 129-133
-
-
Aboul-Enein, H.Y.1
-
2
-
-
0028242781
-
Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro
-
Alin M. H. and Bjorkman A. (1994) Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro. Am J. Trop. Med. Hyg. 50, 771-776.
-
(1994)
Am J. Trop. Med. Hyg.
, vol.50
, pp. 771-776
-
-
Alin, M.H.1
Bjorkman, A.2
-
4
-
-
0028109346
-
Reactions of antimalarial endoperoxides with specific parasite proteins
-
Asawamahasakda W., Ittarat I., Pu Y.-M., Ziffer H. and Meshnick S. R. (1994b) Reactions of antimalarial endoperoxides with specific parasite proteins. Antimicrob. Agents Chemother. 38, 1854-1858.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1854-1858
-
-
Asawamahasakda, W.1
Ittarat, I.2
Pu, Y.-M.3
Ziffer, H.4
Meshnick, S.R.5
-
5
-
-
0027725172
-
Structure-activity relationships for the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin
-
Avery M. A., Gao F., Chong W. K. M., Mehrotra S. and Milhous W. K. (1993) Structure-activity relationships for the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin. J. Med. Chem. 36, 4264-4275.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 4264-4275
-
-
Avery, M.A.1
Gao, F.2
Chong, W.K.M.3
Mehrotra, S.4
Milhous, W.K.5
-
6
-
-
0027300830
-
Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity
-
Baker J. K., McChesney J. D. and Chi H. T. (1993) Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity. Pharm. Res. 10, 662-666.
-
(1993)
Pharm. Res.
, vol.10
, pp. 662-666
-
-
Baker, J.K.1
McChesney, J.D.2
Chi, H.T.3
-
7
-
-
0027992488
-
Fatal neurotoxicity of arteether and artemether
-
Brewer T. G., Grate S. J., Peggins J. O., Weina P. J., Petras J. M., Levin B. S., Heiffer M. H. and Schuster B. G. (1994a) Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg. 51, 251-259.
-
(1994)
Am. J. Trop. Med. Hyg.
, vol.51
, pp. 251-259
-
-
Brewer, T.G.1
Grate, S.J.2
Peggins, J.O.3
Weina, P.J.4
Petras, J.M.5
Levin, B.S.6
Heiffer, M.H.7
Schuster, B.G.8
-
8
-
-
0028338629
-
Neurotoxicity in animals due to arteether and artemether
-
Brewer T. G., Peggins J. O., Grate S. J., Petras J. M., Levine B. S., Weina P. J., Swearengen J., Heiffer M. H. and Schuster B. G. (1994b) Neurotoxicity in animals due to arteether and artemether. Trans. R. Soc. Trop. Med. Hyg. 88, Suppl 1, S33-36.
-
(1994)
Trans. R. Soc. Trop. Med. Hyg.
, vol.88
, Issue.SUPPL. 1
-
-
Brewer, T.G.1
Peggins, J.O.2
Grate, S.J.3
Petras, J.M.4
Levine, B.S.5
Weina, P.J.6
Swearengen, J.7
Heiffer, M.H.8
Schuster, B.G.9
-
9
-
-
0023911130
-
Arteether, a new antimalarial drug: Synthesis and antimalarial properties
-
Brossi A., Venugopalan B., Dominguez Gerpe L., Yeh H. J. C., Flippen-Anderson J. L., Buchs P., Luo X.-D., Milhous W. and Peters W. (1988) Arteether, a new antimalarial drug: synthesis and antimalarial properties. J. Med. Chem. 31, 645-650.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 645-650
-
-
Brossi, A.1
Venugopalan, B.2
Dominguez Gerpe, L.3
Yeh, H.J.C.4
Flippen-Anderson, J.L.5
Buchs, P.6
Luo, X.-D.7
Milhous, W.8
Peters, W.9
-
10
-
-
0027027067
-
Plasmodium vinckei petteri: Identification of the stages sensitive to arteether
-
Caillard V., Beaute-Lafitte A., Chabaud A. G. and Landau I. (1992) Plasmodium vinckei petteri: identification of the stages sensitive to arteether. Exp. Parasitol. 75, 449-456.
-
(1992)
Exp. Parasitol.
, vol.75
, pp. 449-456
-
-
Caillard, V.1
Beaute-Lafitte, A.2
Chabaud, A.G.3
Landau, I.4
-
11
-
-
0023184963
-
The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice
-
Chawira A. N., Warhurst D. C., Robinson B. L. and Peters W. (1987) The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice. Trans. R. Soc. Trop. Med. Hyg. 81, 554-558.
