메뉴 건너뛰기




Volumn 27, Issue 4, 1996, Pages 587-592

The mode of action of the antimalarial artemisinin and its derivatives

Author keywords

Areether; Artemether; Artesunate; Oxidant; Peroxide; Plasmodium; Trioxane

Indexed keywords

ARTEMISININ; ARTEMISININ DERIVATIVE;

EID: 0030176425     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02047-0     Document Type: Review
Times cited : (79)

References (85)
  • 1
    • 0024535442 scopus 로고
    • Evidence that the antimalarial activity of artemisinin is not mediated via intercalation with nucleotides
    • Aboul-Enein H. Y. (1989) Evidence that the antimalarial activity of artemisinin is not mediated via intercalation with nucleotides. Drug. Des. Deliv. 4, 129-133.
    • (1989) Drug. Des. Deliv. , vol.4 , pp. 129-133
    • Aboul-Enein, H.Y.1
  • 2
    • 0028242781 scopus 로고
    • Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro
    • Alin M. H. and Bjorkman A. (1994) Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro. Am J. Trop. Med. Hyg. 50, 771-776.
    • (1994) Am J. Trop. Med. Hyg. , vol.50 , pp. 771-776
    • Alin, M.H.1    Bjorkman, A.2
  • 5
    • 0027725172 scopus 로고
    • Structure-activity relationships for the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin
    • Avery M. A., Gao F., Chong W. K. M., Mehrotra S. and Milhous W. K. (1993) Structure-activity relationships for the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin. J. Med. Chem. 36, 4264-4275.
    • (1993) J. Med. Chem. , vol.36 , pp. 4264-4275
    • Avery, M.A.1    Gao, F.2    Chong, W.K.M.3    Mehrotra, S.4    Milhous, W.K.5
  • 6
    • 0027300830 scopus 로고
    • Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity
    • Baker J. K., McChesney J. D. and Chi H. T. (1993) Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity. Pharm. Res. 10, 662-666.
    • (1993) Pharm. Res. , vol.10 , pp. 662-666
    • Baker, J.K.1    McChesney, J.D.2    Chi, H.T.3
  • 10
    • 0027027067 scopus 로고
    • Plasmodium vinckei petteri: Identification of the stages sensitive to arteether
    • Caillard V., Beaute-Lafitte A., Chabaud A. G. and Landau I. (1992) Plasmodium vinckei petteri: identification of the stages sensitive to arteether. Exp. Parasitol. 75, 449-456.
    • (1992) Exp. Parasitol. , vol.75 , pp. 449-456
    • Caillard, V.1    Beaute-Lafitte, A.2    Chabaud, A.G.3    Landau, I.4
  • 11
    • 0023184963 scopus 로고
    • The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice
    • Chawira A. N., Warhurst D. C., Robinson B. L. and Peters W. (1987) The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice. Trans. R. Soc. Trop. Med. Hyg. 81, 554-558.
    • (1987) Trans. R. Soc. Trop. Med. Hyg. , vol.81 , pp. 554-558
    • Chawira, A.N.1    Warhurst, D.C.2    Robinson, B.L.3    Peters, W.4
  • 12
    • 0020097276 scopus 로고
    • Studies on the toxicity of qinghaosu and its derivatives
    • China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials (1982). Studies on the toxicity of qinghaosu and its derivatives. J. Trad. Chin. Med. 2, 31-38.
    • (1982) J. Trad. Chin. Med. , vol.2 , pp. 31-38
  • 14
    • 0022487617 scopus 로고
    • Oxygen-derived free radicals in the pathogenesis of parasitic disease
    • Clark I. A., Hunt N. H. and Cowden W. B. (1986) Oxygen-derived free radicals in the pathogenesis of parasitic disease. Adv. Parasitol. 25, 1-44.
    • (1986) Adv. Parasitol. , vol.25 , pp. 1-44
    • Clark, I.A.1    Hunt, N.H.2    Cowden, W.B.3
  • 15
    • 0024315920 scopus 로고
    • Artemisinin (qinghaosu) - A new gametocytocidal drug for malaria
    • Dutta G. P., Bajpai R. and Vishwakarma R. A. (1989) Artemisinin (qinghaosu) - a new gametocytocidal drug for malaria. Chemotherapy 35, 200-207.
