Antisense oligonucleotides to the epidermal growth factor receptor

Breast Cancer Research and Treatment

Volumn 53, Issue 1, 1999, Pages 41-50

  Witters, Lois ^a   Kumar, Rakesh ^a,b   Mandal, Mahitosh ^a,b   Bennett, C Frank ^c   Miraglia, Loren ^c   Lipton, Allan ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense; Epidermal growth factor receptor; Human tumor cells; mRNA expression; Oligodeoxynucleotides

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER CELL CULTURE; CELL GROWTH; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG CARCINOMA; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RECEPTOR BLOCKING; RNA ANALYSIS;

BASE SEQUENCE; BLOTTING, NORTHERN; BREAST NEOPLASMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; OVARIAN NEOPLASMS; PRECIPITIN TESTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0033015612     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006127527107     Document Type: Article

References (43)

1. Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, Downward J, Mayes ELV, Whittle N, Waterfield MD, Seeburg PH: Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309: 418-425, 1984
2. Carpenter G, Cohen S: Epidermal growth factor. Ann Rev Biochem 48: 193-216, 1979
3. Guroff G: Growth and Maturation Factors, Vol 1, 1983
4. Rozengurt E: Growth factors, cell proliferation and cancer: an overview. Mol Biol Med 1: 169-181, 1983
5. Cohen S, Carpenter G, King L Jr: Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J Biol Chem 255: 4834-4842, 1980
6. Ushiro H, Cohen S: Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J Biol Chem 255: 8363-8365, 1980
7. Teramoto T, Onda M, Tokunga A, Asano G: Inhibitory effect of anti-epidermal growth factor receptor antibody on a human gastric cancer. Cancer, Supplement 77: 1639-1645, 1996
8. Salomon DS, Brandt R, Ciardiello F, Normanno N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995
9. Kunkel MW, Hook KE, Howard CT, Przybranowski S, Roberts BJ, Elliott WL, Leopold WR: Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs 13: 295-302, 1996
10. 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12: 1397-1403, 1996
11. Harris AL, Nicholson S, Sainsbury JRC, Neal D, Smith K, Farndon JR, Wright C: Epidermal growth factor receptor: a marker of early relapse in breast cancer and tumor stage progression in bladder cancer: interactions with neu. In: Furth M, Greaves M (eds), The Molecular Diagnostics of Human Cancer 7: Cold Spring Harbor, 1989, pp 353-357
12. Sainsbury JRC, Malcolm AJ, Appleton DR, Farndon JR, Harris AL: Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. J Clin Pathol 38: 1225-1228, 1985
13. Neal DE, Marsh C, Bennett MK, Abel PD, Hall RR, Sainsbury JRC, Harris AL: Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumors. Lancet 1: 366-368, 1985
14. Veale D, Ashcroft T, Marsh C, Gibson GJ, Harris AL: Epidermal growth factor receptors in non-small cell lung cancer. Br J Cancer 55: 513-516, 1987
15. Normanno N, Bianco C, Damiano V, de Angelis E, Selvam MP, Grassi M, Magliulo G, Tortora G, Bianco AR, Mendelsohn J, Salomon DS, Ciardiello F: Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. Clin Cancer Res 2: 601-609, 1996
16. Masui H, Kawamoto T, Sato JD, Wolf B, Sato GH, Mendelsohn J: Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 44: 1002-1007, 1984
17. Masui H, Moroyama T, Mendelsohn J: Mechanism of anti-tumor activity in mice for antiepidermal growth factor receptor monoclonal antibodies with different isotypes. Cancer Res 46: 5592-5598, 1986
18. Yoneda T, Lyall RM, Alsina MM, Persons PE, Spada AP, Levitzki A, Zilberstein A, Mundy GR: The anti-proliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res 51: 4430-4435, 1991
19. Agrawal SA: Antisense oligonucleotides as antiviral agents. Trends Biotechnol 10: 152-158, 1992