-
(1987)
Trans. R. Soc. Trop. Med. Hyg.
, vol.81
, pp. 554-558
-
-
Chawira, A.N.1
Warhurst, D.C.2
Robinson, B.L.3
Peters, W.4
-
12
-
-
0020097276
-
Studies on the toxicity of qinghaosu and its derivatives
-
China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials (1982). Studies on the toxicity of qinghaosu and its derivatives. J. Trad. Chin. Med. 2, 31-38.
-
(1982)
J. Trad. Chin. Med.
, vol.2
, pp. 31-38
-
-
-
14
-
-
0022487617
-
Oxygen-derived free radicals in the pathogenesis of parasitic disease
-
Clark I. A., Hunt N. H. and Cowden W. B. (1986) Oxygen-derived free radicals in the pathogenesis of parasitic disease. Adv. Parasitol. 25, 1-44.
-
(1986)
Adv. Parasitol.
, vol.25
, pp. 1-44
-
-
Clark, I.A.1
Hunt, N.H.2
Cowden, W.B.3
-
15
-
-
0024315920
-
Artemisinin (qinghaosu) - A new gametocytocidal drug for malaria
-
Dutta G. P., Bajpai R. and Vishwakarma R. A. (1989) Artemisinin (qinghaosu) - a new gametocytocidal drug for malaria. Chemotherapy 35, 200-207.
-
(1989)
Chemotherapy
, vol.35
, pp. 200-207
-
-
Dutta, G.P.1
Bajpai, R.2
Vishwakarma, R.A.3
-
16
-
-
0025668714
-
Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro
-
Ekong R. and Warhurst D. C. (1990) Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro. Trans R. Soc. Trop. Med. Hyg. 84, 757-758.
-
(1990)
Trans R. Soc. Trop. Med. Hyg.
, vol.84
, pp. 757-758
-
-
Ekong, R.1
Warhurst, D.C.2
-
18
-
-
0022181111
-
3H]-dihydroartemsinine in P. falciparum in vitro
-
3H]-dihydroartemsinine in P. falciparum in vitro. Ann. Trop. Med. Parasitol. 79, 367-374.
-
(1985)
Ann. Trop. Med. Parasitol.
, vol.79
, pp. 367-374
-
-
Ellis, D.S.1
Li, Z.-L.2
Gu, H.-M.3
Peters, W.4
Robinson, B.L.5
Tovey, G.6
Warhurst, D.C.7
-
19
-
-
0028243344
-
Inhibition by antimalarial drugs of haemoglobin denaturation and iron release in acidified red blood cells lysates - A possible mechanism of their antimalarial effect?
-
Gabay T., Krugliak M., Shalmiev G. and Ginsburg H. (1994) Inhibition by antimalarial drugs of haemoglobin denaturation and iron release in acidified red blood cells lysates - a possible mechanism of their antimalarial effect? Parasitology 108, 371-381.
-
(1994)
Parasitology
, vol.108
, pp. 371-381
-
-
Gabay, T.1
Krugliak, M.2
Shalmiev, G.3
Ginsburg, H.4
-
21
-
-
85047695929
-
The redox status of malaria-infected erythrocytes: An overview with an emphasis on unresolved problems
-
Ginsburg H. and Atamna H. (1994) The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems. Parasite 1, 5-13.
-
(1994)
Parasite
, vol.1
, pp. 5-13
-
-
Ginsburg, H.1
Atamna, H.2
-
22
-
-
0024509611
-
Premature release of Plasmodium falciparum from swollen erythrocytes induced by some antimalarials
-
Gu H.-M. and Inselburg J. (1989) Premature release of Plasmodium falciparum from swollen erythrocytes induced by some antimalarials. J. Parasitol. 75, 153-157.
-
(1989)
J. Parasitol.
, vol.75
, pp. 153-157
-
-
Gu, H.-M.1
Inselburg, J.2
-
23
-
-
0019448142
-
Antimalarial effect and toxicity of methyl-dihydro-artemisinine in animals
-
Gu H.-M., Liu M.-Z., Lei B.-F., Xu J.-Y., Chen L.-J., Wang M.-Y., Sun W.-K., Xu B. and Ji R.-Y. (1981) Antimalarial effect and toxicity of methyl-dihydro-artemisinine in animals. Acta. Pharmacol. Sinica 2, 138-144.
