Novel homodimeric and heterodimeric rat γ-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins

Biochemical Journal

Volumn 366, Issue 3, 2002, Pages 847-861

  Kelly, Vincent P ^a   Sherratt, Philip J ^a   Crouch, Dorothy H ^a   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

2 carboxybenzaldehyde; Aflatoxin B1 aldehyde reductase; Drug metabolism; Succinic semialdehyde

Indexed keywords

AMINO ACIDS; CELLS; CHROMATOGRAPHIC ANALYSIS; CLONING; DATABASE SYSTEMS; DIMERS; POLYPEPTIDES;

GOLGI APPARATUS;

ENZYMES;

4 HYDROXYBUTYRIC ACID; AFLATOXIN B1; ALDEHYDE REDUCTASE; AMINO ACID; ARGININE; BENZALDEHYDE DERIVATIVE; DIMER; GAMMA HYDROXYBUTYRATE SYNTHASE; LIVER EXTRACT; POLYPEPTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINIC SEMIALDEHYDE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CELL SECRETION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DETOXIFICATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBUNIT; FEMALE; GOLGI COMPLEX; HUMAN; IMMUNOCYTOCHEMISTRY; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PURIFICATION; RAT; SEQUENCE HOMOLOGY; SYNTHESIS; WESTERN BLOTTING;

ALCOHOL OXIDOREDUCTASES; ALDEHYDE REDUCTASE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CATALYSIS; CELLS, CULTURED; CHROMATOGRAPHY, ION EXCHANGE; CLONING, MOLECULAR; CYTOSOL; DIMERIZATION; DNA, COMPLEMENTARY; FEMALE; GAMMA-AMINOBUTYRIC ACID; GOLGI APPARATUS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KINETICS; LIVER; MALE; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM OXYBATE; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY;

ANIMALIA; MURINAE;

EID: 0037106619     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020342     Document Type: Article

References (50)

