The JAK/STAT pathway and Drosophila development

BioEssays

Volumn 23, Issue 12, 2001, Pages 1138-1147

  Luo, Hong ^a   Dearolf, Charles R ^a,b  

^a TEXAS A AND M UNIVERSITY SYSTEM   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

DNA BINDING PROTEIN; DNA BINDING PROTEINS; DROSOPHILA PROTEIN; GLYCOPROTEIN; HOP PROTEIN; INSECT PROTEIN; PROTEIN TYROSINE KINASE; STAT92E PROTEIN; TRANS ACTIVATORS; TRANSACTIVATOR PROTEIN; UNPAIRED PROTEIN;

ANIMAL; DROSOPHILA; EMBRYOLOGY; EYE; FORELIMB; GENDER AND SEX; GENETICS; LIMB; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EXTREMITIES; EYE; GLYCOPROTEINS; INSECT PROTEINS; PROTEIN-TYROSINE KINASE; SEX DETERMINATION (GENETICS); SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATORS; WING;

EID: 0035542972     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.10016     Document Type: Review

References (69)

1. A protein tyrosine kinase in the interferon alpha/beta signaling pathway
2. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
3. Jaks and Stats in signaling by the cytokine receptor superfamily
4. Cytokine receptor signaling
5. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
6. JAKS and STATS: Biological implications
7. The Jak-Stat pathway in normal and perturbed hematopoiesis
8. Negative regulation of the JAK/STAT pathway
9. SOCS proteins, regulators of intracellular signaling
10. Cooperation of Stat2 and p300/CBP in signaling induced by interferon-alpha
11. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling
12. Functional interactions between Stat5 and the glucocorticoid receptor
13. SH2 signalling in a lower eukaryote: A STAT protein that regulates stalk cell differentiation in Dictyostelium
14. l(1)hopscotch, a larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila
15. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
16. Identification of a stat gene that functions in Drosophila development
17. JAK2, a third member of the JAK family of protein tyrosine kinases
18. JAK protein tyrosine kinases: Their role in cytokine signaling
19. The Drosophila Jak kinase Hopscotch is required for multiple developmental processes in the eye
20. Jak2-Stat5 interactions analyzed in yeast
21. The kinase domain of Jak2 mediates induction of Bcl-2 and delays cell death in hematopoietic cells
22. Interferon-α-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase
23. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
24. Distinct domains of the protein tyrosine kianse tyk2 required for binding of interferon-α/β and for signal transduction
25. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains
26. A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling
27. Regulation of the Jak2 tyrosine kinase by its psedokinase domain
28. The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor βc chain
29. The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals
30. Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1
31. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain
32. The amino termini of FAK and JAKs are divergent members of the band 4.1 family
33. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
34. An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects
35. marrelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs
36. A JAK-STAT pathway regulates wing vein formation in Drosophila
37. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
38. The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family
39. A Drosophila PIAS homologue negatively regulates stat92E
40. Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster
41. Mutations affecting segment number and polarity in Drosophila
42. The molecular genetics of embryonic pattern formation in Drosophila
43. The origin of pattern and polarity in the Drosophila embryo
44. Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
45. The JAK-STAT pathway in Drosophila
46. The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus
47. The circulatory system and associated cells and tissues
48. Fruit fly "leukemia"
49. A genetic melanotic neoplasm of Drosophila melanogaster
50. Transcriptional regulation of the Drosophila-raf proto-oncogene by Drosophila STAT during development and in immune response
51. Serine phosphorylation of STATs
52. Stat5 is essential for the myelo- and lymphoproliferative diseases induced by TEL/JAK2
53. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;120) in a myeloid leukemia
54. A TEL-JAK2 fusion protein with constitutive kianse activity in human leukemia
55. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
56. Stat3 as an oncogene
57. Polarity determination in the Drosophila eye: A novel role for Unpaired and JAK/STAT signaling
58. The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification
59. Four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila
60. Positional information along the dorsal-ventral axis of the Drosophila eye: Graded expression of the four-jointed gene
61. Notch signaling: Cell fate control and signal integration in development
62. Dorsal-ventral signaling in the Drosophila eye
63. Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye
64. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye
65. Dorsoventral patterning in the Drosophila retina by wingless
66. Independent regulation of anterior/posterior and equatorial/polarpolarity in the Drosophila eye: Evidence for the involvement of Wnt signaling in the equatorial/polar axis
67. Planar polarity in the Drosophila eye: A multifaceted view of signaling specificity and cross-talk
68. The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster
69. An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element