-
(1981)
Acta. Pharmacol. Sinica
, vol.2
, pp. 138-144
-
-
Gu, H.-M.1
Liu, M.-Z.2
Lei, B.-F.3
Xu, J.-Y.4
Chen, L.-J.5
Wang, M.-Y.6
Sun, W.-K.7
Xu, B.8
Ji, R.-Y.9
-
25
-
-
0022647925
-
Hemolysis induced by artemisinin and its derivatives in vitro
-
Gu H.-M., Warhurst D. C. and Peters W. (1986) Hemolysis induced by artemisinin and its derivatives in vitro. Acta Pharmacol. Sinica. 7, 269-272.
-
(1986)
Acta Pharmacol. Sinica
, vol.7
, pp. 269-272
-
-
Gu, H.-M.1
Warhurst, D.C.2
Peters, W.3
-
27
-
-
0025126555
-
Role of free radicals and catalytic metal ions in human disease: An overview
-
Halliwell B. and Gutteridge J. M. C. (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Meth. Enzymol. 186, 1-85.
-
(1990)
Meth. Enzymol.
, vol.186
, pp. 1-85
-
-
Halliwell, B.1
Gutteridge, J.M.C.2
-
28
-
-
0027509620
-
Qinghaosu
-
Hien T. T. and White N. J. (1993) Qinghaosu. Lancet 341, 603-608.
-
(1993)
Lancet
, vol.341
, pp. 603-608
-
-
Hien, T.T.1
White, N.J.2
-
29
-
-
0028170770
-
Ro 42-1611 (arteflene), a new effective antimalarial: Chemical structure and biological activity
-
Hofheinz W., Bürgin H., Gocke E., Jaquet C., Masciadri R., Schmid G., Stohler H. and Urwyler H. (1994) Ro 42-1611 (arteflene), a new effective antimalarial: chemical structure and biological activity. Trop. Med. Parasitol. 45, 261-265.
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 261-265
-
-
Hofheinz, W.1
Bürgin, H.2
Gocke, E.3
Jaquet, C.4
Masciadri, R.5
Schmid, G.6
Stohler, H.7
Urwyler, H.8
-
31
-
-
0028088750
-
Antimalarial activity of the bicyclic peroxide Ro 42-1611 (arteflene) in experimental models
-
Jaquet C., Stohler H. R., Chollet J. and Peters W. (1994) Antimalarial activity of the bicyclic peroxide Ro 42-1611 (arteflene) in experimental models. Trop. Med. Parasitol. 45, 266-271.
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 266-271
-
-
Jaquet, C.1
Stohler, H.R.2
Chollet, J.3
Peters, W.4
-
32
-
-
0000916979
-
The decomposition of cis-fused cyclopenteno-1,2,4-trioxanes induced by ferrous salts and some oxophilic reagents
-
Jefford C. W., Favarger F., Vicente M. H. and Jacquier Y. (1995a) The decomposition of cis-fused cyclopenteno-1,2,4-trioxanes induced by ferrous salts and some oxophilic reagents. Helv. Chim. Acta 78, 452-458.
-
(1995)
Helv. Chim. Acta
, vol.78
, pp. 452-458
-
-
Jefford, C.W.1
Favarger, F.2
Vicente, M.H.3
Jacquier, Y.4
-
33
-
-
0029142546
-
Synthesis, structure, and antimalarial activity of some enantiomerically pure cis-fused cyclopenteno-1,2,4-trioxanes
-
Jefford C. W., Kohmoto S., Jaggi D., Timari G., Rossier J. C., Rudaz M., Barbuzzi O., Gerard D., Burger U., Kamalprija P., Mareda J., Bernardinelli G., Manzanares I., Canfield C. J., Fleck S. L., Robinson B. L. and Peters W. (1995b) Synthesis, structure, and antimalarial activity of some enantiomerically pure cis-fused cyclopenteno-1,2,4-trioxanes. Helv. Chim. Acta 78, 647-662.
-
(1995)
Helv. Chim. Acta
, vol.78
, pp. 647-662
-
-
Jefford, C.W.1
Kohmoto, S.2
Jaggi, D.3
Timari, G.4
Rossier, J.C.5
Rudaz, M.6
Barbuzzi, O.7
Gerard, D.8
Burger, U.9
Kamalprija, P.10
Mareda, J.11
Bernardinelli, G.12
Manzanares, I.13
Canfield, C.J.14
Fleck, S.L.15
Robinson, B.L.16
Peters, W.17
-
35
-
-
0028339885
-
Arteether administration in humans: Preliminary studies of pharmacokinatics, safety and tolerance
-
Kager P. A., Schultz M. J., Zijlstra E. E., van den Berg B. and van Boxtel C. J. (1994) Arteether administration in humans: preliminary studies of pharmacokinatics, safety and tolerance. Trans. R. Soc. Trop. Med. Hyg. 88, Suppl 1, S53-54.