20. Wagner RA: Gene inhibition using antisense oligodeoxynucleotides. Nature 372: 333-335, 1994
21. Stein CA, Cheng YC: Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261: 1004-1012, 1993
22. Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LEH: Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA 93: 4851-4856, 1996
23. Dean N, McKay R, Miraglia L, Howard R, Cooper S, Giddings J, Nicklin P, Meister L, Ziel R, Geiger T, Muller M, Fabbro D: Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Res 56: 3499-3507, 1996
24. Mirabelli CK, Crooke ST: Antisense olignucleotides in the context of modern molecular drug discovery and development. In: Crooke ST, LeBleu B (eds), Antisense Research and Applications. CRC Press Inc, Boca Raton, 1993, pp 7-35
25. Dolnick BJ: Antisense agents in cancer research and therapeutics. Cancer Invest 9: 185-194 1991
26. Crooke ST: Therapeutic Applications of Oligonucleotides. RG Landes Co, Austin, TX, 1995, pp 11-38
27. Neckers L, Whitesell L, Rosolen A, Geselowitz DA: Antisense inhibition of oncogene expression. Crit Rev Oncol 3: 175-231, 1992
28. Bertram J, Killian M, Brysch W, Schlingensiepen KH, Kneba M: Reduction of erbB2 gene product in mamma carcinoma cell lines by erbB2 mRNA-specific and tyrosine kinase consensus phosphorothioate antisense oligonucleotides. Biochem Biophys Res Comm 200: 661-667, 1994
29. Akino K, Ohtsuru A, Yano H, Ozeki S, Namba H, Nakashima M, Ito M, Matsumoto T, Yamashita S: Antisense inhibition of parathyroid hormone-related peptide gene expression reduces malignant pituitary tumor progression and metastases in the rat. Cancer Res 56: 77-86, 1996
30. Cerutti J, Trapasso F, Battaglia C, Shang L, Martelli ML, Visconti R, Berlingieri MT, Fagin JA, Santoro M, Fusco A: Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines. Clin Cancer Res 2: 119-126, 1996
31. Monia BP, Johnston JF, Geiger T, Muller M, Fabbro D: Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nature Med 2: 668-675, 1996
32. Chiang M-Y, Chan H, Zounes MA, Freier SM, Lima WF, Bennett CF: Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem 266: 18162-18171, 1991
33. Bennett CF, Chiang M-Y, Chan H, Shoemaker JEE, Mirabelli CK: Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol 41: 1023-1033, 1992
34. Dean NM, McKay R, Condon TP, Bennett CF: Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1(ICAM-1) mRNA by phorbol esters. J Biol Chem 269: 16416-16424, 1994
35. Dean NM, McKay R: Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc Natl Acad Sci USA 91: 11762-11766, 1994
36. Kumar R, Atlas I: Interferon-α induces the expression of retinoblastoma gene product in human Burkitt's lymphoma Daudi cells: role in growth regulation. Proc Natl Acad Sci USA 89: 6599-6603, 1992
37. Korutla L, Cheung JY, Mendelsohn J, Kumar R: Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 16: 1741-1745, 1995
38. Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook PD, Freier SM: Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem 268: 14514-14522, 1993
39. Coulson JM, Poyner DR, Chantry A, Irwin WJ, Akhtar S: A nonantisense sequence-selective effect of a phosphorothioate oligodeoxynucleotide directed against the epidermal growth factor receptor in A431 cells. Mol Pharmacol 50: 314-325, 1996
40. Bennett CF, Condon TP, Grimm S, Chan H, Chiang MY: Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J Immun 152: 3530-3540, 1994
41. Wang S, Lee RJ, Cauchon G, Gorenstein DG, Lowl PS: Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci USA 92: 3318-3322, 1995
42. Krieg AM, Yi AK, Maison S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM: CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-549, 1995
43. 1 arrest in prostatic cancer cell line DU145. Cancer Res 56: 3666-3669, 1996