    • (1989) Chemotherapy , vol.35 , pp. 200-207
    • Dutta, G.P.1    Bajpai, R.2    Vishwakarma, R.A.3
  • 16
    • 0025668714 scopus 로고
    • Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro
    • Ekong R. and Warhurst D. C. (1990) Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro. Trans R. Soc. Trop. Med. Hyg. 84, 757-758.
    • (1990) Trans R. Soc. Trop. Med. Hyg. , vol.84 , pp. 757-758
    • Ekong, R.1    Warhurst, D.C.2
  • 19
    • 0028243344 scopus 로고
    • Inhibition by antimalarial drugs of haemoglobin denaturation and iron release in acidified red blood cells lysates - A possible mechanism of their antimalarial effect?
    • Gabay T., Krugliak M., Shalmiev G. and Ginsburg H. (1994) Inhibition by antimalarial drugs of haemoglobin denaturation and iron release in acidified red blood cells lysates - a possible mechanism of their antimalarial effect? Parasitology 108, 371-381.
    • (1994) Parasitology , vol.108 , pp. 371-381
    • Gabay, T.1    Krugliak, M.2    Shalmiev, G.3    Ginsburg, H.4
  • 21
    • 85047695929 scopus 로고
    • The redox status of malaria-infected erythrocytes: An overview with an emphasis on unresolved problems
    • Ginsburg H. and Atamna H. (1994) The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems. Parasite 1, 5-13.
    • (1994) Parasite , vol.1 , pp. 5-13
    • Ginsburg, H.1    Atamna, H.2
  • 22
    • 0024509611 scopus 로고
    • Premature release of Plasmodium falciparum from swollen erythrocytes induced by some antimalarials
    • Gu H.-M. and Inselburg J. (1989) Premature release of Plasmodium falciparum from swollen erythrocytes induced by some antimalarials. J. Parasitol. 75, 153-157.
    • (1989) J. Parasitol. , vol.75 , pp. 153-157
    • Gu, H.-M.1    Inselburg, J.2
  • 24
    • 0021284125 scopus 로고
    • 3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro
    • 3H] Dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro. Trans R. Soc. Trop. Med. Hyg. 78, 265-270.
    • (1984) Trans R. Soc. Trop. Med. Hyg. , vol.78 , pp. 265-270
    • Gu, H.-M.1    Warhurst, D.C.2    Peters, W.3
  • 25
    • 0022647925 scopus 로고
    • Hemolysis induced by artemisinin and its derivatives in vitro
    • Gu H.-M., Warhurst D. C. and Peters W. (1986) Hemolysis induced by artemisinin and its derivatives in vitro. Acta Pharmacol. Sinica. 7, 269-272.
    • (1986) Acta Pharmacol. Sinica , vol.7 , pp. 269-272
    • Gu, H.-M.1    Warhurst, D.C.2    Peters, W.3
  • 27
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: An overview
    • Halliwell B. and Gutteridge J. M. C. (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Meth. Enzymol. 186, 1-85.
    • (1990) Meth. Enzymol. , vol.186 , pp. 1-85
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 28
    • 0027509620 scopus 로고
    • Qinghaosu
    • Hien T. T. and White N. J. (1993) Qinghaosu. Lancet 341, 603-608.
    • (1993) Lancet , vol.341 , pp. 603-608
    • Hien, T.T.1    White, N.J.2
  • 31
    • 0028088750 scopus 로고
    • Antimalarial activity of the bicyclic peroxide Ro 42-1611 (arteflene) in experimental models
    • Jaquet C., Stohler H. R., Chollet J. and Peters W. (1994) Antimalarial activity of the bicyclic peroxide Ro 42-1611 (arteflene) in experimental models. Trop. Med. Parasitol. 45, 266-271.
    • (1994) Trop. Med. Parasitol. , vol.45 , pp. 266-271
    • Jaquet, C.1    Stohler, H.R.2    Chollet, J.3    Peters, W.4
  • 32
    • 0000916979 scopus 로고
    • The decomposition of cis-fused cyclopenteno-1,2,4-trioxanes induced by ferrous salts and some oxophilic reagents
    • Jefford C. W., Favarger F., Vicente M. H. and Jacquier Y. (1995a) The decomposition of cis-fused cyclopenteno-1,2,4-trioxanes induced by ferrous salts and some oxophilic reagents. Helv. Chim. Acta 78, 452-458.