-
(1994)
Trans. R. Soc. Trop. Med. Hyg.
, vol.88
, Issue.SUPPL. 1
-
-
Kager, P.A.1
Schultz, M.J.2
Zijlstra, E.E.3
Van Den Berg, B.4
Van Boxtel, C.J.5
-
36
-
-
0028212443
-
Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting α-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes
-
Kamchonwongpaisan S., Chandra-ngam G., Avery M. A. and Yuthavong Y. (1994) Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting α-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes. J. Clin. Invest. 93, 467-473.
-
(1994)
J. Clin. Invest.
, vol.93
, pp. 467-473
-
-
Kamchonwongpaisan, S.1
Chandra-Ngam, G.2
Avery, M.A.3
Yuthavong, Y.4
-
38
-
-
0028925926
-
An antimalarial peroxide from Amomum krervanh Pierre
-
Kamchonwongpaisan S., Nilanonta C., Tarnchompoo B., Thebtaranonth C., Thebtaranonth Y., Yuthavong Y., Kongsaeree P. and Clardy J. (1995) An antimalarial peroxide from Amomum krervanh Pierre. Tetrahedron Lett. 36, 1821-1824.
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 1821-1824
-
-
Kamchonwongpaisan, S.1
Nilanonta, C.2
Tarnchompoo, B.3
Thebtaranonth, C.4
Thebtaranonth, Y.5
Yuthavong, Y.6
Kongsaeree, P.7
Clardy, J.8
-
39
-
-
0027771695
-
Morphologic effects of artemether on Plasmodium falciparum in Aotus trivigatus
-
Kawai S., Kano S. and Suzuki M. (1993) Morphologic effects of artemether on Plasmodium falciparum in Aotus trivigatus. Am. J. Trop. Med. Hyg. 49, 812-818.
-
(1993)
Am. J. Trop. Med. Hyg.
, vol.49
, pp. 812-818
-
-
Kawai, S.1
Kano, S.2
Suzuki, M.3
-
40
-
-
0021948029
-
Qinghaosu (artemisinin): An antimalarial drug from China
-
Klayman D. L. (1985) Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049-1055.
-
(1985)
Science
, vol.228
, pp. 1049-1055
-
-
Klayman, D.L.1
-
41
-
-
0001856731
-
Artemisia Annua: From weed to respectable antimalarial plant
-
American Chemical Society, Washington, D. C.
-
Klayman D. L. (1993) Artemisia Annua: from weed to respectable antimalarial plant. In: Human Medicinal Agents from Plants, pp. 242-255. American Chemical Society, Washington, D. C.
-
(1993)
Human Medicinal Agents from Plants
, pp. 242-255
-
-
Klayman, D.L.1
-
42
-
-
0025789734
-
Transdermal artelinic acid: An effective treatment for Plasmodium berghei-infected mice
-
Klayman D. L., Ager A. L., Jr., Fleckenstein L. and Lin A. J. (1991) Transdermal artelinic acid: an effective treatment for Plasmodium berghei-infected mice. Am. J. Trop. Med. Hyg. 45, 602-607.
-
(1991)
Am. J. Trop. Med. Hyg.
, vol.45
, pp. 602-607
-
-
Klayman, D.L.1
Ager A.L., Jr.2
Fleckenstein, L.3
Lin, A.J.4
-
43
-
-
0023622465
-
The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress
-
Krungkrai S. R. and Yuthavong Y. (1987) The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress. Trans. R. Soc. Trop. Med. Hyg. 81, 710-714.
-
(1987)
Trans. R. Soc. Trop. Med. Hyg.
, vol.81
, pp. 710-714
-
-
Krungkrai, S.R.1
Yuthavong, Y.2
-
44
-
-
0025217615
-
Stage-specific gametocytocidal effect in vitro of the antimalarial drug qinghaosu on Plasmodium falciparum
-
Kumar N. and Zheng H. (1990) Stage-specific gametocytocidal effect in vitro of the antimalarial drug qinghaosu on Plasmodium falciparum. Parasitol. Res. 76, 214-218.
-
(1990)
Parasitol. Res.
, vol.76
, pp. 214-218
-
-
Kumar, N.1
Zheng, H.2
-
45
-
-
0025646009
-
Metabolism of antimalarial sesquiterpene lactones
-
Lee I. S. and Hufford C. D. (1990) Metabolism of antimalarial sesquiterpene lactones. Pharmac. Ther. 48, 345-355.
-
(1990)
Pharmac. Ther.
, vol.48
, pp. 345-355
-
-
Lee, I.S.1
Hufford, C.D.2
-
46
-
-
0024392106
-
Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: Effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii
-
Levander O. A., Ager A. L., Jr., Morris V. C. and May R. G. (1989) Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii. Am. J. Clin. Nutr., 50, 346-352.
-
(1989)
Am. J. Clin. Nutr.
, vol.50
, pp. 346-352
-
-
Levander, O.A.1
Ager A.L., Jr.2
Morris, V.C.3
May, R.G.4
-
47
-
-
0006783503
-
A summary of clinical studies on artesunate intravenous injection in malaria patients
-
Sanya Tropical Medicine Institute, Guangzhou, China
-
Li G. Q., Guo F. B., Fu L. C. and Jian H. X. (1990) A summary of clinical studies on artesunate intravenous injection in malaria patients In: Clinical Trials on Qinghaosu and its Derivatives, Gungzhou College of Traditional Chinese Medicine, pp. 1-7, Sanya Tropical Medicine Institute, Guangzhou, China.
-
(1990)
Clinical Trials on Qinghaosu and Its Derivatives, Gungzhou College of Traditional Chinese Medicine
, pp. 1-7
-
-
Li, G.Q.1
Guo, F.B.2
Fu, L.C.3
Jian, H.X.4
-
48
-
-
0023933802
-
A new sesquiterpene peroxide (yingzhaosu C) and sesquiterpenol (yingzhaosu D) from Artabotrys uncinatus (L.)
-
Lian Z., Zhou W.-S. and Xu X.-X. (1988) A new sesquiterpene peroxide (yingzhaosu C) and sesquiterpenol (yingzhaosu D) from Artabotrys uncinatus (L.) Merr. J. Chem. Soc. Chem. Comm. 523-524.
-
(1988)
Merr. J. Chem. Soc. Chem. Comm.
, pp. 523-524
-
-
Lian, Z.1
Zhou, W.-S.2
Xu, X.-X.3
-
50
-
-
0023555532
-
Antimalarial activity of new water-soluble dihydroartemisinin derivatives
-
Lin A. J., Klayman D. L. and Milhous W. K. (1987) Antimalarial activity of new water-soluble dihydroartemisinin derivatives. J. Med. Chem. 30, 2147-2150.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 2147-2150
-
-
Lin, A.J.1
Klayman, D.L.2
Milhous, W.K.3
-
51
-
-
0026587184
-
A randomized trial of mefloquine, artesunate, and artesunate followed by mefloquine in acute uncomplicated falciparum malaria
-
Looareesuwan S., Viravan C., Vanijanonta S., Wilairatana P., Suntharasamai P., Charoenlarp P., Arnold K., Kyle D., Canfield C. and Webster H. K. (1992) A randomized trial of mefloquine, artesunate, and artesunate followed by mefloquine in acute uncomplicated falciparum malaria. Lancet 339, 821-824.
-
(1992)
Lancet
, vol.339
, pp. 821-824
-
-
Looareesuwan, S.1
Viravan, C.2
Vanijanonta, S.3
Wilairatana, P.4
Suntharasamai, P.5
Charoenlarp, P.6
Arnold, K.7
Kyle, D.8
Canfield, C.9
Webster, H.K.10
-
52
-
-
0028182993
-
Single day mefloquine-artesunate combination in treatment of multi-drug resistant falciparum malaria
-
Luxemburger C., ter Kuile F. O., Nosten F., Dolan G., Bradol J. H., Phaipun L., Chongsuphajaisiddhi T. and White N. J. (1994) Single day mefloquine-artesunate combination in treatment of multi-drug resistant falciparum malaria. Trans. R. Soc. Trop Med. Hyg. 88, 213-217.
-
(1994)
Trans. R. Soc. Trop Med. Hyg.
, vol.88
, pp. 213-217
-
-
Luxemburger, C.1
Ter Kuile, F.O.2
Nosten, F.3
Dolan, G.4
Bradol, J.H.5
Phaipun, L.6
Chongsuphajaisiddhi, T.7
White, N.J.8
-
53
-
-
0027364698
-
Morphologic effects of artemisinin in Plasmodium falciparum
-
Maeno Y., Toyoshima T., Fujioka H., Ito Y., Meshnick S. R. Benakis A., Milhous W. K. and Aikawa M. (1993) Morphologic effects of artemisinin in Plasmodium falciparum. Am. J. Trop. Med. Hyg. 49, 485-491.
-
(1993)
Am. J. Trop. Med. Hyg.
