Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells

British Journal of Haematology

Volumn 114, Issue 3, 2001, Pages 608-615

  Wickremasinghe, R Gitendra ^a   Ganeshaguru, Kanagasabai ^a   Jones, Dylan T ^a   Lindsay, Caroline ^a   Spanswick, Victoria J ^a   Hartley, John A ^a   Wadhwa, Meenu ^b   Thorpe, Robin ^b   Hoffbrand, A Victor ^a   Prentice, H Grant ^a   Mehta, Atul B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Akt; Apoptosis; B chronic lymphocytic leukaemia; Chlorambucil; Drug resistance

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHLORAMBUCIL; DYE; GAMMA INTERFERON; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; PROTEIN KINASE B; PROTEIN P85; RECOMBINANT ALPHA INTERFERON; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLOOD AUTOTRANSFUSION; BLOOD CULTURE; CELL VIABILITY; CENTRIOLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; FEMALE; FETAL CALF SERUM; GAMMA RADIATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHATIC LEUKEMIA; MALE; MORPHOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BLOTTING, WESTERN; CHLORAMBUCIL; CHROMONES; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; INTERLEUKIN-4; LEUKEMIA, B-CELL, CHRONIC; MALE; MORPHOLINES; PLASMA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED;

EID: 0034791463     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02978.x     Document Type: Article

References (33)

1. Development of immunoassays for interleukin 3 and interleukin 4, some of which discriminate between different recombinant DNA-derived molecules
2. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
3. Blood-derived 'nurse-like' cells protect chronic lymphocytic leukemia cells from spontaneous apoptosis in vitro
4. Interferon γ inhibits apoptotic cell death in B cell chronic lymphocytic leukemia
5. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates bcl-2 expression
6. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
7. Interleukin 3-induced phosphorylation of BAD through the protein kinase Akt
8. A comparison of the neutralizing properties of monoclonal and polyclonal antibodies to human interferon α
9. Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay
10. Akt signaling: Linking membrane events to life and death decisions
11. Cytokine receptor signalling
12. Growth factors can protect B chronic lymphocytic leukaemia cells against programmed cell death without stimulating proliferation
13. Specific proteolytic cleavage of poly (ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
14. Chronic lymphocytic leukemia
15. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses
16. Haematopoietic cytokines inhibit apoptosis induced by transforming growth factor β1 and cancer chemotherapy compounds in myeloid leukemia cells
17. Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism
18. Theophylline synergizes with chlorambucil in inducing apoptosis of B chronic lymphocytic leukemia cells
19. Interleukin 4 inhibits apoptotic cell death and loss of bcl-2 protein in B chronic lymphocytic leukemia cells in vitro
20. α interferon protects B chronic lymphocytic leukemia cells from apoptotic cell death in vitro
21. Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukemia cells
22. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-β-D-arabinofuranosyl-2-fluoroadenine
23. PIK3CA is implicated as an oncogene in ovarian cancer
24. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
25. Measurement of drug-induced DNA interstrand cross-linking using the single cell gel electrophresis (comet) assay
26. + B cells and preserve expression of bcl-2
27. Caspases: Enemies within
28. Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay
29. The PI3K-PDK1 connection: More than just a road to PKB
30. Biochemical and genetic control of apoptosis: Relevance to normal hematopoiesis and hematological malignancies
31. The phosphatidylinositol 3′-kinase inhibitor increases chlorambucil- and radiation-induced apoptosis of B-CLL cells
32. L