Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site

Genes and Development

Volumn 16, Issue 18, 2002, Pages 2379-2389

  Henriksen, Melissa A ^a   Betz, Aurel ^a   Fuccillo, Marc V ^a   Darnell Jr , James E ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alternative promoters; Differential splicing; Drosophila melanogaster; STAT92E

Indexed keywords

RNA; STAT PROTEIN; STAT92E PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE OVEREXPRESSION; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WILD TYPE;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CELL LINE; DNA; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; STAT TRANSCRIPTION FACTORS; TRANS-ACTIVATORS;

ANIMALIA; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0037106184     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1020702     Document Type: Article

References (51)

1. The genome sequence of Drosophila melanogaster
2. Basic local alignment search tool
3. Three-dimensional structure of the Stat3β homodimer bound to DNA
4. A Drosophila PIAS homologue negatively regulates stat92E
5. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
6. Ectopic expression in Drosophila
7. The role of STATs in transcriptional control and their impact on cellular function
8. Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters
9. The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila
10. The enhanceosome and transcriptional synergy
11. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
12. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
13. Stats and gene regulation
14. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
15. GAL4 activates transcription in Drosophila
16. IFN-γ induces a p91/Stat1a-related transcription factor with distinct activation and binding properties
17. A nuclear protein tyrosine phosphatase is required for the inactivation of Statl
18. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs
19. The significance of tetramerization in promoter recruitment by Stat5
20. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
21. An analysis of vertebrate mRNA sequences: Intimations of translational control
22. SOCS proteins: Negative regulators of cytokine signaling
23. The downstream promoter element DPE appears to be as widely used as the TATA box in Drosophila core promoters
24. STATs: Transcriptional control and biologic impact
25. Statl depends on transcriptional synergy with Sp1
26. The JAK/STAT pathway and Drosophila development
27. Complementation of a mutant cell line: Central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathways
28. A Drosophila complementary DNA resource
29. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
30. Functional differences between Stat3α and Statβ
31. Two promoters of different strengths control the transcription of the mouse α-amylase gene Amy-1a in the parotid gland and the liver
32. Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon α
33. Modulation of STAT signaling by STAT-interacting proteins
34. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
35. Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
36. How cells respond to interferons
37. Negative regulation of the JAK/STAT pathway
38. Functional interactions between Stat5 and the glucocorticoid receptor
39. Identification of a nuclear Statl protein tyrosine phosphatase
40. Quantitative analysis of gene function in the Drosophila embryo
41. 2-terminal domains stabilizes binding of two dimers to tandem DNA sites
42. Structure of the amino-terminal protein interaction domain of STAT-4
43. Naturally occurring dominant negative variants of Stat5
44. Cooperative DNA binding and sequence selective recognition conferred by the Stat amino terminal domain
45. CCAAT/enhancer binding protein ε is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing
46. A JAK-STAT pathway regulates wing vein formation in Drosophila
47. Identification of a Stat gene that functions in Drosophila development
48. The linker domain of Statl is required for γ interferondriven transcription
49. Specific ablation of STAT3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
50. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling
51. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation