Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease

Brain Research

Volumn 916, Issue 1-2, 2001, Pages 229-238

  Picklo Sr , Matthew J ^a   Olson, Sandra J ^a   Hayes, John D ^b   Markesbery, William R ^c   Montine, Thomas J ^a,d  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aflatoxin aldehyde reductase; Gamma hydroxybutyrate; Gliosis; Lipid peroxidation

Indexed keywords

4 HYDROXYBUTYRATE DEHYDROGENASE; ALDEHYDE REDUCTASE; BRAIN ENZYME; NEUROMELANIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN LEVEL; BRAIN NERVE CELL; CONTROLLED STUDY; ENZYME LOCALIZATION; GLIA CELL; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LEWY BODY; MALE; MESENCEPHALON; MICROGLIA; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA; TISSUE DISTRIBUTION;

AGED; ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; BRAIN; CELL COMPARTMENTATION; CEREBRAL CORTEX; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; HUMANS; HYDROXYBUTYRATE DEHYDROGENASE; IMMUNOHISTOCHEMISTRY; LEWY BODY DISEASE; MALE; MICROGLIA; NEURODEGENERATIVE DISEASES; NEUROGLIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM OXYBATE; UP-REGULATION;

EID: 0035914218     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02897-9     Document Type: Article

References (57)

1. Cloning of a rat brain succinic semialdehyde reductase involved in the synthesis of the neuromodulator gamma-hydroxybutyrate
2. The ROS and Michael-acceptor inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene
3. Protein-bound acrolein: A novel marker of oxidative stress in Alzheimer's disease
4. Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain
5. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases
6. Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors
7. A postmortem study of amino acid neurotransmitters in Alzheimer's disease
8. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde, and related aldehydes
9. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus
10. 4-Hydroxybutyric acid and the clinical phenotype of succinic semialdehyde dehydrogenase deficiency, an inborn error of GABA metabolism
11. 4-Hydroxybutyric aciduria: A new inborn error of metabolism. III. Enzymology and inheritance
12. Inborn errors of GABA metabolism
13. Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin
14. Immunohistochemical studies of the localization of neurons containing the enzyme that synthesizes dopamine, GABA, or gamma-hydroxybutyrate in the rat substantia nigra and striatum
15. Human glutathione transferase A4-4: An alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
16. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: Evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase
17. A nomenclature system for the aldo-keto reductase superfamily
18. Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population
19. 4-Hydroxynonenal increases neuronal susceptibility to oxidative stress
20. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
21. Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues
22. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3
23. Distribution of succinic semialdehyde reductase in rat brain
24. Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease
25. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease
26. Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures
27. Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
28. The gamma-hydroxybutyrate signalling system in brain: Organization and functional implications
29. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
30. Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin
31. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
32. The oxidation of a,b,unsaturated aldehydic products in lipid peroxidation by rat liver aldehyde dehydrogenases
33. 4-Hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease
34. Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype
35. GABA transporters (GAT-1) in Alzheimer's disease
36. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin
37. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members
38. Acrolein inhibits respiration in isolated brain mitochondria
39. Expression and activities of aldo-keto oxidoreductases in Alzheimer's disease
40. High-pressure liquid chromatography quantitation of cytochrome c using 393 nm detection
41. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
42. Cloning and expression of succinic semialdehyde reductase from human brain. Identity with aflatoxin B1 aldehyde reductase
43. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
44. (E)-4-Hydroxynonenal may be involved in the pathogenesis of Parkinson's disease
45. Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase
46. Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease
47. 4-Hydroxynonenal inhibits Na+-K+-ATPase
48. Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-Dihydroxynonene is not the main product
49. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
50. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine
51. Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor
52. 4-Hydroxy-2,3-trans-nonenal induces transcription and expression of aldose reductase
53. Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation-derived aldehyde-4-hydroxynonenal
54. Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase
55. Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart
56. Significance of gamma-hydroxybutyric acid in the brain
57. Biological interactions of a,b-unsaturated aldehydes