    • (1995) Helv. Chim. Acta , vol.78 , pp. 452-458
    • Jefford, C.W.1    Favarger, F.2    Vicente, M.H.3    Jacquier, Y.4
  • 34
    • 0021866921 scopus 로고
    • Qinghaosu-induced changes in the morphology of Plasmodium inui
    • Jiang J. B., Jacobs G., Liang D. S. and Aikawa M. (1985) Qinghaosu-induced changes in the morphology of Plasmodium inui. Am. J. Trop. Med. Hyg. 34, 424-428.
    • (1985) Am. J. Trop. Med. Hyg. , vol.34 , pp. 424-428
    • Jiang, J.B.1    Jacobs, G.2    Liang, D.S.3    Aikawa, M.4
  • 36
    • 0028212443 scopus 로고
    • Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting α-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes
    • Kamchonwongpaisan S., Chandra-ngam G., Avery M. A. and Yuthavong Y. (1994) Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting α-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes. J. Clin. Invest. 93, 467-473.
    • (1994) J. Clin. Invest. , vol.93 , pp. 467-473
    • Kamchonwongpaisan, S.1    Chandra-Ngam, G.2    Avery, M.A.3    Yuthavong, Y.4
  • 39
    • 0027771695 scopus 로고
    • Morphologic effects of artemether on Plasmodium falciparum in Aotus trivigatus
    • Kawai S., Kano S. and Suzuki M. (1993) Morphologic effects of artemether on Plasmodium falciparum in Aotus trivigatus. Am. J. Trop. Med. Hyg. 49, 812-818.
    • (1993) Am. J. Trop. Med. Hyg. , vol.49 , pp. 812-818
    • Kawai, S.1    Kano, S.2    Suzuki, M.3
  • 40
    • 0021948029 scopus 로고
    • Qinghaosu (artemisinin): An antimalarial drug from China
    • Klayman D. L. (1985) Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049-1055.
    • (1985) Science , vol.228 , pp. 1049-1055
    • Klayman, D.L.1
  • 41
    • 0001856731 scopus 로고
    • Artemisia Annua: From weed to respectable antimalarial plant
    • American Chemical Society, Washington, D. C.
    • Klayman D. L. (1993) Artemisia Annua: from weed to respectable antimalarial plant. In: Human Medicinal Agents from Plants, pp. 242-255. American Chemical Society, Washington, D. C.
    • (1993) Human Medicinal Agents from Plants , pp. 242-255
    • Klayman, D.L.1
  • 42
    • 0025789734 scopus 로고
    • Transdermal artelinic acid: An effective treatment for Plasmodium berghei-infected mice
    • Klayman D. L., Ager A. L., Jr., Fleckenstein L. and Lin A. J. (1991) Transdermal artelinic acid: an effective treatment for Plasmodium berghei-infected mice. Am. J. Trop. Med. Hyg. 45, 602-607.
    • (1991) Am. J. Trop. Med. Hyg. , vol.45 , pp. 602-607
    • Klayman, D.L.1    Ager A.L., Jr.2    Fleckenstein, L.3    Lin, A.J.4
  • 43
    • 0023622465 scopus 로고
    • The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress
    • Krungkrai S. R. and Yuthavong Y. (1987) The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress. Trans. R. Soc. Trop. Med. Hyg. 81, 710-714.
    • (1987) Trans. R. Soc. Trop. Med. Hyg. , vol.81 , pp. 710-714
    • Krungkrai, S.R.1    Yuthavong, Y.2
  • 44
    • 0025217615 scopus 로고
    • Stage-specific gametocytocidal effect in vitro of the antimalarial drug qinghaosu on Plasmodium falciparum
    • Kumar N. and Zheng H. (1990) Stage-specific gametocytocidal effect in vitro of the antimalarial drug qinghaosu on Plasmodium falciparum. Parasitol. Res. 76, 214-218.
    • (1990) Parasitol. Res. , vol.76 , pp. 214-218
    • Kumar, N.1    Zheng, H.2
  • 45
    • 0025646009 scopus 로고
    • Metabolism of antimalarial sesquiterpene lactones
    • Lee I. S. and Hufford C. D. (1990) Metabolism of antimalarial sesquiterpene lactones. Pharmac. Ther. 48, 345-355.
    • (1990) Pharmac. Ther. , vol.48 , pp. 345-355
    • Lee, I.S.1    Hufford, C.D.2
  • 46
    • 0024392106 scopus 로고
    • Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: Effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii
    • Levander O. A., Ager A. L., Jr., Morris V. C. and May R. G. (1989) Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii. Am. J. Clin. Nutr., 50, 346-352.
