Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase

Nature Genetics

Volumn 29, Issue 2, 2001, Pages 212-216

  Hogema, Boris M ^a,b,c   Gupta, Maneesh ^a   Senephansiri, Henry ^a   Burlingame, Terry G ^a   Taylor, Melissa ^a   Jakobs, Cornelis ^b   Schutgens, Ruud B H ^b   Froestl, Wolfgang ^d   Snead, O Carter ^e   Diaz Arrastia, Ramon ^f   Bottiglieri, Teodoro ^g   Grompe, Markus ^a   Gibson, K Michael ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d NOVARTIS PHARMA AG   (Switzerland)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^g BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID; PHENOBARBITAL; PHENYTOIN; SUCCINATE SEMIALDEHYDE DEHYDROGENASE; VIGABATRIN;

ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; ENZYME DEFICIENCY; EPILEPTOGENESIS; GENOTYPE; GRAND MAL EPILEPSY; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SURVIVAL; TISSUE DISTRIBUTION;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; ANTICONVULSANTS; BASE SEQUENCE; BRAIN; DNA PRIMERS; GENOTYPE; GLIAL FIBRILLARY ACIDIC PROTEIN; HYDROXYBUTYRATES; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; PHENOBARBITAL; PHENYTOIN; RECEPTORS, GABA-B; SEIZURES; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE;

ANIMALIA; ATAXIA;

EID: 0034795729     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng727     Document Type: Article

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