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Biochemistry

Volumn 41, Issue 28, 2002, Pages 8849-8859

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors

(6) Wang, Dong a Pechar, Michal a,d Li, Weijie b Kopečková, Pavla a Brömme, Dieter b Kopeček, Jindřich a,c

a UNIVERSITY OF UTAH (United States)

b MOUNT SINAI SCHOOL OF MEDICINE (United States)

c Department of Electrical and Computer Engineering (United States)

d INSTITUTE OF MACROMOLECULAR CHEMISTRY (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOSOMAL COMPARTMENTS;

AMINO ACIDS; AROMATIC COMPOUNDS; BIOASSAY; BONE; COPOLYMERS; DEGRADATION; DISEASES; ENZYME INHIBITION; JOINTS (ANATOMY);

ENZYMES;

1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE; 1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE 1 (N BENZYLOXYCARBONYLLEUCYL) 5 (PHENYLALANYLLEUCYL)CARBOHYDRAZIDE CONJUGATE; 1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE ALPHA METHOXY POLY(ETHYLENE GLYCOL) CONJUGATE; 1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER CONJUGATE; 1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE] CONJUGATE; 1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]GLYCYLGLYCINE CONJUGATE; 1,5 BIS(N BENZYLOXYCARBONYLLEUCYL)CARBOHYDRAZIDE TERT BUTYLOXYCARBONYL CONJUGATE; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; ENZYME INHIBITOR; PAPAIN; UNCLASSIFIED DRUG;

ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CONJUGATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; FIBROBLAST; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; PRIORITY JOURNAL;

CATHEPSINS; CYSTEINE PROTEINASE INHIBITORS; HUMANS; KINETICS; LYSOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; PAPAIN; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

KOBUS; LACUNA;

EID: 0037118691 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi0257080 Document Type: Article

Times cited : (44)

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