    • (1989) Am. J. Clin. Nutr. , vol.50 , pp. 346-352
    • Levander, O.A.1    Ager A.L., Jr.2    Morris, V.C.3    May, R.G.4
  • 48
    • 0023933802 scopus 로고
    • A new sesquiterpene peroxide (yingzhaosu C) and sesquiterpenol (yingzhaosu D) from Artabotrys uncinatus (L.)
    • Lian Z., Zhou W.-S. and Xu X.-X. (1988) A new sesquiterpene peroxide (yingzhaosu C) and sesquiterpenol (yingzhaosu D) from Artabotrys uncinatus (L.) Merr. J. Chem. Soc. Chem. Comm. 523-524.
    • (1988) Merr. J. Chem. Soc. Chem. Comm. , pp. 523-524
    • Lian, Z.1    Zhou, W.-S.2    Xu, X.-X.3
  • 50
    • 0023555532 scopus 로고
    • Antimalarial activity of new water-soluble dihydroartemisinin derivatives
    • Lin A. J., Klayman D. L. and Milhous W. K. (1987) Antimalarial activity of new water-soluble dihydroartemisinin derivatives. J. Med. Chem. 30, 2147-2150.
    • (1987) J. Med. Chem. , vol.30 , pp. 2147-2150
    • Lin, A.J.1    Klayman, D.L.2    Milhous, W.K.3
  • 54
    • 0027164794 scopus 로고
    • In vitro gametocidal activity of artemisinin and its derivatives on Plasmodium falciparum
    • Mehra N. and Bhasin V. K. (1993) In vitro gametocidal activity of artemisinin and its derivatives on Plasmodium falciparum. Jpn. J. Med. Sci. Biol. 46, 37-43.
    • (1993) Jpn. J. Med. Sci. Biol. , vol.46 , pp. 37-43
    • Mehra, N.1    Bhasin, V.K.2
  • 55
    • 0028307003 scopus 로고
    • The mode of action of antimalarial endoperoxides
    • Meshnick S. R. (1994) The mode of action of antimalarial endoperoxides. Trans. R. Soc. Trop. Med. Hyg. 88, Suppl 1, S31-32.
    • (1994) Trans. R. Soc. Trop. Med. Hyg. , vol.88 , Issue.SUPPL. 1
    • Meshnick, S.R.1
  • 56
    • 0026014249 scopus 로고
    • Artemisinin (qinghaosu): The role of intracellular hemin in its mechanism of antimalarial action
    • Meshnick S. R., Thomas A., Ranz A., Xu C.-M. and Pan H.-Z. (1991) Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Mol. Biochem. Parasitol. 49, 181-189.
    • (1991) Mol. Biochem. Parasitol. , vol.49 , pp. 181-189
    • Meshnick, S.R.1    Thomas, A.2    Ranz, A.3    Xu, C.-M.4    Pan, H.-Z.5
  • 59
    • 0028145091 scopus 로고
    • Ferriprotoporphyrin catalyzed decomposition of artemether: Analytical and pharmacological implications
    • Muhia D. K., Thomas C. G., Ward S. A., Edwards G., Mberu E. K. and Watkins W. M. (1994) Ferriprotoporphyrin catalyzed decomposition of artemether: analytical and pharmacological implications. Biochem. Pharmacol. 48, 889-895.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 889-895
    • Muhia, D.K.1    Thomas, C.G.2    Ward, S.A.3    Edwards, G.4    Mberu, E.K.5    Watkins, W.M.6
  • 60
    • 0022884813 scopus 로고
    • The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes
    • Peters W., Li Z.-L., Robinson B. L. and Warhurst D. C. (1986) The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes. Ann. Trop. Med. Parasitol. 80, 483-489.
    • (1986) Ann. Trop. Med. Parasitol. , vol.80 , pp. 483-489
    • Peters, W.1    Li, Z.-L.2    Robinson, B.L.3    Warhurst, D.C.4
  • 61
    • 0026746574 scopus 로고
    • A regiospecifically oxygen-18 labeled 1,2,4-trixoane: A simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu)
    • Posner G. H. and Oh C. H. (1992) A regiospecifically oxygen-18 labeled 1,2,4-trixoane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (Qinghaosu). J. Am. Chem. Soc. 114, 8328-8329.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 8328-8329
    • Posner, G.H.1    Oh, C.H.2
  • 62
    • 0029038225 scopus 로고
    • Evidence for FE(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin
    • In press
    • Posner G. H., Cumming J. N., Ploypradith P. and Oh C. H. (1995) Evidence for FE(IV)=O in the molecular mechanism of action of the trioxane antimalarial artemisinin. J. Am. Chem. Soc. (In press).