1. Jez, J. M. and Penning, T. M. (2001) The aldo-keto reductase (AKR) superfamily: an update. Chem.-Biol. Interact. 130-132, 499-525
2. 1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem. J. 343, 487-504
3. Penning, T. M., Burczynski, M. E., Hung, C.-F., McCoull, K. D., Palackal, N. T. and Tsuruda, L. S. (1999) Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chem. Res. Toxicol. 12, 1-18
4. Tipton, K. F. and Benedetti, M. S. (2002) Amine oxidases and the metabolism of xenobiotics. In Enzyme Systems that Metabolise Drugs and other Xenobiotics (loamides, C., ed.), pp. 95-146, Wiley, Chichester
5. Rondeau, J.-M., Tête-Favier, F., Podjarny, A., Reymann, J.-M., Barth, P., Biellman, J.-F. and Moras, D. (1992) Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature (London) 355, 469-472
6. Wilson, D. K., Bohren, K. M., Gabbay, K. H. and Quiocho, F. A. (1992) An unlikely sugar substrate site in the 1.65 Å structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science 257, 81-84
7. el-Kabbani, O., Judge, K., Ginell, S. L., Myles, D. A. A., DeLucas, L. J. and Flynn, T. G. (1995) Structure of porcine aldehyde reductase holoenzyme. Nat. Struct. Biol. 2, 687-692
8. Hoog, S. S., Pawlowski, J. E., Alzari, P. M., Penning, T. M. and Lewis, M. (1994) Three-dimensional structure of rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc. Natl. Acad. Sci. U.S.A. 91, 2517-2521
9. Wilson, D. K., Nakano, T., Petrash, J. M. and Quiocho, F. A. (1995) 1.7 Å structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Biochemistry 34, 14323-14330
10. Ye, Q. L., Hyndman, D., Li, X. H., Flynn, T. G. and Jia, Z. C. (2000) Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily. Proteins 38, 41-48
11. + and ursodeoxycholate. Biochemistry 40, 10161-10168.
12. Khurana, S., Powers, D. B., Anderson, S. and Blaber, M. (1998) Crystal structure of 2,5-diketo-D-gluconic acid reductase A complexed with NADPH at 2A-Å resolution. Proc. Natl. Acad. Sci. U.S.A. 95, 6768-6773
13. Hur, E. and Wilson, D. K. (2001) The crystal structure of the GCY1 protein from S-cerevisiae suggests a divergent aldo-keto reductase catalytic mechanism. Chem.-Biol. Interact. 130, 527-536
14. + channels. Science 289, 123-127
15. Bähring, R., Milligan, C. J., Vardanyan, V., Engeland, B., Young, B. A., Dannenberg, J., Waldschütz, R., Edwards, J. P., Wray, D. and Pongs, O. (2001) Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kvβ subunits. J. Biol. Chem. 276, 22923-22929
16. + channel β subunit. Cell 97, 943-952
17. + channels altered by presence of β-subunit. Nature (London) 309, 289-294
18. 1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin. Cancer Res. 53, 3887-3894
19. 1 defines a subfamily of aldo-keto reductases. Proc. Natl. Acad. Sci. U.S.A. 90, 10350-10354
20. Ellis, E. M., Judah, D. J., Neal, G. E., O'Connor, T. and Hayes J. D. (1996) Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors. Cancer Res. 56, 2758-2766
21. Primiano, T., Gastel, J. A., Kensler, T. W. and Sutter, T. R. (1996) Isolation of cDNAs representing dithiolethione-responsive genes. Carcinogenesis 17, 2297-2303
22. 1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer Res. 60, 957-969
23. Kelly, V. P. (1999) Structure and regulation of novel rat members of the aldo-keto reductase superfamily, Ph.D. Thesis, University of Dundee
24. Kelly, V. P., Ireland, L. S., Ellis, E. M. and Hayes, J. D. (2000) Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues. Biochem. J. 348, 389-400
25. Nishi, N., Shoji, H, Miyanaka, H. and Nakamura, T. (2000) Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate. Endocrinology 141, 3194-3199
26. 1 dialdehyde by rat and human aldo-keto reductases. Chem. Res. Toxicol. 14, 727-737
27. 1 aldehyde reductase. Biochem. J. 332, 21-34
28. 1 aldehyde reductase. Eur. J. Biochem. 265, 1056-1060
29. 1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. Carcinogenesis 20, 1215-1223
30. Kozma, E., Brown, E., Ellis, E. M. and Lapthorn, A. J. (2002) The crystal structure of rat liver AKR7A1: a dimeric member of the aldo-keto reductase superfamily. J. Biol. Chem. 277, 16285-16293
31. Ellis, E. M. and Hayes, J. D. (1995) Substrate specificity of an aflatoxin-metabolising aldehyde reductase. Biochem. J. 312, 535-541
32. 1 on cytochrome P450 expression: inhibition of CYP1 mRNA and protein expression in primary rat hepatocytes. Arch. Toxicol. 74, 145-152
33. Leelavathi, D. E., Estes, L. W., Feingold, D. S. and Lombardi, B. (1970) Isolation of a golgi rich fraction from rat liver. Biochem. Biophys. Acta 211, 124-138
34. Celis, J. E. (1998) Cell Biology, 2nd edn, pp. 46-55, Academic Press, San Diego
35. 1-aldehyde reductase gene at 1p35-1 p36.1 in a region frequently altered in human tumor cells. Cancer Res. 58, 5014-5018
36. Tabakoff, B. and von Wartburg, J. P. (1975) Separation of aldehyde reductases and alcohol dehydrogenase from brain by affinity chromatography: metabolism of succinic semialdehyde and ethanol. Biochem. Biophys. Res. Commun. 63, 957-966
37. Rumigny, J. F., Maitre, M., Cash, C. and Mandel, P. (1980) Specific and non-specific succinic semialdehyde reductases from rat brain: isolation and properties. FEDS Lett. 117, 111-116
38. Maitre, M. (1997) The γ-hydroxybutyrate signalling system in brain: organization and functional implications. Progr. Neurobiol. 51, 337-361
39. Bernasconi, R., Mathivet, P., Bischoff, S. and Marescaux, C. (1999) Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential? Trends Pharmacol. Sci. 20, 135-141
40. B receptors in the sedative/hypnotic effect of γ-hydroxybutyric acid. Eur. J. Pharmacol. 428, 315-321
41. Van Cauter, E., Plat, L., Scharf, M. B., Leproult, R., Cespedes, S., L'Hermite-Balériaux, M. and Copinschi, G. (1997) Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J. Clin. Invest. 100, 745-753
42. Vergoni, A. V., Ottani, A., Botticelli, A. R., Zaffe, D., Guano, L., Loche, A., Genedani, S., Gessa, G. L. and Bertolini, A. (2000) Neuroprotective effect of γ-hydroxybutyrate in transient global cerebral ischemia in the rat. Eur. J. Pharmacol. 397, 75-84
43. Gallimberti, L., Ferri, M., Ferrara, S. D., Fadda, F. and Gessa, G. L. (1992) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: a double-blind study. Alcohol. Clin. Exp. Res. 16, 673-676
44. Brankack, J., Lahtinen, H., Koivisto, E. and Riekkinen, P. J. (1993) Epileptogenic spikes and seizures but not high-voltage spindles are induced by local frontal cortical application of gamma-hydroxybutyrate. Epilepsy Res. 15, 91-99
45. Hogema, B. M., Gupta, M., Senephansiri, H., Burlingame, T. G., Taylor, M., Jakobs, C., Schutgens, R. B. H., Froestl, W., Snead, O. C., Diaz-Arrastia, R. et al. (2001) Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Nat. Genet. 29, 212-216
46. Mamelak, M. (1989) Gammahydroxybutyrate: an endogenous regulator of energy metabolism. Neurosci. Biobehav. Rev. 13, 187-198
47. Andriamampandry, C., Siffert, J.-C., Schmitt, M., Garnier, J.-M., Staub, A., Muller C., Gobaille, S., Mark, J. and Maitre. M. (1998) Cloning of a rat-brain succinic semialdehyde reductase involved in the synthesis of the neuromodulator γ-hydroxybutyrate. Biochem. J. 334, 43-50
48. Picklo, Sr, M. J., Olson, S. J., Hayes, J. D., Markesbery, W. R. and Montine, T. J. (2001) Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease. Brain Res. 916, 229-238
49. Nelson, T., Kaufman, E., Kline, J. and Sokoloff, L. (1981) The extraneural distribution of γ-hydroxybutyrate. J. Neurochem 37, 1345-1348
50. Hoffman, P. L., Wermuth, B. and von Wartburg, J.-P. (1980) Human brain aldehyde reductases: relationship to succinic semialdehyde reductase and aldose reductase. J. Neurochem. 35, 354-366