, vol.49
, pp. 485-491
-
-
Maeno, Y.1
Toyoshima, T.2
Fujioka, H.3
Ito, Y.4
Meshnick, S.R.5
Benakis, A.6
Milhous, W.K.7
Aikawa, M.8
-
54
-
-
0027164794
-
In vitro gametocidal activity of artemisinin and its derivatives on Plasmodium falciparum
-
Mehra N. and Bhasin V. K. (1993) In vitro gametocidal activity of artemisinin and its derivatives on Plasmodium falciparum. Jpn. J. Med. Sci. Biol. 46, 37-43.
-
(1993)
Jpn. J. Med. Sci. Biol.
, vol.46
, pp. 37-43
-
-
Mehra, N.1
Bhasin, V.K.2
-
55
-
-
0028307003
-
The mode of action of antimalarial endoperoxides
-
Meshnick S. R. (1994) The mode of action of antimalarial endoperoxides. Trans. R. Soc. Trop. Med. Hyg. 88, Suppl 1, S31-32.
-
(1994)
Trans. R. Soc. Trop. Med. Hyg.
, vol.88
, Issue.SUPPL. 1
-
-
Meshnick, S.R.1
-
56
-
-
0026014249
-
Artemisinin (qinghaosu): The role of intracellular hemin in its mechanism of antimalarial action
-
Meshnick S. R., Thomas A., Ranz A., Xu C.-M. and Pan H.-Z. (1991) Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Mol. Biochem. Parasitol. 49, 181-189.
-
(1991)
Mol. Biochem. Parasitol.
, vol.49
, pp. 181-189
-
-
Meshnick, S.R.1
Thomas, A.2
Ranz, A.3
Xu, C.-M.4
Pan, H.-Z.5
-
57
-
-
0024368304
-
Activated oxygen mediates the antimalarial activity of quinghaosu
-
Meshnick S. R., Tsang T. W., Lin F. B., Pan H. Z., Chang C. N., Kuypers F., Chiu D. and Lubin B. (1989) Activated oxygen mediates the antimalarial activity of quinghaosu. Prog. Clin. Biol. Res. 95-104.
-
(1989)
Prog. Clin. Biol. Res.
, pp. 95-104
-
-
Meshnick, S.R.1
Tsang, T.W.2
Lin, F.B.3
Pan, H.Z.4
Chang, C.N.5
Kuypers, F.6
Chiu, D.7
Lubin, B.8
-
58
-
-
0027197112
-
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)
-
Meshnick S. R., Yang Y.-Z., Lima V., Kuypers V., Kamchonwongpaisan S. and Yuthavong Y. (1993) Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). Antimicrob. Agent Chemother. 37, 1108-1114.
-
(1993)
Antimicrob. Agent Chemother.
, vol.37
, pp. 1108-1114
-
-
Meshnick, S.R.1
Yang, Y.-Z.2
Lima, V.3
Kuypers, V.4
Kamchonwongpaisan, S.5
Yuthavong, Y.6
-
59
-
-
0028145091
-
Ferriprotoporphyrin catalyzed decomposition of artemether: Analytical and pharmacological implications
-
Muhia D. K., Thomas C. G., Ward S. A., Edwards G., Mberu E. K. and Watkins W. M. (1994) Ferriprotoporphyrin catalyzed decomposition of artemether: analytical and pharmacological implications. Biochem. Pharmacol. 48, 889-895.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 889-895
-
-
Muhia, D.K.1
Thomas, C.G.2
Ward, S.A.3
Edwards, G.4
Mberu, E.K.5
Watkins, W.M.6
-
60
-
-
0022884813
-
The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes
-
Peters W., Li Z.-L., Robinson B. L. and Warhurst D. C. (1986) The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes. Ann. Trop. Med. Parasitol. 80, 483-489.
-
(1986)
Ann. Trop. Med. Parasitol.
, vol.80
, pp. 483-489
-
-
Peters, W.1
Li, Z.-L.2
Robinson, B.L.3
Warhurst, D.C.4
-
61
-
-
0026746574
-
A regiospecifically oxygen-18 labeled 1,2,4-trixoane: A simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu)
-
Posner G. H. and Oh C. H. (1992) A regiospecifically oxygen-18 labeled 1,2,4-trixoane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (Qinghaosu). J. Am. Chem. Soc. 114, 8328-8329.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 8328-8329
-
-
Posner, G.H.1
Oh, C.H.2
-
62
-
-
0029038225
-
Evidence for FE(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin
-
In press
-
Posner G. H., Cumming J. N., Ploypradith P. and Oh C. H. (1995) Evidence for FE(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin. J. Am. Chem. Soc. (In press).
