Engineering steroid 5β-reductase activity into rat liver 3α- hydroxysteroid dehydrogenase

Biochemistry

Volumn 37, Issue 27, 1998, Pages 9695-9703

  Jez, Joseph M ^a,b   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 5BETA ANDROSTANOLONE; MUTANT PROTEIN; STEROID 5BETA REDUCTASE; STEROID HORMONE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SUBSTRATE; GENETIC ENGINEERING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; STEROID METABOLISM;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CATALYSIS; ENZYME ACTIVATION; HYDROGEN-ION CONCENTRATION; LIVER; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; POINT MUTATION; PROTEIN ENGINEERING; RATS; SUBSTRATE SPECIFICITY; TYROSINE;

FELIS CATUS;

EID: 0032493468     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980294p     Document Type: Article

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