Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6·U5 tri-snRNP formation and pre-mRNA splicing

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 1148-1157

  Makarova, Olga V ^a   Makarov, Evgeny M ^a   Liu, Sunbin ^a   Vornlocher, Hans Peter ^b   Lührmann, Reinhard ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Pre mRNA splicing; Retinitis pigmentosa; SnRNP protein function; Spliceosome assembly; U4 U6 U5 tri snRNPs

Indexed keywords

GENE PRODUCT; MESSENGER RNA PRECURSOR; PROTEIN 61K; PROTEIN PRPF31; SMALL NUCLEAR RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; BIOCHEMISTRY; CHROMOSOME 19Q; CLINICAL FEATURE; CONTROLLED STUDY; GENE DISRUPTION; GENE ISOLATION; GENETIC COMPLEMENTATION; GENETIC LINKAGE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PRPF31 GENE; REACTION ANALYSIS; RETINITIS PIGMENTOSA; RNA SPLICING; SEQUENCE HOMOLOGY; SPLICEOSOME; TWO HYBRID SYSTEM;

DNA MUTATIONAL ANALYSIS; EYE PROTEINS; FUNGAL PROTEINS; GENES, DOMINANT; GENETIC COMPLEMENTATION TEST; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; PROTEIN INTERACTION MAPPING; RECOMBINANT FUSION PROTEINS; RETINITIS PIGMENTOSA; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RIBONUCLEOPROTEIN, U5 SMALL NUCLEAR; RNA PRECURSORS; RNA SPLICING; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SPLICEOSOMES; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0036500141     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.1148     Document Type: Article

References (40)

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