Cloning and expression of succinic semialdehyde reductase from human brain. Identity with aflatoxin B1 aldehyde reductase

European Journal of Biochemistry

Volumn 265, Issue 3, 1999, Pages 1056-1060

  Schaller, Micheline ^a   Schaffhauser, Matteo ^a   Sans, Notker ^a   Wermuth, Bendicht ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

hydroxybutyrate; Aldo keto reductase; Detoxification; Neurotransmitter

Indexed keywords

4 HYDROXYBUTYRIC ACID; AFLATOXIN B1; ALDEHYDE REDUCTASE; BENZALDEHYDE; BRAIN ENZYME; CARBONYL DERIVATIVE; COMPLEMENTARY DNA; PHENANTHRENE DERIVATIVE; PHENYLGLYOXAL; QUINONE DERIVATIVE; RECOMBINANT PROTEIN; SUCCINATE SEMIALDEHYDE DEHYDROGENASE; XENOBIOTIC AGENT;

ARTICLE; BRAIN; CONTROLLED STUDY; DETOXIFICATION; ENZYME ANALYSIS; ESCHERICHIA COLI; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALDEHYDE REDUCTASE; AMINO ACID SEQUENCE; BASE SEQUENCE; BRAIN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; HYDROXYBUTYRATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS;

EID: 0033231456     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00826.x     Document Type: Article

References (22)

1. 1. Cash, C.D. (1994) Gamma-hydroxybutyrate: an overview of the pros and cons for it being a neurotransmitter and/or useful therapeutic agent. Neurosci. Biobehav. Rev. 18, 291-304.
2. 2. Tunnicliff, G. (1997) Sites of action of gamma-hydroxybutyrate (GHB): a neuroaetive drug with abuse potential. Clin. Toxicol. 35, 581-590.
3. 3. Jacobs, C., Jaeken, J. & Gibson, K.M. (1993) Inherited disorders of GABA metabolism. J. Inher. Metab. Dis. 16, 704-715.
4. 4. Cash, C.D., Maitre, M. & Mandel, P. (1979) Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyrate. J. Neurochem. 33, 1169-1175.
5. 5. Hoffman, P.L., von Wermuth, B. & Wartburg, J.-P. (1980) Human brain aldehyde reductases: relationship to succinic semialdehyde reductase and aldose reductase. J. Neurochem. 35, 354-366.
6. 6. Bohren, K.M., Bullock, B., Wermuth, B. & Gabbay, K.H. (1989) The aldo-keto reductase superfamily: cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. J. Biol. Chem. 264, 9547-9551.
7. 1-aldehyde reductase. Biochem. J. 332, 21-34.
8. 8. Wermuth, C.G. (1979) A convenient synthesis of γ-ethoxy-γ-butyrolactone and of succinic semialdehyde. J. Org. Chem. 44, 2406-2408.
9. 9. Wermuth, B. & Wartburg, J.-P. (1982) Aldose reductase from human tissues. Methods Enzymol. 89, 181-186.
10. 10. Hurn, B.A.L. & Chantler, S.M. (1980) Production of reagent antibodies. Methods Enzymol. 70, 125-126.
11. 11. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
12. 12. Studier, F.W., Rosenberg, A.H., Dunn, J.J. & Bubendorff, J.W. (1990) Use of T7 polymerase to direct expression of cloned genes. Methods Enzymol. 185, 60-89.
13. 13. Lowry, O.H., Rosebrough, N.J., Farr, A.J. & Randall, R.J. (1951) Protein measurment with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
14. 1 defines a subfamily of aldo-keto reductases. Proc. Natl Acad. Sci. USA 90, 10350-10354.
15. 15. Praml, C., Savelyeva, L., Perri, P. & Schwab, M. (1998) Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-36.1 in a region frequently altered in human tumor cells. Cancer Res. 58, 5014-5018.
16. 16. Tabakoff, B. & Wartburg, J.-P. (1975) Separation of aldehyde reductases and alcohol dehydrogenase from brain by affinity chromatography: metabolism of succinic semialdehyde and ethanol. Biochem. Biophys. Res. Commun. 63, 957-966.
17. m aldehyde reductase and aldose reductase, carbonyl reductase, and succinic semialdehyde reductase. J. Neurochem. 44, 1485-1493.
18. +-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate limiting step in this pathway. Neurochem. Res. 16, 965-974.
19. 19. Nelson, T. & Kaufman, E.E. (1994) Developmental time course in the brain and kidney of two enzymes that oxidize γ-hydroxybutyrate. Dev. Neurosci. 16, 352-358.
20. +-dependent oxidoreductase. J. Biol. Chem. 256, 6890-6894.
21. 21. Schaffhauser, M.A. (1992) Bernsteinsäuresemialdehydreduktase aus Menschenhirn: Vergleichsstudien mit Aldehydreduktase in Bezug auf ihre enzymatischen, immunologischen und kinetischen Eigenschaften. Thesis, Universität Bern.
22. 1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytosolic aldehyde-containing metabolite of the toxin. Cancer Res. 53, 3887-3894.