-
(1995)
J. Am. Chem. Soc.
-
-
Posner, G.H.1
Cumming, J.N.2
Ploypradith, P.3
Oh, C.H.4
-
63
-
-
0028305219
-
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to aremisinin: The importance of carbon-centered radical for antimalarial activity
-
Posner G. H., Oh C. H., Wang D., Gerena L., Milhous W. K., Meshnick S. R., and Asawamahasakda W. (1994) Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to aremisinin: the importance of carbon-centered radical for antimalarial activity. J. Med. Chem. 37, 1256-1258.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1256-1258
-
-
Posner, G.H.1
Oh, C.H.2
Wang, D.3
Gerena, L.4
Milhous, W.K.5
Meshnick, S.R.6
Asawamahasakda, W.7
-
64
-
-
0018612308
-
Antimalarial studies on qinghaosu
-
Qinghaosu Antimalarial Co-ordinating Research Group (1979) Antimalarial studies on qinghaosu. Chin. Med. J. 92, 811-816.
-
(1979)
Chin. Med. J.
, vol.92
, pp. 811-816
-
-
-
65
-
-
0028170766
-
Ro 42-1611 in the treatment of patients with mild malaria: A clinical trial in Nigeria and Burkina Faso
-
Salako L. A., Guiguemde R., Mittelholzer M.-L., Haller L. Sorenson F. and Stürchler D. (1994) Ro 42-1611 in the treatment of patients with mild malaria: a clinical trial in Nigeria and Burkina Faso. Trop. Med. Parasitol. 45, 284-287.
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 284-287
-
-
Salako, L.A.1
Guiguemde, R.2
Mittelholzer, M.-L.3
Haller, L.4
Sorenson, F.5
Stürchler, D.6
-
66
-
-
0024432759
-
Qinghaosu-mediated oxidation in normal and abnormal erythrocytes
-
Scott M. D., Meshnick S. R., Williams R. A., Chiu D. T.-Y., Pan H.-C., Lubin B. H. and Kuypers F. A. (1989) Qinghaosu-mediated oxidation in normal and abnormal erythrocytes. J. Lab. Clin. Med. 114, 401-406.
-
(1989)
J. Lab. Clin. Med.
, vol.114
, pp. 401-406
-
-
Scott, M.D.1
Meshnick, S.R.2
Williams, R.A.3
Chiu, D.T.-Y.4
Pan, H.-C.5
Lubin, B.H.6
Kuypers, F.A.7
-
67
-
-
0025060810
-
Oxidative denaturation of red blood cells in thalassemia
-
Shinar E. and Rachmilewitz E. A. (1990) Oxidative denaturation of red blood cells in thalassemia. Semin. Hematol. 27, 70-82.
-
(1990)
Semin. Hematol.
, vol.27
, pp. 70-82
-
-
Shinar, E.1
Rachmilewitz, E.A.2
-
68
-
-
0029112920
-
Molecular modeling studies of the artemisinin (qinghaosu) - Hemin interaction: Docking between the antimalarial agent and its putative receptor
-
Shukla K. L., Gund T. M., and Meshnick S. R. Molecular modeling studies of the artemisinin (qinghaosu) - hemin interaction: docking between the antimalarial agent and its putative receptor. J. Molec. Graphics 13, 215-222.
-
J. Molec. Graphics
, vol.13
, pp. 215-222
-
-
Shukla, K.L.1
Gund, T.M.2
Meshnick, S.R.3
-
69
-
-
0024346251
-
Clinical studies on treatment of cerebral malaria with artemether and mefloquine
-
Shwe T., Myint P. T., Myint W., Htut Y., Soe L. and Thwe M. (1989) Clinical studies on treatment of cerebral malaria with artemether and mefloquine. Trans. R. Soc. Trop. Med. Hyg. 83, 489.
-
(1989)
Trans. R. Soc. Trop. Med. Hyg.
, vol.83
, pp. 489
-
-
Shwe, T.1
Myint, P.T.2
Myint, W.3
Htut, Y.4
Soe, L.5
Thwe, M.6
-
70
-
-
0028170768
-
Efficacy of Ro 42-1611 (arteflene) in the treatment of patients with mild malaria: A clinical trial in Cameroon
-
Somo-Moyou R., Mittelholzer M.-L., Sorenson F., Haller L. and Stürchler D. (1994) Efficacy of Ro 42-1611 (arteflene) in the treatment of patients with mild malaria: a clinical trial in Cameroon. Trop. Med. Parasitol. 45, 288-291.
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 288-291
-
-
Somo-Moyou, R.1
Mittelholzer, M.-L.2
Sorenson, F.3
Haller, L.4
Stürchler, D.5
-
71
-
-
0027280310
-
Plasmodium falciparum: In vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria
-
ter Kuile F., White N. J., Holloway P., Pasvol G. and Krishna S. (1993) Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Exp. Parasitol. 76, 85-95.
