Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors

Cancer Research

Volumn 56, Issue 12, 1996, Pages 2758-2766

  Ellis, Elizabeth M ^a   Judah, David J ^b   Neal, Gordon E ^b   O'Connor, Tania ^a   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; AFLATOXIN B1; BUTYLATED HYDROXYANISOLE; CARBONYL REDUCTASE; ETHOXYQUIN; OLTIPRAZ; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME REGULATION; LIVER; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION INITIATION;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; BARBITURATES; BUTYLATED HYDROXYANISOLE; CARCINOGENS; ENZYME INDUCTION; ETHOXYQUIN; LIVER; METHYLCHOLANTHRENE; OXIDATION-REDUCTION; PHENOBARBITAL; PYRAZINES; RATS;

EID: 0029935829     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Wermuth, B Aldo-keto reductases In: T. G. Flynn, H Weiner (eds ). Enzymology of Carbonyl Metabolism, Vol 2 Aldehyde Dehydrogenase, Aldo-Keto Reductase and Alcohol Dehydrogenase, pp 209-230 New York: Alan R Liss, 1985
2. Maser, E. Xenobiotic carbonyl reduction and physiological steroid oxidoreduction: the pluripotency of several hydroxysteroid dehydrogenases. Biochem. Pharmacol., 49, 421-440, 1995.
3. Flynn, T. G. Aldehyde reductases: monomeric NADPH-dependent oxidoreductases with multifunctional potential. Biochem. Pharmacol., 31: 2705-2712, 1982.
4. Iwata, N., Inazu, N., and Satoh, T. The purification and properties of aldose reductase from rat ovary. Arch. Biochem. Biophys., 282, 70-77, 1990.
5. Penning, T. M., Mukharji, I, Barrows, S., and Talalay, P Purification and properties of a 3α-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs. Biochem. J., 222: 601-611, 1984.
6. Smithgall, T. E., Harvey, R G , and Penning, T M. Regio- and stereospecificity of homogeneous 3α-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons. J Biol. Chem., 261:6184-6191, 1986.
7. Wermuth, B. Purification and properties of an NADPH-dependent carbonyl reductase from human brain: relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem., 256: 1206-1213, 1981.
8. Lind, C., Hochstein, P., and Ernster, L. DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation. Arch. Biochem. Biophys., 216: 178-185, 1982.
9. 1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity toward a cytotoxic aldehyde-containing metabolite of the toxin. Cancer Res., 53: 3887-3894, 1993
10. 1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant. Biochem. J., 292: 13-18, 1993.
11. Ellis, E. M., and Hayes, J. D. Substrate specificity of an aflatoxin-metabolizing aldehyde reductase. Biochem. J., 312: 535-541, 1995.
12. 1 defines a sub-family of aldo-keto reductases. Proc Natl. Acad. Sci USA, 90, 10350-10354, 1993.
13. 1 in rats. Cancer Lett., 19, 125-132, 1983
14. 1 in the rat. Toxicol. Appl Pharmacol., 93: 442-451, 1988.
15. Benson, A. B. Oltipraz a laboratory and clinical review. J. Cell. Biochem., 17 (Suppl. F) 278-291, 1993.
16. Anderson, L., Steele, V. K , Kelloff, G. J , and Sharma, S Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver. J. Cell. Biochem., 22 (Suppl ) 108-116, 1995
17. Bachur, N R. Cytoplasmic aldo-keto reductases: a class of drug metabolizing enzymes. Science (Washington DC), 193: 595-597, 1976.
18. Spencer, S. R , Wilczak, C. A., and Talalay, P. Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues Cancer Res., 50: 7871-7875, 1990.
19. Ciaccio, P J., Stuart, J. E , and Tew, K. D. Overproduction of a 37 5-kDa cytosolic protein structurally related to proslaglandin F synthase in ethacrynic acid-resistant human colon cells Mol. Pharmacol., 43: 845-853, 1993.
20. Ciaccio, P. J., Jaiswal, A. K., and Tew, K. D. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics J. Biol Chem , 269 15558-15562, 1994.
21. Hayes, J D , Nguyen, T., Judah, D J., Petersson, D G., and Neal, G. E. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. J. Biol Chem , 269: 20707-20717, 1994.
22. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem , 72: 248-254, 1976.
23. 2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Biochem. J., 264, 437-445, 1989.