    • (1995) J. Am. Chem. Soc.
    • Posner, G.H.1    Cumming, J.N.2    Ploypradith, P.3    Oh, C.H.4
  • 63
    • 0028305219 scopus 로고
    • Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to aremisinin: The importance of carbon-centered radical for antimalarial activity
    • Posner G. H., Oh C. H., Wang D., Gerena L., Milhous W. K., Meshnick S. R., and Asawamahasakda W. (1994) Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to aremisinin: the importance of carbon-centered radical for antimalarial activity. J. Med. Chem. 37, 1256-1258.
    • (1994) J. Med. Chem. , vol.37 , pp. 1256-1258
    • Posner, G.H.1    Oh, C.H.2    Wang, D.3    Gerena, L.4    Milhous, W.K.5    Meshnick, S.R.6    Asawamahasakda, W.7
  • 64
    • 0018612308 scopus 로고
    • Antimalarial studies on qinghaosu
    • Qinghaosu Antimalarial Co-ordinating Research Group (1979) Antimalarial studies on qinghaosu. Chin. Med. J. 92, 811-816.
    • (1979) Chin. Med. J. , vol.92 , pp. 811-816
  • 67
    • 0025060810 scopus 로고
    • Oxidative denaturation of red blood cells in thalassemia
    • Shinar E. and Rachmilewitz E. A. (1990) Oxidative denaturation of red blood cells in thalassemia. Semin. Hematol. 27, 70-82.
    • (1990) Semin. Hematol. , vol.27 , pp. 70-82
    • Shinar, E.1    Rachmilewitz, E.A.2
  • 68
    • 0029112920 scopus 로고    scopus 로고
    • Molecular modeling studies of the artemisinin (qinghaosu) - Hemin interaction: Docking between the antimalarial agent and its putative receptor
    • Shukla K. L., Gund T. M., and Meshnick S. R. Molecular modeling studies of the artemisinin (qinghaosu) - hemin interaction: docking between the antimalarial agent and its putative receptor. J. Molec. Graphics 13, 215-222.
    • J. Molec. Graphics , vol.13 , pp. 215-222
    • Shukla, K.L.1    Gund, T.M.2    Meshnick, S.R.3
  • 70
    • 0028170768 scopus 로고
    • Efficacy of Ro 42-1611 (arteflene) in the treatment of patients with mild malaria: A clinical trial in Cameroon
    • Somo-Moyou R., Mittelholzer M.-L., Sorenson F., Haller L. and Stürchler D. (1994) Efficacy of Ro 42-1611 (arteflene) in the treatment of patients with mild malaria: a clinical trial in Cameroon. Trop. Med. Parasitol. 45, 288-291.
    • (1994) Trop. Med. Parasitol. , vol.45 , pp. 288-291
    • Somo-Moyou, R.1    Mittelholzer, M.-L.2    Sorenson, F.3    Haller, L.4    Stürchler, D.5
  • 71
    • 0027280310 scopus 로고
    • Plasmodium falciparum: In vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria
    • ter Kuile F., White N. J., Holloway P., Pasvol G. and Krishna S. (1993) Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Exp. Parasitol. 76, 85-95.
    • (1993) Exp. Parasitol. , vol.76 , pp. 85-95
    • Ter Kuile, F.1    White, N.J.2    Holloway, P.3    Pasvol, G.4    Krishna, S.5
  • 72
    • 0025689369 scopus 로고
    • Gametocytocidal activity of the antimalarial α/β arteether
    • Tripathi R., Dutta G. P. and Vishwakarma R. A. (1990) Gametocytocidal activity of the antimalarial α/β arteether. Am. J. Trop. Med. Hyg. 43, 571-575.
    • (1990) Am. J. Trop. Med. Hyg. , vol.43 , pp. 571-575
    • Tripathi, R.1    Dutta, G.P.2    Vishwakarma, R.A.3
  • 73
    • 0023777973 scopus 로고
    • Oxidants, oxidant drugs, and malaria
    • Vennerstrom J. L. and Eaton J. W. (1988) Oxidants, oxidant drugs, and malaria. J. Med. Chem. 31, 1269-1277.
