Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: Tolerance of a CDR peptide to conformational changes of a target

FEBS Letters

Volumn 525, Issue 1-3, 2002, Pages 77-82

  Tsumoto, Kouhei ^a   Misawa, Satoru ^b   Ohba, Yoichi ^b   Ueno, Takamasa ^b   Hayashi, Hideya ^b   Kasai, Nobuhiro ^a   Watanabe, Hideki ^a   Asano, Ryutaro ^a   Kumagai, Izumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN ENERGY CORPORATION   (Japan)

Author keywords

Antibody; CDR peptide; Circularization; Conformational change; NS3 protease

Indexed keywords

COMPLEMENTARITY DETERMINING REGION PROTEIN H1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 8D4; NONSTRUCTURAL PROTEIN 3; PEPTIDASE; PROTEIN; PROTEIN NS4A; PROTEINASE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ENZYME ACTIVITY; HEPATITIS C VIRUS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEINASE INHIBITION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; COMPLEMENTARITY DETERMINING REGIONS; ENZYME ACTIVATION; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 0037077727     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03090-9     Document Type: Article

References (33)