Use of X-ray co-crystal structures and molecular modeling to design potent and selective non-peptide inhibitors of cathepsin K [23]

Journal of the American Chemical Society

Volumn 120, Issue 35, 1998, Pages 9114-9115

  DesJarlais, R L ^a   Yamashita, D S ^a   Oh, H J ^a   Uzinskas, I N ^a   Erhard, K F ^a   Allen, A C ^a   Curtis Haltiwanger, R ^a   Zhao, B ^a   Smith, W W ^a   Abdel Meguid, S S ^a   D'Alessio, K ^a   Janson, C A ^a   McQueney, M S ^a   Tomaszek, T A ^a   Levy, M A ^a   Veber, D F ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; CYSTEINE PROTEINASE INHIBITOR;

CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; LETTER; OSTEOCLAST; OSTEOPOROSIS;

EID: 0032500338     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja981171v     Document Type: Letter

References (0)