Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMR

Chemistry and Biology

Volumn 9, Issue 1, 2002, Pages 79-92

  Archer, Sharon J ^a   Camac, Daniel M ^a   Wu, Zhongren J ^a   Farrow, Neil A ^a   Domaille, Peter J ^a   Wasserman, Zelda R ^a   Bukhtiyarova, Marina ^a   Rizzo, Christopher ^a   Jagannathan, Sharada ^a   Mersinger, Lawrence J ^a   Kettner, Charles A ^a,b  

^a DUPONT COMPANY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS C VIRUS;

BORONIC ACID DERIVATIVE; CARRIER PROTEIN; NS3 PROTEIN, HEPATITIS C VIRUS; NS4A COFACTOR PEPTIDE, HEPATITIS C VIRUS; PROTEINASE INHIBITOR; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CHEMISTRY; ENZYMOLOGY; HEPATITIS C VIRUS; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BORONIC ACIDS; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEASE INHIBITORS; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS;

EID: 0036008110     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00096-5     Document Type: Article

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