    • (1988) J. Med. Chem. , vol.31 , pp. 1269-1277
    • Vennerstrom, J.L.1    Eaton, J.W.2
  • 74
    • 0026487301 scopus 로고
    • The binding of the antimalarial arteether to human plasma proteins in vitro
    • Wanwimolruk S., Edwards G., Ward S. A. and Breckenridge A. M. (1992) The binding of the antimalarial arteether to human plasma proteins in vitro. J. Pharm. Pharmacol. 44, 940-942.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 940-942
    • Wanwimolruk, S.1    Edwards, G.2    Ward, S.A.3    Breckenridge, A.M.4
  • 75
    • 0023546567 scopus 로고
    • Common genetic disorders of the red cell and the "malaria hypothesis"
    • Weatherall D. J. (1987) Common genetic disorders of the red cell and the "malaria hypothesis". Ann. Trop. Med. Parasitol. 81, 539-548.
    • (1987) Ann. Trop. Med. Parasitol. , vol.81 , pp. 539-548
    • Weatherall, D.J.1
  • 76
    • 0027990218 scopus 로고
    • Enhancement of hemin-induced membrane damage by artemisinin
    • Wei N. and Sadrzadeh S. M. (1994) Enhancement of hemin-induced membrane damage by artemisinin. Biochem. Pharmacol. 48, 737-741.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 737-741
    • Wei, N.1    Sadrzadeh, S.M.2
  • 78
    • 0028305816 scopus 로고
    • Artemisinin: Current status
    • White N. J. (1994) Artemisinin: current status. Trans. R. Soc. Trop. Med. Hyg. 88, Suppl 1, S3-4.
    • (1994) Trans. R. Soc. Trop. Med. Hyg. , vol.88 , Issue.SUPPL. 1
    • White, N.J.1
  • 80
    • 0027935551 scopus 로고
    • Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure
    • Yang Y.-Z., Little B. and Meshnick S. R. (1994) Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure. Biochem. Pharmacol. 48, 569-573.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 569-573
    • Yang, Y.-Z.1    Little, B.2    Meshnick, S.R.3
  • 81
    • 0027182356 scopus 로고
    • Alkylation of human albumin by the antimalarial artemisinin
    • Yang Y.-Z., Asawamahasakda W. and Meshnick S. R. (1993) Alkylation of human albumin by the antimalarial artemisinin. Biochem. Pharmacol. 46, 336-339.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 336-339
    • Yang, Y.-Z.1    Asawamahasakda, W.2    Meshnick, S.R.3
  • 82
    • 0027264908 scopus 로고
    • Protection against malaria by thalassemia and haemoglobin variants
    • Yuthavong Y. and Wilairat P. (1993) Protection against malaria by thalassemia and haemoglobin variants. Parasitology Today, 9, 241-245.
    • (1993) Parasitology Today , vol.9 , pp. 241-245
    • Yuthavong, Y.1    Wilairat, P.2
  • 83
    • 0024560090 scopus 로고
    • Decreased sensitivity to artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes
    • Yuthavong Y., Butthep P., Bunyaratvej A. and Fucharoen S. (1989) Decreased sensitivity to artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin Constant Spring erythrocytes. J. Clin. Invest. 83, 502-505.
    • (1989) J. Clin. Invest. , vol.83 , pp. 502-505
    • Yuthavong, Y.1    Butthep, P.2    Bunyaratvej, A.3    Fucharoen, S.4
  • 84
    • 0025223898 scopus 로고
    • Increased susceptibility of malaria-infected variant erythrocytes to mononuclear phagocyte system
    • Yuthavong Y., Bunyaratavej A. and Kamchonwongpaisan S. (1990) Increased susceptibility of malaria-infected variant erythrocytes to mononuclear phagocyte system. Blood Cells 16, 591-597.
    • (1990) Blood Cells , vol.16 , pp. 591-597
    • Yuthavong, Y.1    Bunyaratavej, A.2    Kamchonwongpaisan, S.3
  • 85
    • 0026589410 scopus 로고
    • Hemin-catalyzed decomposition of artemisinin (qinghaosu)
    • Zhang F., Gosser D. K., Jr., and Meshnick S. R. (1992) Hemin-catalyzed decomposition of artemisinin (qinghaosu). Biochem. Pharmacol. 43, 1805-1809.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 1805-1809
    • Zhang, F.1    Gosser D.K., Jr.2    Meshnick, S.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.