-
(1993)
Exp. Parasitol.
, vol.76
, pp. 85-95
-
-
Ter Kuile, F.1
White, N.J.2
Holloway, P.3
Pasvol, G.4
Krishna, S.5
-
73
-
-
0023777973
-
Oxidants, oxidant drugs, and malaria
-
Vennerstrom J. L. and Eaton J. W. (1988) Oxidants, oxidant drugs, and malaria. J. Med. Chem. 31, 1269-1277.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 1269-1277
-
-
Vennerstrom, J.L.1
Eaton, J.W.2
-
75
-
-
0023546567
-
Common genetic disorders of the red cell and the "malaria hypothesis"
-
Weatherall D. J. (1987) Common genetic disorders of the red cell and the "malaria hypothesis". Ann. Trop. Med. Parasitol. 81, 539-548.
-
(1987)
Ann. Trop. Med. Parasitol.
, vol.81
, pp. 539-548
-
-
Weatherall, D.J.1
-
76
-
-
0027990218
-
Enhancement of hemin-induced membrane damage by artemisinin
-
Wei N. and Sadrzadeh S. M. (1994) Enhancement of hemin-induced membrane damage by artemisinin. Biochem. Pharmacol. 48, 737-741.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 737-741
-
-
Wei, N.1
Sadrzadeh, S.M.2
-
78
-
-
0028305816
-
Artemisinin: Current status
-
White N. J. (1994) Artemisinin: current status. Trans. R. Soc. Trop. Med. Hyg. 88, Suppl 1, S3-4.
-
(1994)
Trans. R. Soc. Trop. Med. Hyg.
, vol.88
, Issue.SUPPL. 1
-
-
White, N.J.1
-
79
-
-
0028070809
-
Progress in the research of artemisinin-related antimalarials: An update
-
Woerdenbag H. J., Pras N., van Uden W., Wallaart T. E., Beekman A. C. and Lugt C. B. (1994) Progress in the research of artemisinin-related antimalarials: an update. Pharm. World Sci. 16, 169-180.
-
(1994)
Pharm. World Sci.
, vol.16
, pp. 169-180
-
-
Woerdenbag, H.J.1
Pras, N.2
Van Uden, W.3
Wallaart, T.E.4
Beekman, A.C.5
Lugt, C.B.6
-
80
-
-
0027935551
-
Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure
-
Yang Y.-Z., Little B. and Meshnick S. R. (1994) Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure. Biochem. Pharmacol. 48, 569-573.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 569-573
-
-
Yang, Y.-Z.1
Little, B.2
Meshnick, S.R.3
-
82
-
-
0027264908
-
Protection against malaria by thalassemia and haemoglobin variants
-
Yuthavong Y. and Wilairat P. (1993) Protection against malaria by thalassemia and haemoglobin variants. Parasitology Today, 9, 241-245.
-
(1993)
Parasitology Today
, vol.9
, pp. 241-245
-
-
Yuthavong, Y.1
Wilairat, P.2
-
83
-
-
0024560090
-
Decreased sensitivity to artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes
-
Yuthavong Y., Butthep P., Bunyaratvej A. and Fucharoen S. (1989) Decreased sensitivity to artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin Constant Spring erythrocytes. J. Clin. Invest. 83, 502-505.
-
(1989)
J. Clin. Invest.
, vol.83
, pp. 502-505
-
-
Yuthavong, Y.1
Butthep, P.2
Bunyaratvej, A.3
Fucharoen, S.4
-
84
-
-
0025223898
-
Increased susceptibility of malaria-infected variant erythrocytes to mononuclear phagocyte system
-
Yuthavong Y., Bunyaratavej A. and Kamchonwongpaisan S. (1990) Increased susceptibility of malaria-infected variant erythrocytes to mononuclear phagocyte system. Blood Cells 16, 591-597.
-
(1990)
Blood Cells
, vol.16
, pp. 591-597
-
-
Yuthavong, Y.1
Bunyaratavej, A.2
Kamchonwongpaisan, S.3
-
85
-
-
0026589410
-
Hemin-catalyzed decomposition of artemisinin (qinghaosu)
-
Zhang F., Gosser D. K., Jr., and Meshnick S. R. (1992) Hemin-catalyzed decomposition of artemisinin (qinghaosu). Biochem. Pharmacol. 43, 1805-1809.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 1805-1809
-
-
Zhang, F.1
Gosser D.K., Jr.2
Meshnick, S.R.3
|