24. Laemmli, U K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227 680-685, 1970.
25. Ma, Q., Wang, R , Yang, C S., and Lu, A. Y. H Expression of mammalian DT-diaphorase in Escherichia coli: purification and characterization of the expressed protein Arch. Biochem. Biophys , 283: 311-317, 1990.
26. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem , 162: 156-159, 1987.
27. 1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors. Biochem J., 300 117-124, 1994.
28. Bolton, M G., Muñoz, A., Jacobson, L P , Groopman, J. D., Maxuitenko, Y Y., Roebuck, B. D , and Kensler, T. W. Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis Cancer Res., 55: 3499-3504, 1993.
29. Wattenberg, L W Inhibitors of chemical carcinogens. Adv Cancer Res , 26: 197-226, 1978
30. Kensler, T W., Egner, P. A., Davidson, N E , Roebuck, B D., Pikul, A , and Groopman, J D Modulation of aflatoxin metabolism, aflatoxin-N-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases Cancer Res., 46: 3924-3931, 1986.
31. 1 hepatocarcinogenesis in the rat. Cancer Res , 47 5218-5223, 1987.
32. Talalay, P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. Adv. Enzyme Regul , 28: 237-250, 1989.
33. Presiera, T , Holtzclaw, W. D., Zhang, Y., and Talalay, P Chemical and molecular regulation of enzymes that detoxify carcinogens Proc. Natl. Acad Sci. USA, 90: 2965-2969, 1993.
34. Haves, J. D., and Pulford, D. J., The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol., 30: 445-600, 1995.
35. Skaare, J. U., and Soiheim, E. Studies on the metabolism of the antioxidant ethoxyquin, 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline in the rat. Xenobiotica, 9: 649-657, 1979
36. Kahl, R. Protective and adverse biological actions of phenolic antioxidants In. H Sies (ed.), Oxidative Stress Oxidants and Antioxidants, pp. 245-273. London: Academic Press Ltd, 1991.
37. Esterbauer, H. Lipid peroxidation products: formation chemical properties and biological activities. In: G. Poli, K. H. Cheeseman, M. U Dianzani, and T. F. Slater (eds ), Free Radicals in Liver Injury, pp. 29-47 Oxford, United Kingdom: IRL Press Ltd., 1985.
38. Zollner, H., Schaur, R. J., and Esterbauer, H Biological activity of 4-hydroxyalkenals. In. H. Sies (ed.), Oxidative Stress: Oxidants and Antioxidants, pp. 337-369. London Academic Press Ltd , 1991.
39. Clapper, M. L., Everley, L. C., Strobel, L A., Townsend, A J , and Engstrom, P F. Coordinate induction of glutathione 5-transferase α, μ, and π expression in murine liver after a single administration of oltipraz. Mol Pharmacol, 45: 469-474, 1994.
40. Benson, A M., Batzinger, R P., Ou, S.-Y. L , Bueding, E., Cha, Y-N., Talalay, P. Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants. Cancer Res., 38: 4486-4495, 1978.
41. Favreau, L. V., and Pickett, C. B. Transcriptional regulation of the rat NAD(P)H: quinone reductase gene. J. Biol Chem , 266, 4556-4561, 1991.
42. 1-induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene. Carcinogenesis (Lond ), 7: 1043-1050, 1986.
43. Kensler, T W., Groopman, J D , Eaton, D L., Curphey, T. J , and Roebuck, B. D. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione. Carcinogenesis (Lond.), 13: 95-100, 1992.
44. Wermuth, B., Platts, K. L., Seidel, A., and Oesch, F. Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. Biochem. Pharmacol., 35: 1277-1282, 1986
45. Iwata, N , Inazu, N., and Satoh, T. The purification and properties of NADPH-dependent carbonyl reductases from rat ovary. J. Biochem. (Tokyo), 105: 556-564, 1989.
46. Rumigny, J. F., Maitre, M., Cash, C., and Mandel, P. Specific and non-specific succinic semialdehyde reductases from rat brain: isolation and properties FEBS Lett., 117: 111-116, 1980.
47. Vander Jagt, D. L., Kolb, N S., Vander Jagt, T. J., Chino, J., Martinez, F. J., Hunsaker, L. A., and Royer, R. E. Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate. Biochim Biophys. Acta, 1249: 117-126, 1995.
48. Felsted, R L , Richter, D R., and Bachur, N R. Rat liver aldehyde reductase. Biochem. Pharmacol., 26: 1117-1124, 1977.